巻号一覧
50 巻, 10 号
選択された号の論文の27件中1～27を表示しています
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Regular Articles
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Chia-Ying Li, Tian-Shung Wu原稿種別: Regular Article
専門分野: [not specified]
2002 年 50 巻 10 号 p. 1305-1309
発行日: 2002年
公開日: 2002/10/01
ジャーナル フリーFive new naturally occurring monoterpenoids, crocusatins-A (1), -B (2a), -C (3), -D (4a) -E (5), a new lactate, sodium (2S)-(O-hydroxyphenyl)lactate (6), and eighteen known compounds were isolated and characterized from the pollen of Crocus sativus L. The tyrosinase inhibitory activities of these compounds were also discussed.抄録全体を表示PDF形式でダウンロード (82K) -
Qiao-Hong Chen, Feng-Peng Wang原稿種別: Regular Article
専門分野: [not specified]
2002 年 50 巻 10 号 p. 1310-1317
発行日: 2002年
公開日: 2002/10/01
ジャーナル フリーAfter a series of optimization for the reaction conditions (reagents, reaction temperature, etc.), treatment of the sulfonates 4, 8, 13 and 15 with 8% NaOH (room temperature, 24 h) via a semipinacol rearrangement afforded the corresponding C-nor compounds 5, 9, 12 and 16, as the major of a pair of epimer at C-16, to an excellent extent, in 95%, 92%, 100% and 90% yield, respectively. The 12,13-seco compounds 21 and 22 (23) were obtained in 20% and 60% yield, respectively, by treating 5 with Br2–glacial HOAc (room temperature, 24 h). Treatment of the C-nor compounds 5 or 6, 16 or 17, and 28 from 10 with SOCl2–anhydrous benzene (room temperature, overnight) afforded the 12,13-seco compounds 24, 26 and 30 in 70% or 100%, 40% and 66% yield, respectively. When treatment of the C-nor compound 29 from 9 under same conditions gave the 12,13-seco products 30, 31 and 32 in 33%, 26% and 20% yield. When treating 21 or 24, and 26 with 5% KOH in EtOH afforded the 12,13-seco compounds 25 and 27 quantitatively, respectively. The compound 31 converted to 30 quantitatively by treatment with Na2CO3 in MeOH. All of the new compounds were isolated and fully characterized.抄録全体を表示PDF形式でダウンロード (152K) -
Taisuke Itaya, Tae Kanai原稿種別: Regular Article
専門分野: [not specified]
2002 年 50 巻 10 号 p. 1318-1326
発行日: 2002年
公開日: 2002/10/01
ジャーナル フリーThe first synthesis of (αS,βS)-β-hydroxy-α-[(methoxycarbonyl)amino]-4,6-dimethyl-9-oxo-3-β-D-ribofuranosyl-4,9-dihydro-3H-imidazo[1,2-a]purine-7-butanoic acid methyl ester [(αS,βS)-11] has been achieved by OsO4 oxidation of [S-(E)]-4-[4,6-dimethyl-9-oxo-3-[2,3,5-tris-O-(tert-butyldimethylsilyl)-β-D-ribofuranosyl]-4,9-dihydro-3H-imidazo[1,2-a]purin-7-yl]-2-[(methoxycarbonyl)amino]-3-butenoic acid methyl ester (13) followed by successive γ-deoxygenation through the cyclocarbonates, separation from the (αS,βR)-isomer by means of flash chromatography, and deprotection. On the other hand, the minor nucleoside of rat liver tRNAPhe was isolated on a scale of 100 μg by partial digestion of unfractionated tRNA (1 g) with nuclease P1, followed by reverse-phase column chromatography, complete digestion with nuclease P1/alkaline phosphatase, and reverse-phase HPLC. Comparison of this nucleoside with the synthetic one has unambiguously established its structure to be (αS,βS)-11.抄録全体を表示PDF形式でダウンロード (172K) -
Takashi Iida, Masahiro Hikosaka, Genta Kakiyama, Keisuke Shiraishi, Cl ...原稿種別: Regular Article
専門分野: [not specified]
2002 年 50 巻 10 号 p. 1327-1334
発行日: 2002年
公開日: 2002/10/01
