巻号一覧
52 巻, 1 号
選択された号の論文の29件中1～29を表示しています
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Reviews
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John M. Cassady, Kenneth K. Chan, Heinz G. Floss, Eckhard Leistner原稿種別: Review
専門分野: [not specified]
2004 年 52 巻 1 号 p. 1-26
発行日: 2004年
公開日: 2004/01/01
ジャーナル フリーMaytansine and its congeners have been isolated from higher plants, mosses and from an Actinomycete, Actinosynnema pretiosum. Many of these compounds are antitumor agents of extraordinary potency, yet phase II clinical trials with maytansine proved disappointing. The chemistry and biology of maytansinoids has been reviewed repeatedly in the late 1970s and early 1980s; the present review covers new developments in this field during the last two decades. These include the use of maytansinoids as “warheads” in tumor-specific antibodies, preliminary metabolism studies, investigations of their biosynthesis at the biochemical and genetic level, and ecological issues related to the occurrence of such typical microbial metabolites in higher plants.抄録全体を表示PDF形式でダウンロード (371K)
Regular Articles
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Pittaya Tuntiwachwuttikul, Yupa Pootaeng-on, Photchana Phansa, Walter ...原稿種別: Regular Article
専門分野: [not specified]
2004 年 52 巻 1 号 p. 27-32
発行日: 2004年
公開日: 2004/01/01
ジャーナル フリーA mixture of nine cerebrosides and a monoacylmonogalactosylglycerol were seperated from the leaves of Clinacanthus nutans. The structures of the cerebrosides were characterized as 1-O-β-D-glucosides of phytosphingosines, which comprised a common long-chain base, (2S,3S,4R,8Z)-2-amino-8(Z)-octadecene-1,3,4-triol with nine 2-hydroxy fatty acids of varying chain lengths (C16, C18, C20—26) linked to the amino group. The glycosylglyceride was characterized as (2S)-1-O-linolenoyl-3-O-β-D-galactopyranosylglycerol. The structures were established on the basis of the spectroscopic data and chemical reactions.抄録全体を表示PDF形式でダウンロード (90K) -
Rahmiye Aydın, Ulviye Özer原稿種別: Regular Article
専門分野: [not specified]
2004 年 52 巻 1 号 p. 33-37
発行日: 2004年
公開日: 2004/01/01
ジャーナル フリーThe equilibrium reactions of yttrium(III) ion with dihydroxybenzoic acids (2,3-dihydroxybenzoic acid (2,3-DHBA) and 3,4-dihydroxybenzoic acid (3,4-DHBA)) (H3L) were investigated in aqueous solution by means of potentiometric and spectroscopic methods, in 0.1 mol·l−1 ionic strength medium at 25 °C. The stability constants are reported for YL, YL(HL)2− and YL23−- type mononuclear complexes. 2,3-DHBA can bind Y(III) ion strongly and the salicylate mode is effective over the acidic pH range. But in higher pH range, 2,3-DHBA and 3,4-DHBA act more efficiently through catecholate groups. The complexes of 2,3-DHBA are more stable than the complexes of 3,4-DHBA.抄録全体を表示PDF形式でダウンロード (85K) -
Meeran Mohideen Abdul Kamal Nazer, Abdul Rahman Shahul Hameed, Patel R ...原稿種別: Regular Article
専門分野: [not specified]
2004 年 52 巻 1 号 p. 38-40
発行日: 2004年
公開日: 2004/01/01
ジャーナル フリーA simple and rapid potentiometric method for the estimation of ascorbic acid in pharmaceutical dosage forms has been developed. The method is based on treating ascorbic acid with iodine and titration of the iodide produced equivalent to ascorbic acid with silver nitrate using Copper Based Mercury Film Electrode (CBMFE) as an indicator electrode. Interference study was carried to check possible interference of usual excipients and other vitamins. The precision and accuracy of the method was assessed by the application of lack-of-fit test and other statistical methods. The results of the proposed method and British Pharmacopoeia method were compared using F and t-statistical tests of significance.抄録全体を表示PDF形式でダウンロード (53K) -
