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TAKATSUKA YASHIKI, TAI MATSUZAWA, MASAHIRO YAMADA, TAKAO KONDO, YOSHIA ...
1971 Volume 19 Issue 5 Pages
869-880
Published: May 25, 1971
Released on J-STAGE: February 08, 2011
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In order to elucidate the behavior of BCP in man, plasma concentration of BCP and urinary excretion of total BCP and its metabolites were determined periodically after its oral administration.
By analysis of the data with an analogue computer, the characteristic behavior of BCP was found that the maximum tissue amount of BCP increased almost linearly with dose both in the single and successive administration, whereas the maximum plasma concentration did not increase linearly with dose and approached an asymptotic value.
This behavior of BCP was considered due to its high degree of binding property to plasma albumin which was saturated at the plasma concentration of 13 mg/100 ml, kinetical conditions and to the dosage range in which the maximum plasma water concentration of BCP increased almost linearly with the dose given.
It was also suggested that by increasing the dose to a reasonable extent, increased clinical effect might be expected, though the maximum plasma concentration approached a limiting value.
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TAKATSUKA YASHIKI, TAI MATSUZAWA, MASAHIRO YAMADA, TAKAO KONDO, HIROYU ...
1971 Volume 19 Issue 5 Pages
881-891
Published: May 25, 1971
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In order to support the application of the model 1 to simulate the behavior of 5-nbutyl-1-cyclohexyl-2, 4, 6-trioxoperhydropyrimidine (BCP) in man, further studies were carried out independently in man and in rabbits.
The human plasma concentration and urinary excretion after the intravenous administration of BCPNa in a clinical test were simulated well by the model 1 with the same order of values for the rate constants as in the oral administration.
Then, using rabbits, BCP in organs and tissues along with the plasma concentration and urinary excretion were determined and compared with the simulated values by the model 1.
After correction for the mass balance, the tissue amounts of BCP were simulated fairly well.
These results indicated the applicability of the model 1 both in man and in rabbits.
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Syntheses of Heterocyclic Compounds involving Sulfur. II. Syntheses of 3-Tosyl-1, 2-dihydro-3H-pyrazino [3, 2, 1-kl] phenothiazine-1, 2-dione, 2-Tosyl-1, 2-dihydroimidazo [4, 5, 1-kl] phenothazine-1-one, and N, N'-Bis [tosyl (1-phenothiaziny1)] oxalamide from Reaction between 1-Tosylaminophenothiazine and Oxalyl Chloride
HIDEAKI SHIRAI, TAKANORI HAYAZAKI, TOYOHIKO AOYAMA
1971 Volume 19 Issue 5 Pages
892-895
Published: May 25, 1971
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Reaction of 1-tosylaminophenothiazine (IV) and oxalyl chloride gave 3-tosyl-1, 2-dihydro-3
H- pyrazino [3, 2, 1-
kl] phenothiazine-1, 2- dione (VI), N, N'-bis [tosyl (1-phenothiaziny1)] oxalamide (VII), and 2-tosyl-1, 2-dihydroimidazo [4, 5, 1-
kl] phenothiazine-1-one (VIII).
Reduction of VI with lithium aluminum hydride afforded 1, 2-dihydro-3H-pyrazino [3, 2, 1-
kl] phenothiazine (X), and a similar reaction of VIII gave IV, accompanied with ring-pened product.
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SADAO AOYAMA
1971 Volume 19 Issue 5 Pages
896-905
Published: May 25, 1971
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A small amount of 3β, 20β-diacetoxy-9 (8→7)-abeo-5α-pregn-7 (9)-ene-8, 11-dione (4), a compound with a 6-5-7-5 ring system, was formed in the alumina catalyzed cyclization of 3β, 20β-diacetoxy-8, 9-seco-5α-pregnane-8, 9, 11-trione (1). As it was not at first possible to isolate 4 in a pure state, the structure was deduced from a derivative, the saturated ketone (10), the structure of which was confirmed by its synthesis from the known glycol monomesylate (9b) with a 6-6-6-5 ring system by means of the pinacolic type rearrangement. Later, the compounds (4a, b) were obtained by cyclization of 1 with silica gel followed by alumina treatment and all the features of the reaction were clarified. The stereochemistry of the ketone (10) and its derivatives was also discussed.
