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Volume 16, Issue 9
Displaying 1-41 of 41 articles from this issue
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KEN-ICHIRO MINEGISHI, YUKIO KUROIWA, SEIICHI OKUI1968 Volume 16 Issue 9 Pages 1643-1648
Published: September 25, 1968
Released on J-STAGE: March 31, 2008
JOURNAL FREE ACCESSThe activities of demethylating enzymes were decreased by adrenalectomy, but were stimulated by the administration of phenobarbital or cortisone in the liver of adrenalectomized rats. Incorporation of 14C-labeled amino acid into liver microsomal proteins of adrenalectomized rats was apparently increased by the administration of phenobarbital. The magnitude of phenobarbital-effect was decreased by pretreatment with puromycin and 8-azaguanine in intact animals.View full abstractDownload PDF (753K) -
KENICHIRO MINEGISHI, YUKIO KUROIWA, SEIICHI OKUI1968 Volume 16 Issue 9 Pages 1649-1654
Published: September 25, 1968
Released on J-STAGE: March 31, 2008
JOURNAL FREE ACCESSAdministration of morphine and nalorphine decreased the activity of demethylating enzyme not only in intact rats but also in adrenalectomized rats. Therefore, it is considered that effects of morphine and nalorphine are not mediated through adrenal hormones. On the other hand, single injection of nalorphine antagonized the drug metabolizing enzymes in rats which received a single injection of morphine, but when morphinization was continued, antagonism on the drug metabolizing enzymes of morphine and nalorphine disappeared.View full abstractDownload PDF (754K) -
AKIO HOSHI, REIKO YANAI, KAZUO KURETANI1968 Volume 16 Issue 9 Pages 1655-1660
Published: September 25, 1968
Released on J-STAGE: March 31, 2008
JOURNAL FREE ACCESSThe acute toxicity of terephthalic acid and its sodium salt, the effect of terephthalic acid administration on liver and renal functions, and the chemical composition of blood plasma were studied. LD50 of terephthalic acid in mice was found to be more than 5000 mg/kg by oral administration and 1430 mg/kg by intraperitoneal injection. Those of its sodium salt (Na2TPA) were 6300 mg/kg (oral), 8600 mg/kg (subcutaneous), 4600 mg/kg (intraperitoneal), and more than 1300 mg/kg (intravenous). Terephthalic acid feeding for 7 days (0.5% in diet) did not affect the dye (PSP) excretion from kidney, the transaminase activity (GOT and GPT) in blood plasma, and the contents of sugar, protein, free amino acids, and urea in blood plasma. The BSP retention in liver was not increased, but rather decreased. The barbiturate sleeping-time was shortened markedly by terephthalic acid feeding. In view of these facts, it was concluded that terephthaic acid did not show any toxic indications in mice fed 0.5% terephthalic acid diet.View full abstractDownload PDF (768K) -
JUICHIRO SHIBASAKI, TAMOTSU KOIZUMI, TERUKAZU TANAKA1968 Volume 16 Issue 9 Pages 1661-1673
Published: September 25, 1968
Released on J-STAGE: March 31, 2008
JOURNAL FREE ACCESSHydroxylation of acetanilide and excretion of 4-hydroxyacetanilide in rabbits was investigated kinetically. Formation of 4-hydroxyacetanilide from acetanilide was found to be not a simple first order process but it could be well expressed by Michaelis Menten equation.View full abstractDownload PDF (1207K) -
KINZO NAGASAWA, YOSHIO KATO1968 Volume 16 Issue 9 Pages 1674-1679
Published: September 25, 1968
Released on J-STAGE: March 31, 2008
