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Volume 54, Issue 7
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Regular Articles
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Muhammad Iqbal Choudhary, Sammer Yousuf, Samreen, Syed Adnan Ali Shah ...2006 Volume 54 Issue 7 Pages 927-930
Published: 2006
Released on J-STAGE: July 01, 2006
JOURNAL FREE ACCESSThe transformation of physalin H (1) with Rhizopus stolonifer and Cunninghamella elegans has afforded two new physalins, 6,7-dehydrophysalin H (2) and 6-deoxyphysalin H (3), along with a known isophysalin B (4). Their structures were elucidated by spectroscopic analysis. All of these compounds have shown potent leishmanicidal activity with IC50 values in the range of 6.03—13.80 μM.View full abstractDownload PDF (126K) -
Jie Zhang, Bai-Ping Ma, Li-Ping Kang, He-Shui Yu, Yun Yang, Xian-Zhong ...2006 Volume 54 Issue 7 Pages 931-935
Published: 2006
Released on J-STAGE: July 01, 2006
JOURNAL FREE ACCESSTen furostanol saponins were isolated as five pairs of 25R and 25S epimers from the fresh rhizomes of Polygonatum kingianum. Seven of them were identified as new compounds, (25S)-kingianoside D (2), (25S)-kingiano-side C (4), (25R,22)-hydroxylwattinoside C (5), kingianoside E (7), (25S)-kingianoside E (8), kingianoside F (9) and (25S)-kingianoside F (10), together with three known saponins, kingianoside C (1), kingianoside D (3), and 22-hydroxylwattinoside C (6). The structures of the new saponins were determinded by detailed analysis of their 1D and 2D NMR spectra, and by comparison of the spectral data with those reported.View full abstractDownload PDF (116K) -
Hongmei Lu, Xianjin Wu, Yizeng Liang, Jian Zhang2006 Volume 54 Issue 7 Pages 936-940
Published: 2006
Released on J-STAGE: July 01, 2006
JOURNAL FREE ACCESSHouttuynia THUNB. (Saururaceae) has been used for dozens of years in China for the treatment of cough, leucorrhea and ureteritis. The essential oils from the two species: Houttuynia emeiensis and Houttuynia cordata sold in China under one trade name ‘Yuxingcao’, obtained by hydrodistillation, were analyzed by GC-MS. The results show that fifty-five components were identified and methyl nonyl ketone (2.10—40.36%), bornyl acetate (0.4—8.61%) and β-myrcene (2.58—18.47%) were the most abundant components in oil, but the percentage of most of compounds in different species and parts varied greatly. The two fold broth dilution and agar dilution method were used to study essential oil of two Houttuynia THUNB. species for their antibacterial properties against microorganisms, Staphylococcus aureus and Sarcina ureae. The two fold dilution method was allowed to determine the minimum inhibitory concentration (MIC) of essential oil from different parts and species. Results showed that all essential oils possessed antibacterial effect, with MIC values in the range of 0.0625×10−3 to 4.0×10−3 ml/ml. However, essential oil from different parts and species differed clearly in their antibacterial activities. The essential oil from the aboveground part of the cultivated Houttuynia emeiensis exhibited higher activity than both parts of the wild and cultivated Houttuynia cordata when used on Staphylococcus aureus (MIC=0.25×10−3 ml/ml) and Sarcina ureae (MIC=0.0625×10−3 ml/ml), and had the same activity as the positive control ampicillin sodium.View full abstractDownload PDF (65K) -
Katsuko Komatsu, Yorinobu Nagayama, Ken Tanaka, Yun Ling, Purusotam Ba ...2006 Volume 54 Issue 7 Pages 941-947
Published: 2006
Released on J-STAGE: July 01, 2006
