巻号一覧
32 巻, 7 号
選択された号の論文の59件中1～50を表示しています
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廣瀬 順造, 野路 雅英, 喜谷 喜徳1984 年 32 巻 7 号 p. 2481-2485
発行日: 1984/07/25
公開日: 2008/03/31
ジャーナル フリーOn the basis of magnetic circular dichroic (MCD) spectra, the coordination geometries of various adducts of cobalt (II)-bovine carbonic anhydrase were determined. The 8-quinolinecar-boxylate, acetate and oxalate adducts of cobalt (II)-bovine carbonic anhydrase, which had two clearly separated negative MCD bands at 17500 cm-1 and 21000-22000 cm-1, were five-coordinate. The MCD spectra of the Cl-, Br-, benzoate, and 3-quinolinecarboxylate adducts of cobalt (II)-bovine carbonic anhydrase were very complex and were interpreted in terms of the overlapping of MCD spectra of tetrahedral and five-coordinate adducts. The coordination geometry of the alkaline form of cobalt (II)-bovine carbonic anhydrase is discussed on the basis of the above results.抄録全体を表示PDF形式でダウンロード (595K) -
高木 英利, 小田井 英陽, 三浦 敏明, 木村 道也1984 年 32 巻 7 号 p. 2486-2495
発行日: 1984/07/25
公開日: 2008/03/31
ジャーナル フリーThe 1H-and 13C-nuclear magnetic resonance spectra of progesterone (VII) in 97% H2SO4 indicated the formation of a dication (VIII), which was transformed to another dication χ-301 (X) consisting of a hydroxyalkenyl cation moiety in ring A and a cyclopentenyl one in ring D, when the acid solution was heated at 80°C for 2h. At a reduced acid-strength of the reaction system, X was converted to the hydroxyalkatrienyl cation χ-482 (XIV) through an acid-base equilibrium on the one hand, and to the hydroxyalkatetraenyl cation χ-600 (XV) by an oxidative process on the other. The structures of these cations were confirmed by isolating the corresponding conjugate bases, 17ζ-isopropyl-18-nor-13ζ-androsta-4, 6, 8 (14)-trien-3-one (XII) and 17-isopropyl-18-norandrosta-4, 6, 8 (14), 13 (17)-tetraen-3-one (XIII), from the colored solutions. The pKa values of the cations XIV and XV were-4.6 and -3.8, respectively. On the basis of these results, a mechanism is proposed for the title reaction.抄録全体を表示PDF形式でダウンロード (839K) -
加藤 信治, 浜田 康正, 塩入 孝之1984 年 32 巻 7 号 p. 2496-2502
発行日: 1984/07/25
公開日: 2008/03/31
ジャーナル フリーThe pyrrolidine enamine 1 of deoxybenzoin reacted with diphenyl phosphorazidate (DPPA, (C6H5O)2P (O) N3) to give two amidines, the 1, 2-migration product 7a and the 1, 3-dipolar elimination product 8a in a ratio of 77 : 23. The reaction of DPPA with the enamine 2 of benzyl 2-pyridyl ketone proceeded slightly better in the presence of boron trifluoride etherate, giving both the 1, 2-migration and 1, 3-dipolar elimination products 7b and 8b. However, the main products in the reaction of DPPA with the pyrrolidine enamine 3 of 2-phenacylpyridine were 4-phenyl-5-(2-pyridyl)-1, 2, 3-triazole (11) and diphenyl N-pyrrolidinophosphoramidate (12e). Some other 1, 3-dipolar cycloadditions of enamines with organic azides were also investigated.抄録全体を表示PDF形式でダウンロード (779K) -
恩田 政行, 波田野 朗子, 山口 裕子, 佐藤 倫子1984 年 32 巻 7 号 p. 2503-2515
発行日: 1984/07/25
公開日: 2008/03/31
ジャーナル フリーProton assignments of the cycloadducts of anhydromethylberberines with dienophiles have been made by reference to the carbon-13 nulcear magnetic resonance spectra. The correlation between the molecular geometries and the proton chemical shifts is discussed on the basis of the variable-temperature nuclear magnetic resonance spectral data.抄録全体を表示PDF形式でダウンロード (1036K) -
坂本 正徳, 秋元 孝, 福富 恭子, 石井 啓太郎1984 年 32 巻 7 号 p. 2516-2521
発行日: 1984/07/25
公開日: 2008/03/31
ジャーナル フリーThe reaction of benzimidazoline-2-thione (2) with diketene (1) gave the oxazine derivative 3 and the thiazine derivative 4. However, the reaction of 2-indolinethione (6) with diketene afforded only the thiazine derivative 7. On the other hand, no cyclized compound was obtained from 2-indolinone (8) and diketene. The reactions of N, N'-diphenylthiourea (11) and 2-aminobenzothiol (14) with diketene were also studied ; 11 and 14 gave the thiouracil 12 and the benzothiazine 16, respectively.抄録全体を表示PDF形式でダウンロード (607K) -
塩沢 明, 市川 裕一郎, 小室 主税, 蔵重 修二, 宮崎 浩, 山中 宏, 坂本 尚夫1984 年 32 巻 7 号 p. 2522-2529
発行日: 1984/07/25
公開日: 2008/03/31
ジャーナル フリー5-Methyl-(4a), 7-methyl-(4b), and 8-methyl-5, 6, 7, 8-tetrahydro-1, 6-naphthyridine (4c) were synthesized by chemical modification of pyridine derivatives. On the other hand, the synthesis of the compounds (20b, c) having a methyl group in the aromatic ring of 5, 6, 7, 8-tetrahydro-1, 6-naphthyridine was accomplished by the condensation of 1-benzyl-4-piperidinone with the corresponding 3-amino-enones followed by debenzylation. The pathway of the condensation is briefly discussed.抄録全体を表示PDF形式でダウンロード (790K) -
永田 正典, 高畑 廣紀, 平井 美朗, 青江 啓一, 山崎 高應1984 年 32 巻 7 号 p. 2530-2535
発行日: 1984/07/25
公開日: 2008/03/31
ジャーナル フリー6, 7-Dihydro-6-methyl-5-oxo-5H-pyrrolo [3, 4-b] pyridine (1) was heated with 3, 4-methylene-dioxyphenethyl bromide to give the corresponding quaternary bromide (2), which was subjected to catalytic hydrogenation to afford 2, 3-methylenedioxy-16-methyl-17-oxo-8, 16-diaza-9, 10-seco-estra-1, 3, 5 (10)-triene (5). The cyclization of 5 was achieved with mercuric acetate in 5% acetic acid solution, leading to 2, 3-methylenedioxy-16-methyl-17-oxo-8, 16-diaza-estra-1, 3, 5 (10)-triene (7). The structure of 7 was established by X-ray crystallographic analysis.抄録全体を表示PDF形式でダウンロード (582K) -