Hiromichi Akizawa, Yuji Kitamura, Minako Yamane, Akimasa Iwado, Junko ...原稿種別: Regular Article
専門分野: [not specified]
2004 年 52 巻 1 号 p. 41-46
発行日: 2004年
公開日: 2004/01/01
ジャーナル フリーA comparative study was conducted to elucidate the mechanism underlying the separation of poly-aromatic-hydrocarbons (PAHs) and related compounds thereof on a column packed with silica gels modified with Ni(II)- or Cu(II)-phthalocyanine derivatives (PCS) (Ni- or Cu-PCSD column) and commercially available PYE® and NPE® columns with a non-polar eluent, such as n-hexane. It has been revealed that the dominant interaction responsible to the separation of PAHs on the Cu-PCSD and the PYE® columns with n-hexane is the π–π interaction; however, in the separation of PAHs having 4 rings such as pyrene on the Ni-PCSD column, participation of π–d interaction was indicated. The predominant role of π–π interaction in the separation of PAHs of less than three rings on the Ni-PCSD column was demonstrated using anthracene. All the columns possessed planar recognition ability and were estimated to be potentially useful in the separation and the analysis of PAHs.抄録全体を表示PDF形式でダウンロード (103K) -
Masafumi Goto, Hisashi Tsutsui, Syuuichi Matsuda, Yoshitomo Tanaka, No ...原稿種別: Regular Article
専門分野: [not specified]
2004 年 52 巻 1 号 p. 47-50
発行日: 2004年
公開日: 2004/01/01
ジャーナル フリーThe spectroscopic properties of platinum(II) complexes with 2-aminomethyl-derivatives of small-membered 1-aza-cycloalkane, i.e., =2-aminomethylaziridine=azida and S-2-aminomethylazetidine=S-azeda, and the crystal structures of their dichloro complexes demonstrate that the conformation of the fused three- (azida) or four- (S-azeda) and five-membered chelate ring formed by the coordination of S-azida and S-azeda to platinum(II) has an S(N) absolute configuration at the secondary amine site and that the two alkyl groups extend axially from the five-membered chelate ring. The chelate ring of the azida is more planar than the S-azeda or other 2-aminomethyl-1-azacycloalkanes. The anticancer activity reported for azeda and 2-aminomethylpyrrolidine appears to be related to their coordination structure, namely the presence of cis-fused successive rings.抄録全体を表示PDF形式でダウンロード (87K) -
Akiko Ikuta, Naomi Mizuta, Sumio Kitahata, Takeomi Murata, Taichi Usui ...原稿種別: Regular Article
専門分野: [not specified]
2004 年 52 巻 1 号 p. 51-56
発行日: 2004年
公開日: 2004/01/01
ジャーナル フリーSix novel branched β-cyclodextrins (βCDs) having β-D-galactose residues on the non-reducing terminal of the sugar side chains, namely 61,64-di-O-(β-D-galactosyl)-βCD (10), 6-O-(β-D-galactosyl)-βCD (11), 61,64-di-O-(β-lactosyl)-βCD (14), 6-O-(β-lactosyl)-βCD (15), 61,64-di-O-(4′-O-β-D-galactosyl-β-lactosyl)-βCD (18), and 6-O-(4′-O-β-D-galactosyl-β-lactosyl)-βCD (19), were chemically synthesized using the trichloroacetimidate method. The reaction products were separated by HPLC on an amino column into dibranched and monobranched βCDs. Their structures were confirmed by mass spectrometry (MS) and two-dimensional (2D) NMR spectroscopic analysis. To study the length of the sugar side chains attached to the CD ring, which leads to differences in the functions of the branched CDs, interactions of these compounds with peanut (Arachis hypogaea) agglutinin (PNA) were investigated using an optical biosensor and an inhibition assay based on hemagglutination. The results showed that all branched βCDs interacted with PNA, and the binding affinity was 18>14>10 and 19>15>11 when the derivatives were compared on the basis of side chain length.抄録全体を表示PDF形式でダウンロード (131K) -