ジャーナル フリーEpimeric 3α,7α,16- and 3α,7α,15-trihydroxy-5β-cholan-24-oic acids and some related compounds were synthesized from chenodeoxycholic acid (CDCA) and ursodeoxycholic acid (UDCA), respectively. The key reaction involved one-step remote oxyfunctionalization of unactivated methine carbons at C-17 of CDCA and at C-14 of UDCA as their methyl ester-peracetate derivatives with dimethyldioxirane (DMDO). After dehydration of the resulting 17α- and 14α-hydroxy derivatives with POCl3 or conc. H2SO4, the respective Δ16- and Δ14-unsaturated products were subjected to hydration via hydroboration followed by oxidation to yield the 3,7,16- and 3,7,15-triketones, respectively. Stereoselective reduction of the respective triketones with tert-butylamine-borane complex afforded the epimeric 3α,7α,16- or 3α,7α,15-trihydroxy derivatives exclusively. A facile formation of the corresponding ε-lactones between the side chain carboxyl group at C-24 and the 16α- (or 16β-) hydroxyl group in bile acids is also clarified.抄録全体を表示PDF形式でダウンロード (135K) -
Claire Jarry, Jean-Christophe Leroux, Jonathan Haeck, Cyril Chaput原稿種別: Regular Article
専門分野: [not specified]
2002 年 50 巻 10 号 p. 1335-1340
発行日: 2002年
公開日: 2002/10/01
ジャーナル フリーThe effects of steam sterilization and γ-irradiation on chitosan and thermogelling chitosan-β-glycerophosphate (GP) solutions containing polyol additives were investigated. The selected polyols were triethylene glycol, glycerol, sorbitol, glucose and poly(ethylene glycol) (PEG). They were incorporated to chitosan solutions prior to sterilization in a proportion ranging from 1 to 5% (w/v). The solutions were characterized with respect to their viscosity, thermogelling properties, compressive stress relaxation behavior and chitosan degradation. All polyols reduced the autoclaving-induced viscosity loss and had a positive impact on the solution thermogelling properties and compressive performance of the gels. Steam sterilization in the presence of glucose resulted in a substantial increase in the solution viscosity and gel strength. This was associated with a strong discoloration suggesting chemical alteration of the system. PEG was the most effective agent in preventing hydrolytic degradation of chitosan chains. Gamma-irradiation strongly decreased the chitosan solution viscosity regardless of the presence of additives, even when sterilization was carried out at −80 °C. Moreover, the thermogelling properties were dramatically altered, and thus, γ-irradiation would not be an appropriate method to sterilize chitosan solutions. In conclusion, polyols are potentially useful additive to maximise the viscoelastic and mechanical properties of chitosan-GP after steam sterilization.抄録全体を表示PDF形式でダウンロード (137K) -
Yu Jin, Junpei Yamanaka, Shizuko Sato, Isamu Miyata, Chikako Yomota, M ...原稿種別: Regular Article
専門分野: [not specified]
2002 年 50 巻 10 号 p. 1341-1348
発行日: 2002年
公開日: 2002/10/01
ジャーナル フリーHyaluronate-hydroxyethyl acrylate blend gel (HA-PHEA) were prepared to modify the brittleness of hyaluronate gel (HA) and the characteristics of HA-PHEA gel were compared with those of HA and polyhydroxyethyl acrylate (PHEA) gels. These gels were high in water content and transparent. HA-PHEA gel was improved in viscoelastic properties due to the elasticity and the high affinity with water of PHEA, and the drying-swelling cycles became reversible. The effective charge densities θ of the gels estimated from membrane potentials were −0.002, −0.008 and 0 mol dm−3 for HA-PHEA, HA and PHEA gels. Effects of electro- static and nonelectrostatic interactions on absorptions and releases were studied using sodium benzoate (NaBA) as an anionic solute, and methylene