JOURNAL FREE ACCESSThe preparation and properties of N-acylated derivatives of guanine, 2-amino-6-purinethiol and their related compounds were described. The position of the N-acyl group introduced was deduced to be the 2-amino group of purine ring from the elemental analysis and the comparison of ultraviolet spectra of related compounds. During the acylation procedure, desulfurization of 2-amino-6-purinethiol and alkyl substituted compound was observed.View full abstractDownload PDF (790K) -
ICHIRO MATSUO, KAZURO SUGIMOTO, SADAO OHKI1968 Volume 16 Issue 9 Pages 1680-1685
Published: September 25, 1968
Released on J-STAGE: March 31, 2008
JOURNAL FREE ACCESSThe configurations of the diastereoisomers (Ia and Ib) of 3-(4-chlorobenzyl) quinolizidine were determined from the retention time in gas chromatography, NMR spectra of their methiodides, and from their dipole moments, in comparison with those of 3-lupinine and 3-epilupinine.View full abstractDownload PDF (593K) -
ZENICHI HORII, KOICHI MORIKAWA, CHUZO IWATA, ICHIYA NINOMIYA1968 Volume 16 Issue 9 Pages 1686-1691
Published: September 25, 1968
Released on J-STAGE: March 31, 2008
JOURNAL FREE ACCESSWith additional identification of two products (V) and (VI) from the reaction between β-aminoester (I) and 2-tetralone, and with results of the reactions hitherto investigated, we proposed the whole aspect of the reaction between β-aminoester and cyclic ketone, as possibly yielding at least nine products. And as the extension to 14-azasteroid syntheses, it was examined the reactions between ethyl 2-pyrrolidine- and 2-piperidine-acetates with 3, 4-dihydro-6-methoxy-1H-naphthalen-2-one to afford 1, 2, 3, 5, 6, 11, 12, 12a-octahydro-8-methoxynaphth [2, 1-e] indolizin-11-one (XVIIIa) and 1, 2, 3, 4, 6, 7, 13, 13a-octahydro 9-methoxy-12H-naphtho [1, 2-c] quinolizin-12-one (XVIIIb) as expected, besides two other products in each case.View full abstractDownload PDF (665K) -
TOSHIO KAWASAKI, TATSUO YAMAUCHI1968 Volume 16 Issue 9 Pages 1692-1695
Published: September 25, 1968
Released on J-STAGE: March 31, 2008
JOURNAL FREE ACCESSAcetylation of dioscin (I) with acetic anhydride-pyridine (1 : 1) at 10°for 24 hr gave, as the major product, a heptaacetate (III), mp 130-135°, [α]D-82.0° (MeOH), [α]D-85.3° (CHCl3), in which one hydroxyl group, probably at C-3 of the glucose unit, is free. Dioscin octa (per) acetate (V), mp 145-147°, [α]D -67.5° (MeOH), [α]D -61.9° (CHCl3), was obtained on treatment of I with acetic anhydride-pyridine (2 : 1) at 100°for 3 hr and subsequent purification of the product by recrystallization. Ammonolysis of V provided a dioscin monoacetate (VI), mp 285-289° (decomp.), [α]D-101.2° (pyridine), which was proved to be 2-O- and 4-O-bis-a-L-rhamnopyranosyl-(3-O-acetyl)-β-D-glucopyranoside of diosgenin.View full abstractDownload PDF (628K) -
TETSUJI KAMETANI, HIDEO NEMOTO1968 Volume 16 Issue 9 Pages 1696-1699
Published: September 25, 1968
Released on J-STAGE: March 31, 2008
JOURNAL FREE ACCESSThe Chichibabin reaction of quinoline (I) in dimethylaniline with sodium amide was carried out, to give a mixture of 2-aminoquinoline (II) and unexpected 2-amino-3, 4-dihydroquinoline (III). Furthermore, the mechanism of the formation of III was revealed by comparison of the product obtained from 2-deuterioquinoline by the same method as above from the point of nuclear magnetic resonance and mass spectra.View full abstractDownload PDF (554K) -
TOSHIHIKO OKAMOTO, HIROSHI TAKAHASHI1968 Volume 16 Issue 9 Pages 1700-1704
Published: September 25, 1968
Released on J-STAGE: March 31, 2008