Haruki Sashida, Kazuo Ohyanagi原稿種別: Regular Article
専門分野: [not specified]
2004 年 52 巻 1 号 p. 57-62
発行日: 2004年
公開日: 2004/01/01
ジャーナル フリーThe reactions of the 2-benzoselenopyrylium (1A) and 2-benzotelluropyrylium cations (1B) with a variety of nucleophiles have been investigated. LiAlH4, sodium alkoxide (NaOMe, NaOi-Pr and NaOt-Bu), diethylamine, n-butylamine and acetone reacted with 1 to give the 1H-isochromenes (2) and the corresponding 1-substituted products (4—9) under mild conditions in almost good to high yields. The 1-alkyl(phenyl)isoselenochromenes (10—13) and 1-benzylisochromenes (18A, 18B), which were produced by the reaction of the salts 1 with Grignard reagents, were converted to the corresponding 1,3-disubstituted 2-benzopyrylium salts (14—17, 19) by treatment with triphenylcarbenium tetrafluoroborate (Ph3C+ BF4−), respectively. The 1-benzylselenopyrylium salts (19A) and 1-benzyltelluropyrylium salts (19B) exist in the solvent as an equilibrium mixture of the salts (19) and the corresponding (Z)-benzylidene compounds (20).抄録全体を表示PDF形式でダウンロード (86K) -
Shinichi Imamura, Yuji Ishihara, Taeko Hattori, Osamu Kurasawa, Yoshih ...原稿種別: Regular Article
専門分野: [not specified]
2004 年 52 巻 1 号 p. 63-73
発行日: 2004年
公開日: 2004/01/01
ジャーナル フリーA novel lead compound, N-{3-[4-(4-fluorobenzoyl)piperidin-1-yl]propyl}-1-methyl-5-oxo-N-phenylpyrrolidine-3-carboxamide (1), was identified as a CCR5 antagonist by high-throughput screening using [125I]RANTES and CCR5-expressing CHO cells. The IC50 value of 1 was 1.9 μM. In an effort to improve the binding affinity of 1, a series of 5-oxopyrrolidine-3-carboxamides was synthesized. Introduction of 3,4-dichloro substituents to the central phenyl ring (10i, IC50=0.057 μM; 11b, IC50=0.050 μM) or replacing the 1-methyl group of the 5-oxopyrrolidine moiety with a 1-benzyl group (12e, IC50=0.038 μM) was found to be effective for improving CCR5 affinity. Compound 10i, 11b, and 12e also inhibited CCR5-using HIV-1 envelope-mediated membrane fusion with IC50 values of 0.44, 0.19, and 0.49 μM, respectively.抄録全体を表示PDF形式でダウンロード (147K) -
Hideto Miyabe, Hirotaka Tanaka, Takeaki Naito原稿種別: Regular Article
専門分野: [not specified]
2004 年 52 巻 1 号 p. 74-78
発行日: 2004年
公開日: 2004/01/01
ジャーナル フリーStannyl radical addition-cyclization of oxime ethers connected with olefin moieties was studied. The radical reactions proceeded effectively by the use of triethylborane as a radical initiator to provide the functionalized pyrrolidines via a carbon–carbon bond-forming process.抄録全体を表示PDF形式でダウンロード (91K) -
Atsushi Kamada, Atsushi Sasaki, Noritaka Kitazawa, Tadashi Okabe, Kazu ...原稿種別: Regular Article
専門分野: [not specified]
2004 年 52 巻 1 号 p. 79-88
発行日: 2004年
公開日: 2004/01/01
ジャーナル フリーNew types of selective estrogen receptor modulators (SERMs) were synthesized and evaluated for their binding affinity and biological effect on reproductive cells. A proposed lead structure (B) was derivatized to provide compounds 30 and 44, which showed good estrogen-receptor binding affinity (Ki values: 6.3 and 10 nM, respectively), as well as minimal impact on mammary and uterine carcinoma cells. Introduction of an alkyl group in the core structure considerably enhanced receptor-binding affinity of the compounds tested. Synthesis and structure–activity relationships of these compounds are described.抄録全体を表示PDF形式でダウンロード (176K) -
Kazuhiko Hayashi, Yoshifumi Ikee, Satoru Goto, Motoo Shiro, Yoshimitsu ...原稿種別: Regular Article