blue (MB), chlorpromazine (CPHCl) and benzethonium chloride (BZTCl) as cationic solutes, in which CPHCl and BZTCl are cationic amphiphilic solutes. The releases of MB, CPHCl and BZTCl from HA-PHEA and HA gels were suppressed comparing with those of NaBA. By adding salts, the releases of MB and CPHCl were enhanced but those of BZTCl were suppressed due to enhancement of the intra- and intermicelle formation. In the releases of the cationic solutes from HA-PHEA gel, electrostatic and nonelectrostatic interactions with HA were found to play important roles. Behaviors of the releases from HA-PHEA gel were found to possess the features of HA gel.抄録全体を表示PDF形式でダウンロード (245K) -
Hiroshi Imoto, Eikoh Imamiya, Yu Momose, Yasuo Sugiyama, Hiroyuki Kimu ...原稿種別: Regular Article
専門分野: [not specified]
2002 年 50 巻 10 号 p. 1349-1357
発行日: 2002年
公開日: 2002/10/01
ジャーナル フリーA novel series of oxyiminoacetic acid derivatives were synthesized in an effort to develop a potent antidiabetic agent, which does not contain the 2,4-thiazolidinedione moiety. These compounds were evaluated for glucose and lipid lowering effects in genetically obese and diabetic KKAy mice. Several of the compounds showed strong antidiabetic activity, including functional potency at peroxisome proliferator-activated receptor (PPAR)-γ. (Z)-2-[4-[(5-Methyl-2-phenyl-1,3-oxazol-4-yl)methoxy]benzyloxyimino]-2-(4-phenoxyphenyl)acetic acid (25) significantly reduced plasma glucose (33%, p<0.01) and plasma triglycelide levels (43%, p<0.01) even at a dosage of 0.001% in diet. Pharmacokinetic analyses of 25 are also reported.抄録全体を表示PDF形式でダウンロード (126K) -
Tsutomu Nakanishi, Yuka Inatomi, Hiroko Murata, Naoki Iida, Akira Inad ...原稿種別: Regular Article
専門分野: [not specified]
2002 年 50 巻 10 号 p. 1358-1361
発行日: 2002年
公開日: 2002/10/01
ジャーナル フリーTwo new phenol glucosides termed juniperosides I (1) and II (2) were isolated, together with known two biflavones, cupressuflavone and amentoflavone and a diterpene, 3β-hydroxy sandaracopimaric acid, from leaves of Juniperus occidentalis HOOK. (Cupressaceae) collected in Oregon, U.S.A., and their structures were established as (1S)- and (1R)-1-(2′-hydroxy-6′-methylphenyl)ethanol 2′-O-β-D-glucopyranosides (1, 2), respectively, on the basis of spectral, chemical, and synthetic evidence. The glycosides 1 and 2, as well as the corresponding aglycones 1a and 2a, are apparently novel types of naturally occurring compounds; to our knowledge, isolation of these types of natural phenol derivatives has only rarely been reported from the vegetable kingdom.抄録全体を表示PDF形式でダウンロード (73K) -
Tadashi Shiraiwa, Masahiro Suzuki, Yoshio Sakai, Hisashi Nagasawa, Kaz ...原稿種別: Regular Article
専門分野: [not specified]
2002 年 50 巻 10 号 p. 1362-1366
発行日: 2002年
公開日: 2002/10/01
ジャーナル フリーTo synthesize optically active 2-amino-2-methyl-3-phenylpropanoic acid (1), (RS)-2-benzoylamino-2-benzyl-3-hydroxypropanoic acid [(RS)-2] was first optically resolved using cinchonidine as a resolving agent to yield optically pure (S)- and (R)-2 in yields of about 70%, based on half of the starting amount of (RS)-2. Next, the racemic structure of (RS)-2 was examined based on melting point, solubility, IR spectrum, and binary and ternary phase diagrams, with the aim of optical resolution by preferential crystallization of (RS)-2. Results indicated that the (RS)-2 exists as a conglomerate at room temperature, although it forms a racemic compound at the melting point. The optical resolution by preferential crystallization yielded (S)- and (R)-2 with optical purities of about 90%, which were fully purified by recrystallization. After O-tosylation of (S)- and (R)-2, reduction by zinc powder and sodium iodide gave (R)- and (S)-1, respectively.抄録全体を表示PDF形式でダウンロード (87K)
