All issues
Volume 55, Issue 9
Displaying 1-29 of 29 articles from this issue
- |<
- <
- 1
- >
- >|
Regular Articles
-
Guang-Xiong Zhou, Ren-Wang Jiang, Yan Cheng, Wen-Cai Ye, Jian-Gong Shi ...2007 Volume 55 Issue 9 Pages 1287-1290
Published: September 01, 2007
Released on J-STAGE: September 01, 2007
JOURNAL FREE ACCESSTwo new biflavonoids, daphnogirins A (1) and B (2), were obtained from the roots of Daphne giraldii. Their structures were established on the basis of the spectral data and X-ray diffraction data of the co-crystal of 1 and 2. Daphnogrins A and B have the same configuration at C-1 and opposite configurations at C-16 and C-17. Oxygen radical scavenging assay has indicated that they are of significant antioxidative activity.View full abstractDownload PDF (256K) -
Hui Sun, Haitao Lv, Yanmei Zhang, Xijun Wang, Kaishun Bi, Hongxin Cao2007 Volume 55 Issue 9 Pages 1291-1295
Published: September 01, 2007
Released on J-STAGE: September 01, 2007
JOURNAL FREE ACCESSHigh-performance liquid chromatography coupled with solid phase extraction method was developed for determination of isofraxidin in rat plasma after oral administration of Acanthopanax senticosus extract (ASE), and pharmacokinetic parameters of isofraxidin either in ASE or pure compound were measured. The HPLC analysis was performed on a Dikma Diamonsil RP18 column (4.6 mm×150 mm, 5 μm) with the isocratic elution of solvent A (acetonitrile) and solvent B (0.1% aqueous phosphoric acid, v/v) (A : B = 22 : 78) and the detection wavelength was set at 343 nm. The calibration curve was linear over the range of 0.156—15.625 μg/ml. The limit of detection was 60 ng/ml. The intra-day precision was 5.8%, and the inter-day precision was 6.0%. The recovery was 87.30±1.73%. When the dosage of ASE is equal to pure compound caculated by the amount of isofraxidin, it has been found to have two maximum concentrations in plasma while the pure compound only showed one peak in the plasma concentration–time curve. The determined content of isofraxidin in plasma after oral administration of ASE is the total contents of free isofraxidin and its precursors in ASE in vitro. The pharmacokinetic characteristics of ASE showed the priority of the extract and the properities of traditional Chinese medicine.View full abstractDownload PDF (642K) -
Ping-Jyun Sung, Li-Fan Chuang, Jimmy Kuo, Jih-Jung Chen, Tung-Yung Fan ...2007 Volume 55 Issue 9 Pages 1296-1301
Published: September 01, 2007
Released on J-STAGE: September 01, 2007
JOURNAL FREE ACCESSSix new caryophyllane-related natural products, including two carboxylated sesquiterpenoids, rumphellolides A (1) and B (2), and four norsesquiterpene alcohols, rumphellolides C—F (3—6), were isolated from the Formosan gorgonian coral Rumphella antipathies. The structures of the above new natural products were established on the basis of extensive spectral data analysis. Rumphellolides A (1), D (4), E (5), and F (6) showed weak antibacterial activity.View full abstractDownload PDF (197K) -
Gui-Qing Xu, Peng Guo, Chong Zhang, Qiao-Jun He, Bo Yang, Yong-Zhou Hu2007 Volume 55 Issue 9 Pages 1302-1307
Published: September 01, 2007
Released on J-STAGE: September 01, 2007
JOURNAL FREE ACCESSA series of indolopyrrolemaleimides have been synthesized and evaluated for their cytotoxicity in vitro against human leukemia cell line and four human solid cancer cell lines. Some of the compounds showed high or mediate activity against the lines. 6dc is the most promising compound among them. The inhibition toward topoisomerase I was also studied.View full abstractDownload PDF (205K) -
