巻号一覧
52 巻, 11 号
選択された号の論文の33件中1～33を表示しています
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Regular Articles
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Azhar-Ul-Haq, Abdul Malik, Itrat Anis, Sher Bahadar Khan, Ejaz Ahmed, ...2004 年 52 巻 11 号 p. 1269-1272
発行日: 2004年
公開日: 2004/11/01
ジャーナル フリーTwo new lignans trivially named negundins A (1) and B (2), were isolated along with (+)-diasyringaresinol (3), (+)-lyoniresinol (4), vitrofolal E (5) and vitrofolal F (6), reported for the first time from this species. The structures of the new compounds were established through spectral studies. Compound 2 showed potent inhibitory activity against lipoxygenase enzyme, while 5 showed moderate activity against butyryl-cholinesterase.抄録全体を表示PDF形式でダウンロード (113K) -
Jo. Vandervoort, Krassimira Yoncheva, Annick Ludwig2004 年 52 巻 11 号 p. 1273-1279
発行日: 2004年
公開日: 2004/11/01
ジャーナル フリーPilocarpine HCl-loaded PLGA nanoparticles were prepared by emulsification solvent evaporation. Three different stabilisers, polyvinylalcohol (PVA), Carbopol and Poloxamer were used, as well as mixtures thereof. The influence of the homogenisation pressure and number of cycles on the properties of nanoparticles were studied. Particle size was shown to depend on the stabiliser used. An increase of the homogenisation pressure or the number of cycles resulted in a decrease in particle size. The zeta potential value was influenced mainly by the nature of the stabiliser. Particles stabilised with poloxamer or PVA showed a slightly negative zeta potential value, while samples stabilised with carbopol posessed a more negative zeta potential, which became less negative after homogenisation. Drug encapsulation depended strongly on the stabiliser used. The higher drug entrapment of the carbopol-stabilised particles could be explained by an electrostatic interaction between the negatively charged carboxyl groups of carbopol and the positively charged, protonated pilocarpine. The drug release patterns of the particles prepared were quite similar. Differences between the release patterns of the homogenised particles could be attributed both to differences in size as well as drug encapsulation. Turbidimetric measurements suggested an interaction between mucin and PLGA nanoparticles exclusively stabilised with Carbopol.抄録全体を表示PDF形式でダウンロード (638K) -
Mehmet Suat Aksoy, Ulviye Özer2004 年 52 巻 11 号 p. 1280-1284
発行日: 2004年
公開日: 2004/11/01
ジャーナル フリーThe complexes of chromium(III) ion formed by salicylic acid, SA(H2L), and its derivatives (H2L): 5-nitrosalicylic acid (5-NSA), 5-sulphosalicylic acid (5-SSA) were investigated by means of potentiometry and spectroscopy, at 25 °C and in ionic strength of 0.1 M KNO3 and 0.1 M KCl, respectively. Over the acidic pH range, the coordination of Cr(III) ion to SA and its derivatives in 1 : 1 mole ratio occurs, CrL+ type complex is formed. In the excess of ligand, the coordination of the second ligand molecule is somewhat hindered; as a result CrL(HL) type complex occurs. Their existences were verified and their formation constants were determined. At near neutral pH, CrL(OH) and CrL(HL)(OH)− type hydroxo complexes formed by hydrolytic equilibria and their formation constants were also defined. The stabilities of Cr(III) complexes of SA and its derivatives decrease in the following order: SA>5-SSA>5-NSA. The formation constants of Cr(III) complexes of SA and its derivatives are in comparable ranges with the corresponding complexes of the 2,x-dihydroxybenzoic acid (2,x-DHBA) of Cr(III) ion. The stabilities of SA complexes for V(IV), Cr(III) and Fe(III) ions that have similar ionic radii, increase in the order VOL<CrL+<FeL+. It is worthwhile noting that the binding ability of Cr(III) to salicylate ion is four orders of magnitude higher than to transferin, which is a blood serum protein and is associated with insulin action.抄録全体を表示PDF形式でダウンロード (127K) -
