巻号一覧
15 巻, 6 号
選択された号の論文の30件中1～30を表示しています
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高見沢 映, 平井 健太郎, 石破 暉之, 松本 至博1967 年 15 巻 6 号 p. 731-739
発行日: 1967/06/25
公開日: 2008/03/31
ジャーナル フリーEthyl 2-thio-1, 2, 3, 4-tetrahydropyrimidine-5-carboxylate (VIII) and 2-thio-1, 2, 3, 4-tetrahydropyrimidine-5-carbonitrile (XXIII) were used for various kinds of condensation reactions. From the reaction with ethylene dibromide, VIII gave biscompound IX, and with phenacyl-bromide and p-chlorophenacylbromide thiazolo [3, 2-a] pyrimidine derivatives were obtained. In this reaction, 5H-thiazolo [3, 2-a] pyrimidine derivative (XIII, XVII, XXV) and the 7H-isomer (XIV, XVIII, XXVI) were obtained separately. The structures of these isomers were assigned from NMR and UV spectra. In this thiazolo [3, 2-a] pyrimidine syntheses, 3-hydroxy compounds (XII, XVI, XXIV) were considered to be the key intermediates.抄録全体を表示PDF形式でダウンロード (1047K) -
三浦 喜温1967 年 15 巻 6 号 p. 740-751
発行日: 1967/06/25
公開日: 2008/03/31
ジャーナル フリーThe evaluations of the concentration distributions necessary for predicting the extents of chemical reaction and mass transfer and the length of the apparatus required for obtaining the desired completions of the chemical reaction and mass transfer are permitted by a general theoretical treatment, taken into consideration the effect of longitudinal dispersion of both fluids for two-phase continuous-flow systems accompanying general second order chemical reaction, mass transfer and longitudinal dispersion. The general solutions for the concentration distributions were numerically obtained by a digital computer. The effects of stage number in the finite difference equation, chemical reaction rate and residence time on the concentration distribution were shown by numerical calculations through Equations (11) to (13). The influence of chemical reaction rate on the concentration distribution is less as the resistance to mass transfer in phase with chemical reaction is less than that in the other phase without chemical reaction and for example, the reaction rate or the mass transfer rate in the phase with chemical reaction is higher. The concentration distribution can be estimated analytically in the case where the resistance to mass transfer in the phase without chemical reaction is controlling or the degree of longitudinal dispersion is very high.抄録全体を表示PDF形式でダウンロード (1058K) -
山本 晴彦, 野田 国男, 堀口 浩幸, 管 孝男1967 年 15 巻 6 号 p. 752-755
発行日: 1967/06/25
公開日: 2008/03/31
ジャーナル フリーThe stereoselective hydrogenation of three xylene isomers to yield cis- and trans-dimethylcyclohexane has been investigated on eight kinds of transition metal catalysts by the gas chromatographic pulse technique. The selectivity for the formation of trans-dimethylcyclohexane was found to be of the following sequence with respect to the hydrogenation of o-, m- and p-xylene. [chemicalformula] It was pointed out that the selectivity sequence parallels with the ability of the transition metals to form π-allylic complexes in the case of the hydrogenation of o- and p-xylene and that the remarkable suppression of transformation, as found in the case of m-xylene, is due to the steric hindrance rather than the poor ability of the transition metals to form an adsorbed π-allylic adsorbed intermediate on the surface.抄録全体を表示PDF形式でダウンロード (544K) -
西川 正夫, 神谷 和秀, 小林 栄, 森田 桂, 冨家 勇次郎1967 年 15 巻 6 号 p. 756-760
発行日: 1967/06/25
公開日: 2008/03/31