Masayuki Yoshikawa, Tao Wang, Toshio Morikawa, Haihui Xie, Hisashi Mat ...2007 Volume 55 Issue 9 Pages 1308-1315
Published: September 01, 2007
Released on J-STAGE: September 01, 2007
JOURNAL FREE ACCESSThe methanolic extract from the whole plant of Sinocrassula indica (Crassulaceae) was found to inhibit the increase in serum glucose levels in oral administration of sucrose and glucose in rats at a dose of 250 mg/kg (p.o.). However, the extract did not inhibit the increase in serum glucose levels after intraperitoneal administration of glucose in these animals but did partly inhibit the gastric emptying. On the other hand, this extract significantly inhibited the increase in serum glucose levels after administration for 2 weeks in KK-Ay mice, a genetically type II diabetic mice, at a dose of 250 mg/kg/d (p.o.) without significant changes of the weights of body, liver, and visceral fat. From the extract, four new acylated flavonol glycosides, sinocrassosides A1, A2, B1, and B2, were isolated together with 11 flavonoids and 2 megastigmanes. The absolute stereostructures of the four new compounds were elucidated on the basis of chemical and physicochemical evidence.View full abstractDownload PDF (157K) -
Vatcharin Rukachaisirikul, Ubonta Sommart, Souwalak Phongpaichit, Nong ...2007 Volume 55 Issue 9 Pages 1316-1318
Published: September 01, 2007
Released on J-STAGE: September 01, 2007
JOURNAL FREE ACCESSOne hypoxylonol, xylarenol (1), one hexadienoic acid, xylarenoic acid (2), and one tetralone, xylarenone (3), were isolated from the xylariaceous fungus PSU-A80 together with ten known compounds. The structures were established by analysis of spectroscopic data. 8-Methoxy-1-naphthol, one of the known metabolites, displayed good radical scavenging potency with an IC50 value of 30 μg/ml.View full abstractDownload PDF (68K) -
Yoshihiro Mimaki, Saya Doi, Minpei Kuroda, Akihito Yokosuka2007 Volume 55 Issue 9 Pages 1319-1324
Published: September 01, 2007
Released on J-STAGE: September 01, 2007
JOURNAL FREE ACCESSThe stems of Akebia quinata have been analyzed for their triterpene glycoside constituents, resulting in the isolation of six new triterpene glycosides, along with 19 known ones. On the basis of extensive spectroscopic analysis, including 2D NMR data, and chemical evidence, the structures of the new compounds were deter-mined to be 3β-[(O-β-D-glucuronopyranosyl-(1→3)-α-L-arabinopyranosyl)oxy]olean-12-en-28-oic acid O-α-L-rhamnopyranosyl-(1→4)-O-β-D-glucopyranosyl-(1→6)-β-D-glucopyranosyl ester, 3β-[(O-β-D-glucuronopyranosyl-(1→3)-O-[α-L-rhamnopyranosyl-(1→2)]-α-L-arabinopyranosyl)oxy]olean-12-en-28-oic acid O-α-L-rhamnopyranosyl-(1→4)-O-β-D-glucopyranosyl-(1→6)-β-D-glucopyranosyl ester, 3β-[(O-β-D-glucuronopyranosyl-(1→3)-α-L-arabinopyranosyl)oxy]-23-hydroxyolean-12-en-28-oic acid O-α-L-rhamnopyranosyl-(1→4)-O-β-D-glucopyranosyl-(1→6)-β-D-glucopyranosyl ester, 3β-[(O-β-D-glucuronopyranosyl-(1→3)-O-[α-L-rhamnopyranosyl-(1→2)]-α-L-arabinopyranosyl)oxy]-23-hydroxyolean-12-en-28-oic acid O-α-L-rhamnopyranosyl-(1→4)-O-β-D-glucopyranosyl-(1→6)-β-D-glucopyranosyl ester, 3β-[(O-β-D-glucopyranosyl-(1→3)-O-[α-L-rhamnopyranosyl-(1→2)]-α-L-arabinopyranosyl)oxy]-29-hydroxyolean-12-en-28-oic acid, and 3β-[(O-β-D-glucopyranosyl-(1→3)-O-[α-L-rhamnopyranosyl-(1→2)]-α-L-arabinopyranosyl)oxy]-23,29-dihydroxyolean-12-en-28-oic acid, respectively. The main triterpene glycosides contained in the stems of A. quinata were found to have two sugar units at C-3 and C-28 of the aglycone in this study, whereas those of Akebia trifoliate were reported to possess one sugar unit at C-28 of the aglycone. It may be possible to distinguish between A. quinata and A. trifoliate chemically by comparing their triterpene glycoside constituents.View full abstractDownload PDF (162K) -