Masao Tsukayama, Hironari Wada, Yasuhiko Kawamura, Kazuyo Yamashita, M ...2004 年 52 巻 11 号 p. 1285-1289
発行日: 2004年
公開日: 2004/11/01
ジャーナル フリーThe palladium-catalyzed coupling reaction of 6-iodoisoflavone, prepared from 3′-iodoacetophenone derivative, with 2-methyl-3-butyn-2-ol gave 6-alkynylisoflavone derivative, which was hydrogenated to give 6-alkylhydroxyisoflavone (luteone hydrate) (2). Dehydration of 2 gave 2′,4′,5,7-tetrahydroxy-6-prenylisoflavone (luteone) (1). Wighteone hydrate (3) was also synthesized from 6-iodotris(benzyloxy)isoflavone in a similar manner. 6-Alkyl-4′5,7-trihydroxy-coumaronochromone (4) was synthesized by oxidative cyclization of 2 with o-chloranil.抄録全体を表示PDF形式でダウンロード (171K) -
Kakuji Tojo2004 年 52 巻 11 号 p. 1290-1294
発行日: 2004年
公開日: 2004/11/01
ジャーナル フリーA pharmacokinetic model of ocular drug delivery has been developed for describing the elimination and distribution of ocular drugs in the eye. The model, based on Fick's second law of diffusion, assumes a modified cylindrical eye with three pathways for drug transport across the surface of the eye: the anterior aqueous chamber, the posterior aqueous chamber and the retina/choroids/scleral membrane covering the vitreous body. The model parameters such as the diffusion coefficient and the partition coefficient in various eye tissues can be evaluated from the in vitro membrane penetration experiments using a side-by-side diffusion cell system. The diffusion coefficient for a drug is also predicted by taking account of the effect of the molecular weight of model compounds. The present ocular pharmacokinetic model, which can predict the local concentration distribution in the eye, has well described the in vivo concentration profile in the various eye tissues, the lens, the aqueous humor and the vitreous body, following not only topical eye drop instillation but systemic administration as well. The present model also simulates the effects of binding and metabolism in the eye as well as the individual difference in ocular functions and structure such as cataract surgery and vitreous fluidity on the distribution and elimination of drug molecules in the eye.抄録全体を表示PDF形式でダウンロード (2235K) -
Li Liu, Yiyu Cheng, Haijiang Zhang2004 年 52 巻 11 号 p. 1295-1301
発行日: 2004年
公開日: 2004/11/01
ジャーナル フリーXue-Fu-Zhu-Yu-Tang (血府逐淤汤) is a famous traditional Chinese medicine (TCM) formula for treating cardiovascular disease and related ailments in China for centuries. To profile the phytochemical constituents of the formula, an HPLC-DAD-ESI-MS analytical method has been developed to separate and determinate the medium- or non-polar fraction of the decoction, which has been demonstrated potency to lower the serum total triglyceride concentration, strongly decrease the TXA2/PGI2 ratio and attenuate production of proinflammatory cytokines in high cholesterol-fed rats. By comparing their retention time, UV and MS data with those obtained from the authentic compounds, ferulic acid (1), naringin (2), neohesperindin (3), naringenin (8), marmin (13), senkyunolide A (14), dehydrosafynol (16), safynol (17) and Z-ligustlide (18) are unequivocally determined. Moreover, additional thirteen compounds are tentatively identified as senkyunolide I (4), senkyunolide H (5), poncirin (7), benzoylpaeoniflorin (10), (Z)-6,7-epoxyligustilide (11), senkyunolide G (12), 2-methoxy-safynol (15), cnidilide (19), tangeritin (20), saikosaponin b2 (21), 29-O-acetylsaikosaponin b2 (22), saikosaponin b1 (23) and auraptene (24), according to the comparison of their UV and MS data with the published data. The present study provides an approach to rapidly characterize bioactive constituents in TCM formulae.抄録全体を表示PDF形式でダウンロード (246K) -
