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Volume 8, Issue 1
Displaying 1-19 of 19 articles from this issue
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Sadao Iguchi, Kazuhito Hisatsunne, Shigeru Goto, Eiko Futagami, Hirosh ...1960 Volume 8 Issue 1 Pages 1-4
Published: January 25, 1960
Released on J-STAGE: March 31, 2008
JOURNAL FREE ACCESSIt was found that dehydroacetic acid or its sodium salt reacted in the solution with not only ammonia but with various organic and inorganic ammonium salts under extremely mild condition and formed its imide, 3-(1-iminoethyl)-4-hudroxy-6-methyl-2-pyrone (DHA-imide). Dehydroacetic acid and its sodium salt are known to have low toxicity and examinations were made to see if a similar reaction would occur in vivo when dehydroacetic acid is administered. In a preliminary test with a dog with Eck's fistula, administration of sodium dehydroacetate in hyper-ammonemia was effective to a certain extent in reducing the value of blood ammonia.View full abstractDownload PDF (508K) -
Genkichi Ohta1960 Volume 8 Issue 1 Pages 5-9
Published: January 25, 1960
Released on J-STAGE: March 31, 2008
JOURNAL FREE ACCESSA phenolic compound, oryzanol-C, isolated from rice-bran oil, was shown to be a ferulate of an alcohol, tentatively named alcohol-C. Some derivatives of alcohol-C were prepared. Alcohol-C is a new triterpene of C31-skeleton. Examination of infrared spectra and other chemical properties indicates that alcohol-C contains a vinylidene group and the same ring system as that of cycloartenol (I). Alcohol-C is not identical with cyclolaudenol (II).View full abstractDownload PDF (698K) -
Genkichi Ohta1960 Volume 8 Issue 1 Pages 9-13
Published: January 25, 1960
Released on J-STAGE: March 31, 2008
JOURNAL FREE ACCESSAlcohol-C, obtained by saponification of oryzanol-C, is related to cycloartenol. Ozonolysis of alcohol-C acetate gave formaldehyde and demethyl-oxo-alcohol-C acetate (IV). Wolff-Kishner reduction of (IV) yielded cycloartanol while reduction of carbonyl group of (IV) to the corresponding hydroxyl compound, followed by dehydration, gave cycloartenyl acetate. (IV) was converted to trisnorcycloartanolic acid (X) by Bayer-Villiger oxidation. From the result of these reactions, alcohol-C would be represented as 24-methylenecycloartanol (III).View full abstractDownload PDF (667K) -
San-ya Akaboshi, Teruo Kutsuma, Kazuo Achiwa1960 Volume 8 Issue 1 Pages 14-17
Published: January 25, 1960
Released on J-STAGE: March 31, 2008
JOURNAL FREE ACCESSSynthesis of 1, 2, 3, 4, 6, 7-hexahydro-11bH-benzo[a]quinolizines (IIIa and IIIb) was described. N-Phenethyl-5-bromovaleramide (IV) and 1-phenethyl-2-piperidone (VIIa) were cyclized with a mixture of phosphoryl chloride-phosphorus pentoxide and phosphoryl chloride-polyphosphoric acid, respectively, and were reduced catalytically. Thus, the hexahydro base (IIIa) was obtained. 9, 10-Methylenedioxy-1, 2, 3, 4, 6, 7-hexahydro-11bH-benzo[a]quinolizine (IIIb) was obtained in a good yield from the cyclized product of the corresponding piperidone (VIIb) by the same method.View full abstractDownload PDF (597K) -
Atsushi Yamada1960 Volume 8 Issue 1 Pages 18-24
Published: January 25, 1960
Released on J-STAGE: March 31, 2008
JOURNAL FREE ACCESSAcetyl, dehydro, and 3-epi derivatives of the cardiac aglycones of digitalis, digitoxigenin, gitoxigenin, and digoxigenin, including those reported in past literature, were prepared. The toxicity of these derivatives by the pigeon method was compared and discussed.View full abstractDownload PDF (825K) -
Eiji Ochiai, Yutaka Kawazoe1960 Volume 8 Issue 1 Pages 24-27
Published: January 25, 1960
Released on J-STAGE: March 31, 2008