Haizhou Li, Takashi Tanaka, Ying-Jun Zhang, Chong-Ren Yang, Isao Kouno2007 Volume 55 Issue 9 Pages 1325-1331
Published: September 01, 2007
Released on J-STAGE: September 01, 2007
JOURNAL FREE ACCESSSix new ellagitannins herein, rubusuaviins A—F, were isolated from the aqueous acetone extract of Chinese sweet tea (Tien-cha, dried leaves of Rubus suavissimus S. LEE) together with seven known tannins. Rubusuaviin A was characterized as 1-O-galloyl-2,3-O-(S)-HHDP-4,6-O-(S)-sanguisorboyl-β-D-glucopyranose. Rubusuaviins B, C, and E are dimeric, trimeric, and tetrameric ellagitannins, respectively, in which the sanguisorboyl groups were connected ellagitannin units. Rubusuaviins D and F were desgalloyl derivatives of rubusuaviins C and E, respectively. The inhibition of α-amylase activity by rubusuaviins and related ellagitannins was compared. Ellagitannins with β-galloyl groups at the glucose C-1 positions showed stronger inhibition compared with the α-galloyl and desgalloyl compounds. The molecular weight of these compounds was not important for the inhibition of α-amylase activity.View full abstractDownload PDF (299K) -
Ali Mahmoud El-Halawany, Mi Hwa Chung, Chao-Mei Ma, Katsuko Komatsu, T ...2007 Volume 55 Issue 9 Pages 1332-1337
Published: September 01, 2007
Released on J-STAGE: September 01, 2007
JOURNAL FREE ACCESSThrough an anti-estrogenic bioassay-guided fractionation of the methanol extract of Mansonia gagei, three new coumarins, called mansorins I (1), II (2) and III (3) and a new naphthoquinone, mansonone I (4), were isolated. Their structures were determined based on their NMR data and CD spectroscopy. The anti-estrogenic activity of the fractions and the isolated compounds were investigated using a yeast two-hybrid assay method expressing estrogen receptors α (ERα) and β (ERβ). In addition, an ERα competitor screening system (ligand binding screen) was used to verify the binding affinities of the isolated compounds to the estrogen receptor. 1,2-Naphthoquinones (mansonones) showed more binding affinities to ER in both assay systems. All the tested compounds showed higher binding affinities to ERβ than to ERα in the yeast two-hybrid assay. Mansonones F and S showed the most potent estrogen binding and estrogen antagonistic effects.View full abstractDownload PDF (150K) -
Yoko Hasegawa, Takashi Fukuda, Keiichi Hagimori, Hiroshi Tomoda, Satos ...2007 Volume 55 Issue 9 Pages 1338-1341
Published: September 01, 2007
Released on J-STAGE: September 01, 2007
JOURNAL FREE ACCESSSix new alkylitaconic acids, designated tensyuic acids A to F, were isolated from the culture broth of Aspergillus niger FKI-2342 by solvent extraction, silica gel column chromatography and HPLC. Their structures were elucidated by spectroscopic analysis including UV, NMR, and MS. They are all alkylitaconic acid derivatives. Only tesyuic acid C showed moderate antimicrobial activity against Bacillus subtilis.View full abstractDownload PDF (163K) -
Seikou Nakamura, Sachiko Sugimoto, Hisashi Matsuda, Masayuki Yoshikawa2007 Volume 55 Issue 9 Pages 1342-1348
Published: September 01, 2007
Released on J-STAGE: September 01, 2007