Shin-ichi Kondo, Shouichi Hosaka, Yasushi Sasai, Masayuki Kuzuya2004 年 52 巻 11 号 p. 1302-1306
発行日: 2004年
公開日: 2004/11/01
ジャーナル フリーWe discuss here the effect of water-insoluble pharmaceutical aids on the nature of drug release from composite polymeric prodrugs synthesized by mechanochemical solid-state polymerization. Magnesium stearate (Mgst) and hydrogen castor oil (HCO) were used as water-insoluble pharmaceutical aids. Composite polymeric prodrugs were synthesized by the mechanochemical solid-state polymerization of a vinyl monomer of 5-fluorouracil (I) in the presence of Mgst or HCO. The molecular weight of the resulting polymeric prodrugs increased with increasing the content of Mgst or HCO. Prodrug hydrolysis was carried out in a heterogeneous system in phosphate buffer at pH 6.8 and 37 °C. The rate of drug release from the composite polymeric prodrug containing Mgst (Poly-Mgst) was faster than that from polymeric prodrug containing no pharmaceutical aids (Poly-Non), while hydrolysis of the composite polymeric prodrug containing HCO (Poly-HCO) was slower than Poly-Non. Scanning electron microscope (SEM) photos showed the surface of Poly-HCO was smoother than that of Poly-Non and Poly-Mgst. It was suggested that the slower drug release from Poly-HCO may be responsible for the smaller specific surface area than that of Poly-Non. It was also shown that the rate of drug release from the composite polymeric prodrugs decreases with increasing the content of Mgst or HCO. Hence, novel composite polymeric prodrugs with a variety of drug release rates can be prepared by mechanochemical solid-state polymerization in a totally dry process.抄録全体を表示PDF形式でダウンロード (363K) -
Masanori Inagaki, Akemi Oyama, Kazuyoshi Arao, Ryuichi Higuchi2004 年 52 巻 11 号 p. 1307-1311
発行日: 2004年
公開日: 2004/11/01
ジャーナル フリーFive ceramides, JC-1—JC-5, and four glucocerebrosides, JCer-1—JCer-4, have been isolated from their parent ceramide and glucocerebroside molecular species JC and JCer obtained from the less polar lipid fraction of the chloroform/methanol extract of the feather star Comanthus japonica. The structures of these sphingolipids have been determined on the basis of chemical and spectroscopic evidence. Reversed-phase HPLC was effective at isolating these sphingolipids, revealing very close resemblance in their structures. JC-1, JC-3, JC-4, JC-5 and JCer-2, JCer-4 are newly found ceramides and glucocerebrosides, respectively.抄録全体を表示PDF形式でダウンロード (131K) -
Takashi Ichiyanagi, Yoshihiko Hatano, Seiichi Matsuo, Tetsuya Konishi2004 年 52 巻 11 号 p. 1312-1315
発行日: 2004年
公開日: 2004/11/01
