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Volume 16, Issue 8
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SEIGO SUZUE, TUTOMU IRIKURA1968 Volume 16 Issue 8 Pages 1417-1432
Published: August 25, 1968
Released on J-STAGE: March 31, 2008
JOURNAL FREE ACCESSFor the purpose of elucidating the structural relationship between lathyrism and inhibition of necrosis induced by CCl4 in the liver of the rat, many compounds related to aminoacetonitrile were synthesized. N-Aminoacylaminoacetonitriles (VIII, XIV) were synthesized from phthaloylaminoacylaminoacetonitriles. VIII were converted to 2-hydroxyimino-5-oxopiperazine derivatives (XV) and 5-oxo-2-thio-piperazines (XX). Preparations of N-(N-acylaminoacyl) aminoacetonitriles were also described. Further, N-α-hydroxyacylaminoacetonitriles were prepared from chloralides of α-hydroxyacids with aminoacetonitrile. In addition, XV (R=H) was converted to 2-acetamino-5-acetoxypyrazine by treatment with acetic anhydride.View full abstractDownload PDF (1441K) -
NOBUYOSHI KANENIWA, AKIKO IKEKAWA1968 Volume 16 Issue 8 Pages 1433-1439
Published: August 25, 1968
Released on J-STAGE: March 31, 2008
JOURNAL FREE ACCESSRate of discharge of sodium borate and boric acid powders from acrylic and brass funnels were investigated. Large particles discharge steadily from a funnel but flow behaviour seems to be different in the region below critical size. Flow rate largely depends on materials, outlet diameter, outlet length and cone angle of the funnel. Angle of repose characterized by particle size, kind of particles and the like, is an important parameter controlling flow rate of particles. Drained angle is markedly influenced by particle size in the region below critical size just as is the angle of repose and the sliding angle.View full abstractDownload PDF (642K) -
SAKAE WADA, IKUO MORIGUCHI1968 Volume 16 Issue 8 Pages 1440-1444
Published: August 25, 1968
Released on J-STAGE: March 31, 2008
JOURNAL FREE ACCESSBinding constant, Kac, for 11 N4-acetylsulfonamides with bovine serum albumin was evaluated spectrophotometrically utilizing the competion between 2-(4'-hydroxyphenylazo) benzoic acid and N4-acetylsulfonamides at 37°and 5°, and was compared with Kf, binding constant for free sulfonamides with bovine serum albumin. Free energy and entropy changes for the binding were calculated. The correlations of log (Kac/Kf) with the fraction of unchanged sulfonamides excreted in the urine after the administration, and with half-life for elimination of sulfonamides from human blood plasma were indicated to be significant.View full abstractDownload PDF (539K) -
TERUHIKO MESHI, YOSHISHIGE SATO1968 Volume 16 Issue 8 Pages 1445-1450
Published: August 25, 1968
Released on J-STAGE: March 31, 2008
JOURNAL FREE ACCESSIt was found that in the rat about 50% of orally administered thiamine was decomposed into 4-methyl-5β-hydroxyethylthiazole (HT) and pyrimidyl derivative. It was demonstrated that 2-methyl-4-amino-5-hydroxymethylpyrimidine (HMP) was formed from thiamine as one of pyrimidyl derivatives. However, the amount of excreted HMP was extremely small as compared to that of excreted HT. It was concluded that the main cleavage of thiamine was not a direct hydrolysis into HT and HMP.View full abstractDownload PDF (709K) -
HIROYOSHI YAMAGUCHI1968 Volume 16 Issue 8 Pages 1451-1455
Published: August 25, 1968
Released on J-STAGE: March 31, 2008