JOURNAL FREE ACCESSHPLC methods for the systematic determination of 30 compounds in Rhei Rhizoma (rhubarb) were developed. Using a combination of mobile phase gradient conditions and UV detection at 280 nm, all 30 compounds were separated satisfactorily with low detection limits (0.05—2 μg/ml). The developed methods provided a reliable calibration curve for each compound. By adopting these methods, the determination of 30 compounds in three kinds of rhubarb samples, derived from Rheum tanguticum, R. palmatum and R. officinale, was achieved. The constituent pattern of each rhubarb was clearly characterized through the quantitative composition of 30 major constituents of rhubarb.View full abstractDownload PDF (274K) -
Particle Design Using a 4-Fluid-Nozzle Spray-Drying Technique for Sustained Release of AcetaminophenRicher Chen, Hirokazu Okamoto, Kazumi Danjo2006 Volume 54 Issue 7 Pages 948-953
Published: 2006
Released on J-STAGE: July 01, 2006
JOURNAL FREE ACCESSWe prepared matrix particles of acetaminophen (Act) with chitosan (Cht) as a carrier using a newly developed 4-fluid-nozzle spray dryer. Cht dissolves in acid solutions and forms a gel, but it does not dissolve in alkaline solutions. Therefore, we tested the preparation of controlled release matrix particles using the characteristics of this carrier. Act and Cht mixtures in prescribed ratios were dissolved in an acid solution. We evaluated the matrix particles by preparing a solid dispersion using a 4-fluid-nozzle spray dryer. Observation of the particle morphology by scanning electron microscopy (SEM) revealed that the particles from the spray drying process had atomized to several microns, and that they had become spherical. We investigated the physicochemical properties of the matrix particles by powder X-ray diffraction, differential scanning calorimetry, and dissolution rate analyses with a view to clarifying the effects of crystallinity on the dissolution rate. The powder X-ray diffraction peaks and the heat of the Act fusion in the spray-dried samples decreased with the increase of the carrier content, indicating that the drug was amorphous. These results indicate that the system formed a solid dispersion. Furthermore, we investigated the interaction between the drug and carrier using FT-IR analysis. The FT-IR spectroscopy for the Act solid dispersions suggested that the Act carboxyl group and the Cht amino group formed a hydrogen bond. In addition, the measurement results of the 13C CP/MAS solid-state NMR, indicated that a hydrogen bond had been formed between the Act carbonyl group and the Cht amino group. In the Act-Cht system, the 4-fluid-nozzle spray-dried preparation with a mixing ratio of 1 : 5 obtained a sustained release preparation in all pH test solutions.View full abstractDownload PDF (453K) -
Wen-Bin Pan, Li-Mei Wei, Li-Lan Wei, Yang-Chang Wu2006 Volume 54 Issue 7 Pages 954-958
Published: 2006
Released on J-STAGE: July 01, 2006
JOURNAL FREE ACCESSA new pregnane glycoside, a dibenzylbutyrolactone lignan, 5-hydroxymatairesinol dimethyl ether, and three new flavonoids, including one 8-methylflavan-3-ol, and two 8-methylflavones, together with five known flavonoids and two known alkaloids were isolated from the rhizomes of Tupistra chinensis. The structures of all compounds were elucidated by spectral studies.View full abstractDownload PDF (128K) -
Saied Saeed Hosseiny Davarani, Nahid Mashkouri Najafi, Somayyeh Ramyar ...2006 Volume 54 Issue 7 Pages 959-962
Published: 2006
Released on J-STAGE: July 01, 2006
JOURNAL FREE ACCESSElectrochemical oxidation of catechol and some 3-substituted catechols (1a—c) has been studied in the presence of 2-chloro-5,5-dimethyl-1,3-cyclohexanedione (3) in aqueous solution using cyclic voltammetry and controlled-potential coulometry. The results indicate that the quinones derived from catechols (1a—c) participate in a Michael addition reaction with 2-chloro-5,5-dimethyl-1,3-cyclohexanedione (3) with consumption of only two electrons per molecule of (1a—c) to from the corresponding benzoforans (10a—c). The electrochemical synthesis of benzofurans has been successfully performed at a carbon rod electrode and in an undivided cell with high yields and purity.View full abstractDownload PDF (349K) -