ジャーナル フリーThe reactivities of twelve major anthocyanins identified in bilberry extracts towards nitric oxide (NO·) and peroxynitrite (ONOO−) were studied in vitro using capillary zone electrophoresis (CZE). The reactivities of the anthocyanins towards NO· were slightly weak compared with that of (+)-catechin as a reference antioxidant under anaerobic conditions except delphinidin glycosides (Dp3glys). The reactivities of other anthocyanins were not significantly affected by either the aglycon structure or the type of sugar moiety. Under aerobic conditions, all anthocyanins and catechin showed significant enhancement of the reactivity, indicating that they reacted with other reactive species secondarily generated from NO·. Dp3glys showed rather extraordinally high reactivity towards ONOO− compared to other anthocyanins which showed approximately two times low reactivity than catechin when compared with IC50. Structural divergence in the reactivity was also small for all these anthocyanins.抄録全体を表示PDF形式でダウンロード (132K) -
Akikazu Kakehi, Hiroyuki Suga, Yuuya Yamauchi, Katsuaki Yasuraoka, Tom ...2004 年 52 巻 11 号 p. 1316-1321
発行日: 2004年
公開日: 2004/11/01
ジャーナル フリーThe title compounds, readily available from the S-alkylation of pyridinium 1-[alkylthio(thiocarbonyl)](ethoxycarbonylacetyl)methylides with alkyl halides or alkyl bromoacetates, were treated with a base and then a dehydrogenating agent to provide some unique products such as 3-[bis(alkylthio)methylene]-2(3H)-indolizinones and dialkyl 7-methyl-4-oxo-1,4,8,8a-tetrahydro-1,4-thiazino[3,4,5-cd]indolizine-1,5-dicarboxylates. On the other hand, similar reaction of these pyridinium salts in the absence of the dehydrogenating agent afforded alkyl 2-hydroxyindlizine-3-carboxythiolates, whose yields were increased by adding trifluoroacetic acid to the reaction mixture. The structures of some products were confirmed by the X-ray analyses.抄録全体を表示PDF形式でダウンロード (321K) -
Kin-ya Sohda, Tsuyoshi Minematsu, Tadashi Hashimoto, Ken-ichi Suzumura ...2004 年 52 巻 11 号 p. 1322-1325
発行日: 2004年
公開日: 2004/11/01
ジャーナル フリーZonampanel monohydrate (YM872) has a potent and selective antagonistic effect on the glutamate receptor subtype, α-amino-3-hydroxy-5-methylisoxazole-4-propionic acid (AMPA) receptor. Metabolic fingerprinting in rat urine after a single intravenous administration of 14C-labeled YM872 (14C-YM872) revealed the presence of two metabolites, R1 and R2. The two metabolites were semi-purified by preparative HPLC from rat urine after a single intravenous administration of non-labeled YM872, and their structures were elucidated by various instrumental analyses involving LC-NMR. The results showed that R1 and R2 have a hydroxyamino group and an amino group at the C-7 position of the quinoxalinedione skeleton, respectively. Therefore, the proposed metabolic pathway of YM872 in rats involves the reduction of the nitro group to a hydroxyamino group and then subsequent reduction to an amino group.抄録全体を表示PDF形式でダウンロード (395K) -
Akihiro Daikonya, Shigeki Katsuki, Susumu Kitanaka2004 年 52 巻 11 号 p. 1326-1329
発行日: 2004年
公開日: 2004/11/01
ジャーナル フリーThree novel chalcone derivatives, mallotophilippens C (1), D (2) and E (3) were isolated from the fruits of Mallotus philippinensis MUELL. ARG. These compounds were identified, using chemical and spectral data, as 1-[6-(3,7-dimethyl-octa-2,6-dienyl)-5,7-dihydroxy-2,2-dimethyl-2H-chromen-8-yl]-3-(4-hydroxy-phenyl)-propenone, 3-(3,4-dihydroxy-phenyl)-1-[6-(3,7-dimethyl-octa-2,6-dienyl)-5,7-dihydroxy-2,2-dimethyl-2H-chromen-8-yl]-propenone and 1-[5,7-dihydroxy-2-methyl-6-(3-methyl-but-2-enyl)-2-(4-methyl-pent-3-enyl)-2H-chromen-8-yl]-3-(3,4-dihydroxy-phenyl)-propenone, respectively. They inhibited nitric oxide (NO) production and inducible NO synthase (iNOS) gene expression by a murine macrophage-like cell line (RAW 264.7), which was activated by lipopolysaccharide (LPS) and recombinant mouse interferon-γ (IFN-γ). Furthermore, they downregulated cyclooxygenase-2 (COX-2) gene, interleukin-6 (IL-6) gene and interleukin-1β (IL-1β) gene expression. These results suggest that they have anti-inflammatory and immunoregulatory effects.抄録全体を表示PDF形式でダウンロード (154K) -
