Chemical investigation on CH
2Cl
2 extract of the marine sponge
Diacarnus megaspinorhabdosa resulted in the isolation of two new farnesylacetone derivatives
1–
2, a new γ-lactone
3, a known dinorditerpenone
4 and four known norsesterterpene peroxides
5–
8. Their structures were elucidated by using one and two dimensional (1D and 2D)-NMR, high resolution-electrospray ionization (HR-ESI)-MS, and comparison with the literature. Compounds
1 and
2 were
cis/
trans-olefinic isomers and determined through nuclear Overhauser effect spectroscopy (NOESY) experiment. The absolute configuration of
3 was established by comparison of circular dichroism (CD) data with known lactones. The cytotoxic activities of the compounds were evaluated against five cancer cell lines, and compound
3 showed moderate cytotoxicity activities against cancer cell lines HeLa, H446, NCI-H460, SGC-7901 and MCF-7, with IC
50 values in the range of 18.5 to 47.1 µM.
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