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KINZO NAGASAWA, HISAE YOSHIDOME
1971 Volume 19 Issue 5 Pages
906-911
Published: May 25, 1971
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When riboflavin was dissolved in concd. H
2SO
4, it was quantitatively transformed into sulfated riboflavins without any polymerization or degradation. The sulfated riboflavins were separated by ion-exchange chromatography into four components which were identified to riboflavin mono-, di-, tri-, and tetrasulfates, respectively. The results of periodate oxidation revealed that the riboflavin mono-and disulfates were rather complex in their compositions.
The influence of reaction conditions on the sulfation of riboflavin was examined. It was found that both the temperature and time of reaction did not so much affect the sulfation, but the temperature of ether used for separating products from concd. H
2SO
4, did decisively.
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KIYOYASU ISHIKAWA, KAZUO ACHIWA, SHUN-ICHI YAMADA
1971 Volume 19 Issue 5 Pages
912-929
Published: May 25, 1971
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Optical rotatory dispersion and circular dichroism curves of twenty N-dithiocarbethoxy-L-α-amino acids were measured in water, methanol, dioxane, chloroform, and benzene. Striking solvent effects on Cotton effect curves, due to
n→π* transition of the >N-CSS chromophore, were found. The Cotton effect was inverted by changing solvents. These solvent effects were classified in five groups based on the chemical structure of their amino acids.
Cyclohexylammonium salts of these dithiocarbamates produced different solvent effects on Cotton effect curves due to the same transition of the >N-CSS chromophore.
The most reliable conditions for correlating the absolute configuration of a-amino acids to the sign of Cotton effect curves using dithiocarbamate derivatives were discussed.
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TAKAICHI ARITA, RYOHEI HORI, MASAHIKO TAKADA, AYAKO MISAWA
1971 Volume 19 Issue 5 Pages
930-936
Published: May 25, 1971
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Sulfadimethoxine and its three biotransformed products in man were applied to renal clearance experiments in dogs to elucidate their renal excretion mechanisms.
Clearance ratio of sulfadimethoxine is extremely low compared with each biotransformed product. Of three biotransformed products, clearance ratio of sulfadimethoxine-N1-glucuronide greatly exceeded over the clearance ratio of the other two biotransformed products.
Considerable proximal tubular secretion of sulfadimethoxine-N
4-acetate was observed. On the contrary, the proximal tubular secretion of sulfadimethoxine-N
1-glucuronide and sulfadimethoxine were insufficient.
Sulfadimethoxine-N
1-glucuronide considerably reduced the affinity to dog plasma protein compared with sulfadimethoxine and sulfadimethoxine-N
4-acetate.
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TAKAICHI ARITA, RYOHEI HORI, MASAHIKO TAKADA, SHIGETAKA AKUZU, AYAKO M ...
1971 Volume 19 Issue 5 Pages
937-943
Published: May 25, 1971
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Sulfisomidine, sulfamethizole and their biotransformed products in man (N
4-acetate, N
4-glucuronide, N4-sulfonate) were applied to renal clearance experiments in dogs and protein binding experiments to dog plasma protein in order to elucidate their renal excretion mechanisms.
Clearance ratio of N
4-acetate of both sulfonamides were less than that of original sulfonamides. From the results of inhibitory experiments by iodopyracet, it was found that both sulfonamides and their N
4-acetates were actively secreted and N
4-glucuronides exhibited reduced proximal tubular secretion. It was observed that clearance ratio of sulfamethizole-N
4-glucuronide, in spite of the reduced affinity for plasma protein and increased solubility, were lower than that of sulfamethizole.
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SHIGERU GOTO, OSAMI TSUZUKI, SADAO IGUCHI
1971 Volume 19 Issue 5 Pages
944-953
Published: May 25, 1971
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The combination of aminopyrine and barbital has been recomended from pharmacological point of view and claimed as one of the representative examples of drug interactions. On the other hand, it will be necessary to investigate pharmacokinetically whether such a combination exhibits a tolerable potency or not. The significantly increased plasma level of aminopyrine in rabbit after simultaneous administration of barbital was observed. The most likely reason for positive effect of barbital was investigated in detail. But the potentiation of aminopyrine-barbital interaction in gastrointestinal absorption and the accelerated effect of barbital on metabolic and excretion process of aminopyrine could not be concluded from various in vitro and in vivo experiments. As one of the reasons, an increased rate of stomach emptying induced by barbital may be presented.
