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Volume 61, Issue 4
Displaying 1-20 of 20 articles from this issue
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Regular Articles
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Jung-Myung Ha, Ju-Young Kim, Tack-Oon Oh, Yun-Seok Rhee, Sang-Cheol Ch ...2013 Volume 61 Issue 4 Pages 371-378
Published: April 01, 2013
Released on J-STAGE: April 01, 2013
Advance online publication: February 04, 2013JOURNAL FREE ACCESS FULL-TEXT HTMLDoxazosin mesylate (DXM) sustained release pellets were prepared by an extrusion-spheronization and fluid-bed coating technique. The core pellets containing DXM were prepared by extrusion-spheronization technique, and coated by a fluid-bed coater to control the release of DXM. The factors affecting to properties of pellets, such as diluent content, type and coating level of coating agents and plasticizers were studied in the present study. Polymethacrylate derivatives (Eudragit® RS PO and RL PO) were used for coating agents, and polyethylene glycol 6000 (PEG 6000), triethyl citrate (TEC) and castor oil were as plasticizers. To evaluate the properties of prepared pellets, the size of prepared pellets was investigated by sieve analysis technique and the morphology of pellets was evaluated by scanning electron microscopy. Through the dissolution test, factors that have an effect on the dissolution of the drug were evaluated. As the content ratio of microcrystalline cellulose (MCC) had increased, the dissolution was proportionally sustained. Eudragit® RS PO had more marked sustaining effect on the dissolution rate than Eudragit® RL PO, and the effect was more pronounced with the increased coating level. PEG 6000 was an appropriate plasticizer for DXM pellets, and increasing the content of PEG 6000, was also slightly decreasing the dissolution rate.View full abstractDownload PDF (2021K) Full view HTML -
Kanako Miyachi, Mitsuru Hoshino, Hiroko Kadobayashi, Kenzo Moriyama, M ...2013 Volume 61 Issue 4 Pages 379-383
Published: April 01, 2013
Released on J-STAGE: April 01, 2013
Advance online publication: February 02, 2013JOURNAL FREE ACCESS FULL-TEXT HTMLA simple fluorophotometric method for the determination of histone has been developed. This method involves a fluorescence quenching reaction that results in the formation of a complex of manganese(II), 3,4,5,6-tetrafluoro-2-carboxyphenylfluorone (TFCPF), and histone in a non-ionic surfactant micellar medium. The calibration curve was found to be linear in the range of 0.5 to 2.0 µg/mL. The binding parameters (n, number of binding sites; K, binding constant) and thermodynamic parameters (ΔG0, change in Gibbs free energy; ΔH0, change in enthalpy; ΔS0, change in entropy) were investigated spectrophotometrically for the elucidation of the reaction mechanism. The resulting binding parameters (n=4.08 and K=3.16×104 m−1 at 25°C) and thermodynamic parameters (ΔG=−25.83 kJ/mol, ΔH=−9.83 kJ/mol, and ΔS=53.68 J/(mol K)) suggest that the colored complex in this reaction system is an ion-association complex between manganese(II)–TFCPF and histone.View full abstractDownload PDF (547K) Full view HTML -
Matsutake Higa, Megumi Imamura, Kazuhito Ogihara, Toshimasa Suzuka2013 Volume 61 Issue 4 Pages 384-389
Published: April 01, 2013
Released on J-STAGE: April 01, 2013
JOURNAL FREE ACCESS FULL-TEXT HTMLFive new flavonoids, 5,8-dihydroxy-3,7-dimethoxy-3′,4′-methylenedioxyflavone (1), 7-hydroxy-3,5-dimethoxy-3′,4′-methylenedioxyflavone (2), 7-(2,3-dihydroxy-3-methylbutoxy)-3,5-dimethoxy-3′,4′-methylenedioxyflavone (3), 7-(2,3-dihydroxy-3-methylbutoxy)-3,3′,4′,5-tetramethoxyflavone (4), and 7-(2,3-dihydroxy-3-methylbutoxy)-3,3′,4′,5,8-pentamethoxyflavone (5), were isolated from the leaves of Melicope triphylla. In addition, six known flavonoids were detected: 3,4′,5-trihydroxy-3′,7,8-trimethoxyflavone (6), 5,7-dihydroxy-3-methoxy-3′,4′-methylenedioxyflavone (7), 4′,5,7-trihydroxy-3,3′-dimethoxyflavone (8), 4′,7-dihydroxy-3,3′,5,8-tetramethoxyflavone (9), 4′,7-dihydroxy-3,3′,5-trimethoxyflavone (10), and 4′,5,7-trihydroxy-3,3′,8-trimethoxyflavone (11). The new compound structures were determined by spectroscopic methods. Compounds 1–5 did not exhibit any ichthyotoxic activity against Japanese killifish (medaka in Japanese) (Oryzias latipes var.) at 10 ppm.View full abstractDownload PDF (621K) Full view HTML -