ジャーナル フリーThe chemical and stereochemical structure of lenthionine has been established by the X-ray method. Lenthionine crystallizes in the monoclinic system, space group P21/a-C52h, with four molecules of S5 (CH2)2 in the unit cell. Using a three-dimensional Patterson function and minimum functions, all atomic positions were determined. The least squares method was adopted to distinguish CH2 groups from sulfur by the temperature factors. Thus the three-dimensional molecular geometry has been elucidated to be in a chair form, having C2 pseudo-symmetry.抄録全体を表示PDF形式でダウンロード (617K) -
塩谷 俊作, 三橋 監物1967 年 15 巻 6 号 p. 761-767
発行日: 1967/06/25
公開日: 2008/03/31
ジャーナル フリー3-Oxo-1, 2, 3, 4-tetrahydro-1-naphthoic acid obtained by reduction of 3-methoxy-1-naphthoic acid with sodium amalgam was condensed with N-methyl-N-acetylhydrazine to give the corresponding hydrazone (VIII). VIII was submitted to catalytic reduction over Adams catalyst, methylation with formic acid-formalin, hydrolysis with hydrochloric acid, esterification with methanol and intramolecular cyclization to afford 3, 4-dimethyl-3, 4, 5, 6-tetrahydro-1, 5-methanobenzo [e][1, 2] diazocin-2(1H)-one(XII). Treatment of XII with lithium aluminum hydride gave an abnormally cleft product, 4-methyl-5, 6-dihydro-1H, 4H-1.5-methanobenzo [e][1, 2] diazocine (XVII). XVII was reduced with lithium aluminum hydrode to give 4-methyl-1, 2, 3, 4, 5, 6-hexahydro-1, 5-methanobenzo-[e][1, 2] diazocine (XVIII). Structures of XII, XVII and XVIII were confirmed by chemical as well as spectral methods.抄録全体を表示PDF形式でダウンロード (674K) -
上尾 庄次郎, 入江 寛, 原田 紘1967 年 15 巻 6 号 p. 768-770
発行日: 1967/06/25
公開日: 2008/03/31
ジャーナル フリーA new alkaloid, stenine, has been isolated from the roots of Stemona tuberosa and its structure established as represented by formula II.抄録全体を表示PDF形式でダウンロード (460K) -
桜井 欽夫, 岩口 孝雄1967 年 15 巻 6 号 p. 771-773
発行日: 1967/06/25
公開日: 2008/03/31
ジャーナル フリーLipid content of the ascites tumors and host liver differed much from each other. The ratios of saturated acids to the unsaturated in the neutral lipid fraction of the tumors and the liver were always less than 1. On the contrary, the similar ratios in the phospholipid fraction of the tumors were more than 1 without exception, while that of the liver were less than 1 as in the case of neutral lipid fraction.抄録全体を表示PDF形式でダウンロード (450K) -
関屋 実, 原 明, 伊藤 敬一, 鈴木 次郎, 田中 康三1967 年 15 巻 6 号 p. 774-785
発行日: 1967/06/25
公開日: 2008/03/31
ジャーナル フリーCatalytic hydrogenations of both series of the compounds, N-arylmethylene-1-acylamino-1-arylmethylamines and hydroamides, over Raney nickel catalyst were examined under both conditions, in the presence of formamide and in the absence of it. While under the latter condition either of the hydrogenations proceeded to give secondary amine at least as one of the principal reduction products, under the former condition resulted in the predominant formation of N-formylated priomary amine. In correlation with the previously reported azomethine-formamide hydrogenation the reaction paths for the hydrogenations influenced by formamide were revealed to be of involving intermediates, azomethine, aldimine, and N-arylmethylene-1-formamido-1-arylmethylamine (in the case with hydroamides).抄録全体を表示PDF形式でダウンロード (1443K) -
井上 博之, 奥田 拓男, 平田 康文, 永倉 直敬, 吉崎 正雄1967 年 15 巻 6 号 p. 786-792
発行日: 1967/06/25
公開日: 2008/03/31
ジャーナル フリーCatalpalactone, C15H14O4, a new type of phthalide derivative has been isolated from the wood of Catalpa ovata G.DON and C.bignonioides WALT, and its structure has been determined to be represented by the formula (I).抄録全体を表示PDF形式でダウンロード (868K) -
高橋 誠, 田辺 了資1967 年 15 巻 6 号 p. 793-796
発行日: 1967/06/25
公開日: 2008/03/31
ジャーナル フリーIn Fortsetzung der Versuche 1, 2)zur Ableitung von Derivaten des Octahydroindolochinolizins aus dem entsprechenden Chinolin haben wir trans-9-Methyl-1, 2, 3, 4, 6, 7, 12, 12b-octahydroindolo [2, 3-a]chinolizin (VIII) aus 4-Chlor-6-methylchinolin-1-oxyd hergestellt.抄録全体を表示PDF形式でダウンロード (513K) -