JOURNAL FREE ACCESS3-Nitroquinoline was reacted with potassium cyanide in methanol at refluxing temperature to give 3-methoxycinchoninonitrile (I) and 1-aminoisoxazolo [3, 4-c] quinoline (II) in the yield of 62% and 30%, respectively. 3-Nitrocinchoninonitrile (III), which was prepared by the reaction of 3-nitroquinoline with potassium cyanide in the presence of potassium ferricyanide, was treated with potassium cyanide in methanol to from I, and III was converted into II by reduction with zinc dust and ammonium chloride.View full abstractDownload PDF (626K) -
TETSURO IKEKAWA, NOBUAKI UEHARA, TOMOKO OKUDA1968 Volume 16 Issue 9 Pages 1705-1708
Published: September 25, 1968
Released on J-STAGE: March 31, 2008
JOURNAL FREE ACCESSIt was demonstrated that 3-aminophenoxazone-(2) (questiomycin A) was obtained by photooxidative coupling of o-aminophenol. The photoreaction proceeded in the UV region of o-aminophenol and did not proceed without oxygen. Some photosensitizers could induce the photoreaction by irradiation of wave length longer than 300mμ. The reaction was suggested to be a first order reaction with respect to the concentration of o-aminophenol. By means of electron spin resonance, the reaction mechanism was discussed.View full abstractDownload PDF (548K) -
HIDEKO OGAWA, SHINSAKU NATORI1968 Volume 16 Issue 9 Pages 1709-1720
Published: September 25, 1968
Released on J-STAGE: March 31, 2008
JOURNAL FREE ACCESSFrom the rhizomes of Ardisia japonica 2-hydroxy-5-methoxy-3-pentadecenylbenzoquinone contaminated with 3-tridecenyl and 3-tridecyl compounds (Ia) was obtained. Novel type bisbenzoquinonyl-olefin derivatives, designated ardisiaquinones A, B and C, were isolated from the root bark of Ardisia sieboldii and the structures (V-VII) have been elucidated.View full abstractDownload PDF (1362K) -
TOSHIO MIYAZAKI, TOSHIRO YADOMAE1968 Volume 16 Issue 9 Pages 1721-1725
Published: September 25, 1968
Released on J-STAGE: March 31, 2008
JOURNAL FREE ACCESSMain water-soluble intracellular polysaccharide of P. chrysogenum is a galactomannan consists of D-galactose and D-mannose in an approximate ratio of 2 : 3 with trace of D-glucose. Assay of formic acid and formaldehyde released by periodate oxidation and that of Smith type degradation products showed that the polysaccharide has a linear structure and contains 1→2 main linkage with 1→3 linkage also 1→4 linked galactopyranose or 1→5 or 1→6 linked galactofuranose residue.View full abstractDownload PDF (655K) -
JUICHIRO SHIBASAKI, TAMOTSU KOIZUMI, TERUKAZU TANAKA, MICHIKO NAKATOMI1968 Volume 16 Issue 9 Pages 1726-1731
Published: September 25, 1968
Released on J-STAGE: March 31, 2008
JOURNAL FREE ACCESSMetabolism of an antipyretic and analgesic of aniline derivative, bucetin (β-hydroxybutyro-p-phenetidide, Ia) in rabbits was studied. From the results of estimations of total glucuronic acid and sulfate in the urine, it was deduced that the majority of metabolites was excreted as glucuronides and the excretion of sufates was negligiblly small, if any. By treating the urine with β-glucuronidase, extracting with ether, and purifying the extract through silica gel column, N-(β-hydroxybutyro)-p-aminophenol (Ib) and phydroxyacetanilide (IIIb) were isolated and identified with authentic samples. Moreover, p-hydroxyacetoacetanilide (IIb) was identified in the ether extract by thin-layer chromatography. For the formation of IIIb, there were two reactions involved ; de-ethylation of Ia at ethoxyl group and the loss of two carbons in β-hydroxybutyryl group. Since the latter reaction was not familiar for drug metabolism, the mechanism of the reaction was also discussed in this communication.View full abstractDownload PDF (761K) -
HISASHI NOGAMI, JUN HASEGAWA, KIYOSHI OKAZAKI1968 Volume 16 Issue 9 Pages 1732-1741
Published: September 25, 1968
Released on J-STAGE: March 31, 2008