GuiMin Xia, ZhiJiao An, Yang Wang, Chen Zhao, Mei Li, ZiChen Li, Jie M ...2013 Volume 61 Issue 4 Pages 390-398
Published: April 01, 2013
Released on J-STAGE: April 01, 2013
Advance online publication: February 04, 2013JOURNAL FREE ACCESS FULL-TEXT HTMLThe in vivo distribution of antitumor drugs is usually lack of selectivity, and thus, leading to a low efficacy of chemotherapy on cancers and high toxicity to normal cells. Receptor-mediated targeting liposome with pH-sensitivity as a dual drug delivery system is one of the efficient approaches to overcome the disadvantages. The study was to synthesize a novel smart polymeric material (folate-poly(2-ethyl-2-oxazoline)-distearoyl phosphatidyl ethanolamine, F-PEOz-DSPE), which can combine with the folate-receptor (FR) over-expressed on cancer cells and respond to pH changes in endosome–lysosome system in cancer cells to rapidly release drug simultaneously. The F-PEOz-DSPE was synthesized by the method of asymmetric synthesis of organic polymer and characterized by IR, 1H-NMR, electrospray ionization (ESI)-MS and gel permeation chromatography (GPC). To investigate the properties of targeting and pH-sensitivity of F-PEOz-DSPE, blank liposomes, blank fluorescently labeled liposomes and doxorubicin (DOX)-loaded liposomes containing F-PEOz-DSPE or PEOz-DSPE or DSPE were prepared. The cytotoxicity, cellular uptake and drug cumulative release in vitro were investigated. Blank liposomes modified with PEOz block had little cytotoxicity in vitro. The liposomes containing F-PEOz-DSPE showed a higher affinity to human ovarian cancer cell SKOV3, a FR+ cancer cells, than those with PEOz-DSPE. A higher drug cumulative release from DOX-loaded liposomes containing F-PEOz-DSPE or PEOz-DSPE in vitro was found in phosphate buffered saline at pH 5.0 medium than at pH 7.4. These results indicate that F-PEOz-DSPE exhibits selective targeting, pH-sensitivity and little cytotoxicity, and may be a promising polymeric material for dual receptor and pH-sensitive targeting liposome.View full abstractDownload PDF (2144K) Full view HTML -
Sonthaya Umsumarng, Komsak Pintha, Pornsiri Pitchakarn, Kwankamol Sast ...2013 Volume 61 Issue 4 Pages 399-404
Published: April 01, 2013
Released on J-STAGE: April 01, 2013
Advance online publication: January 26, 2013JOURNAL FREE ACCESS FULL-TEXT HTML
Supplementary materialResistance to chemotherapy in cancer patients has been correlated to the overexpression of the ATP-binding cassette (ABC) drug transporters including P-glycoprotein (P-gp) that actively efflux chemotherapeutic drugs from cancer cells. We examined the mutidrug resistance reversing property of stemofoline derivatives in drug-resistance human cervical carcinoma (KB-V1) and human leukemic (K562/Adr) cell lines that overexpress P-gp. Didehydrostemofoline and eleven of its derivatives were synthesized and the cytotoxicity and their effect on doxorubicin, vinblastine and paclitaxel sensitivity in drug resistant (KB-V1 and K562/Adr) and drug sensitive (KB-3-1 and K562) cell lines by a 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay were determined. We found that three out of the twelve stemofoline derivatives including OH-A1, NH-B6 and NH-D6 showed commitment efficiency to increase sensitivity to doxorubicin, vinblastine and paclitaxel in KB-V1 cells and increase sensitivity to doxorubicin, and paclitaxel in K562/Adr cells whereas the effects have not been seen in their parental sensitive cancer cell lines (KB-3-1 and K562). These results indicate that stemofoline derivatives reversed P-gp-mediated multidrug resistance in vitro, and thus could be developed as effective chemosensitizers to treat multidrug-resistant cancers. The molecular mechanism of modulation of P-gp would be further determined.View full abstractDownload PDF (871K) Full view HTML -
Ashraf Hassan Abadi, Marwa Saeed Hany, Shimaa Awadain Elsharif, Amal A ...2013 Volume 61 Issue 4 Pages 405-410