Isao Kinoyama, Nobuaki Taniguchi, Toru Yoden, Hiroshi Koutoku, Takashi ...2004 年 52 巻 11 号 p. 1330-1333
発行日: 2004年
公開日: 2004/11/01
ジャーナル フリーThe search for novel antiandrogens by high-throughput screening (HTS) of the Yamanouchi chemical library led to the discovery of the lead compound (5), which possesses an arylmorpholine moiety. Through the optimization of the lead compound (5), we have found a series of novel arylpiperazine derivatives. Among them, 4-[4-cyano-(3-trifluoromethyl)phenyl]-N-(4-fluorophenyl)piperazine-1-carboxamide (22; YM-92088) exhibited a potent AR antagonistic activity with an IC50 value of 0.47 μM in the reporter assay, which is more potent than bicalutamide (4) which has an IC50 value of 0.89 μM.抄録全体を表示PDF形式でダウンロード (119K) -
Motoki Asahara, Taku Katayama, Yasuo Tohda, Nagatoshi Nishiwaki, Masah ...2004 年 52 巻 11 号 p. 1334-1338
発行日: 2004年
公開日: 2004/11/01
ジャーナル フリーUnnatural 1-methyl-2-quinolone derivatives were synthesized by regioselective C–C bond formation. When 1-methyl-3,6,8-trinitro-2-quinolone (TNQ) was treated with enamines, nucleophilic addition readily occurred at the 4-position, and succeeding hydrolysis of enamine moiety followed by elimination of nitrous acid furnished 4-acylmethyl-1-methyl-6,8-dinitro-2-quinolones. The same products could be prepared by the reaction of TNQ with ketones in the presence of triethylamine. The present reaction enabled the introduction of various kinds of acylmethyl groups substituted with alkyl, aryl or hetaryl groups.抄録全体を表示PDF形式でダウンロード (143K)
Notes
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Hong-Xia Liu, Wen-Han Lin, Jun-Shan Yang2004 年 52 巻 11 号 p. 1339-1341
発行日: 2004年
公開日: 2004/11/01
ジャーナル フリーCaragaphenol A (1), a new trimeric stilbene, was isolated from the roots of Caragana stenophylla (Leguminosae) along with three known oligomeric stilbenes: (+)-α-viniferin (2), miyabenol C (3) and kobophenol A (4). The stereostructure of 1 was elucidated by one- and two-dimensional (1D- and 2D-)-NMR spectral studies.抄録全体を表示PDF形式でダウンロード (63K) -
Rute Mendonça Xavier de Moura, Paulo Sérgio Pereira, Ana ...2004 年 52 巻 11 号 p. 1342-1344
発行日: 2004年
公開日: 2004/11/01
ジャーナル フリーThe antimicrobial activity of ethanolic extract and pure compounds of Gomphrena celosioides have been screened by Kirby–Bauer method. Quantitative determination of 4-hydroxy-3-methoxy-benzoic acid in stems, leaves, flowers and roots was established by TLC-densitometry. Results showed significant activity against Staphylococcus aureus and Salmonella typhi. There were no significant differences in the determined benzoic acid derivative.抄録全体を表示PDF形式でダウンロード (51K) -
Parvataneni Radhika, Vadali Lakshmana Rao, Hartmut Laatsch2004 年 52 巻 11 号 p. 1345-1348
発行日: 2004年
公開日: 2004/11/01
ジャーナル フリーChemical investigations on the marine soft coral Lobophytum sp., collected from the Andaman and Nicobar Islands, yielded two new acyl glycerol monoalkyl ethers along with two known compounds of this series (1a—d), and a new ceramide (4a). The structures of the new and known compounds were elucidated on the basis of extensive spectroscopic studies and chemical reactions.抄録全体を表示PDF形式でダウンロード (80K) -
Bina Shaheen Siddiqui, Tahsin Gulzar, Azhar Mahmood, Sabira Begum, Bus ...2004 年 52 巻 11 号 p. 1349-1352
発行日: 2004年
公開日: 2004/11/01