専門分野: [not specified]
2004 年 52 巻 1 号 p. 89-94
発行日: 2004年
公開日: 2004/01/01
ジャーナル フリーThe effective formation of 1-azabicyclo[1.1.0]butane (2) by treatment of 2,3-dibromopropylamine hydrobromide (1) with n-BuLi could be understood considering a rational reaction pathway via both transition states 10 and 19 based on the intramolecular Br···Li+ coordination. A similar cyclization pathway starting from N-benzyl-3-bromopropylamine hydrochloride (17) to afford N-benzylazetidine (18) could also be postulated on the basis of a transition state 20 involving the intramolecular Br···Li+ coordination.抄録全体を表示PDF形式でダウンロード (112K) -
Fumiko Kato, Kunio Hiroi原稿種別: Regular Article
専門分野: [not specified]
2004 年 52 巻 1 号 p. 95-103
発行日: 2004年
公開日: 2004/01/01
ジャーナル フリーThe stereochemistry of the asymmetric palladium-catalyzed reaction of allenes with iodobenzene followed by nucleophilic substitution reaction with sodium malonate and N-methylbenzylamine is described. On the basis of the absolute configuration of the product and the stereochemical result of a similar reaction of a chiral allene, the mechanism of the above asymmetric reactions is discussed.抄録全体を表示PDF形式でダウンロード (129K) -
Jian-Mei Huang, Chun-Shu Yang, Ren Zhao, Hironobu Takahashi, Yoshiyasu ...原稿種別: Regular Article
専門分野: [not specified]
2004 年 52 巻 1 号 p. 104-107
発行日: 2004年
公開日: 2004/01/01
ジャーナル フリーSeven new seco-prezizaane-type sesquiterpenes were isolated from the methanol extract of the pericarps of Illicium merrillianum. Their structures were elucidated as 3-deoxypseudoanisatin (1), 2β-hydroxy-3,6-dedioxypseudoanisatin (2), 8α-hydroxy-10-deoxycyclomerrillianolide (3), 10β-hydroxypseudoanisatin (4), 10β-hydroxycyclopseudoanisatin (5), 1,6-dihydroxy-3-deoxyminwanensin (6), and 8-deoxymerrilliortholactone (7) by analyses of their spectroscopic data and chemical transformation. Compounds 4 and 5 as well as 6 and 7 coexist as a keto/acetal equilibrated mixture in methanol solution.抄録全体を表示PDF形式でダウンロード (67K) -
Ya-Ching Shen, Li-Tung Wang, Chih-Hsin Wang, Ashraf Taha Khalil, Jih-H ...原稿種別: Regular Article
専門分野: [not specified]
2004 年 52 巻 1 号 p. 108-110
発行日: 2004年
公開日: 2004/01/01
ジャーナル フリーIn addition to casearlucin A (3), two new clerodane diterpenes, caseamembrols A (1) and B (2) have been isolated from the leaves and twigs of Casearia membranacea by bioassay-guided fractionation. The structures of the new compounds were established on the basis of extensive 1D- and 2D-NMR spectroscopic analysis. Compounds 1—3 exhibited significant cytotoxicity against human prostate (PC-3) cancer cells.抄録全体を表示PDF形式でダウンロード (56K) -
Hiroaki Ohno, Yoshiji Takemoto, Nobutaka Fujii, Tetsuaki Tanaka, Toshi ...原稿種別: Regular Article
専門分野: [not specified]
2004 年 52 巻 1 号 p. 111-119
発行日: 2004年
公開日: 2004/01/01
ジャーナル フリーWhereas treatment of the allylic mesylates of N-protected 2-alkyl-4-amino-(E)-2-alken-1-ols with sodium hydride in DMF yields exclusively the corresponding thermodynamically less stable 2,3-trans-2-alkenyl-3-alkylaziridines, exposure of the methyl carbonates of N-protected 2-alkyl-4-amino-(E)-2-alken-1-ols to a catalytic amount of Pd(PPh3)4 in THF or 1,4-dioxane affords predominantly the corresponding thermodynamically more stable 2,3-cis-2-alkenyl-3-alkylaziridines. The kinetically favored trans-selective aziridination would be attributed to the allylic 1,3-strain in aza-anionic intermediates. The conformational analysis of the sterically highly congested 2-alkenylaziridines thus obtained is also presented.抄録全体を表示PDF形式でダウンロード (160K) -