Published: April 01, 2013
Released on J-STAGE: April 01, 2013
JOURNAL FREE ACCESS FULL-TEXT HTMLAnalogues with the scaffolds of 3-cyano-4-alkoxyphenyl-6-bromoaryl-2-pyridone and 2-amino-3-cyano-4-alkoxyphenyl-6-bromoarylpyridine were synthesized. Cyclization of the 2-amino derivatives with formic acid and formamide gave the corresponding pyrido[2,3-d]pyrimidin-4(3H)-one and the pyrido[2,3-d]-pyrimidin-4-amine derivatives, respectively. Active phosphodiesterase 3 (PDE3) inhibitors were identified from each of the four aforementioned scaffolds. This is the first report that pyrido[2,3-d]pyrimidin-4(3H)-one and pyrido[2,3-d]pyrimidin-4-amine derivatives can inhibit PDE3. The analogues with the pyridone and pyrido[2,3-d]pyrimidin-4(3H)-one scaffolds inhibited both cAMP and cyclic guanosine monophosphate (cGMP) hydrolysis by PDE3, while the amine containing scaffolds were more selective for cGMP hydrolysis. This observation may set the base for substrate-selective pharmacological modulation of this important class of drug targets and with less side effects, particularly tachcardia. The dual inhibitors of PDE3 were more potent inhibitor towards the growth of HT-29 cancer cell lines.View full abstractDownload PDF (796K) Full view HTML -
Susumu Kawakami, Hiroki Toyoda, Liva Harinantenaina, Katsuyoshi Matsun ...2013 Volume 61 Issue 4 Pages 411-418
Published: April 01, 2013
Released on J-STAGE: April 01, 2013
Advance online publication: February 01, 2013JOURNAL FREE ACCESS FULL-TEXT HTMLFrom the stems of Croton cascarilloides, eight new diterpenoids, named crotocascarins A–H (1–8), having a crotofolane skeleton were isolated along with two new nor-diterpenoids (9 and 10), named crotocascarins α and β, derived through rearrangement of the crotofolane skeleton. The structures of these compounds were elucidated by means of extensive one- and two-dimensional NMR spectroscopic analyses. The absolute structures of the diterpene moiety were determined by application of the circular dichroism (CD) rule for the γ-lactone ring. The relative structures of the two crotofolanes (1 and 2) and one rearranged compound (9) were confirmed by X-ray crystallographic analyses. Compounds 1, 2 and 9 possessed 2-methylbutyric acid in their molecules, the absolute configuration of which was found to be 2S by comparison of its HPLC behavior with that of an authentic sample. Therefore, the absolute structures of these crotocascarins (1, 2 and 9) were unambiguously determined. The absolute structures of crotofolanes are reported for the first time in this paper.View full abstractDownload PDF (884K) Full view HTML -
Chi-Hsien Liu, Hsin-Ying Huang2013 Volume 61 Issue 4 Pages 419-425
Published: April 01, 2013
Released on J-STAGE: April 01, 2013
JOURNAL FREE ACCESS FULL-TEXT HTMLPropionibacterium acnes acts a critical role in the development of inflammatory acne when it overgrows in pilosebaceous units. The spread of multiple drug resistance bacteria indicates a growing need for new antimicrobial agents. The objective of this study is to develop lipid vehicles to deliver curcumin and inhibit P. acnes in the skin. The inhibitory activities of the curcumin containing vehicles against P. acnes were studied by the bioluminescence assay. Curcumin accumulation patterns in neonate pig skin were studied using Franz diffusion cells and confocal laser scanning microscopy. The physicochemical properties of the curcumin containing vehicles including interfacial tension, size distribution and viscosity were analyzed. Significant curcumin accumulation (362±8 µg/g skin) was observed with the lipid vehicles developed herein. Curcumin (0.43 µg/mL) in the vehicles significantly inhibited the growth of P. acnes. Confocal laser scanning microscopy confirmed the formation of curcumin reservoir in the skin by the curcumin-loaded vehicles. Curcumin-loaded vehicles could efficiently accumulate in the skin and inhibit P. acnes in vitro. Our results highlight the potential of using vehicles containing lauric acid and curcumin as an alternative treatment for acne vulgaris.View full abstractDownload PDF (648K) Full view HTML -