前田 貞夫, 鈴木 護, 岩崎 為雄, 松本 和男, 岩澤 義郎1984 年 32 巻 7 号 p. 2536-2543
発行日: 1984/07/25
公開日: 2008/03/31
ジャーナル フリーVarious 2-mercapto-4-substituted-5-imidazolecarboxylates (5) were synthesized by the reaction of C-acylamino acid methyl esters (4) with potassium thiocyanate. Hydrolysis followed by decarboxylation of the imidazole carboxylates (5) gave 2-mercapto-4-substituted imidazoles (8) in good yields. Furthermore, the imidazoles (8) were also directly obtained by the reaction of aminoketones (9) with potassium thiocyanate. These compounds (8) exhibited antiinflammatory activities against carrageenan-induced rat paw edema. Among the compounds tested, 2-mercapto-4-(3-thienyl) imidazole (8r) showed the best therapeutic index value, giving a value comparable to that of mefenamic acid.抄録全体を表示PDF形式でダウンロード (739K) -
谷口 幹雄, 安食 富美子, 中川 昌子, 日野 亨1984 年 32 巻 7 号 p. 2544-2554
発行日: 1984/07/25
公開日: 2008/03/31
ジャーナル フリーThe 5-hydroxytryptophan derivative 12 was prepared in 60% yield from the tryptophan derivative 8 by selective oxidation of the cyclic tautomer 9 with Fremy's salt or Pb (OAc)4-CF3COOH to the p-quinoneimine 10, followed by reduction and ring-opening. By analogous oxidation, serotonin was prepared from tryptamine. On the other hand, the oxidation of the Na-acetyl-cyclic tautomers (16 and 22) with Pb (OAc)4-CF3COOH followed by methylation gave the 5-and 6-methoxy derivatives (17, 18, 23, and 24) in 20-40% yields. These compounds were readily converted to the 5-and 6-methoxytryptophan derivatives (20, 21) by acid treatment. These methods are the first practical hydroxylation procedures to be reported for tryptophans.抄録全体を表示PDF形式でダウンロード (922K) -
山本 豊, 森田 恭夫1984 年 32 巻 7 号 p. 2555-2559
発行日: 1984/07/25
公開日: 2008/03/31
ジャーナル フリー6-Methyl-2-phenyl-4H-1, 3-oxazin-4-one (1) underwent initial attack of the anions of lactams (2), such as ε-capro-(2a), δ-valero-(2b), and γ-butyro-lactams (2c), at the 4-position of the ring to give the corresponding α-substituted lactams (3a-c). Reaction of 1 with N-trimethylsilyl derivatives (6a-c) of 2 in the presence of lithium diisopropylamide afforded the 2, 3-dihydro-4H-1, 3-oxazin-4-one derivatives (7a-c), respectively. Similar treatment of 1 with O-methyl derivatives (9a-c) of 2 yielded the corresponding bicyclic heterocycles (10a-c).抄録全体を表示PDF形式でダウンロード (570K) -
上條 哲聖, 原田 弘, 飯塚 欣二1984 年 32 巻 7 号 p. 2560-2564
発行日: 1984/07/25
公開日: 2008/03/31
ジャーナル フリーKetoximes undergo the Beckmann rearrangement and primary carboxamides are dehydrated to nitriles on treatment with N, N'-carbonyldiimidazole and an excess of reactive halide. The reaction can be carried out in high yields under neutral reaction conditions by a simple procedure ; quaternization of the imidazole ring with reactive halides effectively promotes the reaction.抄録全体を表示PDF形式でダウンロード (496K) -
秋元 浩, 河合 昭悦, 橋本 直人, 野村 容朗1984 年 32 巻 7 号 p. 2565-2570
発行日: 1984/07/25
公開日: 2008/03/31
ジャーナル フリーAs part of our recent search for new semisynthetic analogs of maytansinoids having a better therapeutic ratio than maytansine, we synthesized 3-epimaytansinoids (VIIIa-c) starting from ansamitocin P-3, a fermentation product of Nocardia sp., via maytansinol (I). A key intermediate, 3-epimaytansinol (VI), was synthesized by oxidation of I with pyridinium chlorochromate to 3-maytansinone (IV), followed by stereoselective reduction with NaBH4. Esterification of VI with appropriate carboxylic acids gave the corresponding 3-epimaytansinoids (VIIIa-c) in high yields. These compounds did not show the biological activity characteristic of natural maytansinoids to any appreciable degree.抄録全体を表示PDF形式でダウンロード (661K) -
清水 洋, 上田 教博, 片岡 貞, 堀 幹夫1984 年 32 巻 7 号 p. 2571-2590
発行日: 1984/07/25
公開日: 2008/03/31
ジャーナル フリーThe stereochemistry of novel ring expansions of benzothiazoline sulfoxides to benzothiazines by reaction with acetic anhydride was examined. Reaction of trans-3-acetyl-2-ethyl-2-methyl-benzothiazoline 1-oxide with acetic anhydride afforded 4-acetyl-3-ethylidene-2, 3-dihydro-4H-1, 4-benzothiazine and 4-acetyl-3-ethyl-4H-1, 4-benzothiazine, which are the products expanded in the direction of the substituent cis to the sulfoxide moiety, and 4-acetyl-2-methyl-3-methylene-2, 3-dihydro-4H-1, 4-benzothiazine and 4-acetyl-2, 3-dimethyl-4H-1, 4-benzothiazine, which are the products expanded in the opposite direction (trans). Similar results were also obtained from the reaction of the sulfoxides, trans-4-acetyl-2-benzyl-2-methylbenzothiazoline 1-oxide, and cis-and trans-3-acetyl-2-ethoxycarbonylmethyl-2-methylbenzothiazoline 1-oxides, with acetic anhydride. Thus, it was confirmed that this ring expansion is non-stereospecific and quite different from the similar ring transformation of penicillin sulfoxides to cephalosporins. The major factor in this non-stereospecificity was found to be an easy cleavage of the C2-S bond of the benzothiazoline ring due to electronic effects of the nitrogen atom at the β-position to the sulfur atom in comparison with the ring expansions of related six-membered benzothiazine sulfoxides and thiochroman sulfoxides.抄録全体を表示PDF形式でダウンロード (1980K) -
広田 耕作, 北出 幸夫, 岩見 文明, 千田 重男1984 年 32 巻 7 号 p. 2591-2595
発行日: 1984/07/25
公開日: 2008/03/31