津田 喜典, 礒部 公明1967 年 15 巻 6 号 p. 797-801
発行日: 1967/06/25
公開日: 2008/03/31
ジャーナル フリーThe structures of the diol and the conjugated ketone obtained from the osmium tetroxide oxidation of hopa-15, 17(21)-dienes (I) were now revised and correctly assigned as IV and V, respectively, the former being obtained by lithium aluminum hydride decomposition and the latter by hydrogen sulfide decomposition of the intermediate osmate. Hop-17(21)-ene (VI) was also found to give the seco-diketone (VIII) in lesser yield. A probable mechanism for the formation of the seco-diketones was also discussed.抄録全体を表示PDF形式でダウンロード (620K) -
関屋 実, 伊藤 敬一, 原 明, 鈴木 次郎1967 年 15 巻 6 号 p. 802-815
発行日: 1967/06/25
公開日: 2008/03/31
ジャーナル フリーThermal reactions of the representative azomethines of N-benzylidene type with the reagents, trimethylammonium formate given by 5HCO-2H·2N (CH3)3, ammonium formate and formamide, were examined in order to elucidate distinctions among them. The reduction and oxidation coureses as to the formate reaction and the formamide reaction were definitely distinguished from each other ; in the former reaction saturation of the azomethine double bond is induced by ixidation of formic acid to carbon dioxide and in the latter reaction reductive cleavage at the double bond, induced by self-oxidation of the azomethine, leads to the formation of the cleaved N-formylated primary amines. Elucidation on the mechanistic paths as to both of the essential reactions was investigated. Particularly, the pathways of the very complicated formamide reaction were declared to be of involving aldimine, hydroamide, N-arylmethylene-1-formamido-1-arylmethylamine and N, N'-arylmethylenebisformamide as major or minor intermediates.抄録全体を表示PDF形式でダウンロード (1541K) -
高見沢 映, 平井 健太郎, 浜島 好男, 伊藤 寿子1967 年 15 巻 6 号 p. 816-821
発行日: 1967/06/25
公開日: 2008/03/31
ジャーナル フリーThe reaction of phosgene with thiamine chloride (IIa) or nitrate (IIb) gave O-chlorocar-bonylthiamine (IX) in good yield. Treatment of IX with alkali afforded N-[1-(2-oxo-1, 3-oxathian-4-ylidene) ethyl]-N-[(2-methyl-4-amino-5-pyrimidinyl) methyl] formamide (XIII). The reaction of thiamine sodium salt (III) with aryloxycarbonyl chloride (phenoxy-, p-methyl-phenoxy, p-methoxyphenoxy) gave corresponding S-aryloxycarbonylthiamine (XIIa∼c), and further treatment of XIIa∼c with alkali afforded XIII in good yield. On the other hand, IX reacted with sodium salts of phenol, p-cresol, and p-methoxyphenol to give corresponding O-aryloxycarbonylthiamine (XIa∼c). Treatment of XIa∼c with alkali also gave XIII in low yield. Therefore, it was assumed that XI and XII gave XIII in independent way by alkali treatment.抄録全体を表示PDF形式でダウンロード (631K) -
金岡 祐一, 落合 美和子, 伴 義雄1967 年 15 巻 6 号 p. 822-825
発行日: 1967/06/25
公開日: 2008/03/31
ジャーナル フリーA mixture of 3, 4-dihydroisoquinoline derivative and 3, 4-dimethoxyphenethyl bromide afforded dibenzo (a, h) quinolizidine derivative in one step by heating. This cyclization was interpreted in terms of electrophilic reactivity of immonium salt intermediate.抄録全体を表示PDF形式でダウンロード (509K) -
川添 豊, 大西 柾子1967 年 15 巻 6 号 p. 826-832
発行日: 1967/06/25
公開日: 2008/03/31
ジャーナル フリーThe reactivity toward acid-catalyzed deuterium substitution was compared with each other position of quinoline and its 1-oxide. Discussion was made in connection with other electrophilic reactivities in nitration and so on. Many selectively deuterated derivatives were synthesized on the course of the present study.抄録全体を表示PDF形式でダウンロード (663K) -
関屋 実, 原田 雄吉, 田中 康三1967 年 15 巻 6 号 p. 833-839
発行日: 1967/06/25
公開日: 2008/03/31