JOURNAL FREE ACCESSThe kinetics in aqueous solution on the exchange reaction between thiamine tetrahydrofurfuryl disulfide and thiols, i.e., L-cysteine, N-acetyl-L-cysteine, and glutathione, was conducted at the experimental condition of 15° to 37° and pH 3.5 to 8.5 where it was proved that the main reaction could be followed from the formation of thiamine neglecting the possible side reactions examined by paper partition chromatographic procedure. The following conclusions were drawn from the result presented. 1) The formation of thiamine followed the second order reaction concluded as SN2 and was converted to a first order kinetics by the addition of excess amount of reactant. 2) From the analysis of pH-rate profile of the reaction, the following two elementary reactions were postulated, i.e., between the molecular or ionized form of thiamine derivative and thiol anion, which well explained the result obtained. 3) No detectable effect on rate was proved for the ionic strength and concentration of buffer solution used. 4) The kinetical parameters for each elementary reaction, i.e., specific rate constant, activation energy, frequency factor, and activation entropy, were tabulated. 5) The activation energies were around 10 kcal/mole. Larger negative activation entropy was found in reactions between molecular form of thiamine derivative and thiol anions than ones between ions. The reactivity of thiols was -NACyS->-GS->CyS-.View full abstractDownload PDF (923K) -
MISAKO ARAKI, MINEO SANEYOSHI, HARUE HARADA, YUTAKA KAWAZOE1968 Volume 16 Issue 9 Pages 1742-1746
Published: September 25, 1968
Released on J-STAGE: March 31, 2008
JOURNAL FREE ACCESS3-Fluoroquinoline 1-oxide, which was prepared through the Schiemann reaction of 3-aminoquinoline, followed by N-oxygenation, was nitrated to 3-fluoro-4-nitroquinoline 1-oxide. The fluorine atom of this compound was replaced with nucleophiles such as OR- or NR2-containing compounds in neutral or alkaline media to afford 3-substituted 4-nitroquinoline 1-oxide derivatives. The reaction with aqueous hydrogen chloride brought about the replacement of the nitro group to give 3-fluoro-4-chloroquinoline 1-xoide.View full abstractDownload PDF (667K) -
YUICHI KANAOKA, MINORU MACHIDA, HIROSHI KOKUBUN, TAKAMITSU SEKINE1968 Volume 16 Issue 9 Pages 1747-1753
Published: September 25, 1968
Released on J-STAGE: March 31, 2008
JOURNAL FREE ACCESSAmong fluorescent-labeled sulfhydryl reagents hitherto synthesized in this laboratory, N-[p-(2-benzoxazolyl) phenyl] maleimide (I) was selected as a typical example and its fluorescent characteristics were determined. In contrast to that I shows no substantial fluorescence, its cysteine ester-adduct (II) exhibits strong fluorescence with emission maxima at 352 and 365 mμ. This spectroscopic behavior of this type of reagent may be favorably utilized in the application to proteins. Since N-[p-(2-benzoxazolyl) phenyl] succinimide (III) is regarded as the simplest model compound of the adducts of I with sulfhydryl substrates, fluorescent spectra of III in various media were examined. The absorption spectra of III were also systematically examined by comparing spectra of IV, VII, VIII and III. General procedures of fluorescence determination were described and interpretation of the spectra was discussed.View full abstractDownload PDF (775K) -
ZENICHI HORII, MASAYOSHI ITO, MIYOJI HANAOKA1968 Volume 16 Issue 9 Pages 1754-1757
Published: September 25, 1968
Released on J-STAGE: March 31, 2008
JOURNAL FREE ACCESSThe amino-lactone (VII), a degradation product of securinine, cyclized on heating into the isoquinuclidine (VIII). The Hofmann-Loffler reaction of amino-ketone (XVIII) afforded the a-ketol (rac-X), identical with X derived from VIII.View full abstractDownload PDF (560K) -