ジャーナル フリーTreatment of O2, 2'-anhydrouridine (1) with phosphorus oxychloride in dimethylformamide (DMF) at 60°C afforded both 2', 5'-dichloro-2', 5'-dideoxyuridine (2a) and 2', 5'-dichloro-2', 5'-dideoxy-3'-O-formyluridine (3a). The reaction of 1 with phosphorus oxybromide in DMF gave the corresponding 2', 5'-dibromo derivatives (2b) and (3b). O2, 5'-Anhydro-2', 3'-O-isopropylideneuridine (4) was treated with the Vilsmeier reagent (DMF/POX3) to give the corresponding 5'-halogeno-5'-deoxy-2', 3'-O-isopropylideneuridines (5a and 5b) in high yields. Under the same conditions, the reaction of 6, 5'-cyclo-2', 3'-O-isopropylideneuridine (6) with the Vilsmeier reagent (DMF/POX3) afforded the corresponding 1-(5-halogeno-5-deoxy-2, 3-O-isopropylidene-β-D-ribofuranosyl)-5-dimethylaminomethylenebarbituric acids (7a and 7b) in high yields.抄録全体を表示PDF形式でダウンロード (567K) -
松永 尚, 園田 美樹, 冨岡 幸彦, 山崎 企善1984 年 32 巻 7 号 p. 2596-2601
発行日: 1984/07/25
公開日: 2008/03/31
ジャーナル フリーThe reactions of 2-amino-3-cyano-1-ethoxycarbonyl-4, 5-dihydropyrrole (Ia) and 2-amino-3-cyano-1-ethoxycarbonyl-5-methyl (or 4-phenyl)-4, 5-dihydropyrrole (Ib or Ic) with dimethyl acetylenedicarboxylate and methyl propiolate gave the corresponding 7-amino-4-cyano-1-ethoxycarbonyl-2, 3-dihydro-1H-azepines (IIa-c and IIIa-c). On heating with 2, 3-dichloro-5, 6-dicyano-1, 4-benzoquinone, IIc and IIIc were converted into dimethyl 6-amino-3-cyano-5-ethoxycarbonylamino-4-phenyl-1, 2-benzenedicarboxylate (V) and methyl 6-amino-3-cyano-5-ethoxycarbonylamino-4-phenylbenzenecarboxylate (VI), respectively.抄録全体を表示PDF形式でダウンロード (621K) -
佐藤 雅之, 小笠原 弘道, 加藤 鐵三1984 年 32 巻 7 号 p. 2602-2608
発行日: 1984/07/25
公開日: 2008/03/31
ジャーナル フリーThe ring transformation of 2, 2-dimethyl-1, 3-dioxin-4-ones (1) to nitrogen heterocycles was studied. Heating of 1 with imines such as Schiff bases gave rise to [2+4] cycloadducts of imines to acylketenes (2), i.e., 3, 4-dihydro-1, 3-oxazin-4-one derivatives (4). Similarly, 1 reacted with carbodiimides to yield 2-imino-1, 3-oxazin-4-one derivatives (11 and 12). The reaction of 1 with phenyl isocyanate gave 3-phenyl-1, 3-oxazine-2, 4-diones (15), while the reaction with 2-pyridyl isocyanate gave pyrido [1, 2-a] pyrimidin-4-one derivatives (18).抄録全体を表示PDF形式でダウンロード (665K) -
尾崎 茂子, 西口 進, 枡井 雅一郎1984 年 32 巻 7 号 p. 2609-2616
発行日: 1984/07/25
公開日: 2008/03/31
ジャーナル フリーAnodic oxidation of N-alkylhydroxylamines with and without a β-hydroxy group was studied by cyclic voltammetry and controlled potential electrolysis in aqueous buffer solution of pH 8.8. The hydroxylamines with a β-hydroxy group were oxidized initially to the corresponding nitroxides and gave the final products via two routes ; i) cleavage of the (α) C-(β) C bond to give aldehydes and oximes, and ii) disproportionation of the nitroxides to form the nitroso compounds. The hydroxylamines without a β-hydroxy group did not undergo cleavage of the (α) C-(β) C bond and gave nitroso compounds. Substituents on the α and β carbons affected the product distribution. When a phenyl group or two methyl groups were present on the (β) C, or one methyl group was present on both (α) C and (β) C, (α) C-(β) C bond cleavage was predominant.抄録全体を表示PDF形式でダウンロード (778K) -
木島 孝夫, 澤田 徳之助1984 年 32 巻 7 号 p. 2617-2621
発行日: 1984/07/25
公開日: 2008/03/31
ジャーナル フリーTwo monoterpene glycosides 1 and 2 were isolated from the fruits of Gymnocladus chinensis BAILLON (Leguminosae). On the basis of chemical and physicochemical evidence, these glycosides were characterized as (6S)-2-trans-6-α-L-arabinopyranosyloxy-2, 6-dimethyl-2, 7-octadienoic acid and (6S)-2-trans-2, 6-dimethyl-6-[3-O-(β-D-glucopyranosyl)-4-O-(2-methylbutyroyl)-α-L-arabino-pyranosyloxy]-2, 7-octadienoic acid.抄録全体を表示PDF形式でダウンロード (592K) -
藤田 正雄, 山田 美紀子, 中嶋 正一, 河合 賢一, 永井 正博1984 年 32 巻 7 号 p. 2622-2627
発行日: 1984/07/25
公開日: 2008/03/31
ジャーナル フリーThe O-methylation effect on the carbon-13 nuclear magnetic resonance chemical shifts of ortho-disubstituted phenols was investigated. In phenols with nonconjugated ortho-disubstituents (1-10), O-methylation caused a downfield shift by an average of 5.2 ppm for the ortho-carbons (C-2 and -6), and a downfield shift by an average of 4.6 ppm for the para-carbon (C-4). These shift values are significantly different from those observed in ortho-monosubstituted and ortho-nonsubstituted phenols. This regularity is very useful for the spectral interpretation of some natural products with an ortho-disubstituted phenol group and for the determination of the position of the methoxy group in such compounds. Two new phthalides, silvaticol (15) and O-methylsilvaticol (16), were isolated along with nidulol (17) from Aspergillus silvaticus. In the course of the structure determination of these compounds, the O-methylation effects of ortho-mono-and ortho-disubstituted phenols were successfully applied to these phthalides. The structures of silvaticol and O-methylsilvaticol were determined as 6-hydroxy-4-methoxy-5-methylphthalide and 4, 6-dimethoxy-5-methylphthalide, respectively.抄録全体を表示PDF形式でダウンロード (743K) -
広井 邦雄, 北山 隆一, 佐藤 修子1984 年 32 巻 7 号 p. 2628-2638
発行日: 1984/07/25
公開日: 2008/03/31
ジャーナル フリーA highly efficient and general synthetic route to optically active sulfinates by the stereospecific boron trifluoride etherate-catalyzed esterification of sulfinamides was developed. Dramatic solvent effects were observed in the thermal transformation of allyl sulfinate derivatives to sulfones. Heating of chiral trans-and cis-allyl sulfinates, (S)-(-)-3a, c, e and (S)-(-)-3b, d, f, in N, N-dimethylformamide at 90-120°C provided chiral sulfones (S)-(+)-and (R)-(-)-5, 6, 7 in good yields, respectively, with exceedingly high stereospecificity.抄録全体を表示PDF形式でダウンロード (1074K) -
