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Volume 12, Issue 7
Displaying 1-22 of 22 articles from this issue
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Hiroshi Hikino, Yasuko Hikino, Itiro Yosioka1964 Volume 12 Issue 7 Pages 755-760
Published: July 25, 1964
Released on J-STAGE: March 31, 2008
JOURNAL FREE ACCESSAtractylon, the sesquiterpenoid oxide isolated from the rhizomes of Atractylodes japonica and its related plants (Compositae), has been proven to have constitution I on the basis of spectral properties and its conversion into 8, 12-oxido-eudesmane. Autoxidation of atractylon has given two crystalline compounds, the autoxidation product A and B, which have been established as shown in formulae (IV and V), respectively, from the degradative and spectral evidence.View full abstractDownload PDF (868K) -
Motosuke Kikutani, Kazuko Hirose1964 Volume 12 Issue 7 Pages 760-764
Published: July 25, 1964
Released on J-STAGE: March 31, 2008
JOURNAL FREE ACCESS1. The fraction CS-5, extracted and isolated from bovine Harderian gland as the protein component increasing the serum alkaline phosphatase activity of rabbit was further purified by column chromatography using DEAE-cellulose. Resultant fraction CS-5d had almost activity that increases the serum alkaline phosphatase activity contained initially in CS-5, and was affirmed to be almost homogeneous protein through ultracentrifugal and electrophoretic analyses. 2. The sedimentation constant of CS-5d was 2.26×10-13. 3. The isoelectric point of CS-5d was found to be between pH 4.7 and 4.8. 4. The molecular weight of CS-5d was estimated as be 27, 000 by the Archibald's method.View full abstractDownload PDF (727K) -
Hisao Tsukamoto, Seisuke Terada1964 Volume 12 Issue 7 Pages 765-769
Published: July 25, 1964
Released on J-STAGE: March 31, 2008
JOURNAL FREE ACCESSMetabolism of various alkyl p-hydroxybenzoates was investigated in rabbits using oral dose levels of 0.4 and 0.8 g./kg., and compared with than of p-hydroxybenzoic acid, which is a major metabolite of their esters. Metabolism of the esters was very rapid and excretion of the free p-hydroxybenzoic acid in the urine after administration was much less than that of p-hydroxybenzoic acid but output of the acid conjugated with glycine and glucuronic acid was much larger. When various alkyl esters were administered, those were converted into the free acid (25∼39%), glycine conjugate (15∼29%), ester-type glucuronide (5∼8%), ether-type glucuronide (10∼18%), and the sulfate (7∼12%) during 24 hours.View full abstractDownload PDF (655K) -
Toshiro Murata, Shoko Eto, Kiyomi Yamatsu, Kuniko Sugiura1964 Volume 12 Issue 7 Pages 770-773
Published: July 25, 1964
Released on J-STAGE: March 31, 2008
JOURNAL FREE ACCESSFor the estimation of urinary creatinine, DNSK-reagent was used and the estimation was satisfactorily carried out under the conditions as follows ; 1) Sample urine is prepared by diluting with water to contain 10∼80γ per ml. of creatinine. 2) To 4 ml. of sample urine, each 0.5 ml. of 2% DNSK-reagent and 5% KOH solution is added, and after 25 minutes the color developed is estimated at 530 mμ.View full abstractDownload PDF (464K) -
Yuichi Kanaoka, Osamu Yonemitsu, Kazutaka Tanizawa, Yoshio Ban1964 Volume 12 Issue 7 Pages 773-778
Published: July 25, 1964
Released on J-STAGE: March 31, 2008
JOURNAL FREE ACCESSPolyphosphate ester (PPE, or ethyl metaphosphate) was proposed as a synthetic reagent in Phillips' benzimidazole synthesis. By the use of PPE, 2-substituted benzimidazoles were prepared in very mild conditions. Literatures on the polyphosphate ester were briefly reviewed and its constitution was discussed.View full abstractDownload PDF (691K) -
Ken'ichi Takeda, Tameto Okanishi, Hitoshi Minato, Ariyoshi Shimaoka1964 Volume 12 Issue 7 Pages 779-783
Published: July 25, 1964
Released on J-STAGE: March 31, 2008
JOURNAL FREE ACCESSThe steroidal constituents of Hosta montana F.MAEKAWA var. liluflora F. MAEKAWA was investigated, and seven sapogenins were isolated. These sapogenins were tigogenin (Ia), hecogenin (IIa), 9-dehydrohecogenin (IIIa), gitogenin (IVa), neogitogenin (Va), manogenin (VIa) and 9-dehydromanogenin (VIIa).View full abstractDownload PDF (609K) -