JOURNAL FREE ACCESSDie Synthese einiger Cyanine mit dem 1, 3-Oxathioliumring als Endglied wurde beschrieben. Der Bildungsmechanismus dieser Farbstoffe wurde kurz erortert.View full abstractDownload PDF (646K) -
AKIRA KASAHARA, TAKESHI ONODERA, YASUO OSHIMA, MASAO SHIMIZU1968 Volume 16 Issue 8 Pages 1456-1459
Published: August 25, 1968
Released on J-STAGE: March 31, 2008
JOURNAL FREE ACCESS17β-Hydroxy-5α-androstano [2, 3-c] furazan (I) has been shown to possess a high myotrophic activity and a low androgenic activity by subcutaneous injection, but its activities by oral route are very low. On the other hand, when given orally, 17-(2-tetrahydropyranyl) and 17-(1-cyclopentenyl) ethers of I are highly myotrophic and have shown a good separation of myotrophic and androgenic activities. The myotrophic and androgenic activities of 17α-ethyl, vinyl, ethynyl, 16-methylene, 16β-methyl, 16α-, and 16β-hydroxy derivatives of I are less than those of I.View full abstractDownload PDF (514K) -
AKIRA KASAHARA1968 Volume 16 Issue 8 Pages 1460-1465
Published: August 25, 1968
Released on J-STAGE: March 31, 2008
JOURNAL FREE ACCESS17β-Hydroxy-5α-androstano [2, 3-c] furazan (I) was incubated with rat-liver mince in the presence of NAD and nicotinamide in oxygen atmosphere. It has been demonstrated that at least 23% of the steroid (I) is converted into 17-oxo-5α-androstano [2, 3-c] furazan. This oxidation rate at the 17-position is the same as that observed for testosterone, indicating the substituted furazan ring has no significantly different effect on the metabolic oxidation at this position. The relation of this fact to myotrophic activity of I by oral route has been discussed.View full abstractDownload PDF (771K) -
AKITADA NAKAMURA, SHOZO KAMIYA1968 Volume 16 Issue 8 Pages 1466-1471
Published: August 25, 1968
Released on J-STAGE: March 31, 2008
JOURNAL FREE ACCESSThe Mannich reaction of 3-hydroxy-2 (1H)-pyridone, in which both a phenolic OH and a lactam NH are present in a molecule, was examined, and 3-hydroxy-6-piperidinomethyl-2(1H)-pyridone (IXa) and 3-hydroxy-4, 6-bis (piperidinomethyl)-2(1H)-pyridone (X) were obtained in 82 and 5% yields, respectively. The reaction of IXa with the cyclohexanone pyrrolidine enamine gave 4a, 7-dihydroxy-1, 2, 3, 4, 4a, 10a-hexahydrobenzo [b] indolizin-6 (10H)-one (XVI) in 82% yield.View full abstractDownload PDF (716K) -
ZENICHI HORII, KOICHI MORIKAWA, ICHIYA NINOMIYA1968 Volume 16 Issue 8 Pages 1472-1480
Published: August 25, 1968
Released on J-STAGE: March 31, 2008
JOURNAL FREE ACCESSReduction of 1, 2, 3, 4, 4a, 5, 7, 8, 9, 10-decahydro-6H-benzo [c] quinolizin-6-one (I) under varying conditions were examined and afforded two aminoketones, cis-and trans-dodecahydro-6H-benzo [c] quinolizin-6-ones (IV and V), and three amino-alcohols, cis-and trans-6α-, and trans-6β-hydroxyperhydrobenzo [c] quinolizidines (VIa, VIIa and VIIIa), of which the unusual formation of VIa from trans-aminoketone (V) was discussed. B/C trans-perhydrobenzo [c] quinolizidine (III) was afforded in good yield from trans-aminoketone (V) via thioketalization followed by desulfurization with Raney nickel. Chemical evidences and NMR data made possible to establish the configurations of these aminoalcohols and their derivatives.View full abstractDownload PDF (1193K) -
KIICHIRO KAKEMI, HITOSHI SEZAKI, NORIO TAKASUGI, KIKUO IWAMOTO1968 Volume 16 Issue 8 Pages 1481-1486
Published: August 25, 1968