AKIRA TAKAMIZAWA, KENTARO HIRAI, YOSHIO HAMASHIMA1968 Volume 16 Issue 9 Pages 1758-1763
Published: September 25, 1968
Released on J-STAGE: March 31, 2008
JOURNAL FREE ACCESS2-Morpholino-, 2-piperidino-3-(2-methyl-4-aminopyrimidin-5-yl) methyl-3a-methylperhydrofuro [2, 3-d] thiazole (VI, IX), and N, N'-bis {2-[3-(2-methyl-4-aminopyrimidin-5-yl) methyl-3a-methylperhydrofuro [2, 3-d] thiazolyl} piperazine (X) were synthesized by the reaction of B1 hydrochloride (I) or B1-Na (II) with corresponding amines. Reactions of II with aniline and benzylamine were also undertaken to result in giving N-[1-methyl-2-phenylimino (or 2-oxo-)-4-hydroxybutyl]-N-[(2-methyl-4-aminopyrimidin-5-yl) methyl]-formamide (XIV, XVII). Brief reaction mechanisms are discussed.View full abstractDownload PDF (804K) -
AKIRA TAKAMIZAWA, KENTARO HIRAI, YOSHIO HAMASHIMA, YOSHIHIRO MATSUMOTO ...1968 Volume 16 Issue 9 Pages 1764-1772
Published: September 25, 1968
Released on J-STAGE: March 31, 2008
JOURNAL FREE ACCESSSyntheses of dialkyl 2-{3-(2-methyl-4-aminopyrimidin-5-yl) methyl-3a-methylperhydrofuro-[2, 3-d]-thiazole} phosphonates (Va-f), and their thermal isomerization affording dialkyl 7-[2, 9a-dimethyl-9-(2-hydroxyethyl)-5, 6, 7, 9, 9a, 10-hexahydropyrimido [4, 5-d]-thiazolo [3, 4-a] pyrimidine] phosphonates (VIIa-f) are described. Transesterification was occurred in the reaction of thiamine (B1) with diphenyl hydrogen phosphite in methanol. Regeneration of V from VII was also detected. O-allyl 7-[2, 9a-dimethyl-9-(2-hydroxyethyl)-5, 6, 7, 9, 9a, 10-hexahydropyrimido [4, 5-d] thiazolo [3, 4-a] pyrimidine] phosphinic acid (IX), O-allyl 2-[3-(2-methyl-4-aminopyrimidin-5-yl) methyl-4-methyl-5-(2-hydroxyethyl) thiazoline (4)] phosphinic acid (X), methyl and ethyl 2-[3-(2-methyl-4-aminopyrimidin-5-yl) methyl-3 a-methylperhydrofuro [2, 3-d] thiazole] phenylphosphonate (XIIa-b) were obtained. Brief reaction mechanisms are discussed.View full abstractDownload PDF (1121K) -
AKIRA TAKAMIZAWA, YOSHIO MORI, HISAO SATO, SACHIKO TANAKA1968 Volume 16 Issue 9 Pages 1773-1778
Published: September 25, 1968
Released on J-STAGE: March 31, 2008
JOURNAL FREE ACCESSThe reaction of deuterioamino-O-acetylthiamine (Id) with dialkyl acetylphosphonate afforded 1-methyl-1-deuterio-3-(2-acetoxy) ethyl-4, 9-dimethyl-1, 6-dihydropyrimido-[4', 5'-4, 5] pyrimido [2, 3-c] [1, 4] thiazine (IIIf). Treatment of 2-methyl-4-(2-methyl-4-amino-5-pyrimidinyl) methyl-5-methyl-6-(2-acetoxy) ethyl-2H-1, 4-thiazin-3 (4H)-one (IVa) with hydrogen peroxide in acetic acid gave 2-acetyl-2-hydroxy-3-(2-methyl-4-amino-5-pyrimidinyl) methyl-4-methyl-5-(2-acetoxy) ethylthiazoline (Va).View full abstractDownload PDF (647K) -
HIROSHI HIKINO, YASUKO HIKINO, KUNIO AGATSUMA, TSUNEMATSU TAKEMOTO1968 Volume 16 Issue 9 Pages 1779-1783
Published: September 25, 1968
Released on J-STAGE: March 31, 2008
JOURNAL FREE ACCESSChemical and physico-chemical studies of the new sesquiterpenic ketone, faurinone, isolated from the valerian indigenous to Mt. Ibuki, Japan, have indicated it to be represented by the stereostructure I having a novel ring-contracted skeleton.View full abstractDownload PDF (720K) -
YOSHIRO KOBAYASHI, CHIGEN AKASHI, KUNIO MORINAGA1968 Volume 16 Issue 9 Pages 1784-1787
Published: September 25, 1968
Released on J-STAGE: March 31, 2008