JOURNAL FREE ACCESSFive new dammarane-type triterpene glycosides, floralquinquenosides A, B, C, D, and E, were isolated from the flower buds of American ginseng, Panax quinquefolium L., together with 18 known dammarane-type triterpene glycosides and 3 flavonoid glycosides. The structures of new floralquinquenosides were elucidated on the basis of chemical and physicochemical evidence.View full abstractDownload PDF (228K) -
Pierre-Jean Aragon, Ange-Désiré Yapi, Frédé ...2007 Volume 55 Issue 9 Pages 1349-1355
Published: September 01, 2007
Released on J-STAGE: September 01, 2007
JOURNAL FREE ACCESSIndoloquinoline alkaloid cryptolepine and pyridocarbazole alkaloid ellipticine are of great interest because in vitro and in vivo studies revealed their good cytotoxic properties. In order to obtain some biologically active analogs of these compounds, we developed a synthesis based on the photocyclization of tertiary N-substituted enaminones derived from 1,3-cyclohexandione and 3 or 6-aminoquinoline. The angular cyclized compounds thus obtained were tested in vitro on K 562 cells and A 2780 doxorubicin sensitive and resistant cells. All compounds were less effective than doxorubicin in sensitive cells but their activity wasn't decreased by MDR resistance.View full abstractDownload PDF (191K) -
Bina Shaheen Siddiqui, Zhanat Zhymabekovna Karzhaubekova, Gauhar Shahm ...2007 Volume 55 Issue 9 Pages 1356-1360
Published: September 01, 2007
Released on J-STAGE: September 01, 2007
JOURNAL FREE ACCESSStudies on the chemical constituents of the aerial parts of Kalidium foliatum have led to the isolation of three new and one known compounds. The structures of new constituents have been elucidated through spectral studies including 2D-NMR experiments (HMQC, HMBC, COSY, NOESY and J-resolved) and MS/MS fragmentation using Q-TOF mass spectrometer equipped with an ESI source as kalidiumoside C (=3β-hydroxy-29-methylmalonoxy-olean-12-en-23,28-dioic acid-23-methyl-28-β-D-glucopyranosyl ester; 1), kalidiunin (=3β,23,29-trihydroxy-olean-12-en-28-methyl-oate; 2) and kalidiumoside D (=3β,23,29-trihydroxyolean-12-en-28-oic acid-β-D-glucopyranosyl ester; 3). The known compound was identified as 3β,23,29-trihydroxy-olean-12-en-28-oic acid 4) through comparison of its spectral data with those reported in literature. Acid hydrolysis of both 2 and 3 yielded the known compound 4 providing a conclusive evidence of the proposed structures.View full abstractDownload PDF (175K) -
Takeru Ehara, Shin Tanikawa, Machiko Ono, Hiroyuki Akita2007 Volume 55 Issue 9 Pages 1361-1364
Published: September 01, 2007
Released on J-STAGE: September 01, 2007
JOURNAL FREE ACCESSSolvolysis reaction of methyl (4S,5S)-4-(4′-methoxyphenyl)-5-tosyloxy-2(E)-hexenoate 5 in water-saturated MeNO2 gave the 1,2-migration product, (4S,5S)-5-hydroxy-4-(4′-methoxyphenyl)-2-(E)-hexenoate 6 (55% yield), which was converted to methyl (R)-(4′-methylphenyl)hexanoate 11 in 25% overall yield (5 steps). Treatment of (R)-11 with MeLi gave tertiary alcohol congener 12, which was subjected to dehydration to afford (R)-(−)-curcumene 1. An introduction of hydroxyl group at meta-position of the aromatic ring in (R)-11 was achieved based on consecutive treatment [1) selective iodination, 2) conversion of aryl iodide to aryl boronate, 3) conversion of aryl boronate to phenol]. Thus obtained phenol (R)-16 was treated with MeLi to give tertiary alcohol congener 17, which was subjected to dehydration to afford (R)-(−)-xanthorrizol 2.View full abstractDownload PDF (161K) -