Released on J-STAGE: March 31, 2008
JOURNAL FREE ACCESSWith furylmethylketone isonicotinoylhydrazone (FKI) used as an example, factors affecting drug stability in various culture media and its implications on the in vitro activity tests have been studied. In buffer solution (pH 2-10), FKI was stable in the neutral pH and unstable in acidic and alkaline pH regions. It became evident that in culture media the degradative reaction was greatly influenced by medium components such as serum and amino acids. The rate of degradation was four to ten times more rapid than in buffer solutions and considerable amounts of isoniazid were released long before one could expect growth of test organisms in culture. Among the medium components tested, amino acids such as asparagine and glutamic acid exhibited a dominant effect and the data seemed to indicate non-protonated amino group as catalytic species. Suggestions are made relative to the significance of these observations for the in vitro evaluation of anti-bacterial agents.View full abstractDownload PDF (643K) -
GENKICHI OHTA, KATSUMI KOSHI, KAZUNAGA OBATA1968 Volume 16 Issue 8 Pages 1487-1497
Published: August 25, 1968
Released on J-STAGE: March 31, 2008
JOURNAL FREE ACCESSSteroidal oxazoles, imidazoles, and triazoles were synthesized for biological studies. 2α-Acetoxy-or 2α-bromo-3-ketones of androstane and cholestane series were converted into 2'-methylsteroidal [3, 2-d] oxazoles (III) by reaction with ammonium acetate. Reductive acetylation of 2-hydroxyimino-3-oxo steroids (V) gave 2α-acetamido-3-ketones (VI) which were cyclized by the use of sulfuric acid to 2'-methyl-steroidal [2, 3-d] oxazoles (XI). 2'-methyl-steroidal [2, 3-d] imidazoles (XII) were prepared from VI by reaction with ammonium acetate. 2α-Amino-3-ketone hydrochlorides, obtained by catalytic hydrogenation of V, were converted by reaction with thiocyanate into steroidal [2, 3-d] imidazoline-2'-thiones which were desulfurized to afford imidazoles (XIV). Androst-4-eno[2, 3-d]-triazoles (XX) were prepared from the 2-acetoxymethylene-3-ketone via the 2-hydroxyimino-3-one hydrazone by application of the established procedures. The ORD (and CD) data of VI and the corresponding 3β-alcohol (VIIId) are presented.View full abstractDownload PDF (1347K) -
TETSUJI KAMETANI, KUNIO OGASAWARA1968 Volume 16 Issue 8 Pages 1498-1502
Published: August 25, 1968
Released on J-STAGE: March 31, 2008
JOURNAL FREE ACCESSThe mass spectra of several kinds of cryptaustoline type compounds, namely, dibenzopyrrocoline derivatives, were investigated and the characteristic fragmentation patterns were revealed.View full abstractDownload PDF (479K) -
MITSUO WATATANI1968 Volume 16 Issue 8 Pages 1503-1512
Published: August 25, 1968
Released on J-STAGE: March 31, 2008
JOURNAL FREE ACCESSSome nucleophilic reactions of 2-imino-2H-cycloheptoxazoles including their hydrolysis and reactions with hydrogen sulfide, thiols, and active methylene compounds were examined. Both acid and alkaline hydrolyses of 2-imino-2H-cycloheptoxazole (I) gave 2-ureidotropone (III). On the other hand, a simple standing of the aqueous solution of 2-imino-2H-cycloheptoxazole (I) gave 2-(2-troponylamino) cycloheptimidazole (XIV). Reaction of I with hydrogen sulfide gave 2-ureidotropothione (XVI), while the reaction with thiols gave 2-alkylthiocycloheptimidazoles (XXVI-XXVIII), besides N-carbamoyl-2-alkylthiotroponeimines (XXIX-XXXI). Reactions of I with