Md. Iqbal Mahmood, Xinli Liu, Saburo Neya, Tyuji Hoshino2013 Volume 61 Issue 4 Pages 426-437
Published: April 01, 2013
Released on J-STAGE: April 01, 2013
JOURNAL FREE ACCESS FULL-TEXT HTML
Supplementary materialβ2 Adrenergic receptor (β2AR) is a kind of G-protein coupled receptors (GPCRs) which transduce a wide range of extracellular signals into intracellular messages responsible for the regulation of diverse cell functions. Because of their functional ubiquity, GPCR is one of the most important drug targets in pharmaceutical industry. Although recent crystallographic studies provided both the active and the inactive states of some families of GPCRs, the influence of lipid composition of bilayer membrane on their activation is still poorly understood. In this work, we address the influence of lipid composition on the structural stability of GPCR, performing molecular dynamics simulations of three kinds of states: apo-, and agonist epinephrine-, or antagonist alprenolol-bound β2AR. These three kinds of β2ARs were embedded in four types of lipid membranes: (i) pure palmitoyl-oleoyl-phosphatidyl-choline (POPC), (ii) POPC/cholesterol (CHL), (iii) POPC/CHL/GM1 (GM1 ganglioside), (iv) POPC/palmitoyl-oleoyl-phosphatidyl-ethanolamine (POPE)/CHL/sphingomyeline (SM). The side chains of Lys2676.29 and Asp3317.58 showed different conformations among the three states in all types of lipid membranes. The distances between Lys2676.29 and Asp3317.58 of apo- and alprenolol-bound β2ARs are smaller than that of the epinephrine-bound β2AR. In contrast, β2ARs in POPC/CHL bilayer were unstable in which the salt bridge; i.e., ionic lock, was not formed between Arg1313.50 and Glu2686.30. We have also examined the distribution of lipid molecules. A stable hydrophobic interaction between CHL and β2AR was observed at transmembrane helix5 in POPC/CHL/GM1 and POPC/POPE/CHL/SM membranes. These results suggest that the lipid composition strongly affects the conformation of GPCR and essentially concerns the GPCR activation.View full abstractDownload PDF (4887K) Full view HTML -
Hisato Ishikawa, Takayuki Sugiyama, Akihiro Yokoyama2013 Volume 61 Issue 4 Pages 438-444
Published: April 01, 2013
Released on J-STAGE: April 01, 2013
JOURNAL FREE ACCESS FULL-TEXT HTMLQuinoxaline derivatives having bis(fluoromethyl), bis(chloromethyl), or bis(iodomethyl) groups at the 2- and 3-positions, and various electron-donating/withdrawing substituents at the 6- and/or 7-positions, were synthesized. Their antibacterial and antifungal activities were evaluated by means of minimum inhibitory concentration assays. The relationships between the substituents and the antimicrobial activities of the quinoxaline derivatives indicate that the electrophilicity of the halomethyl units plays an important role in generating the antimicrobial activity.View full abstractDownload PDF (453K) Full view HTML -
Katsuyoshi Fujimoto, Seikou Nakamura, Takahiro Matsumoto, Tomoe Ohta, ...2013 Volume 61 Issue 4 Pages 445-451
Published: April 01, 2013
Released on J-STAGE: April 01, 2013
JOURNAL FREE ACCESS FULL-TEXT HTMLThe methanolic extract from the flower buds of Prunus mume, cultivated in Zhejiang province, China, showed an inhibitory effect on aldose reductase. From the methanolic extract, five new acylated sucroses, mumeoses F–J, were isolated together with 29 known compounds. The chemical structures of the new compounds were elucidated on the basis of chemical and physicochemical evidence. The inhibitory effects of the isolated compounds on aldose reductase were also investigated. Acylated quinic acid analogs, which are one of the major compounds of the flower buds of P. mume, were shown to substantially inhibit aldose reductase. In particular, mumeic acid-A was found to exhibit a potent inhibitory effect [IC50=0.4 µm].View full abstractDownload PDF (505K) Full view HTML -
Hirofumi Yamamoto, Masataka Oda, Mayo Nakano, Kenta Yabiku, Masahiro S ...2013 Volume 61 Issue 4 Pages 452-459
Published: April 01, 2013
Released on J-STAGE: April 01, 2013
