巻号一覧
8 巻, 10 号
選択された号の論文の20件中1～20を表示しています
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進藤 英世1960 年 8 巻 10 号 p. 845-855
発行日: 1960/10/25
公開日: 2008/03/31
ジャーナル フリーInfrared spectra of 20 kinds of monosubstituted quinolines, quinoline 1-oxides, and isoquinoline 2-oxides, and 18 kinds of monosubstituted quinoline 1-oxides were determined. By comparison with the spectra of corresponding quinolines, two strong absorptions in the regions of 1280∼1340 cm-1 and 1210∼1260 cm-1 of the N-oxide compounds were assigned to the characteristic N-O absorptions. By examining the solvation effect of methanol and water, however, it was clarified that the N-O stretching vibration contributes to two or more absorptions in the region of 1150 and 1350 cm-1 due to complex coupling with the vibrations originating in the quinoline ring and ring hydrogens, and there was not found any correlation between these frequencies and the structure. Ring CH out-of-plane bending frequencies were assigned and interpreted by considering the number of adjacent free hydrogens on heterocyclic and carbocyclic rings, and it was found that all the frequencies of monosubstituted quinoline 1-oxides, except the band near 770 cm-1 in 4-substituted derivatives, show an appreciable shift to a lower frequency than those of the corresponding quinolines.抄録全体を表示PDF形式でダウンロード (1019K) -
佐藤 善重1960 年 8 巻 10 号 p. 856-859
発行日: 1960/10/25
公開日: 2008/03/31
ジャーナル フリーIn order to determine the amount of crystal water in calcium 5-ethyl-5-pentylbarbiturate, examinations were made on the action of water vapor on the hydrate and the anhydrate by the use of a quartz spring balance and a mercury manometer which may be able to estimate the reaction amount and equilibrium pressure. The amount of crystal water obtained from the flat part of the desorption curves corresponds to dihydrate. The rate of dehydration was examined over the temperature range of 20°to 50°and the rate of dehydration may be expressed by the formula (1-α)1/8=1-<kt>/r, where k is the rate constant, the fraction dehydrated at time t is α, and r is the initial radius of particle. From the experimental data, it was estimated that the activation energy for dehydration reaction of the hydrate is 9.5 kcal. / mole.抄録全体を表示PDF形式でダウンロード (480K) -
村岡 全子, 伊藤 知男, 水間 豊治, 豊島 滋1960 年 8 巻 10 号 p. 860-866
発行日: 1960/10/25
公開日: 2008/03/31
ジャーナル フリーCompounds of 2-dimethylaminoethyl p-alkylbenzhydryl ether and p, p'-dialkylbenzbydryl ether series were synthesized and their activity was examined using the Nakayama strain of Japanese B encephalitis and the PR-8 strain of influenza A virus. p, p'-Dipropyl-, p, p'-dibutyl, and p, p'-dibutyl derivatives were found to have considerable activity on the PR-8 strain in membrane culture, and p-dodecyl derivative was recognized to be effective on the Japanese B encephalitis virus in mice.抄録全体を表示PDF形式でダウンロード (709K) -
古川 潮, 上田 武雄1960 年 8 巻 10 号 p. 867-870
発行日: 1960/10/25
公開日: 2008/03/31