的場 勝英, 苅部 則夫, 山崎 高應1984 年 32 巻 7 号 p. 2639-2645
発行日: 1984/07/25
公開日: 2008/03/31
ジャーナル フリー2-Methoxy-4, 4-dimethyl-2-cyclohexenone (II) afforded 5, 6-epoxy-6-methoxy-4, 4-dimethyl-6-hexanolide (III) upon reaction with m-chloroperbenzoic acid in 1, 1, 1-trichloroethane. On the other hand, the treatment of II with the same reagent in an aqueous disodium orthophosphate-methylene chloride system at 4°C gave 2, 3-epoxy-2-methoxy-4, 4-dimethylcyclohexanone (V), which could be converted to methyl 2-hydroxy-1-methoxy-3, 3-dimethylcyclopentanecarboxylate (VI). 2-Methoxy-4, 4-dimethyl-2, 5-cyclohexadienone (I) afforded 5, 6-epoxy-2-methoxy-4, 4-dimethyl-2-cyclohexenone (VIII) upon reaction with hydrogen peroxide in a basic medium. The reaction of I with m-chloroperbenzoic acid at room temperature gave 5, 6-epoxy-6-methoxy-4, 4-dimethyl-2-cyclohexenone (X). Neither VIII nor X gave the expected 2, 3, 5, 6-diepoxy-2-methoxy-4, 4-dimethylcyclohexanone (VII), but afforded 2, 3, 5, 6-diepoxy-6-methoxy-4, 4-dimethyl-6-hexanolide (IX).抄録全体を表示PDF形式でダウンロード (809K) -
岸本 彰二, 千代 道行, 冨本 光美, 橋口 昌平, 松尾 泰介, 落合 道彦1984 年 32 巻 7 号 p. 2646-2659
発行日: 1984/07/25
公開日: 2008/03/31
ジャーナル フリーIn the course of the chemical modification of sulfazecin, 3-[2-(2-aminothiazol-4-yl)-(Z)-2-(substituted oxyimino) acetamido]-4-methoxycarbonyl-2-azetidinone-1-sulfonic acids were synthesized starting from cis-1-(2, 4-dimethoxybenzyl)-4-methoxycarbonyl-3-phthalimido-2-azetidinone (2). These new 4-substituted derivatives showed more potent antimicrobial activities against gram-negative bacteria than did the corresponding 4-unsubstituted compounds, and the derivatives having 3, 4-cis stereochemistry were more active than the trans isomers, especially against P. aeruginosa and some β-lactamase-producing bacteria. The reported procedure for the cycloaddition reaction used to prepare 2 was investigated in detail ; by the use of a 20% excess of triethylamine, 2 was easily obtained in the yield of 72% as colorless crystals. A possible intermediate of β-lactam formation in this cycloaddition reaction, an acyl iminium salt (6), was isolated as crystals and converted into β-lactams by treatment with 1, 8-diazabicyclo [5. 4. 0]-7-undecene.抄録全体を表示PDF形式でダウンロード (1333K) -
Studies on Peptides. CXXI. Nin-Mesitylenesulfonyl-tryptophan, a New Derivative for Peptide Synthesis藤井 信孝, 二木 史朗, 安村 貢一, 矢島 治明1984 年 32 巻 7 号 p. 2660-2665
発行日: 1984/07/25
公開日: 2008/03/31
ジャーナル フリーThe mesitylenesulfonyl (Mts) group was introduced at the Nin of tryptophan by Illi's method. This group is stable under various conditions required for practical peptide synthesis, such as treatments with dil. alkali, hydrazine hydrate, TFA and even 4 N HCl-dioxane or 25% HBr-AcOH. HF is not able to remove this protecting group, but it can be smoothly cleaved by 1 M trifluoromethanesulfonic acid/TFA or methanesulfonic acid. The usefulness of this new tryptophan derivative, Trp (Mts), for practical peptide synthesis was demonstrated by the synthesis of cholecystokinin-heptapeptide as an example.抄録全体を表示PDF形式でダウンロード (727K) -
片岡 貞, 冨松 公典, 清水 洋, 堀 幹夫1984 年 32 巻 7 号 p. 2666-2675
発行日: 1984/07/25
公開日: 2008/03/31
ジャーナル フリーSelenoxanthene 10-oxides (5a-d) reacted with methyl propiolate, dimethyl and diethyl acetylenedicarboxylates to afford selenoxanthen-10-io [formyl (or alkoxalyl) alkoxycarbonyl]-methanides (6a-i). The 9-isopropyl derivative gave only trans-ylides and the 9-phenyl congener formed cis-and trans-ylides. The stereochemistry is discussed on the basis of the nuclear magnetic resonance spectral data. Reduction of the selenoxanthenium ylides with sodium borohydride afforded the ylide lactones (16a-c) and the ylide alcohols (17a-f). The product ratio depended on the solvent used.抄録全体を表示PDF形式でダウンロード (934K) -
田中 隆, 末安 都貴子, 野中 源一郎, 西岡 五夫1984 年 32 巻 7 号 p. 2676-2686
発行日: 1984/07/25
公開日: 2008/03/31
ジャーナル フリーSix new galloyl and p-hydroxybenzoyl esters (2-7) of benzophenone C-glucosides have been isolated, together with a new benzophenone C-glucoside (1), from the leaves of Mangifera indica L. (Anacardiaceae). On the basis of chemical and spectroscopic evidence, the structures of these compounds have been established as maclurin 3-C-β-D-glucoside (1), maclurin 3-C-(6"-O-p-hydroxybenzoyl)-β-D-glucoside (2), maclurin 3-C-(2"-O-galloyl-6"-O-p-hydroxybenzoyl)-β-D-glucoside (3), maclurin 3-C-(2"-O-p-hydroxybenzoyl-6"-O-galloyl)-β-D-glucoside (4), maclurin 3-C-(2", 3", 6"-tri-O-galloyl)-β-D-glucoside (5), iriflophenone 3-C-(2", 6"-di-O-galloyl)-β-D-glucoside (6) and iriflophenone 3-C-(2", 3", 6"-tri-O-galloyl)-β-D-glucoside (7). (-)-Epicatechin 3-O-gallate (9), mangiferin (10), isomangiferin (11) and a new xanthone C-glucoside gallate, mangiferin 6'-O-gallate (8), have also been isolated and their structures have been similarly characterized. Furthermore, the above plant source contained polygalloylglucoses which were characterized on the basis of chemical and high performance liquid chromatographic analyses as a mixture of penta-to undecagalloylglucoses based on a 1, 2, 3, 4, 6-penta-O-galloyl-β-D-glucose core. Maclurin 3-C-glucoside (1) has been transformed enzymatically to mangiferin (10) and isomangiferin (11), and it has become clear that 1 is a key intermediate in the biosynthesis of 10 and 11.抄録全体を表示PDF形式でダウンロード (1049K) -