Yumiko Yamano, Yumi Fujita, Yukari Mizuguchi, Kimie Nakagawa, Toshio O ...2007 Volume 55 Issue 9 Pages 1365-1370
Published: September 01, 2007
Released on J-STAGE: September 01, 2007
JOURNAL FREE ACCESSAn improved synthesis of γ-hydroxybutenolides 1a—d was achieved via crossed aldol condensation between aldehydes 2a—d and the protected γ-hydroxy-β-methylbutenolides 3 or 4 using the bulky Lewis acid, aluminum tris(2,6-diphenylphenoxide) (ATPH). Using this same methodology, the γ-hydroxybutenolides 17a—d having various heteroaromatic rings were synthesized and their anti-tumor activities were evaluated.View full abstractDownload PDF (235K)
Notes
-
Rajender Singh Sangwan, Narayan Das Chaurasiya, Payare Lal, Laxminarai ...2007 Volume 55 Issue 9 Pages 1371-1375
Published: September 01, 2007
Released on J-STAGE: September 01, 2007
JOURNAL FREE ACCESSMultiple shoot cultures of two experimental lines of Withania somnifera plants (RS-Selection-1 and RS-Selection-2) were established using nodal segments as explants. The hormonal combinations of benzyl adenine and kinetin not only influenced their morphogenetic response but also differentially modulated the level of biogeneration of withanolide A in the in vitro shoots of the two lines. Interestingly, withanolide-A, that was hardly detectable in the aerial parts of field-grown Withania somnifera (explant source), accumulated considerably in the in vitro shoot cultures of the plant. The productivity of withanolide A in the cultures varied considerably (ca. 10-fold, 0.014 to 0.14 mg per gram fresh weight) with the change in the hormone composition of the culture media as well as genotype used as source of the explant. The shoot culture of RS-Selection-1 raised at 1.00 ppm of BAP and 0.50 ppm of kinetin displayed the highest concentration of withanolide A in the green shoots of 0.238 g per 100 g dry weight tissue. This was a more analytical concentration keeping in view the isolation yields so far reported from the dried roots of the field-grown plant (ca. 0.015 g per 100 g dry weight), even if isolation losses are considered during purification. The enhanced de novo biogenesis of withanolide A in shoot cultures was corroborated with radiolabel incorporation studies using [2-14C] acetate as a precursor. Production of withaferin A was also found in the in vitro shoot cultures. As this compound is a predominant withanolide of native shoots as well and has been already reported to be accumulated in in vitro shoot cultures, its biogeneration observed in these shoot cultures is not discussed in detail.View full abstractDownload PDF (689K) -
IkSoo Lee, Jae Kuk Yoo, MinKyun Na, Byung Sun Min, JongPill Lee, Bong ...2007 Volume 55 Issue 9 Pages 1376-1378
Published: September 01, 2007
Released on J-STAGE: September 01, 2007
JOURNAL FREE ACCESSBioassay-guided fractionation of a MeOH extract of the whole plant of Aceriphyllum rossii (Saxifragaceae) led to the isolation of two new triterpenes, 3α,23-isopropylidenedioxyolean-12-en-27-oic acid (1) and 23-hydroxy-3-oxoolean-12-en-27-oic acid (2), together with six known triterpenes, 3-oxoolean-12-en-27-oic acid (3), 3α-hydroxyolean-12-en-27-oic acid (4), β-peltoboykinolic acid (5), aceriphyllic acid A (6), oleanolic acid (7), and gypsogenic acid (8). The structures of these compounds were elucidated on the basis of physicochemical and spectroscopic analyses. These compounds were evaluated for in vitro cytotoxicity against the K562 and HL-60 cell lines. Olean-12-en-27-oic acid derivatives (1—6) exhibited considerable cytotoxicity against K562 and HL-60 cell lines with IC50 values ranging from 12.2 to 28.7 μM and from 12.1 to 25.8 μM, respectively.View full abstractDownload PDF (95K) -