ジャーナル フリーThermal reactions of some representative N, N'-benzylidenebisamides with the reagents, trimethylammonium formate given by 5HCO2H·2N (CH3)3, ammonium formate and formamide, were examined to see reaction nature and to elucidate distinctions among them. In the formate reaction reductive fission at the carbon-nitrogen bond of bisamide was mainly induced by oxidation of formic acid to carbon dioxide resulting in formation of the corresponding N-benzylamide and in the formamide reaction formation of N-benzylformamide was induced by self-oxidation of bisamide. Ammonium formate behaved in the reaction in a poition between formate and formamide.抄録全体を表示PDF形式でダウンロード (936K) -
小澤 光, 佐藤 進1967 年 15 巻 6 号 p. 840-844
発行日: 1967/06/25
公開日: 2008/03/31
ジャーナル フリー[2-(Methylphenylamino) ethyl] guanidine sulfate (MPG) was found to be an effective antihypertensive agent during repeated administration at 10mg./kg. subcutaneously to conscious renal hypertensive rats. Prolonged reduction of contractions evoked by preganglionic stimulation of the cervical sympathetic nerve in the nictitating membrane of cat was observed following a single intravenous administration of 10mg./kg. of MPG. This procedure also caused the potentiation of norepinephrine-induced responses and suppression of tyramineor amphetamine-induced response in the nictitating membrane of the cat and blood pressure of the dog. In the experiment of intra-arterial administration, the postganglionic cervical sympathetic nerve blocking activity was observed to be one-half as potent as guanethidine in the nictitating membrane of cat. The hypotensive effect of MPG would be considered to be depletion of catecholamines and blockade of sympathetic transmission at adrenergic nerve level.抄録全体を表示PDF形式でダウンロード (613K) -
友枝 宗光, 金原 三郎, 浦田 睦子, 吉沢 潤治1967 年 15 巻 6 号 p. 845-853
発行日: 1967/06/25
公開日: 2008/03/31
ジャーナル フリーPyrolytic cleavage of the azo-bridge of diethyl azodicarboxylate (Ia) at 200∼210° was studied and was shown to give diethyl oxalate (VI), tetraethyl hydrazine-N1, N1, N2, N2-tetra-carboxylate (VIII), triethyl hydrazine-N1, N1, N2-tricarboxylate (IX), diethyl hydrazine-N1, N2-dicarboxylate (X), and carbon dioxide, proving formation of the ethoxycarbonyl radical (III) as an important transitionally formed intermediate of the reaction. A homolytic mechanism with the diradical (IV) and ethoxycarbonyl radical (III) as intermediates was tentatively sug-gested for the reaction. Surprisingly, Ia, when treated with alumina or silica gel at room temperature, gave almost same pattern of products obtained by the pyrolysis, yielding VIII, IX, X and carbon dioxide. A photolysis of Ia on a tungsten lamp also gave IX, X, and carbon dioxide.抄録全体を表示PDF形式でダウンロード (1035K) -
矢島 治明, 西村 紀, 川崎 絋一, 岡田 芳男1967 年 15 巻 6 号 p. 854-862
発行日: 1967/06/25
公開日: 2008/03/31
ジャーナル フリーA partially protected hexapeptide, lysyl-S-benzylcysteinylalanylglutaminyl-S-benzyl-cysteinylhistidine, related to the heme portion of horse heart cytochrome C was described. In addition, S-benzylcysteinylalanylglutaminyl-S-benzylcysteine, lysyl-S-benzylcysteinylalanylglutaminyl-S-benzylcysteine and some S-benzylcysteine peptides were prepared.抄録全体を表示PDF形式でダウンロード (1323K) -
石墨 紀久夫, 塩入 孝之, 山田 俊一1967 年 15 巻 6 号 p. 863-872
発行日: 1967/06/25
公開日: 2008/03/31
ジャーナル フリーA general synthesis of cycloalkan[b]indolones from 3-indolealkanoic acids is described. Effect of 1-alkyl substitution of indole was observed on the ultraviolet spectra of 1-methyl-3-indolealkanoic acids. Cyclization of 3-indolealkanoic acids was mostly effected with polyphosphoric acid. Ring closure of Vc and Vd with PPA brought about concomitant expected monomers (VIIc and VIId) and dimers (VIIIa and VIIIb). The structure proof of the dimers was obtained from analytical and spectral data.抄録全体を表示PDF形式でダウンロード (1120K) -