Monitored Aminolysis of 3-Acyl-1, 3-thiazolidine-2-thiones : Synthesis of Amides and Amide Alkaloids長尾 善光, 瀬野 薫, 川端 浩二, 宮坂 忠与, 高尾 佐知子, 藤田 栄一1984 年 32 巻 7 号 p. 2687-2699
発行日: 1984/07/25
公開日: 2008/03/31
ジャーナル フリーA functional heterocycle, 3-acyl-1, 3-thiazolidine-2-thione [ATT (1)] has been shown to be effective as an acylating reagent for the amino group. ATT (1) was readily prepared by several methods, and reacted with various amino compounds in CHCl3, CH2Cl2, THF, EtOH, THF-H2O, or sulfolane to afford the corresponding amides, 2a-w and 3-10 in very high yields within a short time. This reagent exhibits high chemo-selectivity. Its reaction with the diamines 13 and 15 and the triamine 29, which include a primary amino group (s) and a secondary amino group, gave the products acylated only at the primary amino group (s), 14, 16, and 30, respectively, in high yields. Aminoalcohols and aminophenols were chemoselectively converted into acylaminoalcohols and acylaminophenols, respectively, by ATT (1). By utilizing this method, several amide alkaloids (26, 28, 30, and 34) were efficiently synthesized. This new aminolysis can be monitored by the disappearance of the yellow color of the starting materials, ATT (1) ; it is remarkably characteristic of this reaction.抄録全体を表示PDF形式でダウンロード (1223K) -
津島 進, 吉岡 義夫, 谷田 清一, 野村 容朗, 野島 庄七, 穂積 本男1984 年 32 巻 7 号 p. 2700-2713
発行日: 1984/07/25
公開日: 2008/03/31
ジャーナル フリーVarious carbamate analogs of lysophospholipids, N-alkyl-and alkenylcarbamoyl phospholipids (ACPLs), were synthesized and their antimicrobial properties were examined. The ACPLs studied differed in certain aspects of their chemical structure : the polar-head base, the aliphatic nonpolar tail attached to the carbamate nitrogen and the molecular backbone, e.g., 2-O-methylglycerol and 1, 3-propanediol. In contrast to lysolecithin and lecithin, the majority of the ACPLs showed inhibitory activities against Tetrahymena pyriformis (protozoan) and a range of fungi. In the series of ACPLs studied, the maximal inhibitory activities were observed with 2-O-methyl-1-O-(N-tetradecyl) carbamoylglycero-3-phosphocholine (3-C14-A) and its 2-demethoxy compound (4-C14-A). In comparison with clotrimazole, these compounds showed more potent activities against T. pyriformis, and comparable or lower activities against human pathogenic and phytopathogenic fungi. The relationships between structure and antimicrobial activity are discussed.抄録全体を表示PDF形式でダウンロード (1213K) -
高橋 浩, 千田 康裕, 鈴木 勉, 大西 啓, 柳浦 才三1984 年 32 巻 7 号 p. 2714-2723
発行日: 1984/07/25
公開日: 2008/03/31
ジャーナル フリーNew optically pure (1S, 1'S)-and (1R, 1'R)-1-cycloalkyl-N-2'-hydroxy-1'-isopropylethyl-2-phenylethylamine hydrochlorides (3a-j) were synthesized in good yields. The analgesic activities of these hydrochlorides were evaluated by the acetic acid writhing method and the bradykinin-induced flexor reflex method. The structure of 3f'·HCl was elucidated by X-ray analysis. The relationship between the analgesic activity and the conformation of the 1-2 bond of these amines is discussed.抄録全体を表示PDF形式でダウンロード (932K) -
久保 道徳, 松田 秀秋, 田中 基晴, 木村 善行, 奥田 拓道, 東野 正行, 谿 忠人, 難波 健輔, 有地 滋1984 年 32 巻 7 号 p. 2724-2729
発行日: 1984/07/25
公開日: 2008/03/31
ジャーナル フリーA 70% methanol extract of Scutellariae Radix, the dried root of Scutellaria baicalensis GEORGI, and its main flavonoid components, baicalin, baicalein and wogonin, have been screened in comparison with three standard anti-inflammatory agents, phenylbutazone, indomethacin and dexamethasone, for activity in various experimental models of inflammation. All of the test substances were found to inhibit an increase in vascular permeability in mice induced by acetic acid and to reduce acute paw edema in rats induced by compound 48/80. They also suppressed the secondary lesion in developing adjuvant-induced arthritis in rats. Since these substances from Scutellariae Radix were found to be effective in both the acute and chronic phases of inflammation, the crude drug Scutellariae Radix can be considered as having anti-inflammatory activity.抄録全体を表示PDF形式でダウンロード (746K) -
塚本 博樹, 久田 末雄, 西部 三省1984 年 32 巻 7 号 p. 2730-2735
発行日: 1984/07/25
公開日: 2008/03/31
ジャーナル フリーFour new lignans, (+)-1-acetoxypinoresinol [(1S, 2R, 5R, 6S)-1-acetoxy-2, 6-bis (4-hydroxy-3-methoxyphenyl)-3, 7-dioxabicyclo [3. 3. 0] octane] (1), (+)-1-hydroxypinoresinol (2), (+)-1-acetoxypinoresinol 4"-O-methyl ether (3) and (+)-1-hydroxypinoresinol 4"-O-methyl ether (4), and two known lignans, (-)-olivil (5) and (+)-cyclo-olivil (6), were isolated from the bark of Olea europaea L. (Oleaceae). Their structures were elucidated on the basis of spectroscopic analysis and chemical evidence. The lignans 1, 2 and 3 were also isolated from the bark of Olea africana MILL. (Olea europaea L. subsp. africana (MILL.) GREEN), and lignans 5 and 6 from the bark of Olea capensis L.抄録全体を表示PDF形式でダウンロード (766K) -
北川 隆康, 岩倉 久美子, 大杉 昌子, 平井 瑛三1984 年 32 巻 7 号 p. 2736-2744
発行日: 1984/07/25
公開日: 2008/03/31