malononitrile, cyanoacetamide, and benzoylacetonitrile gave 3-substituted 2-imino-1, 2-dihydrocyclohepta [b] pyrroles (XXXII-XXXIV), and a similar reaction with ethyl cyanoacetate gave ethyl 2-imino-1, 2-dihydrocyclohepta [b] pyrrole-3-carboxylate (XXXV) and 2-oxo-1, 2-dihydrocyclohepta [b] pyrrole-3-carbonitrile (XXXVI). Reactions with ethyl acetoacetate, ethyl benzoylacetate, acetylacetone, and diethyl malonate gave 3-acetyl-(XXXVIII) and 3-benzoylcyclohepta [b] pyrrol-2 (1H)-one (XXXIX), 3-acetyl-2-methylcyclohepta [b] pyrrole (XL), and ethyl 1, 2-dihydro-2-oxocyclohepta [b] pyrrole-3-carboxylate (XLI), respectively.View full abstractDownload PDF (1178K) -
MITSUO WATATANI1968 Volume 16 Issue 8 Pages 1513-1520
Published: August 25, 1968
Released on J-STAGE: March 31, 2008
JOURNAL FREE ACCESSReactions of 2-imino-2H-cycloheptoxazoles with amines and hydrazines were examined. Reactions of 2-imino-2H-cycloheptoxazole derivatives with primary amines such as methylamine, benzylamine, and p-toluidine gave 1-substituted cycloheptimidazol-2(1H)-one derivatives (II : R=CH3, R=C6H5CH2, R=p-CH3C6H5). In the reaction with benzylamine, a trace of 2-benzylaminocycloheptimidazole (IV) and 1-benzyl-2-imino-1, 2-dihydrocycloheptimidazole (III) were obtained as by-products. Reaction of I with dimethylamine gave 2-dimethylaminocycloheptimidazole (XII) and cycloheptimidazol-2(1H)-one (XIII). Reaction with cyanamide gave 2-aminocycloheptimidazole (XIV). Hydrolyses of 4-bromo-(IIe) and 8-bromo-1-benzylcycloheptimidazol-2(1H)-one (IIg) gave 1-benzyl-(X) and 3-benzyl-cycloheptimidazole-2, 4(1H, 3H)-dione (XI), respectively. Reaciton of I with hydrazine hydrate, phenylhydrazine, m-nitrophenylhydrazine, and benzylhydrazine gave the corresponding 1-aminocycloheptimidazol-2 (1H)-one derivatives (XV, XVIII-XX) shown in Table I. Reaction of I with benzoylhydrazine, isonicotinoylhydrazine, and acetylhydrazine gave 2-ureidotropone acylhydrazones (XXII-XXIV), which were easily converted to 1-acylaminocycloheptimidazol-2 (1H)-ones (XXV-XXVII). Reaction of I with 2-hydrazinotropone gave 2-ureidotropone 2-troponylhydrazone (XXVIII).View full abstractDownload PDF (864K) -
KAN UEDA, ITIRO YOSIOKA1968 Volume 16 Issue 8 Pages 1521-1526
Published: August 25, 1968
Released on J-STAGE: March 31, 2008
JOURNAL FREE ACCESSThe N-bromosuccinimide (NBS) bromination of six 1-methylphenazine derivatives (I-VI) possessing either a methoxyl or an acetoxyl function at C4, C6, or C9 was studied. It has been found that a methoxyl group attached at C4 disturbs the allylic bromination of C1-methyl by NBS while a methoxyl group at C6 or C9 does only partly. An acetoxyl group existing at C4, C6, or C9, however, has been noticed not to disturb the allylic bromination at C1-methyl function, but the expected product has been secured.View full abstractDownload PDF (661K) -
ISAO SUGIMOTO1968 Volume 16 Issue 8 Pages 1527-1532
Published: August 25, 1968
Released on J-STAGE: March 31, 2008