Sellappan Senthil Kumar, Sangilimuthu Sriman Narayanan2006 Volume 54 Issue 7 Pages 963-967
Published: 2006
Released on J-STAGE: July 01, 2006
JOURNAL FREE ACCESSA new approach was attempted to prepare a chemically modified electrode using Cobalt hexacyanoferrate (CoHCF) as the redox mediator and to study its stability and electrocatalytic activity for ascorbic acid (AA) oxidation. The basic principle underlying the electrode modification is the coordination of cobalt ion with the amino nitrogen of aniline adsorbed on the surface of a graphite rod. This surface was subsequently derivatized with ferrocyanide to get CoHCF film on the electrode surface. The CoHCF modified electrode as prepared above was characterized using cyclic voltammetry. The effect of scan rate, supporting electrolyte and pH of the medium on the performance of the modified electrode was investigated. The CoHCF modified electrode exhibited good electrocatalytic activity towards the oxidation of ascorbic acid and gave a linear response from 5.52×10−5 M to 3.23×10−2 M with a correlation coefficient of 0.9929. The detection limit was found to be 3.33×10−5 M. Hydrodynamic voltammetry and chronoamperometry studies for the oxidation of ascorbic acid were also carried out. The electrode was highly stable and exhibited good reproducibility. This modified electrode was also applied for the determination of ascorbic acid in commercial samples.View full abstractDownload PDF (148K) -
Ramanaboyina Sudhir Kumar, Devagondanahalli Hadagali Manjunatha, Sarfa ...2006 Volume 54 Issue 7 Pages 968-971
Published: 2006
Released on J-STAGE: July 01, 2006
JOURNAL FREE ACCESSTwo simple, rapid and sensitive extractive spectrophotometric methods have been developed for the assay of trazodone hydrochloride (TRH) in pure and pharmaceutical formulations. These methods are based on the formation of chloroform soluble ion-association complexes of TRH with bromothymol blue (BTB) and with bromocresol purple (BCP) in KCl–HCl buffer of pH 2.0 (for BTB) and in NaOAc–AcOH buffer of pH of 3.6 (for BCP) with absorption maximum at 423 nm and at 408 nm for BTB and BCP, respectively. Reaction conditions were optimized to obtain the maximum color intensity. The absorbance was found to increase linearly with increase in concentration of TRH, which was corroborated by the calculated correlation coefficient values (0.9996, 0.9945). The systems obeyed Beer's law in the range of 0.2—14.5 and 0.2—14.1 μg/ml for BTB and BCP, respectively. Various analytical parameters have been evaluated and the results have been validated by statistical data. No interference was observed from common excipients present in pharmaceutical formulations. The proposed methods are simple, accurate and suitable for quality control applications.View full abstractDownload PDF (95K) -
Keisuke Kitamura, Ahmed Ahmed Omran1), Chieyo Nagata, Yoshiko Kamijima ...2006 Volume 54 Issue 7 Pages 972-976
Published: 2006
Released on J-STAGE: July 01, 2006
JOURNAL FREE ACCESSThe effects of inorganic salts, NaCl, NaBr, NaI, Na2SO4, KCl, KBr, KI, on the binding constants (Ks) of psychotropic phenothiazine drugs, triflupromazine (TFZ) and chlorpromazine, to bovine serum albumin (BSA) were examined by using second-derivative spectrophotometry. All of the salts examined, with the exception of Na2SO4, decreased the K values significantly, depending on the concentration of the salt, e.g., the decrease in the K values of both drugs were about 40% for 0.1 M NaCl. The results obtained with Na2SO4 indicated that neither Na+ nor SO42− had any affect on the binding of the phenothiazines to BSA. Based on the Na2SO4 results and the finding that the effect of each potassium salt on binding was quite similar to that of the corresponding sodium salt, the effects of these halogen salts