ジャーナル フリーIsouron (1) and its isomer, 1-(3-tert-butylisoxazol-5-yl)-3, 3-dimethylurea (2), were determined by a colorimetric method with p-dimethylaminocinnamaldehyde (DACA) as the reagent. Compounds 1 and 2 were hydrolyzed to give 3-amino-5-tert-butylisoxazole (3) and 5-amino-3-tert-butylisoxazole (4), respectively, which were transformed into colored substances by reaction with DACA. The former colored product was a Schiff base but the latter product had a different absorption maximum from the corresponding Schiff base. The latter color reaction resulted in a bathochromic shift as compared with Schiff base formation at the 5-position. Traces of 2 (more than 0.05%) in 1 could be estimated precisely together with the quantitation of 1 by making use of this bathochromic effect.抄録全体を表示PDF形式でダウンロード (763K) -
渡辺 一弘, 木村 礼志, 吉沢 逸雄1984 年 32 巻 7 号 p. 2745-2751
発行日: 1984/07/25
公開日: 2008/03/31
ジャーナル フリーWhen estradiol 17-sulfate was incubated with rat liver microsomes in the presence of a reduced nicotinamide adenine dinucleotide phosphate (NADPH)-generating system, 4-hydroxyestradiol 17-sulfate was obtained as a minor product accompanying the major metabolite, 2-hydroxyestradiol 17-sulfate. This 4-hydroxylation was shown to occur without cleavage of the conjugate group. At the substrate concentration of 200 μM, which is about twice the Km value of estradiol 17-sulfate 2-hydroxylase, the amounts of 2-and 4-hydroxylated products formed by liver microsomes from male rats were 15.03±1.43 and 0.23±0.01%, respectively. Analogous results were obtained with microsomes from female rats under the same conditions : the yields of 2-and 4-hydroxylated metabolites were 8.75±0.97 and 0.14±0.02%, respectively. Thus, the relative ratios of 2-and 4-hydroxylation of estradiol 17-sulfate were approximately 60 : 1 in both sexes. A synthesis of the authentic conjugate, 4-hydroxyestradiol 17-sulfate, and a method for its assay by high-performance liquid chromatography with an electrochemical detector are also described.抄録全体を表示PDF形式でダウンロード (814K) -
萩中 淳, 安田 博幸, 宇野 豊三, 中川 照眞1984 年 32 巻 7 号 p. 2752-2758
発行日: 1984/07/25
公開日: 2008/03/31
ジャーナル フリーAlthough sulbactam has no ultraviolet (UV) absorption maximum above 200 nm, it was found to be easily degraded in alkaline methanol and in alkaline aqueous solution to yield products having UV absorption maxima at 267 nm and 278 nm, respectively. An ion-pair reversed-phase high-performance liquid chromatographic (HPLC) method utilizing this alkaline degradation as a postcolumn reaction has been developed for the determination of sulbactam in plasma and urine. A high and reproducible detector response due to the degradation product (s) was obtained when methanol was used as an organic modifier of the eluent. The HPLC and postcolumn reaction conditions were as follows : column, Develosil ODS-10 (25 cm×4.6 mm i.d.) ; eluent, 5mM tetra-n-butylammonium bromide+1mM Na2HPO4+1mM NaH2PO4 solution/methanol=3/1 (v/v) for urine samples and 2/1 (v/v) for plasma samples ; flow rate, 1.2 ml/min ; postcolumn reagent, 0.5 N aqueous NaOH solution at a flow rate of 0.6ml/min ; reaction coil, 2m×0.25mm i.d.; detection, 276nm. The procedure was quantitative over a wide range of sulbactam concentrations in plasma and urine down to 0.2 μg/ml and 1.0 μg/ml, respectively. The intra-and inter-assay precisions for plasma at a sulbactam level of 0.53 μg/ml were of the order of 2.0% and 3.5%, respectively.抄録全体を表示PDF形式でダウンロード (682K) -
岩本 義久, 三渕 一二1984 年 32 巻 7 号 p. 2759-2765
発行日: 1984/07/25
公開日: 2008/03/31
ジャーナル フリーTreatment of yeast cells with acriflavine followed by illumination with fluorescent lamps resulted in extensive "petite" induction in addition to rapid cell inactivation and nuclear gene mutation. There was no petite induction or cell inactivation in the un-illuminated cells. Such photobiological damage induced by acriflavine was not observed under deoxygenated conditions, such as in the presence of NaN3, which is a scavenger of singlet oxygen (1O2). Photodynamic treatment of yeast cells did not cause marked changes in the CsCl sedimentation profile of mitochondrial DNA. These results showed that the petite induction and the cell inactivation after acriflavine treatment are mainly due to type II photodynamic action.抄録全体を表示PDF形式でダウンロード (716K) -
横澤 隆子, 小林 妙子, 大浦 彦吉, 川島 祐次1984 年 32 巻 7 号 p. 2766-2772
発行日: 1984/07/25
公開日: 2008/03/31
ジャーナル フリーIn order to clarify the mechanism of action of ginsenoside-Rb2 in rats, time course experiments were carried out. The maximum decrease in the hepatic glycogen content was found 8h after the treatment, but the content had nearly recovered to the control level 24h after the treatment. In contrast, the level of hepatic glucose-6-phosphate increased, reaching the maximum at 8h. There was also a dramatic increase in the phosphofructokinase activity, peaking at 12h. In addition, accumulation of lipid in adipose tissue was observed 10-12h after the administration of ginsenoside-Rb2, whereas no significant changes in the total lipid, triglyceride, total cholesterol, phospholipid, glucose, pyruvate, and lactate levels of the liver were observed throughout the experimental period. An increase of hepatic glucose-6-phosphate dehydrogenase activity was observed 2-4h after the treatment, but this response was transitory.抄録全体を表示PDF形式でダウンロード (774K) -
Vibrational Test for Evaluation of Creams. I. The Effect of Vertical Vibration Imposed on O/W Creams黒田 稔1984 年 32 巻 7 号 p. 2773-2780
発行日: 1984/07/25
公開日: 2008/03/31