JOURNAL FREE ACCESSThe effect of complex formation on drug absorption from rat small intestine by recirculating perfusion method has been studied by following systems : sodium p-aminosalicylate (NaPAS)-sulfisoxazole, NaPAS-sulfisomidine, NaPAS-sulfamethoxypyridazine, sodium salicylate-caffeine, hydroxyethyltheophylline-nicotinamide, and its reverse combination, and the absorption rate of the latter of the each combinations was measured in the presence of the former. It was found that the absorption rate of each drug could be modified by the complex formation. Results of these studies were correlated with kinetic analysis based on the absorption rate constant in the absence and in the presence of complexing agent, and the equilibrium constant. It appears under the experimental conditions and used combinations of drugs that the complex itself may be absorbed, and that its absorption rate is slower than that of free drug. Complexation of the drug with complexing one decreased the apparent partition coefficient of the former. This suggests one possible mechanism for the absorption of complex.View full abstractDownload PDF (688K) -
AKINORI KUBO, SHIN-ICHIRO SAKAI, SACHIKO YAMADA, ICHIRO YOKOE, CHIKARA ...1968 Volume 16 Issue 8 Pages 1533-1542
Published: August 25, 1968
Released on J-STAGE: March 31, 2008
JOURNAL FREE ACCESSThe mass spectra of a series of quinoline 1-oxides have been determined in conjunction with those of the related compounds, such as quinolines and benz [d]-1, 3-oxazepines derived photochemically from these N-oxides. For example, the major decomposition processes of 2-cyanoquinoline 1-oxide (1) are loss of O and loss of CO. Existence of the latter process requires prior formation of a C-O bond and virtually demands isomerization to the corresponding oxaziridine ion (c). This species would then undergo rearrangement to the corresponding benzoxazepine ion (d) before the fragmentation takes place. This supposition seems to be testified by comparison of the spectra of 1 and the corresponding oxazepine (3). The results obtained provide a striking example of parallel behavior of 1 and its related N-oxides in photolysis and electron impact. It is also shown that on electron impact the molecular ions of benz [d]-1, 3-oxazepine derivatives eliminate carbon monoxide as a neutral molecule and the resultant ions behave as indole derivatives. The mass spectrum of 1-cyanoisoquinoline 2-oxide (18), on the contrary, contains M-O and M-(CN)2 ions, and the occurence of M-CO ion is very weak. The presence of M-(CN)2 ion can be regarded as a criterion for the intermediary of the corresponding oxazepine ion, since this ion is a base peak in the spectrum of the corresponding photoproduct, benz [f]-1, 3-oxazepine-2-carbonitrile (20). Exceptions from these rules can be explained in terms of the presence of specific structural features, and general decomposition sequences of benz [d]-and benz [f]-1, 3-oxazepines have also been clarified.View full abstractDownload PDF (953K) -
AKIKO IKEKAWA, NOBUYOSHI KANENIWA1968 Volume 16 Issue 8 Pages 1543-1549
Published: August 25, 1968
Released on J-STAGE: March 31, 2008
JOURNAL FREE ACCESSInfluence of particle size of boric acid, aspirin or magnesium alumino silicate on fluidity and packing property of the binary mixtures of starch was investigated. For the mixtures of starch and boric acid or aspirin, angle of repose decreases gradually with the increase of proportion of boric acid or aspirin above critical size, while minimum angle is obtained for the mixture containing a certain proportion of smaller particles. It is suggested that cohesion of starch particles is scarcely influenced by adhesion of starch to particles above critical size, and that it decreases by the adhesion to them below critical size. Porosity of the mixture is a little larger than the arithmetic mean value of porosity of starch and boric acid or aspirin. Remarkably small values of angle of repose and porosity are obtained for the mixture of starch and magnesium alumino silicate. Magnesium alumino silicate particle is suggested to take moisture away from starch particle.View full abstractDownload PDF (1104K) -