can be considered to be derived from their anions, although the phenothiazines are positively charged at pH 7.4. The effectiveness of the anions was determined to occur in the following order: I−>>Br−>Cl−; these results coincided with the published order of the binding affinity of these anions to albumin. The 19F-NMR spectra of TFZ in the presence of each of these halogen salts revealed a concentration-dependent decrease in the intensity of the signal at 13.8 ppm that had previously been assigned to the TFZ bound to Site II. Consequently, the effects of these anions on the binding of positively charged phenothiazine drugs are thought to be local steric effects caused by the binding of these anions to Site II.View full abstractDownload PDF (206K) -
Xiang-gen Wu, Gao Li, Yong-liang Gao2006 Volume 54 Issue 7 Pages 977-981
Published: 2006
Released on J-STAGE: July 01, 2006
JOURNAL FREE ACCESSNalmefene-loaded poly(lactic-co-glycolic acid) microspheres were prepared by O/O emulsification/solvent evaporation method. The central composite design-response surface methodology was used to optimize and predict the preparation microspheres. Effects of three independent variable variables i.e., Span80 concentration in outer phase, poly(lactic-co-glycolic acid) concentration in inner phase and theoretical drug content were evaluated on a number of response variables. Response variables selected in this study were drug content, encapsulation efficiency, mean diameter, diameter span and the cumulative percentage of the drug released in the first day after incubation (marked as F1d, and it was also calculated as the initial burst). Multiple linear regression and second-order polynomial model were fitted to the data, and the resulting equations were used to produce five dimensional response graphs, by which optimal experimental conditions were selected. The results showed that all response variables were greatly dependent on three independent variables, and the optimal conditions were Span80 concentration 1.5%, poly(lactic-co-glycolic acid) concentration 17.5%, and theoretical drug content 6%. According to the optimal conditions, the drug content, encapsulation efficiency, mean diameter, diameter span and F1d of prepared microspheres were 4.37%, 72.8%, 64.1μm, 1.36 and 8.93%, respectively.View full abstractDownload PDF (607K) -
Fumiaki Kisa, Koji Yamada, Tomofumi Miyamoto, Masanori Inagaki, Ryuich ...2006 Volume 54 Issue 7 Pages 982-987
Published: 2006
Released on J-STAGE: July 01, 2006
JOURNAL FREE ACCESSThree new monosialo-gangliosides, CEG-3 (3), CEG-4 (4), and CEG-5 (5), were obtained, together with two known gangliosides, SJG-1 (1) and CG-1 (2), from the lipid fraction of the chloroform/methanol extract of the sea cucumber Cucumaria echinata. The structures of the new gangliosides were determined on the basis of chemical and spectroscopic evidence to be 1-O-[4-O-acetyl-α-L-fucopyranosyl-(1→11)-(N-glycolyl-α-D-neuraminosyl)-(2→6)-β-D-glucopyranosyl]-ceramide (3) and 1-O-[α-L-fucopyranosyl-(1→11)-(N-glycolyl-α-D-neuraminosyl)-(2→6)-β-D-glucopyranosyl]-ceramide (4, 5). The ceramide moieties of each compound were composed of heterogeneous sphingosine or phytosphingosine bases, and 2-hydroxy or nonhydroxylated fatty acid units. These gangliosides showed neuritogenic activity toward the rat pheochromocytoma cell line PC-12 in the presence of nerve growth factor.View full abstractDownload PDF (210K) -
Joanna Matysiak2006 Volume 54 Issue 7 Pages 988-991
Published: 2006
Released on J-STAGE: July 01, 2006