ジャーナル フリーThe steady flow behavior, dynamic characteristics and particle size (microscopical counting) of a semisolid O/W cream prepared with cetomacrogol and cetostearyl alcohol were studied. The continuous shear flow curve of this cream was in the form of an anti-clockwise hysteresis loop. Vertical vibration imposed on the cream, using a Sanki viscoelasto recorder, caused a first-order breakdown of viscoelastic structure formed in the cream at a rate of 10-5 s-1 for dynamic viscosity and 10-4 s-1 for dynamic modulus, while the vibration caused coalescence of the oil globules dispersed in the cream at a rate of 10-15 s-1. The destruction of viscoelastic structure was much more rapid than the coalescence.抄録全体を表示PDF形式でダウンロード (779K) -
平手 純司, 渡辺 淳, 尾関 昭二1984 年 32 巻 7 号 p. 2781-2787
発行日: 1984/07/25
公開日: 2008/03/31
ジャーナル フリーThe effect of convulsions on teh dispositions of creatinine and urea, which are considered to pass through the water-filled pores of biological membranes easily, was examined by means of plasma analysis and whole-body autoradiography following intravenous administration of each compound to rats during tonic convulsions induced by pentylenetetrazole or electricity. The data on the plasma levels showed that, in convulsed rats, the transfer of creatinine and urea from plasma to tissues was suppressed and the total body clearance of both chemicals was significantly decreased. The results of whole-body autoradiography, which showed decreased or almost stopped blood flow in the intestinal tract, skin, and kidney of convulsed rats, were in good agreement with the above observations.抄録全体を表示PDF形式でダウンロード (1044K) -
渡辺 義久, 近藤 保, 宮本 正樹, 笹川 滋1984 年 32 巻 7 号 p. 2788-2794
発行日: 1984/07/25
公開日: 2008/03/31
ジャーナル フリーTwo types of microcapsules with different negative surface potentials, poly (1, 4-piperazinediylterephthaloyl) microcapsules containing various concentrations of sodium polystyrene sulfonate solution and hemolysate-loaded polyamide microcapsules of different degrees of carboxylation, were prepared by using an interfacial polymerization technique, and the interactions of these microcapsules with human polymorphonulcear leucocytes (PMNs) were investigated as a function of the surface potential of the microcapsules in the absence and presence of plasma proteins. The rate of oxygen consumption by PMNs was taken as a measure of the interaction. In the absence of plasma proteins, the rate of oxygen consumption by PMNs increased with increasing difference in surface potential between the microcapsules and PMNs. The presence of plasma proteins affected the rate of oxygen consumption, which was dependent on the protein species present and related to the surface potential of the microcapsules. This was interpreted as showing that the surface potential of the microcapsules exerts a great influence on the mode and amount of protein adsorption on the microcapsule surface.抄録全体を表示PDF形式でダウンロード (862K) -
児島 強, 中野 眞汎, 従二 和彦, 井上 祥平, 吉田 泰彦1984 年 32 巻 7 号 p. 2795-2802
発行日: 1984/07/25
公開日: 2008/03/31
ジャーナル フリーTo achieve sustained release of local anesthetics from injectable formulations, polycarbonate microspheres were prepared by a solvent-evaporation process. Release patterns of benzocaine, lidocaine, and dibucaine from polycarbonate microspheres in vitro were investigated. Drug contents and sizes of microspheres affected the release patterns of the local anesthetics. The release rate of drugs from smaller microspheres was greater than that from larger microspheres, and with increase in the drug contents, the release rate increased. Microspheres before and after release studies were observed by scanning electron microscopy. It was confirmed that the use of polycarbonate microspheres resulted in sustained release of local anesthetics.抄録全体を表示PDF形式でダウンロード (1551K) -
鈴木 潤三, 八木 菜穂美, 鈴木 静夫1984 年 32 巻 7 号 p. 2803-2808
発行日: 1984/07/25
公開日: 2008/03/31
ジャーナル フリーPhotochemical reaction of phenol with nitrite ion was investigated by ultraviolet irradiation in aqueous solution. The main product of the photochemical reaction was isolated and identified as p-nitrosophenol on the basis of spectral data and high performance liquid chromatography analysis. The production of p-nitrosophenol increased with increases in nitrite ion concentration and irradiation time. The production rate of p-nitrosophenol was enhanced under basic condition or under a nitrogen atmosphere, and was suppressed by the addition of sodium thiocyanate or under an oxygen atmospheres. These results suggested that the photo-nitrosation was caused by NO and OH radicals produced by the photolysis of nitrite ion.抄録全体を表示PDF形式でダウンロード (622K) -
村井 不二男, 田川 素子, / / , SOREN ROSENDAL JENSEN, BENT JUHL NIELSEN1984 年 32 巻 7 号 p. 2809-2814
発行日: 1984/07/25
公開日: 2008/03/31
ジャーナル フリーOn the basis of exhaustive 1H-and 13C-nuclear magnetic resonance (NMR) spectral studies and chemical transformations, the structure of an iridoid glucoside formerly designated as 5-epideoxyloganic acid, isolated from Nepeta cataria L., has been revised to (1R, 5R, 8S, 9S)-deoxyloganic acid, which is renamed 1, 5, 9-epideoxyloganic acid. The absolute configuration of this glucoside was established by its chemical conversion to an antipode of boschnialactone.抄録全体を表示PDF形式でダウンロード (643K) -
沼田 敦, 保木本 和子, 竹村 鶴子, 勝野 孝子, 山本 恭子1984 年 32 巻 7 号 p. 2815-2820
発行日: 1984/07/25
公開日: 2008/03/31