Abd-Elgawad Radi, Nadia Abd-Elghany, Tarek Wahdan2007 Volume 55 Issue 9 Pages 1379-1382
Published: September 01, 2007
Released on J-STAGE: September 01, 2007
JOURNAL FREE ACCESSThe electrochemical oxidation of the antineoplastic agent etoposide was studied at carbon paste electrode in Britton–Robinson buffer solutions over the pH range 2.0—10.0 using cyclic, linear sweep and differential pulse voltammetry. Oxidation of the drug was effected in a single reversible, diffusion-controlled step within the pH range 2.0—4.0, a second oxidation process was produced above pH 4.0. Using differential pulse voltammetry (DPV), the drug yielded a well-defined voltammetric response in Britton–Robinson buffer, pH 3.0 at 0.500 V (vs. Ag/AgCl) on carbon paste electrode. This process could be used to determine etoposide concentrations in the range 2.5×10−7 to 2.5×10−5 M with a detection limit of 1.0×10−7 M. The method was successfully applied to the determination of the drug in spiked human serum.View full abstractDownload PDF (104K) -
Vatcharin Rukachaisirikul, Juthanat Kaeobamrung, Wannarat Panwiriyarat ...2007 Volume 55 Issue 9 Pages 1383-1384
Published: September 01, 2007
Released on J-STAGE: September 01, 2007
JOURNAL FREE ACCESSOne new pyrone derivative, named penicillone (1), together with paxilline, pyrenocines A (2) and B (3) were isolated from the endophytic fungus Penicillium paxilli PSU-A71. The structures were elucidated by spectroscopic methods. Pyrenocine B (3) mildly inhibited the growth of Microsporum gypseum SH-MU-4 with a MIC value of 32 μg/ml.View full abstractDownload PDF (57K) -
Takayuki Yakura, Yuya Yoshimoto, Chisaki Ishida2007 Volume 55 Issue 9 Pages 1385-1389
Published: September 01, 2007
Released on J-STAGE: September 01, 2007
JOURNAL FREE ACCESSDirhodium(II)-catalyzed C–H amination reaction of (S)-3-(tert-butyldimethylsilyloxy)-2-methylpropyl carbamate, which was easily prepared from methyl (S)-2-methyl-3-hydroxypropanoate, proceeded more smoothly than those of their 2-(methoxycarbonyl)propyl derivative to give the corresponding oxazolidinone in excellent yield. The resulting oxazolidinone was converted efficiently into both (R)-monoprotected and (S)-monoprotected 2-amino-2-methyl-1,3-propanediols.View full abstractDownload PDF (133K) -
Xian-Long Cheng, Shuang-Cheng Ma, Feng Wei, Gang-Li Wang, Xin-Yue Xiao ...2007 Volume 55 Issue 9 Pages 1390-1392
Published: September 01, 2007
Released on J-STAGE: September 01, 2007
JOURNAL FREE ACCESSA new sesquiterpene, neolindenenonelactone (1), was first isolated from the dried roots of Lindera aggregata (SIMS) KOSTERM., along with four known compounds, linderane (2), isolinderalactone (3), linderalactone (4), and 8-hydroxylindestenolide (5). Their chemical structures were elucidated using spectral analysis of fast atom bombardment mass spectroscopy, one-dimensional nuclear magnetic resonance spectroscopy and two-dimensional-nuclear magnetic resonance spectroscopy including 1H-NMR, 13C-NMR, distortionless enhancement by polarization transfer, heteronuclear multiple-bond coherence, and single-crystal X-ray diffraction techniques.View full abstractDownload PDF (139K) -
Yuji Yamauchi, Akiko Nakamura, Miki Kitai, Kirara Hatanaka, Iho Kohno, ...2007 Volume 55 Issue 9 Pages 1393-1396
Published: September 01, 2007