Notes
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Ondognii Purev, Cserendash Purevsuren, Samdan Narantuya, Sodnombaljir ...原稿種別: Note
専門分野: [not specified]
2002 年 50 巻 10 号 p. 1367-1369
発行日: 2002年
公開日: 2002/10/01
ジャーナル フリーTwo new isoflavones, 6, 3′, 4′-trimethoxy-7, 8, 5′-trihydroxyisoflavone (1), 7, 4′-dimethoxy-8, 3′, 5′-trihydroxy-6-O-β-D-glucopyranosylisoflavone (2), and 5, 3, 3′-trihydroxy-7, 4′-dimethoxyflavanone (3) have been isolated from the underground parts of Iris potaninii along with known isoflavones (4—8) and iriflophenone (9). The structures of the new compounds were determined using NMR and mass spectroscopic methods.抄録全体を表示PDF形式でダウンロード (63K) -
Shuji Kitagawa, Masatoshi Kasamaki原稿種別: Note
専門分野: [not specified]
2002 年 50 巻 10 号 p. 1370-1372
発行日: 2002年
公開日: 2002/10/01
ジャーナル フリーWe examined the enhancement effects of the double-chained cationic surfactants of n-dimethyldialkylammoniums (CH3)2N+(CnH2n+1)2 on the permeation of anionic salicylate through excised guinea pig dorsal skin at pH 7.4. Among them, n-dimethyldidecylammonium (2C10), which seemed to form micelles, had dose-dependent enhancement effects at concentrations of more than 0.1 mM, and about a ninety-fold increase in the permeability coefficient of salicylate was observed at 2 mM. The enhancement effect of 2C10 was larger than those of single-chained cationic surfactants of n-alkyltrimethylammoniums. n-Dimethyldilaurylammonium (2C12), which seemed to form bilayer vesicles, induced about a twenty five-fold increase in the permeability coefficient. The enhancement effects of n-dimethyldialkylammoniums decreased with the increase in their alkyl chain lengths. In contrast, only slight stimulation by these cationic surfactants was observed for silicon rubber membrane permeation of salicylate. Analysis of the retention of the salicylate in the skin suggested that the double-chained cationic surfactants-induced increase in the transfer of salicylate to the skin is the main reason for the marked stimulation of the skin permeation.抄録全体を表示PDF形式でダウンロード (59K) -
Eun-Young Hwang, Je-Hyun Lee, Yong-Moon Lee, Seon-Pyo Hong原稿種別: Note
専門分野: [not specified]
2002 年 50 巻 10 号 p. 1373-1375
発行日: 2002年
公開日: 2002/10/01
ジャーナル フリーIn boiling aqueous solution, D-amygdalin usually begins to convert into neoamygdalin in 3 min and more than 30% of the initial D-amygdalin is found as neoamygdalin after 30 min. In this report, we establish methods for simple HPLC analysis and the inhibition of D-amygdalin conversion. D-Amygdalin and its conversion product, neoamygdalin, were clearly separated on reverse-phase column chromatography by an optimized eluent of 10 mM sodium phosphate buffer (pH 3.8) containing 6% acetonitrile. Linearity for analyzing D-amygdalin and neoamygdalin was observed in the range from 0.05 to 0.5 mM. The detection limits for D-amygdalin and neoamygdalin were ca. 5 μM per injected amount. We found that D-amygdalin conversion was completely inhibited by adding 0.05% citric acid to the aqueous solution before boiling. To prevent the loss of pharmaceutical potency of Tonin, we applied this method to measure the conversion rate of D-amygdalin. We confirmed that D-amygdalin conversion in Tonin is effectively inhibited by acidic boiling solution with 0.1% citric acid.抄録全体を表示PDF形式でダウンロード (59K) -