Hiroshi Imoto, Mitsuharu Matsumoto, Hiroyuki Odaka, Junichi Sakamoto, ...原稿種別: Regular Article
専門分野: [not specified]
2004 年 52 巻 1 号 p. 120-124
発行日: 2004年
公開日: 2004/01/01
ジャーナル フリーPreparation and biological activity of the metabolites of the potent antihyperglycemic and antihyperlipidemic agent, (E)-4-{4-[(5-methyl-2-phenyl-1,3-oxazol-4-yl)methoxy]benzyloxyimino}-4-phenylbutyric acid (TAK-559) (1), were investigated. Metabolites M-I (2), M-II (3), M-III (4) and M-IV (5) were synthesized and their biological activities were evaluated by in vitro and in vivo experiments. Compounds 2—4 activate human peroxisome proliferator-activated receptor gamma one (hPPARγ1) and hPPARα, but their activities are weaker than those of TAK-559 (1). Compound 5 only activates hPPARγ1 weakly. TAK-559 (1) showed potent in vivo plasma glucose and triglyceride lowering activities in Wistar fatty rats after intraperitoneal administration, while its metabolites (2—5) showed comparatively weak activities.抄録全体を表示PDF形式でダウンロード (82K) -
Mayu Iguchi, Hirohisa Doi, Seiji Hata, Kiyoshi Tomioka原稿種別: Regular Article
専門分野: [not specified]
2004 年 52 巻 1 号 p. 125-129
発行日: 2004年
公開日: 2004/01/01
ジャーナル フリーThe reaction of lithium ester enolate with enones provides a challenge for chemoselectivity, that is, discrimination between a conjugate addition and a 1,2-addition. Asymmetric conjugate addition of a lithium enolate of α-trimethylsilanylacetate to acyclic and cyclic α,β-unsaturated ketones was mediated by an external chiral ligand to give the corresponding 1,4-adducts in good enantioselectivity of 74% and good chemoselectivity.抄録全体を表示PDF形式でダウンロード (81K)
Notes
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José Andrés Pérez, Carlos Boluda, Hermelo López, J ...原稿種別: Note
専門分野: [not specified]
2004 年 52 巻 1 号 p. 130-131
発行日: 2004年
公開日: 2004/01/01
ジャーナル フリーAn uncommon, previously unreported p-quinone-lignan compound called justicidone (4-(1,3-benzodioxol-5-yl)-6-methoxynaphtho[2,3-c]furan-1,5,8(3H)-trione) (2), along with the known savinin (1) were isolated from Justicia hyssopifolia (Acanthaceae). Their structures were determined by spectroscopic methods.抄録全体を表示PDF形式でダウンロード (44K) -
Akimori Wada, Kyoko Sawada, Naomi Ono, Masayoshi Ito原稿種別: Note
専門分野: [not specified]
2004 年 52 巻 1 号 p. 132-135
発行日: 2004年
公開日: 2004/01/01
ジャーナル フリーA convenient and improved annulation method for the synthesis of bicyclic ketones was developed. A 2,2-dimethyl-6-(2-phenylsulfonyl)ethylcyclohexanone was converted into a sulfonylester by the addition of ethyl acetate and subsequent dehydration. A Dieckmann type condensation of the sulfonylester followed by desulfonylation afforded the 8,8-dimethyl-1,2,3,4,5,6,7,8-octahydronaphthalene-2-one in good yield. This annulation method was also applicable for the synthesis of the benzocyclooctanone derivative.抄録全体を表示PDF形式でダウンロード (70K) -
Wenyuan Gao, Rong Zhang, Wei Jia, Jun Zhang, Yoshihisa Takaishi, Hongq ...原稿種別: Note
専門分野: [not specified]
2004 年 52 巻 1 号 p. 136-137
発行日: 2004年
公開日: 2004/01/01
ジャーナル フリーTwo new diterpenes, named sibiriquinone A (1) and B (2), along with four known diterpenes have been isolated from the aerial part of Veronicastrum sibiricum. Their structures were elucidated by spectroscopy. The isolated compounds showed significant immunosuppressive activities.抄録全体を表示PDF形式でダウンロード (48K) -
Momoyo Ichimaru, Noriyoshi Nakatani, Tomoko Takahashi, Yumi Nishiyama, ...原稿種別: Note
専門分野: [not specified]
2004 年 52 巻 1 号 p. 138-141
発行日: 2004年
公開日: 2004/01/01