ジャーナル フリーThree compounds having antifeeding activities for the larvae of the yellow butterfly, Eurema hecabe mandarina DE L'ORZA, were isolated from Osmunda japonica THUNB. These compounds were identified as (4R, 5S)-osmundalactone (II), (4R, 5S)-5-hydroxy-2-hexen-4-olide (III) and succinic acid (V), of which the former is the main antifeedant in this plant. (4R, 5S)-5-Hydroxyhexan-4-olide (I) and (3S, 5S)-3-hydroxyhexan-5-olide (IV) were isolated in addition to the antifeedants, and various sterols, fatty alcohols and fatty acid esters were obtained as a mixture. This is the first report of the occurrence of I, II and III as natural products, though they have been artificially prepared.抄録全体を表示PDF形式でダウンロード (635K) -
秋山 泰伸, 阿部 順子, 高野 徳子, 川崎 知己, 坂本 正徳1984 年 32 巻 7 号 p. 2821-2824
発行日: 1984/07/25
公開日: 2008/03/31
ジャーナル フリーThe reactions of 3-benzoylacrylonitrile (1a) with 3-amino-5, 5-dimethyl-2-cyclohexenone (2) and ethyl 3-aminocrotonate (4) gave the corresponding pyridine derivatives, 3 and 5, respectively. 3-Ethoxycarbonylacrylonitrile (1b) also reacted with ethyl 3-benzylaminocrotonate (6) and 1-ethoxycarbonylmethylene-1, 2, 3, 4-tetrahydroisoquinoline (9) to give the pyrrolin-5-one derivatives, 7 and 10, respectively.抄録全体を表示PDF形式でダウンロード (508K) -
辛 重基, 米沢 養躬, 山田 豊文1984 年 32 巻 7 号 p. 2825-2831
発行日: 1984/07/25
公開日: 2008/03/31
ジャーナル フリーThe synthesis of dehydrotripeptides, composed of an α-amino acid and two α-dehydroamino acid (DHA) residues, by the direct coupling of N-protected △1-dehydrodipeptide with DHA ester and by the β-elimination of △1-dehydrotripeptide containing a threonine residue is described. Moreover, the configurational determination of all the new products is discussed.抄録全体を表示PDF形式でダウンロード (618K) -
松永 功, 長瀧 重智, 田村 善蔵1984 年 32 巻 7 号 p. 2832-2835
発行日: 1984/07/25
公開日: 2008/03/31
ジャーナル フリーFluorescein monoglucuronide (III), the main metabolite of fluorescein (I), was chemically synthesized by means of the Koenigs-Knorr reaction. Nuclear magnetic resonance (NMR) spectra and mass spectra (MS) showed that the synthesized material was monoglucuronidated fluorescein. The changes in absorption spectra with pH indicated that this material was an "ether" glucuronide. The glucuronoside linkage was concluded to be β, since this material was hydrolyzed by β-glucuronidase. Thus, the synthesized material was confirmed to be fluorescein mono-β-D-glucuronide.抄録全体を表示PDF形式でダウンロード (461K) -
榊原 仁作, 貝谷 トヨ, 飯高 洋一1984 年 32 巻 7 号 p. 2836-2840
発行日: 1984/07/25
公開日: 2008/03/31
ジャーナル フリーAcidic treatment of a grayanol derivative (3), easily formed from grayanotoxin-II (1), afforded a novel cyclization product (7), whose structure was elucidated as 3 (S), 20 : 5 (R), 10 (R)-diepoxy-14 (R), 16 (R)-dihydroxy-1-epi-leucothane by direct X-ray crystallographic analysis.抄録全体を表示PDF形式でダウンロード (485K) -
北川 隆康, 大杉 昌子, 平井 瑛三1984 年 32 巻 7 号 p. 2841-2844
発行日: 1984/07/25
公開日: 2008/03/31
ジャーナル フリーSome isoxazole herbicides were determined by a colorimetric method with p-dimethyl-aminocinnamaldehyde (DACA) as the reagent. The compounds (2, 3 and 4) having various substituents at the 3-position were hydrolyzed to 3-amino-5-tert-butylisoxazole (5). The assay method was based on the coloration of 5 with DACA, which was reported previously. The optimum hydrolysis conditions were determined. Compound 5 was obtained from 2, 3 and 4 with sufficient recoveries under neutral, alkaline and acidic conditions, respectively. The raw materials could thus be evaluated effectively by simple assay methods.抄録全体を表示PDF形式でダウンロード (450K) -
友田 正司, 清水 訓子, 加藤 桂子1984 年 32 巻 7 号 p. 2845-2847
発行日: 1984/07/25
公開日: 2008/03/31
ジャーナル フリーProcedures for the identification of decoction of Alismatis Rhizoma (rhizome of Alisma orientale JUZEPCZUK or related species) by cellulose acetate membrane electrophoresis, paper partition chromatography, and thin-layer chromatography were developed. These methods are due to the presence of a characteristic new component.抄録全体を表示PDF形式でダウンロード (409K) -
平手 純司, 渡辺 淳, 尾関 昭二1984 年 32 巻 7 号 p. 2848-2850
発行日: 1984/07/25
公開日: 2008/03/31
ジャーナル フリーThe plasma levels of creatinine following intravenous administration to chronically (4 months) CCl4-treated rats, which have been extensively used as an experimental model of cirrhosis, were compared with those of control rats. The total body clearance of creatinine in chronically CCl4-treated rats (6.95 ml/min/kg) was about 70% of the control value (9.85 ml/min/kg). This result suggested that the kidney as well as the liver is impaired by CCl4 treatment. This means that the renal clearance of drugs whose elimination is mainly dependent on the kidney might be decreased by CCl4 treatment.抄録全体を表示PDF形式でダウンロード (417K) -
谷岡 功邦, 安田 幸雄, 青柳 伸男, 緒方 宏泰, 鹿庭 なほ子, 江島 昭1984 年 32 巻 7 号 p. 2851-2854
発行日: 1984/07/25
公開日: 2008/03/31
ジャーナル フリーA surgical procedure for chronic jugular vein cannulation of Gottingen miniature pig for repeated blood samplings is described. Cannulated minipigs G were used for a preliminary study of the bioavailabilities of nalidixic acid tablets showing different dissolution rates and to investigate the elimination profiles of nalidixic acid in blood after intravenous administration of the drug. The results indicate the usefulness of these catheterized minipigs G for bioavailability studies requiring fequent blood samplings.抄録全体を表示PDF形式でダウンロード (485K)