Shiro Takahashi, Hideo Kano1964 Volume 12 Issue 7 Pages 783-788
Published: July 25, 1964
Released on J-STAGE: March 31, 2008
JOURNAL FREE ACCESSThe reactivity of 1-methylbenzimidazole 3-oxide (I), which is a five-membered heteroaromatic N-oxide, was investigated. Deoxygenation with phosphorus trichloride, reactions with acetic anhydride and some anionide reagents, and the Reissert reaction were examined. Normal products were obtained in all cases, a result which can be expected from the reactions of the six-membered N-oxide. I reacted with methyl cyanoacetate to give methyl α-cyano-1-methyl-2-benzimidazoleacetate. I and 1-methoxybenzimidazole reacted with methyl iodide to give 1-methyl-3-methoxybenzimidazolium iodide in both cases. In solution, I is liable to rearrange to 1-methyl-2-benzimidazolinone and pyrolysis of I gave 1, 1'-dimethyl-2, 2'-bibenzimidazole 3-oxide and 1, 1'-dimethyl-2, 2'-bibenzimidazole.View full abstractDownload PDF (705K) -
Yasuo Makisumi1964 Volume 12 Issue 7 Pages 789-796
Published: July 25, 1964
Released on J-STAGE: March 31, 2008
JOURNAL FREE ACCESSThe thermal rearrangement of allyl, methallyl, and crotyl ethers (Ia, Ib, and Ic) of 2-methyl-4-quinolinol was investigated and the ortho-Claisen rearrangement products (IIa, IIb, and IIc) with the inversion of the migrating group and their consecutive intramolecular cyclization products, the 2, 3-dihydro [3, 2-c] quinoline derivatives (IIIa, IIIb, and IIIc) were obtained. No detectable amounts of the 1-allyl-2-methyl-4(1H)-quinolones resulting from the alkyl rearrangement were formed. The different results between the thermal rearrangement of the allyl 2-methyl-4-quinolyl ethers and that of the 7-allyloxy-s-triazolo [1, 5-α] pyrimidines were discussed.View full abstractDownload PDF (945K) -
Kenya Kawashima, Koji Nakanishi, Hidejiro Nishikawa1964 Volume 12 Issue 7 Pages 796-803
Published: July 25, 1964
Released on J-STAGE: March 31, 2008
JOURNAL FREE ACCESSThe structure of tauranin, a metabolic pigment from Oospora aurantia, has been established as shown by I. The relations of the three C16-acids derived from ambrein, sclareol, and manool have been clarified.View full abstractDownload PDF (885K) -
Akira Takamizawa, Kentaro Hirai1964 Volume 12 Issue 7 Pages 804-808
Published: July 25, 1964
Released on J-STAGE: March 31, 2008
JOURNAL FREE ACCESSEthyl 2-methoxymethylene-3-ethoxypropionate (III) undergoes condensation with urea, and N-substituted urea in ethanol solution in the presence of hydrochloric acid. With urea, III gave ethyl 2-oxo-1, 2, 3, 4-tetrahydro-5-pyrimidinecarboxylate (V), with N-methyl-urea a mixture of ethyl 2-oxo-methyl-1, 2, 3, 4-tetrahydro-5-pyrimidinecarboxylate (XIII) and its isomeric 1-methyl compound (XIV), which was separated into each isomer, and with N-phenylurea the 1-phenyl compound (XV) was exclusively obtained. Conversion into pyrimidines was achieved by dehyrogenation and subsequent chlorination of V.View full abstractDownload PDF (663K) -
Terumi Aoki, Hiroko Yamamura, Kyoko Takei, Hiromu Mori1964 Volume 12 Issue 7 Pages 808-812
Published: July 25, 1964
Released on J-STAGE: March 31, 2008
JOURNAL FREE ACCESSSome 16-oxygenated androst-5-ene steroids, which are all steroid metabolites, were prepared from 3β-acetoxy-5α, 6β-dichloroandrostan-17-one.View full abstractDownload PDF (693K) -
Issei Iwai, Tetsuo Hiraoka1964 Volume 12 Issue 7 Pages 813-820
Published: July 25, 1964
Released on J-STAGE: March 31, 2008
JOURNAL FREE ACCESSIntramolecular cyclization of propargylammonium halide derivatives was carried out giving methylated heterocyclic aromatic compounds with fused thiazole and imidazole nuclei. Some of these reactions were accompanied by rearrangement which might be caused by ring opening of the quaternary heterocyclic compounds.View full abstractDownload PDF (944K) -
Akira Ogiso, Issei Iwai1964 Volume 12 Issue 7 Pages 820-824
Published: July 25, 1964
Released on J-STAGE: March 31, 2008