ジャーナル フリーTwo new C-benzylated dihydrochalcones, isochamuvaritin (1) and acumitin (2), have been isolated from the African medicinal plant Uvaria acuminata, together with the previously reported benzylbenzoate (3), uvaretin (4), isouvaretin (5), diuvaretin (6), and uvangoletin (7). The structural elucidation of compounds 1 and 2 in spectroscopic studies is described. C-Benzylated dihydrochalcones, especially 1, 2, 4, and 6, showed considerable cytotoxicity toward human promyelocytic leukemia HL-60 cells.抄録全体を表示PDF形式でダウンロード (66K) -
Tsuyoshi Ikeda, Hidetsugu Tsumagari, Masafumi Okawa, Toshihiro Nohara原稿種別: Note
専門分野: [not specified]
2004 年 52 巻 1 号 p. 142-145
発行日: 2004年
公開日: 2004/01/01
ジャーナル フリーTwo furostane-type steroidal oligoglycosides (1, 2), together with a new pregnane-type oligoglycoside (3), were obtained from the seeds of Allium tuberosum ROTTLER. On the basis of spectroscopic analysis, the structures of three new oligoglycosides (1—3) were elucidated as 26-O-β-D-glucopyranosyl-(25R)-3β,22ξ,26-trihydroxyl-5α-furostane 3-O-β-chacotrioside, 26-O-β-D-glucopyranosyl-(25S)-3β,5β,6α,22ξ,26-pentahydroxyl-5β-furostane 3-O-α-L-rhamnopyranosyl-(1→4)-β-D-glucopyranoside, and 3-O-α-L-rhamnopyranosyl-(1→4)-β-D-glucopyranosyl 3β,5β,6α,16β-tetrahydroxypregnane 16-(5-O-β-D-glucopyranoyl-4(S)-methyl-5-hydroxypentanoic acid) ester, respectively.抄録全体を表示PDF形式でダウンロード (74K) -
Hidehiko Nakagawa, Mitsuko Takusagawa, Hiromi Arima, Kumiko Furukawa, ...原稿種別: Note
専門分野: [not specified]
2004 年 52 巻 1 号 p. 146-149
発行日: 2004年
公開日: 2004/01/01
ジャーナル フリーThe inhibitory effect on tyrosine nitration and oxidation of peroxynitrite was evaluated for more than 40 reagents including natural and synthetic compounds, and the inhibiting efficiency of each compound for nitration was compared with that for oxidation, to characterize its property as a peroxynitrite scavenger. In the presence of various concentrations of testing compounds, the nitrating and oxidizing activities were measured by monitoring the formation of 3-nitrotyrosine and dityrosine with an HPLC-UV-fluorescence detector. The IC50 values for nitration and oxidation were determined, and the ratio of these two IC50 values was calculated for each compound. Although the IC50 values varied from compound to compound, it was revealed that the ratio of two IC50 values (IC50 for oxidation/IC50 for nitration) was 1 in almost all the compounds tested, except five indole derivatives (L-tryptophan, melatonin, 5-methoxytryptamine, tryptamine, and tetrahydro-beta-carboline) and one synthetic selenium-containing compound ((2R,3R,4S)-2-amino-3,4-dihydroxy-5-phenylselenopentan-1-ol, ADPP). The indole derivatives showed a specific inhibitory effect on tyrosine nitration without affecting the oxidation. ADPP was confirmed to have a preferable inhibitory activity for tyrosine oxidation. It was suggested that compounds showing an IC50 value ratio of 1 scavenged the common species for nitration and oxidation, while the indole derivatives and ADPP preferably scavenged the nitrating and oxidizing species, respectively. From a stopped flow study, it was also revealed that the nitrotyrosine formation was relatively slow, unlike an OH radical reaction. These results imply that the peroxynirite reaction at least partly proceeds through specific species for nitration.抄録全体を表示PDF形式でダウンロード (72K) -
Zhao Luhua, Tu Ying, Zhao Zhengyu, Wang Guangji原稿種別: Note
専門分野: [not specified]
2004 年 52 巻 1 号 p. 150-152
発行日: 2004年
公開日: 2004/01/01