ジャーナル フリーdl-1-(3, 4-Dimethylphenyl)-2-aminopropanol derivatives and dl-1-(3, 4-dimethylphenyl)-2-aminoethanol were prepared from the corresponding amino ketones by catalytic hydrogenation in the presence of palladium-carbon catalyst. Though 3, 4-dimethylphenyl 1-methylaminoethyl ketone and 3, 4-dimethylphenyl 1-dimethylaminoethyl ketone were obtained by treatment with the corresponding bromo ketone and methylamine or dimethylamine, 3, 4-dimethylphenyl 1-aminoethyl ketone was prepared from isonitroso ketone, which was synthesized from 3, 4-dimethylphenyl ethyl ketone and methyl nitrite, by catalytic hydrogenation in the presence of palladium-carbon catalyst. dl-1-(3, 4-Dimethylphenyl)-2-amino-1-propanol derivatives obtained by such a method were found to be the erythro form. The inverted isomers of these compounds were prepared by applying the method of Taguchi, et al. or by treatment with thionyl chloride.抄録全体を表示PDF形式でダウンロード (622K) -
森本 浩, 木全 清一1960 年 8 巻 10 号 p. 871-874
発行日: 1960/10/25
公開日: 2008/03/31
ジャーナル フリーJudging from the properties of some its derivatives, peimine (I) was found to be a saturated tertiary base having two secondary and one tertiary hydroxyl groups. Oxidation of (I) with chromium trioxide gave a diketone, peiminone (V), and an oxidation of the product (V) with selenium dioxide afforded dehydropeiminone. Dehydropeiminone was assumed to have a 1-en-3-one structure from the ultraviolet spectrum of its perchlorate (VII).抄録全体を表示PDF形式でダウンロード (590K) -
金子 光1960 年 8 巻 10 号 p. 875-879
発行日: 1960/10/25
公開日: 2008/03/31
ジャーナル フリーThe cell-free enzyme system of Foeiculum plant synthesized anethole from phenylalanine on addition of ATP, DPN+, Mg2+, and 2-oxoglutarate in anaerobic condition. In this enzyme reaction, p-hydroxycinnamic, cinnamic, and phenylpyruvic acids seem to be a powerful intermediate of the anethole biosynthesis, which was detected by the inhibition method.抄録全体を表示PDF形式でダウンロード (622K) -
菅澤 重彦, 出口 義雄1960 年 8 巻 10 号 p. 879-884
発行日: 1960/10/25
公開日: 2008/03/31
ジャーナル フリーA new method for synthsis of β-carboline derivatives reported in the previous papers was now extended to include the preparation of tetrahydrobenzindoloquinolizine derivative (XIII). Thus, N-(3, 4-dimethoxyphenethyl)-2-indoleacetamide was cyclized by Bischler-Napieralski-Perkin method to yield the corresponding 3, 4-dihydroisoquinoline. The latter, after being dehydrogenated, was condensed with formaldehyde and diethylamine to give the gramine-type compound (V), from which benzindoloquinolizinium base (XII) was prepared as previously. Reduction of the latter to (XIII) was effected either catalytically or by means of sodium borohydride.抄録全体を表示PDF形式でダウンロード (712K) -
柴田 承二, 北川 勲1960 年 8 巻 10 号 p. 884-888
発行日: 1960/10/25
公開日: 2008/03/31
ジャーナル フリーThe infrared absorption band of C-O in rubroskyrin, which appeared in unexpectedly higher frequency, was discussed in comparison with that of the synthesized model compounds. The presence of alcoholic groups in the molecules of rubroskyrin and luteoskyrin was established by the infrared spectra of O-diacetylrubroskyrin and O-hexaacetylluteoskyrin which showed alcoholic acetate C=O band at 1749 and 1751 cm-1, respectively. These results are incompatible with the proposed structures for rubroskyrin (I) and luteoskyrin (II).抄録全体を表示PDF形式でダウンロード (614K) -
柴田 承二, 池川 哲郎, 貴志 光雄1960 年 8 巻 10 号 p. 889-891
発行日: 1960/10/25
公開日: 2008/03/31