JOURNAL FREE ACCESS1-Athoxyisochinolin ergab bei der Nitrierung mit Salpeter in konz. Schwefelsaure bei Zimmertemperatur das 5-Nitroderivat. 1-Aminoisochinolin sowie 5, 6, 7, 8-Tetrahydroisocarbostyril ergab bei der analogen Nitrierung das 4-Nitroderivat. Isocarbostyril wurde bei der Bromierung unter einer milden Bedingung das 4-Bromderivat. 4-Nitroisochinolin und sein 1-Athoxyderivat wurden neu hergestellt.View full abstractDownload PDF (585K) -
Eiji Ochiai, Chikara Kaneko1960 Volume 8 Issue 1 Pages 28-32
Published: January 25, 1960
Released on J-STAGE: March 31, 2008
JOURNAL FREE ACCESSPyridin-1-oxyd ergab bei der Nitrierung mit einer aquivalenten Menge von p-Nitrobenzoylchlorid und Silbernitrat in Chloroform-Losung das 3-Nitroderivat und 3, 5-Dinitroderivat mit der Ausbeute von je ca. 9∼10% unter 40∼50% Regenerierung des Ausgangsmaterials. 3, 5-Dinitropyridin-1-oxyd ist sehr empfindlich gegen Alkalien. Es ist in NaHCO3-bzw. K2CO3-Losung mit roter Farbe und in NaOH-Losung mit gelber Farbe loslich und verandert sich in der Losung langsam. Der Farbumschlag in der Karbonat- und Lauge-Losung ist reversibel. 3-Nitropyridin-1-oxyd bzw. 3, 5-Dinitropyidin-1-oxyd ergab beim Erhitzen mit Phosphoroxychlorid oder Phosphorpentachlorid das entsprechende 2-Chlorpyridin-Derivat.View full abstractDownload PDF (566K) -
Hideyo Shindo1960 Volume 8 Issue 1 Pages 33-45
Published: January 25, 1960
Released on J-STAGE: March 31, 2008
JOURNAL FREE ACCESSThe infrared spectra of pyrazine, its eight mono-substituted derivatives, and their ten N-oxide derivatives were analyzed. Their characteristic N-O streching frequencies (a strong absorption in the region of 1250 and 1350 cm-1) were found to be correlated to the nature of a substituent present and the linear relationship between the N-O frequency and the σ-value of a substituent in substituted pyridine N-oxides could be extended to that in substituted pyrazine N-oxides by applying the σ-value of ring nitrogen (0.93) and the N-oxide group (0.25) toward 4-position of pyridine for mono- and di-N-oxides, respectively. The considerably higher frequency shift of the N-O frequency was shown to be characteristic for the methyl group at β-position with respect to the N-oxide group. Ring and ring CH vibrations were discussed on the basis of the correlations found in the pyridine ring system. The splitting of the carbonyl stretching frequency of ester group adjacent to ring nitrogen was pointed out and discussed. The infrared spectra of pyrimidine N-oxide and its eight derivatives were also examined and discussed in comparison with the above results.View full abstractDownload PDF (1274K) -
Eiji Ohki1960 Volume 8 Issue 1 Pages 46-50
Published: January 25, 1960
Released on J-STAGE: March 31, 2008
JOURNAL FREE ACCESSIn order to examine the vitamin D activity, 4, 4-dimethylcholecalciferol (IV), m.p. 71∼73°, [α]D +23.7°, was prepared by irradiation of ultraviolet rays on 4, 4-dimethyl-7-de-hydrocholesterol (V). Pyrolysis reaction of (IV) was found to result in preferential cyclization to pyrocalciferol-type compound and 4, 4-dimethyl-10-isocholesta-5, 7-dien-3β-ol (XI), m.p. 71∼73°, [α]D +543°, was obtained in a good yield.View full abstractDownload PDF (662K) -
Haruo Saikachi, Takuzo Hisano1960 Volume 8 Issue 1 Pages 51-53
Published: January 25, 1960
Released on J-STAGE: March 31, 2008
JOURNAL FREE ACCESSCondensation of quinaldine with seven kinds of aromatic primary amines in the presence of sulfur was carried out at an elevated temperature. With the exception of p-phenetidine and p-isopropoxyaniline, which yielded only the corresponding thioanilides, these amines gave N-(2-quinolinecarbothionoyl) anilines and also 2-(2-quinolyl) benzothiazoles, without much difference in the yield. The results of microbiological screening will be reported elsewhere in due course.View full abstractDownload PDF (454K) -