Mariko Kitajima, Masashi Yokoya, Hiromitsu Takayama, Norio Aimi原稿種別: Note
専門分野: [not specified]
2002 年 50 巻 10 号 p. 1376-1378
発行日: 2002年
公開日: 2002/10/01
ジャーナル フリーThe structure including the absolute configuration of a new glucoalkaloid, 3,4-dehydro-5(S)-5-carboxystrictosidine, isolated from Peruvian Uña de Gato (Cat's Claw, original plant: Uncaria tomentosa), was confirmed by synthesis starting from secologanin and L-tryptophan.抄録全体を表示PDF形式でダウンロード (68K) -
Antonio Rodríguez Hergueta, María José Figueira, ...原稿種別: Note
専門分野: [not specified]
2002 年 50 巻 10 号 p. 1379-1382
発行日: 2002年
公開日: 2002/10/01
ジャーナル フリーA new and general method is described for the synthesis, in three steps and in good overall yields, of tetrasubstituted xanthines from an easily prepared imidazole precursor. The method is especially useful for the preparation in standardized conditions of series of xanthines combining a broad variety of primary or secondary alkyl, benzyl or aryl groups at N1 and of alkyl or arylmethyl groups at N3, that are not readily available by other methods.抄録全体を表示PDF形式でダウンロード (58K) -
Chang-Soo Yook, Xiang-Qian Liu, Seung-Yeup Chang, Sang-Yong Park, Tosh ...原稿種別: Note
専門分野: [not specified]
2002 年 50 巻 10 号 p. 1383-1385
発行日: 2002年
公開日: 2002/10/01
ジャーナル フリーA novel lupane-triterpene glycoside, called wujiapioside B (1), was isolated from the leaves of Acanthopanax gracilistylus (Araliaceae) together with three known lupane-triterpene glycosides, acankoreoside C (2), acantrifoside A (3) and 3-epibetulinic acid 28-O-α-L-rhamnopyranosyl-(1→4)-β-D-glucopyranosyl-(1→6)-β-D-glucopyranosyl ester (4). Based on spectroscopic data, the chemical structure of 1 was determined as 3α,23-dihydroxy-lup-20(29)-en-28-oic acid 28-O-α-L-rhamnopyranosyl-(1→4)-β-D-glucopyranosyl-(1→6)-β-D-glucopyranosyl ester. Compounds 2—3 were obtained for the first time from this plant and compound 4 has not been isolated from Acanthopanax genus yet.抄録全体を表示PDF形式でダウンロード (56K) -
Satoshi Kawatake, Masanori Inagaki, Ryuichi Isobe, Tomofumi Miyamoto, ...原稿種別: Note
専門分野: [not specified]
2002 年 50 巻 10 号 p. 1386-1389
発行日: 2002年
公開日: 2002/10/01
ジャーナル フリーTwo monomethylated GM3-Type ganglioside molecular species, 1 and 2, have been obtained from the polar lipid fraction of the chloroform/methanol extract of the starfish Luidia maculata. The structures of these gangliosides have been determined on the basis of chemical and spectroscopic evidence as 1-O-[8-O-methyl-(N-acetyl-α-D-neuraminosyl)-(2→3)-β-D-galactopyranosyl-(1→4)-β-D-glucopyranosyl]-ceramide (1) and 1-O-[8-O-methyl-(N-glycolyl-α-D-neuraminosyl)-(2→3)-β-D-galactopyranosyl-(1→4)-β-D-glucopyranosyl]-ceramide (2). The ceramide moieties were composed of heterogeneous unsubstituted fatty acid, 2-hydroxy fatty acid, sphingosine and phytosphingosine units. Compound 1, designated as LMG-3, represents new ganglioside molecular species. Compound 2 was a known ganglioside molecular species.抄録全体を表示PDF形式でダウンロード (74K) -
Masao Toyota, Takuji Shimamura, Hikari Ishii, Matt Renner, John Braggi ...原稿種別: Note
専門分野: [not specified]
2002 年 50 巻 10 号 p. 1390-1392
発行日: 2002年
公開日: 2002/10/01
ジャーナル フリーThe ether extract of the New Zealand liverwort Radula marginata afforded a new cannabinoid type bibenzyl compound named perrottetinenic acid, and two new bibenzyls, together with a known cannabinoid, perrottetinene. Their structures were established by two dimensional (2D) NMR spectral data. The structure of perrottetinenic acid was a similar to that of Δ1-tetrahydrocannabinol, a known hallucinogen. Cannabinoid type bibenzyls have been isolated from liverwort Radula perrottetii, though have not previously been reported from the liverwort R. marginata.抄録全体を表示PDF形式でダウンロード (69K) -