WATARU NAGATA, SHOICHI HIRAI1968 Volume 16 Issue 8 Pages 1550-1555
Published: August 25, 1968
Released on J-STAGE: March 31, 2008
JOURNAL FREE ACCESSN-Sulfonylated 3-methoxycholestane (5→3)-lactams (Vc), (VIc) and (VId) were subjected to reductive fragmentation initiated with lithium aluminum hydride giving in good yields N-sulfonylated cis-amino alcohols (3α, 5α and 3β, 5β) (XIIIa), (XIVc), and (XIVa). These compounds were smoothly cyclized to 3α, 5-iminomethano-5α-and 3β, -5-iminomethano-5β-cholestane derivatives, (Ia), (IIa), and (IIb), which were then desulfonylated to give 3α, 5α-and 3β, 5β-pyrrolidinocholestanes (Ib) and (IIc), respectively.View full abstractDownload PDF (775K) -
WATARU NAGATA, TSUTOMU SUGASAWA, TSUTOMU AOKI1968 Volume 16 Issue 8 Pages 1556-1560
Published: August 25, 1968
Released on J-STAGE: March 31, 2008
JOURNAL FREE ACCESSCholestane derivative (IIb) having a bridged 3-azabicyclo [3. 3. 1] nonane ring system was synthesized from 3-oxo-5α-cholestane-5-carbonitrile (III) by a six-step reaction sequence. The over-all yield was very high indicating high stereospecificity or uniformity of the reaction used. Reduction of 3α-formyl-3β-methyl-5α-cholestane-5-carbonitrile (VIII) to the amino alcohol (Xa) was effected by means of lithium aluminum hydride reduction in the presence of aluminum chloride.View full abstractDownload PDF (659K) -
AKIHIRO YAMAZAKI, IZUMI KUMASHIRO, TADAO TAKENISHI1968 Volume 16 Issue 8 Pages 1561-1566
Published: August 25, 1968
Released on J-STAGE: March 31, 2008
JOURNAL FREE ACCESSSome isopropylidene derivatives of N1-methyl-2-substituted inosines were synthesized from 2', 3'-O-isopropylidene-N1-methyl-2-methylthioinosine (VII). Phosphorylation of the isopropylidene derivatives (VIII and X) of N1-methylinosine and N1-methylguanosine followed by acidic treatment afforded N1-methylinosine 5'-phosphate (XVIII) and N1-methylguanosine 5'-phosphate (XIX), respectively, the flavoring activities of which were qualitatively investigated.View full abstractDownload PDF (753K) -
SUSUMU ISHIGURO, SETSUZO TEJIMA1968 Volume 16 Issue 8 Pages 1567-1572
Published: August 25, 1968
Released on J-STAGE: March 31, 2008
JOURNAL FREE ACCESSMethyl 2, 3-dideoxy-2, 3-dimercapto-α-D-mannopyranoside, isolated as sirupy tetraacetate (XIII), was synthesized in 13% yield by reduction of methyl 2, 3-dithio-4, 6-O-benzylidene-α-D-mannopyranoside 2, 3-S-carbonate (IX) with sodium in liquid ammonia. The product was also obtainable in the same yield by alkaline treatment of methyl 2, 3-dithio-4, 6-di-O-acetyl-α-D-mannopyranoside 2, 3-S-carbonate (XII). Dithiocarbonate (IX), a key intermediate of the synthesis was obtained by the following route : epoxide opening in methyl 2, 3-anhydro-4, 6-O-benzylidene-α-D-allopyranoside (II) with sodium N, N-dimethyldithiocarbamate (I) to give methyl 2-deoxy-2 (N, N-dimethyl dithiocarbamoyl)-4, 6-O-benzylidene-α-D-altropyranoside (III), sulfonation of III, and successive intramolecular ring formation in the pyranose ring involving trans-diaxial elimination by treatment of the sulfonate (VII or VIII) with potassium acetate.View full abstractDownload PDF (842K) -