関口 慶二, 大和田 栄治, 伊藤 圭二1967 年 15 巻 6 号 p. 873-878
発行日: 1967/06/25
公開日: 2008/03/31
ジャーナル フリーIn order to obtain wider knowledges on the physico-pharmaceutical properties of the molecular compounds of organic medicinals, the dissolution behaviors, solubility equilibrium and the nature of the bonding between components were investigated with the compound of homosulfanilamide and sulfathiazole. When the molecular compound was dissolved, the stable equilibrium, not the metastable one was rapidly attained. On the contrary, much differences in dissolution behaviors were observed with the corresponding physical mixture and the equilibrium was not reached even after 24 hours due to deposition of the compound on sulfathiazole particles. From the phase diagram constructed, it was confirmed that the system belongs to the type where the formed compound is not decomposed by water. By applying the solubility product principle, formation constants at various temperatures were obtained and the changes of enthalpy, free energy and entropy for the molecular compound formation in solutionwere calculated. It was supposed from these thermodynamic constants and the data of IR and electric conductance measurements that in the compound, the bonding between homosulfanilamide and sulfathiazole is caused by ionic interaction.抄録全体を表示PDF形式でダウンロード (692K) -
亀谷 哲治, 菊地 豊彦1967 年 15 巻 6 号 p. 879-883
発行日: 1967/06/25
公開日: 2008/03/31
ジャーナル フリーBischler-Napieralski cyclization of the phenethylamide (VII) having a benzyloxyl group in the 3-position of the benzene ring was found to take place in the position para and ortho to the benzyloxyl group, but both isoquinoline derivatives could not be separated in the stage of 3, 4-dihydroisoquinolines (VIIIa and VIIIb), its methiodides (IXa and IXb), and 1, 2, 3, 4-tetrahydroisoquinolines (Xa and Xb), even if various procedures as thin-layer chromatography were examined. Accordingly, after Xa and Xb had been hydrolysed, attempt to separate both compounds (I and XI) by thin-layer chromatography was successfully carried out. After all, so-called corpaverine (I), namely, 8-hydroxy-6, 7-dimethoxy-1, 2, 3, 4-tetrahydro-1-(4-methoxybenzyl)-2-methylisoquinoline, was obtained besides its isomer (XI) in a comparatively better yield than that of our previous method. Furthermore, selective methylation of XIII with diazomethane also gave both compounds (I and XI), which were characterized as perchlorate and oxalate, respectively.抄録全体を表示PDF形式でダウンロード (609K) -
安孫子 雍史, 清水 正夫1967 年 15 巻 6 号 p. 884-886
発行日: 1967/06/25
公開日: 2008/03/31
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友枝 宗光, 石田 昭彦, 古賀 俊隆1967 年 15 巻 6 号 p. 887-892
発行日: 1967/06/25
公開日: 2008/03/31
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亀谷 哲治, 小笠原 国郎1967 年 15 巻 6 号 p. 893
発行日: 1967/06/25
公開日: 2008/03/31
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佐々木 琢磨, 水野 義久1967 年 15 巻 6 号 p. 894-896
発行日: 1967/06/25
公開日: 2008/03/31
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今成 登志男, 田村 善蔵1967 年 15 巻 6 号 p. 896-898
発行日: 1967/06/25
公開日: 2008/03/31
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古谷 力, 児嶋 脩, 庄野 邦彦1967 年 15 巻 6 号 p. 901-903
発行日: 1967/06/25
公開日: 2008/03/31
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戸田 敬, 鄭 玉瑕, 野副 鉄男1967 年 15 巻 6 号 p. 903-905
発行日: 1967/06/25
公開日: 2008/03/31
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花木 昭1967 年 15 巻 6 号 p. 906-908
発行日: 1967/06/25
公開日: 2008/03/31
ジャーナル フリーPDF形式でダウンロード (422K)
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