Huiming Hua, Maosheng Cheng, Xian Li, Yuehu Pei原稿種別: Note
専門分野: [not specified]
2002 年 50 巻 10 号 p. 1393-1394
発行日: 2002年
公開日: 2002/10/01
ジャーナル フリーA new alkaloid, 1,2,3,9-tetrahydropyrrolo(2,1-b)quinazolin-1-carboxylic acid (1), together with eight known compounds, 7-hydroxy vasicine (2), benzyl alcohol β-D-(2′-O-β-xylopyranosyl)glucopyranoside (3), benzyl alcohol O-β-D-glucopyranoside (4), benzyl alcohol O-β-D-primveroside (5), 3,5-dimethyl-4-hydroxy benzaldehyde (6), gluco-syringic acid (7), syringin (8), and liriodendrin (9), were isolated from the plants of Linaria vulgaris. Their structures were established by spectroscopic methods.抄録全体を表示PDF形式でダウンロード (56K) -
Yoshio Takeda, Hideko Shimidzu, Kenta Mizuno, Sachiyo Inouchi, Toshiya ...原稿種別: Note
専門分野: [not specified]
2002 年 50 巻 10 号 p. 1395-1397
発行日: 2002年
公開日: 2002/10/01
ジャーナル フリーA new iridoid glucoside dimer (1) and a non-glycosidic iridoid (2) was isolated together with the known compounds, asperuloside (3), paederoside (4), daphylloside (5), citroside A (6) and benzyl 6-O-α-L-rhamnopyranosyl-β-D-glucopyranoside (7), from the leaves of Lasianthus wallichii. The structures of the new compounds were elucidated by spectroscopic and chemical evidence.抄録全体を表示PDF形式でダウンロード (67K) -
Yasuyuki Takeda, Toshiharu Yoshino, Kouichi Uoto, Hirofumi Terasawa, T ...原稿種別: Note
専門分野: [not specified]
2002 年 50 巻 10 号 p. 1398-1400
発行日: 2002年
公開日: 2002/10/01
ジャーナル フリーA new method for the synthesis of 7-deoxytaxane analogues has been established through hydrogenation of Δ6,7-taxane derivatives. Among several catalysts examined, Pd–C was found to be a most effective catalyst for the preparation of target compound.抄録全体を表示PDF形式でダウンロード (70K) -
Akihiro Ambo, Takanori Terashima, Yusuke Sasaki原稿種別: Note
専門分野: [not specified]
2002 年 50 巻 10 号 p. 1401-1403
発行日: 2002年
公開日: 2002/10/01
ジャーナル フリーTen Tyr-D-Arg-Phe-βAla-NH2 (YRFB) analogs in which specific amino acid side chains are shifted to the Nα-position were synthesized, and the binding to these analogs to the μ receptor and their in vitro biological properties were evaluated. Some analogs in which a N,N-bis(p-hydroxybenzyl)-Gly residue was substituted for Tyr1 exhibited μ receptor antagonist activities (pA2) between 5.3 and 6.1. Of these analogs, [N,N-bis(p-hydroxybenzyl)-Gly1]YRFB was found to be the most potent specific antagonist for the μ-opioid receptor.抄録全体を表示PDF形式でダウンロード (103K) -
Shuji Yasuike, Satoru Okajima, Jyoji Kurita原稿種別: Note
専門分野: [not specified]
2002 年 50 巻 10 号 p. 1404-1406
発行日: 2002年
公開日: 2002/10/01
ジャーナル フリーNovel, enantiomerically pure organoantimony compounds having a C-chiral amine moiety, (S)-(α-methyl-2-di-p-tolylstibanobenzyl)dimethylamine [AMSb] (2) and its (η6-arene)chromium complex [AMSb–Cr(CO)3] (4), were prepared from common (S)-(α-methylbenzyl)dimethylamine (1) via its ortho-lithiated intermediates in short steps. The catalytic activity and enantioselectivity of the ligands 2 and 4 for asymmetric reaction are evaluated, and the optically active (η6-arene)chromium complex 4 has been shown to be an effective ligand for rhodium-catalyzed asymmetric hydrosilylation of ketones.抄録全体を表示PDF形式でダウンロード (65K) -
Toshiya Noguchi, Akira Onodera, Kazuyuki Tomisawa, Sadakazu Yokomori原稿種別: Note