EIICHI FUJITA, TETSURO FUJITA, MASAYUKI SHIBUYA1968 Volume 16 Issue 8 Pages 1573-1575
Published: August 25, 1968
Released on J-STAGE: March 31, 2008
JOURNAL FREE ACCESSThe chemical and spectral evidence led to a conclusion that isodocarpin, a new diterpenoid from the leaves of Isodon trichocarpus KUDO and I. japonicus HARA, has the structure and absolute configuration VII.View full abstractDownload PDF (478K) -
TETSUO HIRAOKA, YUKICHI KISHIDA1968 Volume 16 Issue 8 Pages 1576-1583
Published: August 25, 1968
Released on J-STAGE: March 31, 2008
JOURNAL FREE ACCESSSeveral reactions of azlactones were explored in order to find a new method for extending carbon chains utilizing the 4-position of 2-oxazolin-5-one derivatives. Treatment of 4-ethoxymethylene-2-phenyl-2-oxazolin-5-one (I) with phenylethynylmagnesium bromide (IIa) gave a ring opened product, ethyl 2-benzoylamino-5-phenyl-2-penten-4-ynoate (IIIa). The reaction of I with diethyl 3-oxoglutarate (X) in benzene in the presence of sodium hydride afforded ethyl 3-carbethoxy-5-benzoylamino-β-resorcylate (XI), whereas 3-benzoylamino-5-carbethoxy-6-carbethoxymethyl-2H-pyran-2-one (XII) was obtained when this reaction was carried out in methylene dichloride using triethylamine as a catalyst. Analogously, 3-benzoylamino-5-cyano-6-phenyl-2H-pyran-2-one (XIV) was synthesized by the reaction of I with 5-phenylisoxazole (XIII). The reaction of 2-phenyl-2-oxazolin-5-one (XVI) with benzoylacetylene (XVII) in acetic anhydride gave 3-benzoylamino-6-phenyl-2H-pyran-2-one (XVIII).View full abstractDownload PDF (976K) -
TETSUJI KAMETANI, KUNIO OGASAWARA, TSUNEKAZU TERUI, KAZUYA YAMAKI, KEI ...1968 Volume 16 Issue 8 Pages 1584-1588
Published: August 25, 1968
Released on J-STAGE: March 31, 2008
JOURNAL FREE ACCESSNovel cyanomethylation of halogeno-benzene derivatives was investigated by benzyne reaction to give our expected variuos benzyl cyanides which seemed to be the important intermediates for amines (II) and acids (III).View full abstractDownload PDF (569K) -
HARUO KITAGAWA1968 Volume 16 Issue 8 Pages 1589-1592
Published: August 25, 1968
Released on J-STAGE: March 31, 2008
JOURNAL FREE ACCESSThe relationship between the duration of pentobarbital induced sleep and respiratory oxygen tension was investigated in mice and cats. Pentobarbital, when administered to cats in a high dose (70 mg/kg), resulted in irregular respiration, and prolonged biologic half life. And found that the characteristic curve of disappearance of pentobarbital obtained from a high dose administration of pentobarbital were caused by low activity of liver microsomal oxidative enzyme and not by the tissue accumulation. The low activity was assumed to be caused by insufficiency of oxygen required by oxidative enzymes.View full abstractDownload PDF (538K) -
HIROMU MORI, KENYU SHIBATA, KIYOSHI TSUNEDA, MASANOBU SAWAI1968 Volume 16 Issue 8 Pages 1593-1600
Published: August 25, 1968
Released on J-STAGE: March 31, 2008
JOURNAL FREE ACCESSA novel synthetic method of 14α-hydroxy-6-oxo-7-ene steroid from 6-oxo-7-ene steroid was developed. The enol acetylation of 7-en-6-one with acetic anhydride in the presence of perchloric acid afforded 6-acetoxy-6, 8 (14)-diene, which on treatment with monoperphthalic acid gave 14α-hydroxy-7-en-6-one. 2β, 3β, 14α-Trihydroxy-5β-cholest-7-en-6-one (XXVIII), the nuclear structure of which is the same as that of ecdysone, was prepared by this method, and the stereochemistry of XXVIII and related compounds was studied.View full abstractDownload PDF (980K) -