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TOSHIO NAMBARA, TOSHIYUKI SHIBATA, MASAAKI MIMURA, HIROSHI HOSODA
1971 Volume 19 Issue 5 Pages
954-958
Published: May 25, 1971
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As the modified cardenolide N-(steroid-17-yl)-maleimide (VII), which is capable of reacting with SH group, has been prepared. Condensation of 17-aminosteroid (IV) with maleic anhydride gave N-(steroid-17-yl)-maleamic acid (V), which on treatment with acetic anhydride was led to VII by intramolecular dehydration (see Chart 2). Formation of isomaleimide (VI), an intermediate leading to VII, is also described.
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HARUO SAIKACHI, HIROSHI MUTO
1971 Volume 19 Issue 5 Pages
959-969
Published: May 25, 1971
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The Wittig reaction of aromatic
p-substituted bisphosphoranes with bisaldehydes was carried out in dimethylformamide to give four kinds of poly-
p-xylylidene series, as the oligopolymers in good yield. In the process of the reaction, the cyclic olefins were also given in very poor yield.
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HISASHI ISHII, YOSHIMI ISHIKAWA, KEIZO MIZUKAMI, HIDEKI MITSUI, NISABU ...
1971 Volume 19 Issue 5 Pages
970-976
Published: May 25, 1971
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Oxidation of 6-methyl-2-phenylbenzofuran with chromium trioxide in acetic acid gave an unusual dimeric oxidation product, 2, 2'-dibenzoyloxy-4, 4'-dimethylbenzil (II). Structural establishment came from several chemical evidences including an interesting acyl migration from 2, 2'-dibenzoyloxy-4, 4'-dimethylhydrobenzoin (III) to 2, 2'-dimethoxy-4, 4'-dimethylhydrobenzoin dibenzoate (IV) during methylation with diazomethane.
On the other hand, oxidation of the same benzofuran with Jones' reagent afforded 2-hydroxy-4-methylbenzil (IX). Furthermore, on treatment with chromium trioxide. pyridine complex, the material (II) was recovered quantitatively.
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TOYOZO TAKADA, SADAO OHKI
1971 Volume 19 Issue 5 Pages
977-981
Published: May 25, 1971
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As an approach to the synthesis of mitomycin structure, 2-methoxy-10b, 11-dihydro-6
H-isoindolo [2, 1-a] indole (X) and 2-methoxy-6
H-isoindolo [2, 1-a] indole (XI) were synthesized. By the oxidative cyclization of 1-(2, 5-dihydroxybenzyl) isoindoline (VII) with alkaline potassium ferricyanide, a dihydroindole compound, 2-hydroxy-10b, 11-dihydro-6
H-isoindolo [2, 1-a] indole (IX) was obtained as a main product beside a small amount of indole compound, 2-hydroxy-6
H-isoindolo [2, 1-a] indole (VIII).
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TOYOZO TAKADA, SACHIKO KUNUGI, SADAO OHKI
1971 Volume 19 Issue 5 Pages
982-989
Published: May 25, 1971
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In connection with synthesis of the ring system of mitomycins, 1
H-pyrrolo [1, 2-a] indoles (HI to VI) were synthesized. Indole (XVIII) was synthesized by the reaction of aminodiester (XVII) and 2-chloro-5-nitrobenzaldehyde in one step. Dieckmann reaction of XVIII afforded pyrroloindole (III). By the carbene cyclization reaction, tosylhydrazone (XX) of aldehyde (XIX) gave the compound IV in poor yield, and tosylhydrazones (XXV and XXX) of ketones (XXIV and XXVIII) afforded the desired pyrroloindoles (V and VI) in good yield, respectively.
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TOSHIO NAMBARA, MITSUTERU NUMAZAWA
1971 Volume 19 Issue 5 Pages
990-994
Published: May 25, 1971
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Isolation and characterization of the conjugated metabolites formed from 3-deoxyestrone have been carried out. The urine of rabbit with a large dosage of the steroid was collected and extracted with
n-butanol. The extract was in turn chromatographed on Sephadex LH-20 to give 2-hydroxy-3-deoxyestrone glucuronide (Conjugate I). This procedure, however, failed to separate the remaining conjugates and therefore the glucuronides were transformed into the acetate-methyl esters. Upon column chromatography on alumina 17α-estradiol 17-glucuronide (Conjugate II), 6βA-hydroxy-3-deoxyestrone glucuronide (Conjugate III) and 16, 17-epiestriol 3, 17 (or 3, 16)-diglucuronide (Conjugate IV) were isolated as their derivatives and the structures were elucidated by dcgradative means (see Chart 1). The biochemical significance of the occurrence of these conjugates has been discussed.