JOURNAL FREE ACCESSNew compounds of N-substituted 2-amino-5-(2,4-dihydroxyphenyl)-1,3,4-thiadiazole set were synthesized and tested for their antiproliferative activity as part of our research in the antitumour field. Title compounds were obtained by reaction of sulfinylbis(2,4-dihydroxythiobenzoyl) (STB) with 4-substituted 3-thiosemicarbazides. The structures of compounds were identified from elemental, IR, 1H-, 13C-NMR and MS spectra analyses. The cytotoxicity in vitro against human bladder cancer HCV29T cells was determined. The most active compounds were also tested against human cancer cell lines: SW707 (rectal), A549 (lung) and T47D (breast). The antiproliferative effect of some compounds was higher than cisplatin studied comparatively.View full abstractDownload PDF (82K) -
Hai-Yang Liu, Wei Ni, Bai-Bo Xie, Ling-Yun Zhou, Xiao-Jiang Hao, Xin W ...2006 Volume 54 Issue 7 Pages 992-995
Published: 2006
Released on J-STAGE: July 01, 2006
JOURNAL FREE ACCESSFive new withanolides named plantagiolides A—E (1, 3—6), together with a known withanolide glucoside, chantriolide A (2) were isolated from the whole plants of Tacca plantaginea (HANCE). Their structures were elucidated by means of spectroscopic methods including extensive 1D and 2D-NMR techniques.View full abstractDownload PDF (100K) -
Mai Furusawa, Toshihiro Hashimoto, Yoshiaki Noma, Yoshinori Asakawaa2006 Volume 54 Issue 7 Pages 996-1003
Published: 2006
Released on J-STAGE: July 01, 2006
JOURNAL FREE ACCESSReboulia hemisphaerica, the thalloid liverwort, contained four new cyclomyltaylane- and two new ent-β-chamigrane-type sesquiterpenoids of which the absolute stereostructures were established by a combination of two-dimensional NMR spectroscopy, X-ray crystallographic analysis, and the modified Mosher's method. Cyclomyltaylan-5α-ol and ent-β-chamigren-1α-ol were biotransformed by the fungus Aspergillus niger to afford new oxygenated matabolites. Their structures were also elucidated in the same manner as described above.View full abstractDownload PDF (547K) -
Keiko Komagoe, Keietsu Tamagake, Takashi Katsu2006 Volume 54 Issue 7 Pages 1004-1009
Published: 2006
Released on J-STAGE: July 01, 2006
JOURNAL FREE ACCESSThe pH-dependence of the ability of coproporphyrin (CP) and uroporphyrin (UP) to photogenerate hydrogen peroxide (H2O2) in aqueous solution was investigated, with special attention to the structure–activity relationship related to the aggregation of the porphyrins. It was found that the efficiency was strongly dependent on the aggregation of CP and UP mediated by changes in the pH of the solution, and a dimeric form had a weak ability to produce H2O2, while a highly aggregated form had a good ability. The increased efficiency of the highly aggregated porphyrin to produce H2O2 was further demonstrated using a different type of aggregate formed by the electrostatic interaction of cationic tetrakis-5,10,15,20-(N-methyl-4-pyridyl)porphin (TMPyP) with anionic tetrakis-5,10,15,20-(4-sulfonatophenyl)porphin (TSPP). The present results demonstrated the importance of the state of aggregation of porphyrin to photogenerate H2O2, and the results may help to develop a new type of medicine for photodynamic therapy.View full abstractDownload PDF (393K) -
Ploenthip Puthongking, Chamnan Patarapanich, Surattana Amnuoypol, Khan ...2006 Volume 54 Issue 7 Pages 1010-1016
Published: 2006
Released on J-STAGE: July 01, 2006
JOURNAL FREE ACCESSA large amount of stable ecteinascidin 770 (1b) was isolated from the Thai tunicate, Ecteinascidia thurstoni, which was pretreated with potassium cyanide in buffer solution (pH 7), along with a minor metabolite, ecteinascidin 786 (1c). A number of 6′-O-acyl derivatives 3—19 and three diacetyl derivatives 2a—c of the stable 1b were prepared and evaluated for activity against human tumor cell lines HCT116, QG56, and DU145. Nitrogen-containing heterocyclic ester derivatives such as 12, 13, and 16—19 showed similar in vitro cytotoxicity to 1b, whereas the other derivatives were less cytotoxic than 1b. Furthermore, we discovered that the N-indole-3-carbonyl derivative of ecteinascidin 770 (22) has higher cytotoxicity than 1b.View full abstractDownload PDF (185K) -