専門分野: [not specified]
2002 年 50 巻 10 号 p. 1407-1412
発行日: 2002年
公開日: 2002/10/01
ジャーナル フリーAn efficient and practical procedure for the synthesis of esonarimod, (R,S)-2-acetylthiomethyl-4-(4-methylphenyl)-4-oxobutanoic acid (1), a new antirheumatic drug, has been developed. The intermediate, 2-methylene-4-(4-methylphenyl)-4-oxobutanoic acid (2), was prepared by Friedel–Crafts acylation of toluene with itaconic anhydride (3) in the presence of aluminum trichloride and nitrobenzene in 63% yield without silica gel column purification. Compound 1 was prepared by Michael addition of 2 with thioacetic acid (4) in 74% yield. Overall, 1 was obtained in 47% yield from 3. The structures and synthetic mechanisms of by-products (five compounds) of 2 were also clarified.抄録全体を表示PDF形式でダウンロード (90K) -
Chikako Masuoka, Masateru Ono, Yasuyuki Ito, Masafumi Okawa, Toshihiro ...原稿種別: Note
専門分野: [not specified]
2002 年 50 巻 10 号 p. 1413-1415
発行日: 2002年
公開日: 2002/10/01
ジャーナル フリーA new megastigmane glycoside, called pipeloside A, and a new aromadendrane type sesquiterpenoid, pipelol A, were isolated from the MeOH extract of the aerial part of Piper elongatum VAHL. along with a known megastigmane glycoside, byzantionoside B. The structures of these compounds were elucidated on the basis of spectroscopic data and chemical evidence.抄録全体を表示PDF形式でダウンロード (66K) -
Masateru Ono, Chikako Masuoka, Mihoko Koto, Michiko Tateishi, Haruki K ...原稿種別: Note
専門分野: [not specified]
2002 年 50 巻 10 号 p. 1416-1417
発行日: 2002年
公開日: 2002/10/01
ジャーナル フリーA new ortho-benzoyloxyphenyl acetic acid ester, called vaccihein A (1), was isolated from the fruit of rabbiteye blueberry (Vaccinium ashei). The chemical structure was determined on the basis of spectroscopic data. Compound 1 had antioxidative activity using the ferric thiocyanate method. In addition, 1 showed a scavenging effect on the stable free radical 1,1-diphenyl-2-picrylhydrazyl.抄録全体を表示PDF形式でダウンロード (52K) -
Yoshiaki Isobe, Masanori Tobe, Osamu Takahashi, Yuso Goto, Yoshifumi I ...原稿種別: Note
専門分野: [not specified]
2002 年 50 巻 10 号 p. 1418-1420
発行日: 2002年
公開日: 2002/10/01
ジャーナル フリーCX-659S (1) [(S)-6-amino-5-(6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxamido)-3-methyl-1-phenyl-2,4-(1H,3H)-pyrimidinedione], has been developed as a new type anti-inflammatory agent for the treatment of dermatitis. The structure of a major metabolite of CX-659S was determined as (S)-6-amino-5-[2-hydroxy-2-methyl-4-(2,4,5-trimethyl-3,6-dioxo-1,4-cyclohexadienyl)butanamide]-3-methyl-1-phenyl-2,4-(1H,3H)-pyrimidinedione (2) by direct comparison with the synthesized authentic compound. The anti-inflammatory activity of 2 was equipotent with that of 1 on the contact hypersensitivity reaction (CHR) induced by picryl chloride (PC) in mice, suggesting that compound 2 contributes, at least in part, to the anti-inflammatory activity of CX-659S.抄録全体を表示PDF形式でダウンロード (73K)
Communicatins to the Editor
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Shive Murat Singh Chauhan, Srinivas Appan Kandadai, Anil Kumar原稿種別: Communication to the Editor
専門分野: [not specified]
2002 年 50 巻 10 号 p. 1421-1422
発行日: 2002年
公開日: 2002/10/01
ジャーナル フリーThe biomimetic reduction of anti-inflammatory drug, nimesulide (1) with sodium borohydride catalyzed by 5,10,15,20-tetraarylporphyrinatoiron(III) chlorides [TAPFe(III)Cl] has been studied in organic solvents under anaerobic and aerobic conditions.抄録全体を表示PDF形式でダウンロード (51K)
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