Haruo Saikachi, Keizo Suzuki1960 Volume 8 Issue 1 Pages 53-55
Published: January 25, 1960
Released on J-STAGE: March 31, 2008
JOURNAL FREE ACCESSTwenty-two kinds of 4-(5-nitrofurfurylidene)-2-cyanocrotonamides were prepared by condensation of 4-(5-nitrofurfurylidene)-2-cyanocrotonoyl chloride and various amines. These acid amides are almost insoluble in water and did not show the desired anti bacterial activity.View full abstractDownload PDF (455K) -
Kono Kinoshita, Shoichi Nakajima1960 Volume 8 Issue 1 Pages 56-58
Published: January 25, 1960
Released on J-STAGE: March 31, 2008
JOURNAL FREE ACCESSA new method was devised for identification of fatty acids of C1∼C10 series as colored p-aminoazobenzene derivatives, which were prepared by condensation between p-aminoazobenzene and the fatty acid. On accout of their high melting point and large crystal form, they were considered to be convenient derivatives for the identification of fatty acids. The mixture of p-formamidoazobenzene, p-acetamidoazobenzene, and p-propionylaminoazobenzene was separated clearly into the components by chromatography on alumina.View full abstractDownload PDF (466K) -
Naokata Morita1960 Volume 8 Issue 1 Pages 59-65
Published: January 25, 1960
Released on J-STAGE: March 31, 2008
JOURNAL FREE ACCESSA flavonoid, isolated from the leaves of sesame (Sesamum indicum L. ), was determined as 5, 3', 4'-trihydroxy-6-methoxyflavone 7-glucoside.View full abstractDownload PDF (843K) -
Naokata Morita1960 Volume 8 Issue 1 Pages 66-71
Published: January 25, 1960
Released on J-STAGE: March 31, 2008
JOURNAL FREE ACCESSThe structure of the demethylated product of pedalitin, the aglycone of pedaliin, the flavonoid from sesame leaves, was unequivocally established by the synthesis of 5, 6, 7, 3', 4'-pentahydroxyflavone.View full abstractDownload PDF (696K) -
Noboru Kutani1960 Volume 8 Issue 1 Pages 72-76
Published: January 25, 1960
Released on J-STAGE: March 31, 2008
JOURNAL FREE ACCESSExaminations were made on the chemical structure of aceritannin (acertannin), an oligogalloylated, crystalline tannin, C20H20O13·2H2O, m.p. 164∼166°, [α]12D +20°(Me2CO and EtOH, each), which was first isolated by Perkin and Uyeda from the leaves of Acer Ginnala MAXIM. It has now been proved that aceritannin should be formulated as 3, 6-di-O-galloyl-1, 5-anhydro-D-glucitol, i.e., no other than 1-deoxy derivative of 3, 6-di-O-galloyl-D-glucopyranose, a compound first isolated by Freudenberg (Ber., 52, 1238 (1919)) as one of the partial hydrolysis products of chebulinic acid, and later, unequivocally synthesized by Schmidt and Schach (Ann., 571, 29(1951)).View full abstractDownload PDF (675K) -
Yutaka Kuwada1960 Volume 8 Issue 1 Pages 77-78
Published: January 25, 1960
Released on J-STAGE: March 31, 2008
JOURNAL FREE ACCESSConditions for reduction of substitute N, N-bis(2-chloroethyl) carbonamides with lithium aluminium hydride into substituted N, N-bis(2-chloroethyl) amines were examined and the method was proved to be widely applicable for the preparation of the derivatives of nitrogen mustard.View full abstractDownload PDF (372K) -
SHIGEHARU INOUE, HIROSHI OGAWA1960 Volume 8 Issue 1 Pages 79-80
Published: January 25, 1960
Released on J-STAGE: March 31, 2008
JOURNAL FREE ACCESSDownload PDF (381K) -
TYUNOSIN UKITA, MASACHIKA IRIE1960 Volume 8 Issue 1 Pages 81-83
Published: January 25, 1960
Released on J-STAGE: March 31, 2008
JOURNAL FREE ACCESSDownload PDF (451K) -
HIKOICHI HAGIWARA, SHUNSAKU NOGUCHI, MASAMOTO NISHIKAWA1960 Volume 8 Issue 1 Pages 84-85
Published: January 25, 1960
Released on J-STAGE: March 31, 2008
JOURNAL FREE ACCESSDownload PDF (293K)
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