Released on J-STAGE: September 01, 2007
JOURNAL FREE ACCESSWe have improved sample pre-treatment for the effective removal of polyphenols and simple analysis of caffeine in tea using a cartridge filled with polyvinylpolypyrroridone (PVPP). Nearly 100% of catechins were removed from the green tea sample and caffeine was completely recovered in the range of 98.2—101.3% by sample pre-treatment with a PVPP cartridge. Reproducibility of preparing PVPP pre-treatment cartridges was sufficient for quantitative analysis, because RSDs of analytical values for caffeine obtained by using three individual pre-treatment cartridges filled with 10—200 mg PVPP were 0.60—2.8%. The PVPP pre-treatment cartridge also removed polyphenols perfectly and recovered caffeine faultlessly from oolong and black tea samples. Comparison with the conventional method without sample pre-treatment indicated that the present pre-treatment method with a PVPP cartridge was useful for the simple and precise analysis of caffeine in green, oolong and black tea samples.View full abstractDownload PDF (94K) -
Krishna Prasad Devkota, Bruno Ndjakou Lenta, Muhammad Iqbal Choudhary, ...2007 Volume 55 Issue 9 Pages 1397-1401
Published: September 01, 2007
Released on J-STAGE: September 01, 2007
JOURNAL FREE ACCESSBioguided phytochemical investigation of Sarcococca hookeriana with respect to the cholinesterase enzyme inhibitory assay yielded two new pregnane-type steriodal alkaloids hookerianamide H (1) and hookerianamide I (2), along with three known alkaloids Na-methylepipachysamine D (3), sarcovagine C (4) and dictyophlebine (5). Their structures were determined with the aid of extensive spectroscopic analysis. All compounds showed good inhibitory activities against the enzymes acetylcholinesterase (IC50 2.9—34.1 μM) and butyrylcholinesterase (IC50 0.3—3.6 μM). These compounds also showed moderate antiplasmodial activity (IC50 2.4—10.3 μM) against the Plasmodium falciparum chloroquine resistant W2 strain.View full abstractDownload PDF (102K) -
Alembert Tiabou Tchinda, Shamsun Nahar Khan, Victorine Fuendjiep, Fran ...2007 Volume 55 Issue 9 Pages 1402-1403
Published: September 01, 2007
Released on J-STAGE: September 01, 2007
JOURNAL FREE ACCESSA new geranylated isoflavone, 7-O-geranyl-6-methoxypseudobaptigenin (1) was isolated from the stem barks of Millettia conraui, along with known compounds 5-methoxydurmillone (2), conrauinone A (3), β-amyrine (4), sitosterol (5), 3-O-β-D-glucopyranosyl sitosterol (6) and n-docosanol (7). Compounds 1 and 4 showed a significant α-glucosidase inhibitory activity. The structures of the compounds were determined by analysis of their spectroscopic data.View full abstractDownload PDF (88K) -
Wipapan Pongcharoen, Vatcharin Rukachaisirikul, Souwalak Phongpaichit, ...2007 Volume 55 Issue 9 Pages 1404-1405
Published: September 01, 2007
Released on J-STAGE: September 01, 2007
JOURNAL FREE ACCESSOne new dihydrobenzofuran derivative, botryomaman (1), was isolated from the broth extract of the endophytic fungus Botryosphaeria mamane PSU-M76 along with six known compounds, 2,4-dimethoxy-6-pentylphenol, (R)-(−)-mellein, primin, cis-4-hydroxymellein, trans-4-hydroxymellein and 4,5-dihydroxy-2-hexenoic acid. The structures were assigned by spectroscopic methods. All compounds were tested for antibacterial activity against Staphylococcus aureus ATCC 25923 and methicillin-resistant S. aureus SK1. Primin showed the best activity against both strains with equal MIC values of 8 μg/ml.View full abstractDownload PDF (63K) -