HIROSHI HIKINO, DAIICHIRO KUWANO, TSUNEMATSU TAKEMOTO1968 Volume 16 Issue 8 Pages 1601-1604
Published: August 25, 1968
Released on J-STAGE: March 31, 2008
JOURNAL FREE ACCESSA new guaianolide C15H20O3, helenium lactone, has been isolated from the common sneezweed, Helenium autumnale (Compositae), cultivated in Japan. The structure of helenium lactone has been shown to be I by chemical and physico-chemical studies of it and its derivatives.View full abstractDownload PDF (623K) -
HIROSHI HIKINO, YOJIRO SAKURAI, TSUNEMATSU TAKEMOTO1968 Volume 16 Issue 8 Pages 1605-1607
Published: August 25, 1968
Released on J-STAGE: March 31, 2008
JOURNAL FREE ACCESSThe structure of procurcumenol, a new sesquiterpenic keto-alcohol isolated from zedoary, Curcuma zedoaria (Zingiberaceae), has been shown to be I.View full abstractDownload PDF (464K) -
HIROSHI HIKINO, KUNIO ITO, TSUNEMATSU TAKEMOTO1968 Volume 16 Issue 8 Pages 1608-1610
Published: August 25, 1968
Released on J-STAGE: March 31, 2008
JOURNAL FREE ACCESSFrom patchouli oil, obtained from patchouli, Pogostemon cablin (Labiatae), has been isolated a new sesquiterpenic alcohol, pogostol, of the formula C15H26O, whose structure has been established as shown in formula I on the basis of chemical and physico-chemical data.View full abstractDownload PDF (425K) -
KEI OKABE, KUNIO HAYASHI, YOSHIROK. SAWA1968 Volume 16 Issue 8 Pages 1611-1615
Published: August 25, 1968
Released on J-STAGE: March 31, 2008
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MINEO SANEYOSHI1968 Volume 16 Issue 8 Pages 1616-1619
Published: August 25, 1968
Released on J-STAGE: March 31, 2008
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SHOJI KOJIMA, HISASHI ICHIBAGASE1968 Volume 16 Issue 8 Pages 1619-1622
Published: August 25, 1968
Released on J-STAGE: March 31, 2008
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TETSUJI KAMETANI, HIDEO IIDA, KUNIYOSHI SAKURAI1968 Volume 16 Issue 8 Pages 1623-1625
Published: August 25, 1968
Released on J-STAGE: March 31, 2008
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TETSUJI KAMETANI, SEIICHI TAKANO, TAKASHI KOBARI, HIDEO IIDA, MASAFU S ...1968 Volume 16 Issue 8 Pages 1625-1628
Published: August 25, 1968
Released on J-STAGE: March 31, 2008
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SHIRO SUZUKI, TAMOTSU KONDO, STANLEYG. MASON1968 Volume 16 Issue 8 Pages 1629-1631
Published: August 25, 1968
Released on J-STAGE: March 31, 2008
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MASAMICHI FUKUOKA, HIROSHI MITSUHASHI1968 Volume 16 Issue 8 Pages 1634-1636
Published: August 25, 1968
Released on J-STAGE: March 31, 2008
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TSUNEMATSU TAKEMOTO, YASUKO HIKINO, HISANORI JIN, TOMIO ARAI, HIROSHI ...1968 Volume 16 Issue 8 Pages 1636
Published: August 25, 1968
Released on J-STAGE: March 31, 2008
JOURNAL FREE ACCESSDownload PDF (261K) -
SADAO OIDA, EIJI OHKI1968 Volume 16 Issue 8 Pages 1637-1639
Published: August 25, 1968
Released on J-STAGE: March 31, 2008
JOURNAL FREE ACCESSDownload PDF (465K) -
SHOJI SHIBATA, YOSHIHIRO NISHIKAWA, TADAHIRO TAKEDA, MAMORU TANAKA, FU ...1968 Volume 16 Issue 8 Pages 1639-1641
Published: August 25, 1968
Released on J-STAGE: March 31, 2008
JOURNAL FREE ACCESSDownload PDF (429K)
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