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MARI SAKUMA, MASAYOSHI YOSHIKAWA, YOSHISHIGE SATO
1971 Volume 19 Issue 5 Pages
995-1005
Published: May 25, 1971
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The distribution of a
14C-labeled coronary vasodilator, 3-acetoxy-2, 3-dihydro-5-[2-(dimethylamino) ethyl]-2-(
p-methoxyphenyl)-1, 5-benzothiazepin-4 (5H)-one hydrochloride-(
14C-CRD-401), in mice was studied by means of whole body autoradiographic technique. Immediately after intravenous injection,
14C-CRD-401 disappeared from the blood and accumulated in the heart muscle, lung, adrenal cortex, kidney, skeletal muscle and brain. The high radioactivity appeared rapidly in the stomach mucosa and bile, and consequently in the lumen of the stomach and intestine. Most organs which exhibited the highest radioactivity immediately after the injection showed gradually diminishing radioactivity during the first 24 hours. When administered orally to mice,
14C-CRD-401 was rapidly and easily absorbed from the intestinal tract, and the radioactivity in various organs reached their maximal levels within 30 minutes. The experiments with pregnant mice administered
14C-CRD-401 intravenously and orally demonstrated that there was a slow and slight penetration of radioactive materials to the fetuses through the placenta.
Chromatographic investigation on the tissue-extracts of mice treated with
14C-CRD-401 demonstrated the compound was rapidly metabolized in mice after intravenous administration as well as after oral one.
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AKIRA HANAKI, HIROKO KAMIDE
1971 Volume 19 Issue 5 Pages
1006-1010
Published: May 25, 1971
Released on J-STAGE: February 08, 2011
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The copper-catalyzed oxidation of cysteine was followed from the consumption of oxygen using the conventional Warburg method and from the formation of hydrogen peroxide using the spectrophotometric method. The rate of oxygen uptake varied with pH and showed a maximum at pH 7.2. Hydrogen peroxide was produced progressively during the oxidation, which indicated the possibility of the successive four equivalent reduction of oxygen via hydrogen peroxide to water. The amounts of oxygen uptake and of hydrogen peroxide formed decreased with the increase of pH. From the peroxide formation and the oxygen consumption, the mode of the utilization of molecular oxygen was discussed. In the low pH region, the two equivalent redox-reaction, in which oxygen is reduced to hydrogen peroxide, may be predominant. As pH increases, hydrogen peroxide formed is utilized for the reoxidation of copper (I) ion, and thereupon the successivefour equivalent redox-reaction becomes predominant.
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KIYOMI KIKUGAWA, MOTONOBU ICHINO
1971 Volume 19 Issue 5 Pages
1011-1016
Published: May 25, 1971
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Cytidine diphosphate choline (CDP-choline), one of the nucleotide coenzymes, is known to be a precursor of phospholipid and play an important role in the living organisms. The coenzyme was synthesized in a fairly good yield by direct condensation of cytidine-5' monophosphate (5'-CMP) and choline phosphate (P-choline) by the use of
p-toluenesulfonyl chloride or methanesulfonyl chloride combined with dimethylformamide.
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YUTAKA ASAHI, MICHIYO NAGAOKA
1971 Volume 19 Issue 5 Pages
1017-1021
Published: May 25, 1971
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Reversible cleavages of thiamine mononitrate (I), dimethialium mononitrate (II), 3, 4-dimethyl-5-(2'-hydroxyethyl) thiazolium iodide (III), thiamic acid (IV) and N-methylbenzothiazolium iodide (V) were automatically followed by anodic waves of the thiol forms. Pseudo-first-order rate constants for the cleavage, (k
N) or the recyclization (k
s), are proportional to (OH
-) or (H
+), respectively. The pH where k
N is equal to k
S, corresponds to p
Kav: 9.3 (I), 9.4 (II), 10.3 (III), 11.2 (IV) and 6.5 (V). Electron donating groups seem to stabilize the thiazolium rings for OH
- and to decrease the acidities.