Liva Harinantenaina, Michi Tanaka, Shigeru Takaoka, Munehiro Oda, Orie ...2006 Volume 54 Issue 7 Pages 1017-1021
Published: 2006
Released on J-STAGE: July 01, 2006
JOURNAL FREE ACCESSBioguided fractionation of the methanol extract of Momordica charantia dried gourds led to the isolation of three new cucurbitane triterpenoids (1—3), together with eight known compounds (4—11). The aglycone of momordicoside I was isolated from the ether soluble fraction in a high amount. The structures of the metabolites were established on the basis of one and two dimensional NMR spectroscopic evidence, X-ray analysis, and comparison with the reported data in the literature. A number of phytochemicals have been isolated from Momordica charantia but the constituents responsible for the hypoglycaemic/antihyperglycaemic activities have not been determined. Therefore, in order to evaluate the contribution of the cucurbitane triterpenoids of the ether fraction of M. charantia methanol extract to in vivo anti-diabetic effects, the major compounds, 5β,19-epoxy-3β,25-dihydroxycucurbita-6,23(E)-diene (4), and 3β,7β,25-trihydroxycucurbita-5,23(E)-dien-19-al (5) have been tested and have shown blood hypoglycaemic effects in the diabetes-induced male ddY mice strain at 400 mg/kg. The two aglycones of charantin did not show any hypoglycaemic effects. Our finding is the first demonstration that major pure cucurbutanoid compounds of M. charantia have in vivo hypoglycaemic effects.View full abstractDownload PDF (176K) -
He-Ran Li, Yu-Lin Feng, Zhi-Gang Yang, Jue Wang, Akihiro Daikonya, Sus ...2006 Volume 54 Issue 7 Pages 1022-1025
Published: 2006
Released on J-STAGE: July 01, 2006
JOURNAL FREE ACCESSIn vitro anti-allergic screening of medicinal herbal extracts revealed that the chloroform extract of the rhizoma of Kadsura coccinea inhibited nitric oxide (NO) production in a lipopolysaccharide (LPS) and recombinant mouse interferon-γ (IFN-γ) activated murine macrophage like cell line RAW 264.7. Further fractionation of the chloroform extract led to the isolation of three new lignans, including two dibenzocyclooctadiene lignans and one arylnaphthalene lignan, together with other three known dibenzocyclooctadiene lignans. This is the first report of NO production inhibitory activity of Kadsura coccinea and first report about the isolation of arylnaphthalene lignan from K. coccinea.View full abstractDownload PDF (206K)
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Mohamed Abdelfattah El Dawya, Mokhtar Mohamed Mabrouk, Riad Ahmed El B ...2006 Volume 54 Issue 7 Pages 1026-1029
Published: 2006
Released on J-STAGE: July 01, 2006
JOURNAL FREE ACCESSA spectrofluorimetric method was described for the determination of drugs containing active methylene groups adjacent to carbonyl groups. The method was applied successfully to the determination of three life saving cardiovascular drugs, with narrow therapeutic indices: pentoxifylline (I), propafenone hydrochloride (II) and acebutolol hydrochloride (III), in laboratory-prepared mixtures, in commercial tablets and in plasma samples. The method involved the reaction of each of the tested drugs with N1-methyl nicotinamide chloride (NMNCl) in the presence of alkali, followed by addition of formic acid, where highly fluorescent reaction products were produced. The produced fluorescence were measured quantitatively at 472 nm (λex 352 nm), 409 nm (λex 310 nm) and 451 nm (λex 266 nm) for (I), (II), and (III) respectively. The method was linear over concentration ranges of 10—1000 μg/ml , 0.2—12 μg/ml and 0.08—10 μg/ml in standard solutions for (I), (II), and (III) respectively. In spiked human plasma samples, calibration graphs were linear over concentration ranges of 20—1000 μg/ml, 0.2—15 μg/ml and 0.08—10 μg/ml for (I), (II), and (III) respectively. The method showed good accuracy, specificity and precision in both laboratory-prepared mixtures and spiked human plasma samples. The proposed method is simple, with low instrumentation requirements, suitable for quality control application, bioavailability and bioequivalency studies.View full abstractDownload PDF (170K) -