JOURNAL FREE ACCESSThe tetracyclic anisole compound (I) was converted into the N-acetyl carboxylic ester (XII). The infrared spectrum of the latter was coincided with that of a degradation product of atisine and veatchine.View full abstractDownload PDF (703K) -
Kazukichi Kato1964 Volume 12 Issue 7 Pages 824-827
Published: July 25, 1964
Released on J-STAGE: March 31, 2008
JOURNAL FREE ACCESSA method for the colorimetric determination of allylestrenol with anhydrous aluminum chloride and anisaldehyde is proposed. The procedure for the determination of ethylestrenol has been considerably modified for application to this steroid which has another double bond in the side chain. This fact is consistent with the previous observation that a double bond in the steroidal molecule may be a fundamental factor for the coloration.View full abstractDownload PDF (494K) -
Tyunosin Ukita, Ryoya Funakoshi, Yuji Hirose1964 Volume 12 Issue 7 Pages 828-835
Published: July 25, 1964
Released on J-STAGE: March 31, 2008
JOURNAL FREE ACCESSOn condensation of chloromercuri-salt of 2-pyridinol and 2, 3, 5-tri-O-benzoylribofuranosyl chloride, 2-O-(2, 3, 5-tri-O-benzoylribofuranosyl)-pyridine (VII) was obtained, the ribosyl group of which migrated to furnish N1-(2, 3, 5-tri-O-benzoylribofuranosyl)-2-(1H)-pyridone (VIII) on treatment with mercuric bromide. 1-β-D-Ribofuranosyl-2(1H)-pyridone (III) obtained from VIII by alkaline hydrolysis and two other nucleosides, 1-β-D-ribofuranosyl-2(1H)-pyrimidinone (I) and -6(1H)-pyrimidinone (II) were converted to respective 5'-trityl-3'-cyanoethylphosphates, (Ic), (IIc) and (IIIc), and the property of these nucleotides as substrates of bovine pancreatic ribonuclease was investigated. The result was that Ic revealed about three fourth activity as substrate of the enzyme compared with 5'-trityl-3'-cyanoethylphosphate of uridine (IVc), but IIc and IIIc were much less active than Ic. The relation between structure of base group of these nucleotides and their properties as substrate of RNase-A was discussed.View full abstractDownload PDF (1022K) -
Toshio Nambara, Kohichi Hirai1964 Volume 12 Issue 7 Pages 836-840
Published: July 25, 1964
Released on J-STAGE: March 31, 2008
JOURNAL FREE ACCESSEpoxidation and catalytic hydrogenation of the 16-double bond of 5α, 14β-androst-16-ene were examined. It was concluded that in the C/D cis-14β-steroid, the reagents could attack the less hindered β-side of the molecule, presumably because of the cage-like structure of C/D-ring juncture.View full abstractDownload PDF (684K) -
Masakazu Aritomi1964 Volume 12 Issue 7 Pages 841-843
Published: July 25, 1964
Released on J-STAGE: March 31, 2008
JOURNAL FREE ACCESSA flavonid glycoside (I), C21H20O11·3H2O, m.p. 243∼244°(decomp.), was isolated in pure form from the leaves of Acer cissifolium K.KOCH, and identified as luteolin 4'-β-D-glucoside, first isolated by Horhammer, et al.5) from Spartium junceum L. (Leguminosae).View full abstractDownload PDF (485K) -
Takashi Seki, Tomio Segawa1964 Volume 12 Issue 7 Pages 843-845
Published: July 25, 1964
Released on J-STAGE: March 31, 2008
JOURNAL FREE ACCESSThe hypnotic effects of some imidazolidinone derivatives were examined and the results suggested us that the most potent activity was obtained when carbon number is four in alkyloxy or is five in alkenyloxy group.View full abstractDownload PDF (625K) -
Masayuki Nakagaki, Naofumi Koga, Shuzo Iwata1964 Volume 12 Issue 7 Pages 848-850
Published: July 25, 1964
Released on J-STAGE: March 31, 2008
JOURNAL FREE ACCESSDownload PDF (439K) -
Saburo Mizutani, Terumi Nakajima, Akiko Matsumoto, Zenzo Tamura1964 Volume 12 Issue 7 Pages 850-853
Published: July 25, 1964
Released on J-STAGE: March 31, 2008
JOURNAL FREE ACCESSDownload PDF (489K) -
Masaru Tada, Yasuji Yamada, Norman S. Bhacca, Koji Nakanishi, Mamoru O ...1964 Volume 12 Issue 7 Pages 853-855
Published: July 25, 1964
Released on J-STAGE: March 31, 2008
JOURNAL FREE ACCESSDownload PDF (443K) -
Koji Nakanishi, Masaru Tada, Yasuji Yamada1964 Volume 12 Issue 7 Pages 856-857
Published: July 25, 1964
Released on J-STAGE: March 31, 2008
JOURNAL FREE ACCESSDownload PDF (323K)
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