JOURNAL FREE ACCESS FULL-TEXT HTMLTrehalose 6,6′-dicorynomycolate (TDCM) was first characterized in 1963 as a cell surface glycolipid of Corynebacterium spp. by Ioneda and co-workers. TDCM shows potent anti-tumor activity due to its immunoadjuvant properties. Furthermore, the toxicity of TDCM in mice is much weaker than the related trehalose diester of mycolic acid; trehalose 6,6′-dimycolate (TDM, formerly known as cord factor). We have investigated the chemical modification of this class of compound to generate novel agents that display increased immunoadjuvant activity with minimal associated toxicity. During the course of this work we recently developed 6,6′-bis-O-(3-nonyldodecanoyl)-α,α′-trehalose (designated as vizantin). Our results show that vizantin exhibited a potent prophylactic effect on experimental lung metastasis of B16-F0 melanoma cells without a loss of body weight and death in mice. Furthermore, vizantin effectively stimulated human macrophages in an in vitro model, making it a promising candidate for a safe adjuvant in clinical applications. In order to elucidate the pharmacokinetics of vizantin, a probe molecule with similar activity was developed on the basis of a structure–activity relationship (SAR) study with vizantin. The distribution of the probe molecule after intravenous administration into a mouse was assessed by macro confocal microscopy, where it was found to accumulate in the lungs and liver.View full abstractDownload PDF (1301K) Full view HTML
Notes
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Masayuki Kirihara, Takumi Goto, Takuya Noguchi, Michitaka Suzuki, Yuki ...2013 Volume 61 Issue 4 Pages 460-463
Published: April 01, 2013
Released on J-STAGE: April 01, 2013
JOURNAL FREE ACCESS FULL-TEXT HTMLThe oxidation of dithioacetals with 16 eq of 30% hydrogen peroxide in the presence of 10 mol% niobium(V) chloride at room temperature provides bissulfonylmethylenes in high yields.View full abstractDownload PDF (501K) Full view HTML -
Machiko Ono, Keisuke Kato, Hiroyuki Akita2013 Volume 61 Issue 4 Pages 464-470
Published: April 01, 2013
Released on J-STAGE: April 01, 2013
JOURNAL FREE ACCESS FULL-TEXT HTMLAlkaline hydrolysis of 4-hydroxy- or/and 5-hydroxy-(2E)-alkenoate followed by acid treatment gave the corresponding (2E)-alkenoic acids which were subjected to lactone formation reaction without further purification. The crude acids were treated with 2,4,6-trichlorobenzoyl chloride in pyridine to afford γ-lactone or δ-lactone, respectively, accompanied by trans–cis isomerization. By this procedure, (±)-(4,5)-trans-5-benzyloxy-2-hexen-4-olide (90% overall yield), (S)-5-hydroxy-2-penten-4-olide (86% overall yield), (4S,5R)-5-hydroxy-2-hexen-4-olide (86% overall yield), (4R,5S)-5-hydroxy-2-hexen-4-olide (82% overall yield), (S)-parasorbic acid (58% overall yield) and natural product, (5R,7S)-7-hydroxy-2-octen-5-olide (euscapholide: 20% overall yield) were synthesized.View full abstractDownload PDF (805K) Full view HTML -
Wei Li, Yan Ding, Ya Nan Sun, Xi Tao Yan, Seo Young Yang, Chun Whan Ch ...2013 Volume 61 Issue 4 Pages 471-476
Published: April 01, 2013
Released on J-STAGE: April 01, 2013
Advance online publication: January 25, 2013JOURNAL FREE ACCESS FULL-TEXT HTML
Supplementary materialIn the present study, a new oleanane-type triterpenoid saponin, pulsatilloside F (1), along with 21 known compounds (2–22), were isolated from the root of Pulsatilla koreana. Their chemical structures were elucidated by mass, 1H-, 13C-NMR, correlation spectroscopy (COSY), heteronuclear multiple quantum coherence (HMQC) and heteronuclear multiple bond connectivity (HMBC) spectroscopy. Anti-inflammatory effects of the compounds were evaluated in terms of inhibitory of tumor necrosis factor α (TNF-α) secretion in the lipopolysaccharide (LPS)-stimulated murine RAW264.7 macrophage cell line. Compounds 19 and 20 exhibited particularly inhibitory effects with respective IC50 values of 0.32 and 0.65 µm. Compounds 1–4, 7 and 10–13 exhibited inhibitory effects with inhibition rates up to 41.55–73.76% at a concentration of 5 µm, respectively.View full abstractDownload PDF (521K) Full view HTML -
Kuaile Lin, Zhengyan Cai, Fei Wang, Wei Zhang, Weicheng Zhou2013 Volume 61 Issue 4 Pages 477-482