Biswanath Dinda, Sudhan Debnath, Shiho Arima, Nariko Sato, Yoshihiro H ...2006 Volume 54 Issue 7 Pages 1030-1033
Published: 2006
Released on J-STAGE: July 01, 2006
JOURNAL FREE ACCESSFour new iridoid glucosides, 5-dehydro-8-epi-adoxosidic acid, 5-dehydro-8-epi-mussaenoside, 10-O-dihydroferuloyldeacetyldaphylloside, and wendoside, together with one known iridoid glucoside, 8-epi-mussaenoside, β-D-glucose, D-mannitol and β-sitosterol have been isolated from the roots of Wendlandia tinctoria. On the basis of chemical and spectral analyses, the structures of new iridoid glucosides have been elucidated.View full abstractDownload PDF (96K) -
Juliette Catherine Vardamides, Alain Bertrand Dongmo, Michèle M ...2006 Volume 54 Issue 7 Pages 1034-1036
Published: 2006
Released on J-STAGE: July 01, 2006
JOURNAL FREE ACCESSFractionation of the methanol extract of the stem bark of Turraeanthus africanus led to the isolation of two new alkaloids designated turraeanthin A and B, together with two known alkaloids. The structures of the new alkaloids were elucidated by means of spectroscopic analysis and characterized as 10-O-demethyl-17-O-methyl isoarnottianamide and 11-demethoxyl-12-methoxyl oxynitidine respectively.View full abstractDownload PDF (94K) -
Wen Zhang, Yue-Wei Guo2006 Volume 54 Issue 7 Pages 1037-1039
Published: 2006
Released on J-STAGE: July 01, 2006
JOURNAL FREE ACCESSEuphoheliosnoid D (1), a new jatrophone-type diterpenoid, was isolated together with 22 known metabolites from the Chinese medicinal herb Euphorbia helioscopia L. The structure and relative stereochemistry of 1 was elucidated on the basis of spectroscopic methods. Compounds 14—23 were obtained from the species for the first time while compound 14, 2α-hydroxy helioscopinolide B, was isolated as a new natural product.View full abstractDownload PDF (91K) -
Yu-Hsuan Lan, Fang-Rong Chang, Yu-Liang Yang, Yang-Chang Wu2006 Volume 54 Issue 7 Pages 1040-1043
Published: 2006
Released on J-STAGE: July 01, 2006
JOURNAL FREE ACCESSTwo new compounds, goniothalesacetate (1) and goniothalesdiol A (2) together with goniodiol-7-monoacetate, goniodiol-8-monoacetate, leiocarpin C, liriodenine, griffithazanone A, 4-methyl-2,9,10-(2H)-1-azaanthracencetrione, velutinam and aristolactam BII were isolated and characterized from the stems of Goniothalamus amuyon. Structures of new compounds were determined by spectral analysis.View full abstractDownload PDF (162K) -
Biswanath Das, Bommena Ravikanth, Ravirala Ramu, Bommena Vittal Rao2006 Volume 54 Issue 7 Pages 1044-1045
Published: 2006
Released on J-STAGE: July 01, 2006
JOURNAL FREE ACCESSAn efficient one-pot synthesis of polyhydroquinolines by four-component coupling reactions of aldehydes, ethyl acetoacetate, dimedone and ammonium acetate in the presence of HY-zeolite at ambient temperature has been achieved. The conversions took shorter times to form the products in excellent yields. HY-zeolite can be recovered and reused.View full abstractDownload PDF (103K) -
Liva Harinantenaina, Yusuke Takahara, Takashi Nishizawa, Chie Kohchi, ...2006 Volume 54 Issue 7 Pages 1046-1049
Published: 2006
Released on J-STAGE: July 01, 2006
JOURNAL FREE ACCESS3β,4β:15,16-Diepoxy-13(16),14-clerodadiene (1) and a new clerodane diterpenoid designated thysaspathone (2) were isolated from the liverwort Thysananthus spathulistipus, while Radula appressa produced radulannin A (3), radulannin L (4), 2-geranyl-3,5-dihydroxybibenzyl (5), 2(S)-2-methyl-2-(4-methyl-3-pentenyl)-7-hydroxy-5-(2-phenylethyl) chromene (o-cannabichromene) (6), 6-hydroxy-4-(2-phenylethyl) benzofuran (7), and o-cannabicyclol (8). All of the isolated compounds inhibited nitric oxide (NO) production in lipopolysaccharide (LPS)-stimulated RAW 264.7 cells and the greatest inhibition was attributed to compound 5, with an IC50 value of 4.5 μM.View full abstractDownload PDF (107K) -