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AKIRA TAKAMIZAWA, KENTARO HIRAI, TERUYUKI ISHIBA
1971 Volume 19 Issue 5 Pages
1022-1026
Published: May 25, 1971
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Reaction of thiamine Na salt with COS gave the compound having 1, 2-dithiolane ring (IV). This compound was readily obtained from the reaction of thiamine anhydride (I) and H
2S in DMF solution. Reaction of I with D
2S gave deuterium incorporated derivatives and the mechanism for the formation of IV was suggested.
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AKIKO IKEKAWA, KANJI IMAGAWA, TOSHIE OMORI, NOBUYOSHI KANENIWA
1971 Volume 19 Issue 5 Pages
1027-1033
Published: May 25, 1971
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Ball-milling of thirty-two kinds of powders were investigated. Equation (1) was applied for rate of increase of surface area.
dS/
dt=k
1 exp (-k
2S)(1) Parameter k
1, was proportional to 1/Mohrs' es hardness and tended to be small for the samples with high melting point. Rarameter k
2 was small for the sample with high melting point and little solubility in water.
Critical particle size, Dc
2, was found at which maximum porosity in loosest packing was obtained not only for crushed samples but for samples of equal particle size. For particles below Dc
2, gravitational force of a particle may be negligibly small compared with cohesive force between particles. Dmin was proportional to Dc
2. Parameter k
1 tended to decrease and k
2 to increase with increase of ρ·
Dmin. Rate of increase of surface area by ball-milling is considered to depend on coherency of powder particles expressed as a function of surface energy, melting point, solubility in water, true density and so on.
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IKUZO HIMURO, YOJI TSUDA, KEIJI SEKIGUCHI, ISAMU HORIKOSHI, MOTOKO KAN ...
1971 Volume 19 Issue 5 Pages
1034-1040
Published: May 25, 1971
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Crystals of chloramphenicol obtained from about 30 kinds of solvents were analyzed by differential scanning calorimetry (DSC) for the detection of solvate formation. It was found that heterocyclic solvents such as pyridine and picolines formed solvates with chloramphenicol. Thermal behaviours of these solvates were further investigated by DSC under various conditions, by gas evolution analysis and by thermogravimetric analysis. The one-to-one solvate with pyridine was found most suitable to the size reduction by solvation and desolvation. The specific surface area of the desolvated chloramphenicol was 3.0-3.1m
2/g. The heat of desolvation and the heat of transformation from the pyridinate to the desolvated chloramphenicol were 6.3±0.5 kcallmole and 5.0±0.5kcal/mole, respectively. Also, the activation energy for the desolvation reaction was estimated by boththe methods of ozawa and Kissinger to be 20.6±1.6 kcallmole and 20.0±0.8 kca1/mole, respectively.
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HIDEKO ISHIHARA, OTOHARU ISHIZAKA
1971 Volume 19 Issue 5 Pages
1041-1045
Published: May 25, 1971
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A procedure and an apparatus of two-order microdiffusion analysis have been devised and applied to the simultaneous determination of ethanol and carbon dioxide. The conditions and the limitation of the assay method are as follows:
1. Amount of outer chamber solution; 3ml
2. pH of outer chamber solution; 1.3-8.7
3. Range of determination and value of coefficient of variation; ethanol, less than 23mg, 2% carbon dioxide, less than 14mg, less than 6%
4. Diffusion temperature; 30-37°5. Diffusion time; either more than 24hr at 37° or 30 hr at 30°
6. Rate of recovery; ethanol, 99%(pH 1.3), carbon dioxide 100%(pH 1.3)
The assay method was also applied to simultaneous determination of ethanol and carbon dioxide evolved in the process of alcoholic fermentation.
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MASATAKA ICHIKAWA, HISASHI ICHIBAGASE
1971 Volume 19 Issue 5 Pages
1046-1050
Published: May 25, 1971
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TOZO FUJII, SHIGEYUKI YOSHIFUJI
1971 Volume 19 Issue 5 Pages
1051-1052
Published: May 25, 1971
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AKIE IJIMA, HISAKO MIZUNO, KIYOSHI TAKAHASHI
1971 Volume 19 Issue 5 Pages
1053-1055
Published: May 25, 1971
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ISAO MATSUNAGA, ZENZO TAMURA
1971 Volume 19 Issue 5 Pages
1056-1057
Published: May 25, 1971
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NAOKI NAMBU, TSUNEJI NAGAI, HISASHI NOGAMI
1971 Volume 19 Issue 5 Pages
1058-1060
Published: May 25, 1971
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Mechanisms of pharmacological actions of phenothiazines have been known to be more or less based on the membrane actions.