Published: April 01, 2013
Released on J-STAGE: April 01, 2013
Advance online publication: January 28, 2013JOURNAL FREE ACCESS FULL-TEXT HTML
Supplementary materialA series of xanthine derivatives in which a methylene was inserted at position 8 of xanthine scaffold was synthesized and evaluated as inhibitors of dipeptidyl peptidase 4 (DPP-4) for the treatment of type 2 diabetes. As the results of structure–activity relationship (SAR) study of the series, the compounds with 4-methyl-quinazoline-2-yl-methyl group at N-1 position and 2-aminoethylaminomethyl group gave better activities. Compounds H4 and H9 showed good DPP-4 inhibition and more than 100-fold selectivity over DPP-7 and DPP-8.View full abstractDownload PDF (1445K) Full view HTML -
Alain Simplice Leutou, Keumja Yun, Jung Sook Kang, Byeng Wha Son2013 Volume 61 Issue 4 Pages 483-485
Published: April 01, 2013
Released on J-STAGE: April 01, 2013
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Supplementary materialThe addition of metal bromides (NaBr and CaBr2) during fermentation of a marine isolate of the fungus Aspergillus sp. induced production of two new brominated dihydroxyphenylacetic acid derivatives, methyl 2-(6-bromo-3,4-dihydroxyphenyl)acetate (1) and methyl 2-(2,5-dibromo-3,4-dihydroxyphenyl)acetate (2), and a known compound, 2-(3,4-dihydroxyphenyl)acetic acid (3). The structures of the two new compounds (1, 2) were assigned through the combination of spectroscopic data analyses and comparison with the spectral data of compound 3. Compounds 1–3 exhibited potent radical-scavenging activity against 1,1-diphenyl-2-picrylhydrazyl (DPPH) with IC50 values (14.2, 12.1, 11.0 µm, respectively) demonstrating greater activity than the positive control (l-ascorbic acid; IC50, 20.0 µm).View full abstractDownload PDF (253K) Full view HTML -
Mi Kyoung Kim, Hyunjun Yoon, Dale Lynn Barnard, Youhoon Chong2013 Volume 61 Issue 4 Pages 486-488
Published: April 01, 2013
Released on J-STAGE: April 01, 2013
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Supplementary materialPreviously, we have confirmed that the antiviral activities of the chromone derivatives were controlled by the type as well as the position of the substituents attached to the chromone core structure. In the course of our ongoing efforts to optimize the antiviral activity of the chromone derivatives, we have been attempting to derivatize the chromone scaffold via introduction of various substituents. In this proof-of-concept study, we introduced a 3-amino-4-piperazinylphenyl functionality to the chromone scaffold and evaluated the antiviral activities of the resulting chromone derivatives. The synthesized 2-(3-amino-4-piperazinylphenyl)-chromones showed severe acute respiratory syndrome-corona virus (SARS-CoV)-specific antiviral activity. In particular, the 2-pyridinylpiperazinylphenyl substituents provided the resulting chromone derivatives with selective antiviral activity. Taken together, this result indicates the possible pharmacophoric role of the 2-pyridinylpiperazine functionality attached to the chromone scaffold, which warrants further in-depth structure–activity relationship study.View full abstractDownload PDF (407K) Full view HTML -
Gang Wang, Jian-Guang Luo, Ming-Hua Yang, Xiao-Bing Wang, Ling-Yi Kong2013 Volume 61 Issue 4 Pages 489-495
Published: April 01, 2013
Released on J-STAGE: April 01, 2013
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Supplementary materialSix new cyclic peptides, gypsophin A–F (1–6), were isolated from Gypsophila oldhamiana. Their structures were elucidated by extensive NMR and chemical degradation. Compound 3 exhibited moderate activity of antiplatelet aggregation in vitro.View full abstractDownload PDF (577K) Full view HTML
Errata
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Takashi Ichiyanagi, Yoshihiko Hatano, Seiichi Matsuo, Tetsuya Konishi2013 Volume 61 Issue 4 Pages 496
Published: April 01, 2013
Released on J-STAGE: April 01, 2013
JOURNAL FREE ACCESS FULL-TEXT HTMLDownload PDF (93K) Full view HTML
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