ジャーナル フリーThe petroleum ether extract of dried ground whole fruits of Piper nigrum L. afforded 20 compounds (1—20) including two new insecticidal amides named as pipnoohine (1), and pipyahyine (2), seven reported for the first time from this plant (12, 13, 15—17, 19, 20), and eleven known compounds (3—11, 14, 18). The structure of 1 has been elucidated as (2E,4E,12Z)-N-(4-methylpentyl)octadeca-2,4,12-trienamide and that of 2 as (2E,4E,11E)-12-(benzo[1,3]dioxol-5-yl)-N-(3-methylbutyl)dodeca-2,4,11-trien-amide through extensive ID-, 2D-NMR spectral studies and chemical reactions. The known compounds have been identified through comparison of their spectral data with those reported in literature. 1 and 2 exhibited toxicity at 35.0 and 30.0 ppm respectively against fourth instar larvae of Aedes aegypti L. by WHO method.抄録全体を表示PDF形式でダウンロード (114K) -
Marc Sautour, Anne-Claire Mitaine-Offer, Tomofumi Miyamoto, Alain Dong ...2004 年 52 巻 11 号 p. 1353-1355
発行日: 2004年
公開日: 2004/11/01
ジャーナル フリーThe new 26-O-β-D-glucopyranosyl-3β,26-dihydroxy-20,22-seco-25(R)-furost-5-en-20,22-dione-3-O-α-L-rhamnopyranosyl-(1→4)-α-L-rhamnopyranosyl-(1→4)-[α-L-rhamnopyranosyl-(1→2)]-β-D-glucopyranoside (1), along with the known methyl protodioscin (2), asperoside (3) and prosapogenin A of dioscin (4) were isolated from the rhizomes of Dioscorea cayenensis LAM.-HOLL (Dioscoreaceae). Their structures were established mainly on the basis of 600 MHz 2D-NMR spectral data. 4 exhibited antifungal activity against the human pathogenic yeasts Candida albicans, C. glabrata and C. tropicalis (MICs of 20.8, 6.25, 25 μg/ml, respectively), whereas saponins 1—3 were inactive.抄録全体を表示PDF形式でダウンロード (75K) -
Young Lim Kim, Young-Won Chin, Jinwoong Kim, Jong Hee Park2004 年 52 巻 11 号 p. 1356-1357
発行日: 2004年
公開日: 2004/11/01
ジャーナル フリーTwo new acylated iridoid glucosides were isolated from the aerial parts of Paederia scandens along with six known iridoid glucosides. The structures of two new compounds were elucidated as 6′-O-E-feruloylmonotropein (1) and 10-O-E-feruloylmonotropein (2) by spectroscopic methods.抄録全体を表示PDF形式でダウンロード (60K) -
Muhammad Iqbal Choudhary, Sammer Yousuf, Sarfraz Ahmad Nawaz, Shakil A ...2004 年 52 巻 11 号 p. 1358-1361
発行日: 2004年
公開日: 2004/11/01
ジャーナル フリーA total of two new (1, 2) and four known (3—6) withanolides were isolated from the whole plant of Withania somnifera. Their structures were elucidated on the basis of spectroscopic techniques and were characterized as 6α,7α-epoxy-3β,5α,20β-trihydroxy-1-oxowitha-24-enolide (1), 5β,6β-epoxy-4β,17α,27-trihydroxy-1-oxowitha-2,24-dienolide (2), withaferin-A (3), 2,3-dihydrowithaferin-A (4), 6α,7α-epoxy-5α,20β-dihydroxy-1-oxowitha-2,24-dienolide (5), and 5β,6β-epoxy-4β-hydroxy-1-oxowitha-2,14,24-trienolide (6), respectively. Compounds 2, 3, 5, and 6 displayed inhibitory potential against butyrylcholinesterase, but only compounds 3, 4, and 6 were found to be active against acetylcholinesterase.抄録全体を表示PDF形式でダウンロード (99K) -
Ying Xiao, Yi Ding, Jian-Bei Li, Toshihiro Nohara2004 年 52 巻 11 号 p. 1362-1364
発行日: 2004年
公開日: 2004/11/01
ジャーナル フリーTwo new type dicoumarins (dicoumaro-p-menthanes), named dibothrioclinins I (1) and II (2) were isolated from the roots and rhizomes of Gerbera piloselloides (L.) CASS., collected in Yunnan Province, China. Their structures were elucidated on the basis of MS, 1D (1H-NMR, 13C-NMR, DEPT and NOE) and 2D (1H–1H COSY, HMQC, HMBC) NMR spectral analyses. The relative structures of the two compounds were established by NOE difference spectroscopy and further confirmed by single-crystal X-ray diffraction studies.抄録全体を表示PDF形式でダウンロード (121K) -
Sang Jun Han, Su Noh Ryu, Sam Sik Kang2004 年 52 巻 11 号 p. 1365-1366
発行日: 2004年
公開日: 2004/11/01