Li-Mei Li, Sheng-Xiong Huang, Li-Yan Peng, Guo-You Li, Wei-Lie Xiao, Y ...2006 Volume 54 Issue 7 Pages 1050-1052
Published: 2006
Released on J-STAGE: July 01, 2006
JOURNAL FREE ACCESSA phytochemical investigation on the leaves of Isodon parvifolius yielded three new ent-abietanoids parvifolines L—N (1—3), together with five known ent-abietanoids (4—8) and one known ent-labdane diterpenoid (9). Their structures were determined on the basis of extensive spectroscopic analysis.View full abstractDownload PDF (86K) -
Chun-Suo Yao, Mao Lin, Lin Wang2006 Volume 54 Issue 7 Pages 1053-1057
Published: 2006
Released on J-STAGE: July 01, 2006
JOURNAL FREE ACCESSOne new stilbenolignan, gnetucleistol F (1), and four known stilbenolignans, gnetofuran A (2), lehmbachol D (3), gnetifolin F (4) and gnetumontanin C (5) were isolated from the lianas of Gnetum cleistostachyum C. Y. CHENG (Gnetaceae). Their structures and relative configurations were determined by means of spectroscopic evidence. Compounds 1, 2, 3 and 4 were synthesized for the first time on the basis of their biogenetic pathway, and their possible biomimetical synthetic mechanisms were discussed. The pharmacological activities of all stilbenolignans have been tested. Among them, 1, 2, 3, 4 and 5 showed moderate inhibitory activities on TNF-α and 1 also showed potent inhibitory activity on malondialdehyde.View full abstractDownload PDF (209K) -
Shi-Kai Yan, Wei-Dong Zhang, Run-Hui Liu, Yong-Cheng Zhan2006 Volume 54 Issue 7 Pages 1058-1062
Published: 2006
Released on J-STAGE: July 01, 2006
JOURNAL FREE ACCESSHigh-performance Liquid Chromatography (HPLC) with evaporative light scattered detection (ELSD) and electrospray ionization mass spectrometric detection (ESI-MS) was employed to establish chemical fingerprint of Shexiang Baoxin Pill (SBP) and to simultaneously determinate its seven major constituents, including cholic acid, deoxycholic acid, ursodeoxycholic acid, chenodeoxycholic acid, cinobufagin, recibufogenin, and ginsenoside Rb1. The analysis was performed on a C18 column with water–acetonitrile gradient elution, and the investigated constituents were authenticated by comparing their retention times and mass spectra with those of reference compounds. The proposed method was applied to analyze nine SBP samples and produced data with acceptable linearity, precision, stability and accuracy. Both the chemical fingerprints and quantification data were used to evaluate the quality of various SBP products. The proposed method allows obtaining chemical fingerprint and quantification of multi-components in one run, and therefore can be readily utilized as a comprehensive quality control approach for traditional Chinese medicine.View full abstractDownload PDF (203K) -
Yann-Lii Leu, Tsong-Long Hwang, Yu-Ming Chung, Pao-Yun Hong2006 Volume 54 Issue 7 Pages 1063-1066
Published: 2006
Released on J-STAGE: July 01, 2006
JOURNAL FREE ACCESSOne new 1,3-diphenylpropane, viscolin (1), and one new flavanone, (2S)-7,4′-dihydroxy-5,3′-dimethoxyflavanone (2), together with thirty-nine known compounds, which included eleven known flavanones, two chromones, fourteen benzenoids, one inositol, two pyrimidines, four triterpenoids and five steroids, were isolated and characterized from Viscum coloratum. Structures of new compounds were determined by spectral analysis. Among them, viscolin (1) showed the most significant inhibition on superoxide anion generation by human neutrophils in response to fMLP (formyl-L-methionyl-L-leucyl-L-phenylalanine).View full abstractDownload PDF (88K)
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