ジャーナル フリーA non-aqueous reversed phase HPLC was developed for determining α-tocopherol in Sea buckthorn oil capsule without the need for saponification. A reversed phase column (Alltima C18, 4.6×250 mm, 5 μm) was used with a mobile phase of methanol–acetonitrile (95 : 5, v/v) and flow rate of 1 ml/min. The contents in capsule were extracted with n-hexane. Detection wavelength was set at 292 nm. Each analysis requires no longer than 20 min. The linearity range for α-tocopherol was 9.4—47.0 μg/ml. The detection limit was 0.94 μg/ml. The mean recovery was 95.82 (RSD 2.3%). This method is suitable for quantitative analysis of α-tocopherol in Sea buckthorn oil or its Traditional Chinese Medicinal preparation.抄録全体を表示PDF形式でダウンロード (52K) -
Toshihiro Akihisa, Harukuni Tokuda, Motohiko Ukiya, Toshie Suzuki, Fum ...原稿種別: Note
専門分野: [not specified]
2004 年 52 巻 1 号 p. 153-156
発行日: 2004年
公開日: 2004/01/01
ジャーナル フリーThe structure of a triterpenoid isolated from the nonsaponifiable lipid (NSL) of the seed oil of the camellia (Camellia japonica L.; Theaceae) was established to be (20S)-3β-hydroxy-25,26,27-trisnordammaran-24,20-olide (1; 3-epicabraleahydroxylactone) on the basis of spectroscopic and chemical methods. Six other triterpenoids isolated from the NSL were identified as 3-epicabraleadiol (2), ocotillol II (3), ocotillol I (4), dammarenediol II (5), (20R)-taraxastane-3β,20-diol (6), and lupane-3β,20-diol (7). Upon evaluation of the seven triterpenoids (1—7) with respect to their inhibitory effects on the induction of Epstein–Barr virus early antigen (EBV-EA) by 12-O-tetradecanoylphorbol-13-acetate (TPA) in Raji cells, three compounds (5—7) showed potent inhibitory effects against EBV-EA induction (IC50 values of 277—420 mol ratio/32 pmol TPA).抄録全体を表示PDF形式でダウンロード (65K) -
Hyun Ah Jung, Hae Young Chung, Jee H. Jung, Jae Sue Choi原稿種別: Note
専門分野: [not specified]
2004 年 52 巻 1 号 p. 157-159
発行日: 2004年
公開日: 2004/01/01
ジャーナル フリーA new triterpenoid, 2α,3α,24-trihydroxyurs-12-en-28-oic acid-28-O-β-D-glucopyranosyl ester (4) along with four known triterpenoids, ursolic acid (1), 2α-hydroxyursolic acid (2), 2α,3α,24-trihydroxyurs-12-en-28-oic acid (3), and 2α,3α,19α,24-tetrahydroxyurs-12-en-28-oic acid-28-O-β-D-glucopyranosyl ester (5), were isolated from the leaves of Prunus serrulata var. spontanea (Rosaceae). Compounds 3—5 showed ONOO− scavenging activity, whereas compounds 1 and 2 were virtually inactive.抄録全体を表示PDF形式でダウンロード (58K) -
Mamoru Kaname, Kazuo Yoshinaga, Yasushi Arakawa, Shigeyuki Yoshifuji原稿種別: Note
専門分野: [not specified]
2004 年 52 巻 1 号 p. 160-162
発行日: 2004年
公開日: 2004/01/01
ジャーナル フリーThe synthesis of hexahydropyridazine-3-phosphonic acid (piperidazine-3-phosphonic acid) was performed via a hetero-Diels–Alder reaction followed by Lewis acid-catalyzed phosphonylation. This two-step procedure was improved to a one-pot reaction.抄録全体を表示PDF形式でダウンロード (58K)
Communicatins to the Editor
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Hiroki Sakoh, Shunji Sakuraba, Yuichi Sugimoto, Hideaki Imamura, Hidek ...原稿種別: Communication to the Editor
専門分野: [not specified]
2004 年 52 巻 1 号 p. 163-165
発行日: 2004年
公開日: 2004/01/01
ジャーナル フリーAsymmetric total synthesis of benzene analogues of galbonolide, a 14-membered antifungal macrolide, possessing a benzene ring instead of a conjugated diene structure, was achieved starting from chiral 1-aryl-1-propanol obtained by enzyme-catalyzed kinetic resolution with high enantioselectivity. Representatively, a method for the introduction of a methylthio and chloride function at the vinyl position was also established. The resulting analogues unfortunately exhibited very little antifungal potency in comparison with galbonolide A.抄録全体を表示PDF形式でダウンロード (88K)
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