ジャーナル フリーEmodin was obtained by the air-oxidation of flavoskyrin in the presence of magnesium acetate, which gave an evidence for the proposed structural formula (I). By the action of chromium trioxide or active manganese dioxide, flavoskyrin yielded dianhydrorugulosin which resulted by oxidative coupling. In methanolic alkaline solution flavoskyrin was converted into a skyrin-like compound.抄録全体を表示PDF形式でダウンロード (421K) -
岡本 敏彦, 早津 彦哉, 馬場 義彦1960 年 8 巻 10 号 p. 892-899
発行日: 1960/10/25
公開日: 2008/03/31
ジャーナル フリーReaction rates of 4-haloquinoline 1-oxides, 4-haloquinolines, 4-halo-1-nitronaphthalenes, and 4-halo-1-acetonaphthone with piperidine were compared. Rate coefficients, heat constants of activation, and entropies of activation were calculated. 4-Haloquinoline 1-oxides were most reactive and activating power of the N-oxide group was greater than that of the nitro group.抄録全体を表示PDF形式でダウンロード (801K) -
宮木 高明, 林 誠, 千葉 剛久, 那須 嘉資雄, 畝本 力, 小野寺 邦介1960 年 8 巻 10 号 p. 900-903
発行日: 1960/10/25
公開日: 2008/03/31
ジャーナル フリーEffect of 2-aminoethanol, 2-methylaminoethanol, 2-dimethylaminoethanol, choline, and their phosphorylated compounds on the growth of Ehrlich solid tumor and in vitro growth of Yoshida sarcoma cells was examined and following facts were revealed. 1) On the Ehrlich tumor, 2-aminoethyl dihydrogenphosphate and 2-methylaminoethyl dihydrogenphosphate had a growth-promoting effect while the others had no effect. 2) 2-Aminoethanol and 2-aminoethyl dihydrogenphosphate were inhibitive to the in vitro growth of Yoshida sarcoma cells but others had no effect. 3) There was entirely no difference in the lipids between the groups administered and not administered 2-aminoethyl dihydrogenphosphate.抄録全体を表示PDF形式でダウンロード (508K) -
林 誠, 宮木 高明, 畝本 力1960 年 8 巻 10 号 p. 904-907
発行日: 1960/10/25
公開日: 2008/03/31
ジャーナル フリーAs a new method for determination of serine and 2-aminoethanol in phospholipid, the lipid hydrolyzate was fractionated by cation exchange resin, each fraction was oxidized with periodic acid to produce formaldehyde, and the color developed by chromotropic acid was submitted to colorimetry. This method is more simple and accurate than the existing methods and is thought to be suitable for micro-determination.抄録全体を表示PDF形式でダウンロード (552K) -
二木 清, 土佐 宜治1960 年 8 巻 10 号 p. 908-912
発行日: 1960/10/25
公開日: 2008/03/31
ジャーナル フリーThe chemical structure of the compounds found by the reaction of cyanogen bromide and acylhydrazines was determined as 2-alkyl-5-amino-1, 3, 4-oxadiazoles (I). 3-Alkyl-5, 6, 7, 8-tetrahydro-s-triazolo [4, 3-b] [1, 2, 4] triazine-6, 7-diones (III), which are listed in Table III, were prepared from 4, 5-diamino-1, 2, 4-triazoles (II) and diethyl oxalate. Several unreported intermediates of these compounds - 2-alkyl-5-amino-1, 3, 4-oxadiazoles (I) and 4, 5-diamino-1, 2, 4-triazoles (II)-were also prepared and are listed in Tables I and II.抄録全体を表示PDF形式でダウンロード (640K) -
塚本 赳夫, 古森 徹哉1960 年 8 巻 10 号 p. 913-917
発行日: 1960/10/25
公開日: 2008/03/31