JOURNAL FREE ACCESSThe reactions of diphenyltrifluorophosphorane with alcohols were studied, and it was found to be a more excellent one-step fluorinating reagent for substituting the hydroxyl group of alcohols. Compared with difluorotriphenylphosphorane discussed in the previous paper, this reagent is superior in its being able to be produced at less cost and its reaction starting at the lower temperature. The reaction mechanism when solvent was used is presumed to be the same as in the case of difluorotriphenylphosphorane, but reaction modes differ when solvent was not used. To use solvent is better for preparing alkyl fluoride.View full abstractDownload PDF (498K) -
TOHRU UEDA, YUKIHIKO IIDA, KAZUYOSHI IKEDA, YOSHIHISA MIZUNO1968 Volume 16 Issue 9 Pages 1788-1794
Published: September 25, 1968
Released on J-STAGE: March 31, 2008
JOURNAL FREE ACCESSStarting from 2, 4-dithio-1-methyluracil (II) various 1-methylpyrimidines were obtained through the intermediate pyrimidine (III). Some comparisons were made on the methylation of oxo- and thio-pyrimidines. A protected 4-thiouridine (XIII) afforded 2, 4-dithiouridine (XV) by the direct thiation with phosphorus pentasulfide at elevated temperature and subsequent deblocking. 2-Thiocytidines were prepared from XV and the possible tautomeric form of 2-thiocytidine was discussed by the UV spectral behaviors.View full abstractDownload PDF (931K) -
HIROMU MORI, JOJI YAMADA, YOSHIO TAKAHASHI, KIKUO YASUDA, KIYOSHI TSUN ...1968 Volume 16 Issue 9 Pages 1795-1801
Published: September 25, 1968
Released on J-STAGE: March 31, 2008
JOURNAL FREE ACCESSSome 2-hydroxy-3-oxo-4, 4-dimethyl-1-ene steroids and two 4-hydroxy-3-oxo-2, 2-dimethyl-4-ene steroids were prepared in order to obtain anti-tumor substances against sex hormone dependent cancer such as breast cancer and prostatic cancer. These diosphenols were synthesized by the autoxidation of the corresponding 3-oxo steroids in the presence of potassium tert-butoxide in tert-butanol.View full abstractDownload PDF (933K) -
TOSHIO NAMBARA, HIROSHI HOSODA, MASAHIRO USUI, JACK FISHMAN1968 Volume 16 Issue 9 Pages 1802-1807
Published: September 25, 1968
Released on J-STAGE: March 31, 2008
JOURNAL FREE ACCESSFour epimeric 16-deuterio-5α, 13α-androstane-3β, 17-diols were prepared starting from 3β-hydroxy-5α, 13α-androstan-17-one, and the conformation of ring D in 13α-steroids is discussed based upon the correlation of dihedral angles with the observed coupling constants of H16, 17. The chemistry of the 16β, 17β-epoxy and Δ16 compounds is also described.View full abstractDownload PDF (764K) -
ZENZO TAMURA, YASUMASA KIDO1968 Volume 16 Issue 9 Pages 1808-1815
Published: September 25, 1968
Released on J-STAGE: March 31, 2008
JOURNAL FREE ACCESSThe mechanism of the Millon reaction of p-cresol using the Hopkins-Cole reagent was investigated and three kinds of pigments as the final coloring substances were isolated. Namely, Pigment 1, 2 and 3 were obtained from the reaction mixture under various qualitative conditions using a 10% solution of mercuric sulfate. Pigment 1 was found to consist of 2-mercuri-4-methylphenol (MMP) and 2-nitroso-4-methylphenol (NMP), Pigment 2 of NMP and mercuric ion, and Pigment 3 was a polymer consisting of NMP and a compound assumed to be a mercurated nitrosocresol. On the other hand, the main pigment produced under the quantitative condition was demonstrated to be Pigment 2 by its isolation. MMP which is assumed to be an intermediate of these pigments, produces Pigment 1 on treatment with sodium nitrite in acidic medium. Consequently, Millon reaction of p-cresol proceeds through the mercuration at the o-position of hydroxyl group, which is followed by the electrophillic substitution of mercury atom with nitrosyl cation generated from sodium nitrite in acidic medium to give nitrosocresol. This resulted nitrosocresol, finally, coordinates to either organic or inorganic mercury to develop the characteristic Millon color.View full abstractDownload PDF (1025K) -