ジャーナル フリーFrom the black colored rice bran of Oryza sativa cv. Heugjinjubyeo, a new 2-arylbenzofuran, 2-(3,4-dihydroxyphenyl)-4,6-dihydroxybenzofuran-3-carboxylic acid methyl ester, oryzafuran (1), was isolated. Its structure has been elucidated on the basis of spectral data. This compound showed strong antioxidative activity in a 1,1-diphenyl-2-picrylhydrazyl free radical scavenging assay.抄録全体を表示PDF形式でダウンロード (55K) -
Toshiaki Morimoto, Akira Yamazaki, Kazuo Achiwa2004 年 52 巻 11 号 p. 1367-1371
発行日: 2004年
公開日: 2004/11/01
ジャーナル フリーEnantiopure bicyclo[2.2.1]heptane derivatives having both (2S,3S)-bis[(diphenylphosphino)methyl] and 7-syn-oxygen functional groups were synthesized by using diastereoselective Diels–Alder reaction of di-(1R)-menthyl fumarate and 5-trimethylsilylcyclopentadiene followed by silver-promoted stereospecific frame rearrangement of a bromolactone intermediate. Rhodium-catalyzed asymmetric hydrogenations were carried out using the diphosphines as a chiral ligand.抄録全体を表示PDF形式でダウンロード (196K) -
Wimal Herath, Daneel Ferreira, Julie Rakel Mikell, Ikhlas Ahmad Khan2004 年 52 巻 11 号 p. 1372-1374
発行日: 2004年
公開日: 2004/11/01
ジャーナル フリーPreparative scale fermentation of (6S)-dihydrokawain (1) with Rhizopus arrhizus (ATCC 11145) gave 3′-hydroxydihydrokawain (2) and (8S)-hydroxydihydrokawain (3). Structure elucidation of the metabolites was based on spectroscopic data. The C-8 absolute configuration of (3) was assessed via its Mosher's esters.抄録全体を表示PDF形式でダウンロード (87K) -
Xia Wu, JunShan Yang, Liang Zhou, YueSheng Dong2004 年 52 巻 11 号 p. 1375-1377
発行日: 2004年
公開日: 2004/11/01
ジャーナル フリーFive new lanostane-type triterpenes, named fomefficinic acid A—E (1—5), were isolated from the dried sclerotium of Fomes officinalis, respectively. Their structures were established as 24-methylene-3-oxo-lanost-8-en-21-oic acid (1), 3α,15α-dihydroxy-24-methylene-lanosta-7,9(11)-dien-21-oic acid (2), 3α,15α-dihydroxy-24-methylene-lanost-8-en-21-oic acid (3), 15α-hydroxy-3-oxo-24-methylenelanost-8-en-21-oic acid (4), 15α-acetoxy-3-oxo-24-methylenelanosta-7,9(11)-dien-21-oic acid (5), by spectral analysis and chemical methods as well as comparison with known compounds.抄録全体を表示PDF形式でダウンロード (66K) -
Jun Kobayashi, Ryoichi Kizu, Kazuyuki Torii, Hideo Sugiyama2004 年 52 巻 11 号 p. 1378-1381
発行日: 2004年
公開日: 2004/11/01
ジャーナル フリーIn recent years, trials to reuse fused slags, obtained through the further treatment of incinerated ash produced in the process of the disposal of garbage or sewer sludge, such as for building materials including bricks, have drawn attention. To establish the safety of using such substances, elution tests for metals and metal contents were investigated in this study. As the result of examining 13 slags, which were made by different methods, little elution of toxic metals was found in the elution tests when water was used as a solvent. However when acid was used, there was a tendency for the elution of many kinds of metals to become greater. On other hand, the results of content measurements showed that arsenic and selenium, which were not seen to be eluted from any of the slags tested, were detected; and that aluminum and manganese existed in the slags in high concentrations.抄録全体を表示PDF形式でダウンロード (47K) -
Liva Harinantenaina, Yoshinori Asakawa2004 年 52 巻 11 号 p. 1382-1384
発行日: 2004年
公開日: 2004/11/01