ジャーナル フリーA Ninhydrin reagent for use in the quantitative determination of amino acids separated by paper partition chromatography was worked out. It was confirmed that the best concentration of the reagent is 0.5%. The reagent had to be added with ascorbic acid as 1% solution in metaphosphoric acid if the optical density of the blank test was not to exceed 0.04∼0.05 (log I0/I). The blank test value was 0.04 (log I0/I) or less when the reagent to be used in paper partition chromatography was kept in alkaline state by the addition of sodium hydroxide and left standing overnight in a reduced pressure over sulfuric acid in a desiccator before it was used. Amino acid spotted at a concentration of 0.08∼0.4 mμM/cc. was recovered quantitatively within the error of 5%.抄録全体を表示PDF形式でダウンロード (567K) -
梅沢 文輔1960 年 8 巻 10 号 p. 918-921
発行日: 1960/10/25
公開日: 2008/03/31
ジャーナル フリーThe order of the activity of the active methylene of 1-(2-pyridylmethyl)- (I), 1-(1-oxido-2-pyridylmethyl)pyridinium salt (II) and 1'-methyl-1, 2'-methylenebis-pyridinium salt (III) was determined.抄録全体を表示PDF形式でダウンロード (507K) -
上田 武雄, 豊島 滋, 高橋 廉, 村岡 全子, 鯉淵 弘子, 瀬戸 淑子1960 年 8 巻 10 号 p. 921-929
発行日: 1960/10/25
公開日: 2008/03/31
ジャーナル フリーTo find chemotherapeutic agents for influenza and adenoviruses, 3-(alkoxyphenoxy)-1, 2-propanediols were synthesized. Among these derivatives, 3-(m-dodecyloxyphenoxy)-1, 2-propanediol possessed a fairly inhibitory effect on the multiplication of the PR-8 strain of influenza virus in chorioallantoic membrane culture. By the primary screening test on the type-1 strain of adenovirus, 3-(p-decyloxyphenoxy)-, 3-(p-dodecyloxyphenoxy)-, 3-(o-hexyloxyphenoxy)-, 3-(o-octyloxyphenoxy)-, 3-(o-decyloxyphenoxy)-, 3-(m-butoxyphenoxy)-, 3-(m-pentyloxyphenoxy)-, 3-(m-hexyloxyphenoxy)-, 3-(m-octyloxyphenoxy)-, 3-(m-decyloxyphenoxy)-, and 3-(m-dodecyloxyphenoxy)-1, 2-propanediols were selected. By the secondary screening test, 3-(o-hexyloxyphenoxy)-, 3-(o-octyloxyphenoxy)-, and 3-(p-dodecyloxyphenoxy)-1, 2-propanediols were found to be effective on 10×TCD50 of the type-1 of adenovirus. Among these three compounds, 3-(o-hexyloxyphenoxy)-1, 2-propanediol was effective on the type-4 and -6 strains, and 3-(o-octyloxyphenoxy)-1, 2-propanediol was effective on the type-4 strain virus, while 3-(p-dodecyloxyphenoxy)-1, 2-propanediol did not show any effect on the type-2, -3, -4, -6, and -7 strains of adenovirus. These three compounds did not possess any direct action for inactivating adenovirus and it was suggested from the experiments that the effectiveness of the compounds was due to the inhibition of viral multiplication.抄録全体を表示PDF形式でダウンロード (884K) -
川畑 潤三, 鯉淵 弘子, 豊島 滋1960 年 8 巻 10 号 p. 930-932
発行日: 1960/10/25
公開日: 2008/03/31
ジャーナル フリーThe six compounds of N-alkanoyl-5-acetamido-8-quinolinesulfonamide were synthesized and their antiviral effect was tested by employing the Nakayama strain of Japanese B encephalitis virus. The decanoyl derivative was more effective in vitro than PANS-610 or N-decanoyl-8-ethoxy-5-quinolinesulfonamide. Moreover, the decanoyl derivative was found to possess significant in vivo effect against the Nakayama strain.抄録全体を表示PDF形式でダウンロード (419K) -
宮木 高明, 林 誠, 千葉 剛久, 那須 嘉資雄1960 年 8 巻 10 号 p. 933
発行日: 1960/10/25
公開日: 2008/03/31
ジャーナル フリーPDF形式でダウンロード (280K) -
多賀 淳一1960 年 8 巻 10 号 p. 934-935
発行日: 1960/10/25
公開日: 2008/03/31
ジャーナル フリーPDF形式でダウンロード (403K) -
野副 鉄男, 竹下 斉, 伊東 椒, 大関 孝夫, 瀬戸 秀一1960 年 8 巻 10 号 p. 936-937
発行日: 1960/10/25
公開日: 2008/03/31
ジャーナル フリーPDF形式でダウンロード (360K)
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