Nobuko Mibu, Kazumi Yokomizo, Takeshi Miyata, Kunihiro Sumoto2007 Volume 55 Issue 9 Pages 1406-1411
Published: September 01, 2007
Released on J-STAGE: September 01, 2007
JOURNAL FREE ACCESSSome new N-monocarbamoyl symmetrical diamines have been prepared by the addition of symmetrical amines to isocyanates or isothiocyanates. 2,6-Diaminopyridine (1), (1R,2R)-1,2-diaminocyclohexane [(1R,2R)-2], meso-1,2-diaminocyclohexane (meso-2), or (1R,2R)-1,2-diphenylethylenediamine (3) were used as the starting symmetrical diamine frameworks. All of the newly synthesized compounds were subjected to an evaluation of antiviral activity with herpes simplex virus (HSV)-1. N-Monocarbamoyl 2,6-diaminopyridines (5a, b) showed significant antiviral activity (EC50=17.0, 6.2 μg/ml) comparable to that of N-monododecanoyl 2,6-diaminopyridine (A2). As a result, compound 5a showed a better selectivity index (CC50/EC50 = ca. 10.0) than that of A2.View full abstractDownload PDF (101K) -
Hui-Chi Huang, Wei-Jern Tsai, Chia-Ching Liaw, Shih-Hsiung Wu, Yang-Ch ...2007 Volume 55 Issue 9 Pages 1412-1415
Published: September 01, 2007
Released on J-STAGE: September 01, 2007
JOURNAL FREE ACCESSBioassay-directed fractionation of an ethanolic extract of the galls of Sapindus mukorossi has resulted in the isolation of two new tirucallane-type triterpenoid saponins, sapinmusaponins Q (1) and R (2), along with three known oleanane-type triterpenoid saponins (3—5). Their structures were elucidated on the basis of spectroscopic analysis and chemical hydrolysis. Biological evaluation showed that both sapinmusaponins Q and R demonstrated more potent anti-platelet aggregation activity than aspirin.View full abstractDownload PDF (100K) -
Huan Chen, Yu-zhi Zhou, Li Qiao, Jia-qing Cao, Yao Yao, Hui-ming Hua, ...2007 Volume 55 Issue 9 Pages 1416-1418
Published: September 01, 2007
Released on J-STAGE: September 01, 2007
JOURNAL FREE ACCESSA new androstane, 17β-hydroxy-androsta-4,6,15-trien-3-one (1) and a new monoterpene glucoside sinapoyl ester, (3R)-8-hydroxylinalool 3,8-di-O-β-D-(6′-O-E-sinapoyl)glucopyranoside (2) were isolated from the roots of Cynanchum amplexicaule SIEB. et ZUCC. (Asclepiadaceae), along with two known monoterpenes, (3R)-8-hydroxylinalool (3) and (6R)-menthiafolic acid (4). Their structures were elucidated on the basis of analyses of physical, chemical, and spectral data.View full abstractDownload PDF (109K)
Communicatins to the Editor
-
Kazuaki Oda, Yuki Yamaguchi, Teruki Yoshimura, Keiji Wada, Naozumi Nis ...2007 Volume 55 Issue 9 Pages 1419-1421
Published: September 01, 2007
Released on J-STAGE: September 01, 2007
JOURNAL FREE ACCESSFuranocoumarin derivatives (dimers and monomers) present in commercially available grapefruit juice have the capacity to inhibit the activity of human CYP3A4. Such interactions are believed to result from the mechanism-based inhibition of CYP3A4 activity in the intestine. The aim of this work was to synthesize and test a series of dimers with a view to determining the relationship between structure and inhibitory activity and determining whether they might make suitable probes of CYP3A4 activity. We prepared a series of furanocoumarin, coumarin, and benzofuran derivatives that have inhibitory effects on the activity of human CYP3A4. A synthetic benzofuran dimer, which is more accessible than furanocoumarin dimers, exhibited activity against CYP3A4 comparable to that of furanocoumarin dimers.View full abstractDownload PDF (135K)
- |<
- <
- 1
- >
- >|