ジャーナル フリーIn the course of our chemotaxonomic study of the liverworts growing in Madagascar, mastigophoric acid methyl ester, along with eleven known compounds were isolated from Mastigophora diclados. Isolated metabolites showed that the Malagasy Mastigophora is more related to the samples from Borneo and Japan than to the Taiwanese or Malaysian ones. The biosynthesis of the herbertane type sesquiterpenoids from Mastigophora diclados is suggested to be similar to those found in the genus Herbertus. The herbertane-type sesquiterpenoids were screened for Staphylococcus aureus strain inhibition.抄録全体を表示PDF形式でダウンロード (103K) -
Makoto Hashimoto, Yasumaru Hatanaka2004 年 52 巻 11 号 p. 1385-1386
発行日: 2004年
公開日: 2004/11/01
ジャーナル フリーThe synthesis of trifluoromethyl diazirine with a stable isotope tag is reported. We found that both Friedel–Crafts acylation and reduction of aryl carbonyl to methylene, using commercially available stable-isotope reagents, were utilized for the synthesis of diazirinyl fatty acid derivatives. The stable isotope labeled diazirine may be valuable for identifying binding sites by mass spectrometry.抄録全体を表示PDF形式でダウンロード (77K) -
Toshio Morikawa, Hisashi Matsuda, Norihisa Nishida, Teruki Ohgushi, Ma ...2004 年 52 巻 11 号 p. 1387-1390
発行日: 2004年
公開日: 2004/11/01
ジャーナル フリーThree new aromatics glycosides, hyuganosides II, IIIa, and IIIb, were isolated from a Japanese folk medicine, the roots of Angelica furcijuga KITAGAWA. The structures of the new glycosides were determined on the basis of chemical and physicochemical evidence.抄録全体を表示PDF形式でダウンロード (156K) -
Miyuki Fukasawa, Sakaé Obara2004 年 52 巻 11 号 p. 1391-1393
発行日: 2004年
公開日: 2004/11/01
ジャーナル フリーThe molecular weight of hypromellose acetate succinate (HPMCAS), a polymer used for enteric coating, was determined by means of size exclusion chromatography with a multi-angle laser light scattering detector. The weight-average molecular weight (Mw) of several lots and grades ranged approximately from 17000 to 20000, and the number-average molecular weight (Mn) was around 13000. The inter-day precision of measurement, in terms of the coefficient of variation, was less than 5%.抄録全体を表示PDF形式でダウンロード (53K)
Communications to the Editor
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Yusuke Shibata, Yoshihisa Yamamoto, Makiko Fujii, Masuo Kondoh, Yoshit ...2004 年 52 巻 11 号 p. 1394-1395
発行日: 2004年
公開日: 2004/11/01
ジャーナル フリーA tableting process analyzer (TabAll) was used to predict disintegration time in the mouth of rapidly disintegrating tablet. Analyzer profiles recorded upper punch displacement and die wall force encountered during tablet processing. Changes in the mixing ratio of spherical sugar granules and microcrystalline cellulose or lactose affected upper punch displacement and die wall force profiles. Analysis of the compaction process revealed a strong association between disintegration time in the mouth and stationary time, relaxation time of upper punch displacement, and relaxation time of die wall force; disintegration time in the mouth decreased as the three parameters increased. Thus, analysis of the compaction process is useful for predicting disintegration time in the mouth of rapidly disintegrating tablet, which can assist the formulation of new rapidly disintegrating tablets.抄録全体を表示PDF形式でダウンロード (63K) -
Akihito Yokosuka, Yoshihiro Mimaki, Yutaka Sashida2004 年 52 巻 11 号 p. 1396-1398
発行日: 2004年
公開日: 2004/11/01
ジャーナル フリーThree novel C28-sterol oligoglucosides, named taccasterosides A—C (1—3), were isolated from the rhizomes of Tacca chantrieri (Taccaceae). Their structures were determined by detailed spectroscopic analysis, including 2D NMR data, and a few chemical transformations.抄録全体を表示PDF形式でダウンロード (108K)
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