As
in vitro studies of the membrane action, there have been often discussed the area occupied by one molecule of each phenothiazine compound at an interface, which is also important in discussing the interaction with other drugs at the interface.
The present study was attempted to obtain the area occupied by one molecule of phenothiazines upon the adsorption from aqueous solution and the cross-sectional area evaluated from Stokes' radius of the molecule upon the permeation through cellulose membrane, discussing the results in comparison with the existing data concerning the similar values obtained from surface activity, the maximal stabilization of erythrocyte membrane and the steric structure.
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1, 3, 6, 8-Tetramethy1-2, 4, 5, 7 (1H, 3H, 6H, 8H) pyrimido [5, 4-g] pteridinetetrone and 1, 3, 5, 7-Tetramethy1-2, 4, 6, 8 (1H, 3H, 5H, 7H)-pyrimido [4, 5-g] pteridinetetrone
FUMIO YONEDA, SADAO NISHIGAKI
1971 Volume 19 Issue 5 Pages
1060-1062
Published: May 25, 1971
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1, 3, 6, 8-Tetramethy1-2, 4, 5, 7 (1H, 3H, 6H, 8H) pyrimido [5, 4-g] pteridinetetrone (I) is the common product which has frequently been observed during the reactions using 6-amino-1, 3-dimethyl-5-nitrosouracil and 5, 6-diamino-1, 3-dimethyluracil. The identity of the products with I has been established in following reactions:(a) the condensation of the monohydrochloride of 5, 6-diamino-1, 3-dimethyluracil with 1, 3-dimethylalloxan in aqueous solution, (b) the action of 2N sulfuric acid or hydrochloric acid on 5, 6-diamino-1, 3-dimethyluracil or its monoacetyl derivative, (c) the reaction of 6-amino-1, 3-dimethyl-5-nitrosouracil with 1, 3-dimethylbarbituric acid, and (d) the thermal and acid induced reaction of 6-amino-1, 3-dimethy1-5-nitrosouracil. Furthermore I has often been obtained as a byproduct in the purine and pteridine syntheses from 5, 6-diamino-1, 3-dimethyluracil and 6-amino-1, 3-dimethy1-5-nitrosouracil.
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Yo MORI, KAZUSHIGE TANUMA, SHINKICHI NIINOBE, RIZA BASHEY
1971 Volume 19 Issue 5 Pages
1062-1065
Published: May 25, 1971
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Administration of penicillamine (β, β-dimethylcysteine) results in a great loss of strength of skin with increase in solubility of collagen as in lathyrism. However, the chemical nature of penicillamine and the difference in its effect on crosslinking formation of elastin and collagen, suggest a different mechanism of action from that of lathyrogen such as β-aminaprapionitrile.
Previous investigation of penicillamine dealt almost exclusively with the mode of action. of collagen and elastin maturation, but there is no information available concerning the glycosaminoglycan.
A preliminary investigation was undertaken, therefore, to study the alteration of glycosaminoglycan as well as collagen in aorta when penicillamine was given to rats.
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MASAHIKO FUJINO, CHITOSHI HATANAKA, OSAMU NISHIMURA
1971 Volume 19 Issue 5 Pages
1066-1068
Published: May 25, 1971
Released on J-STAGE: January 31, 2011
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YASUMITSU TAMURA, YOSHINOBU YOSHIMURA, YASUYUKI KITA
1971 Volume 19 Issue 5 Pages
1068-1070
Published: May 25, 1971
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ITIRO YOSIOKA, KATSUHIKO HINO, MIZUE FUJIO, ISAO KITAGAWA
1971 Volume 19 Issue 5 Pages
1070-1073
Published: May 25, 1971
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KAZUTAKE SHIMADA, TOSHIO NAMBARA
1971 Volume 19 Issue 5 Pages
1073-1074
Published: May 25, 1971
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MASAHIKO FUJINO, CHITOSHI HATANAKA, OSAMU NISHIMURA, SUSUMU SHINAGAWA
1971 Volume 19 Issue 5 Pages
1075-1077
Published: May 25, 1971
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