SHUNICHI YAMADA, SHIRO TERASHIMA1968 Volume 16 Issue 9 Pages 1816-1828
Published: September 25, 1968
Released on J-STAGE: March 31, 2008
JOURNAL FREE ACCESSThe reaction mechanism of the base-induced rearrangement of ketone trimethylhydrazonium iodide (Ia) was studied using the optically active open chain compound, S (+)-3-methyl-4-phenyl-2-butanone trimethylhydrazonium iodide (S (+)-VIII). According to the nearly complete racemization of the rearrangement product (IXa) and little but evident optical retention of the recovered ketone (XIa), it appeared more probable that this rearrangement had proceeded through vinyl nitrene (V). Then, it became difficult to prepare the optically active α-amino ketone (II) from the ketone involving the optically active C-H bond at α-position with this rearrangement. Preliminary examinations using racemic compounds were also reported.View full abstractDownload PDF (1646K) -
KENICHIRO MINEGISHI, YUKIO KUROIWA, SEIICHI OKUI1968 Volume 16 Issue 9 Pages 1829-1830
Published: September 25, 1968
Released on J-STAGE: March 31, 2008
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HISAO YAMAMOTO, TOSHIO ATSUMI1968 Volume 16 Issue 9 Pages 1831-1834
Published: September 25, 1968
Released on J-STAGE: March 31, 2008
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TETSUZO KATO, HIROSHI YAMANAKA, JUNSHI KAWAMATA, TETSUICHI SHIBATA1968 Volume 16 Issue 9 Pages 1835-1837
Published: September 25, 1968
Released on J-STAGE: March 31, 2008
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HIROSHI MIURA, NOBUSUKE KAWANO1968 Volume 16 Issue 9 Pages 1838-1840
Published: September 25, 1968
Released on J-STAGE: March 31, 2008
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GENJI OTANI, YASUO KIKUGAWA, SHUNICHI YAMADA1968 Volume 16 Issue 9 Pages 1840-1841
Published: September 25, 1968
Released on J-STAGE: March 31, 2008
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MASAKAZU ARITOMI, TOSHIO KAWASAKI1968 Volume 16 Issue 9 Pages 1842-1843
Published: September 25, 1968
Released on J-STAGE: March 31, 2008
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TETSUJI KAMETANI, KUNIO OGASAWARA1968 Volume 16 Issue 9 Pages 1843-1845
Published: September 25, 1968
Released on J-STAGE: March 31, 2008
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TOSHIO OGINO, TAKASHI HAYASAKA, SHO ITO, TOSHIO TAKAHASHI1968 Volume 16 Issue 9 Pages 1846-1847
Published: September 25, 1968
Released on J-STAGE: March 31, 2008
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TADASHI KANAI, MOTONOBU ICHINO1968 Volume 16 Issue 9 Pages 1848-1850
Published: September 25, 1968
Released on J-STAGE: March 31, 2008
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SHOJI KOJIMA, HISASHI ICHIBAGASE1968 Volume 16 Issue 9 Pages 1851-1854
Published: September 25, 1968
Released on J-STAGE: March 31, 2008
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KAZUHIRO IMAI, ZENZO TAMURA1968 Volume 16 Issue 9 Pages 1854-1857
Published: September 25, 1968
Released on J-STAGE: March 31, 2008
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TOSHIHIKO OKAMOTO, YOSHIHIKO TORII, YO ISOGAI1968 Volume 16 Issue 9 Pages 1860-1864
Published: September 25, 1968
Released on J-STAGE: March 31, 2008
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ZENZO TAMURA, TOSHIO IMANARI, YASUAKI ARAKAWA1968 Volume 16 Issue 9 Pages 1864-1865
Published: September 25, 1968
Released on J-STAGE: March 31, 2008
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