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Volume 8, Issue 5
Displaying 1-20 of 20 articles from this issue
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Tatsuo Ohta, Yo Mori, Chiaki Noda, Toru Aoki1960 Volume 8 Issue 5 Pages 377-379
Published: May 25, 1960
Released on J-STAGE: March 31, 2008
JOURNAL FREE ACCESSThe leaves of Ruta graveolens L. contained skimmianine and kokusaginine. The latter was hydrogenated to give 2, 3-dihydrokokusaginine, which was identical with 4, 6, 7-trimethoxy-2, 3-dihydrofuro [2, 3-b] quinoline prepared from 4, 6, 7-trimethoxy-3- (2-ethoxyethyl) carbostyril by cyclization with polyphosphoric acid.View full abstractDownload PDF (441K) -
Fumiyoshi Ishikawa, Akihiko Nomura, Tohru Ueda, Morio Ikehara, Yoshihi ...1960 Volume 8 Issue 5 Pages 380-384
Published: May 25, 1960
Released on J-STAGE: March 31, 2008
JOURNAL FREE ACCESSAcetolysis of 2', 3', 5'-tri-O-benzoylguanosine with glacial acetic acid, acetic anhydride, and sulfuric acid gave rise to 1-O-acetyl-2, 3, 5-tri-O-benzoyl-β-D-ribofuranose in a fairly good yield (overall yield from guanosine was 50%). This method will afford a most convenient procedure for preparing 1-O-acetyl-2, 3, 5-tri-O-benzoyl-β-D-ribofuranose which is a key intermediate in the synthesis of ribonucleosides and ribonucleotides. The direct acetolysis is one of the rare cases in which N-glycosides are easily acetolyzed without cleavage of the furanoside ring. Some observations on hydrolysis and acetolysis of 2', 3', 5'-tri-O-benzoylguanosine were also described.View full abstractDownload PDF (632K) -
Mitsuru Uchiyama, Tyunosin Ukita1960 Volume 8 Issue 5 Pages 384-388
Published: May 25, 1960
Released on J-STAGE: March 31, 2008
JOURNAL FREE ACCESSAluminum citrate, aluminum tricarballylate, and aluminum lactate were prepared to test their activity for insolubilization of the phosphate, both in vitro and in vivo, and for facilitating the excretion of administered radioactive strontium, in comparison with those of dihydroxyaluminum aminoacetate, which was previously reported as an effective agent for elimination of strontium. According to the results of experiments in vitro, aluminum tricarballylate and aluminum lactate have a stronger tendency to make phosphate insoluble, but aluminum citrate has almost no activity. In the case of experiment in vivo, on the contrary, aluminum citrate showed a considerable inhibition of gastrointestinal absorption of phosphate, and moreover, it showed no untoward effect on the growth of animals, while the other two salts seem to reduce their appetite. The effect of aluminum citrate on the elimination of strontium is shown in Tables I and II. By aluminum citrate treatment, 60% of administered 90Sr was excreted in 24 hours and 70% in 6 days, compared with respective 35% and 45% in control animals.View full abstractDownload PDF (637K) -
Shigeru Yoshida1960 Volume 8 Issue 5 Pages 389-394
Published: May 25, 1960
Released on J-STAGE: March 31, 2008
JOURNAL FREE ACCESSInfrared absorptions of benzoic acid, its esters and chloride, and their para-substituted derivatives in the region of 900∼650 cm-1 were examined. It was revealed that an extra band, similar in nature to the CH deformation vibration, was present in these compounds and considerations were made on the origin of the extra band. Clarification of this extra band enabled clarification of CH deformation band.View full abstractDownload PDF (625K) -
Shichiro Akiya, Otomatsu Hoshino1960 Volume 8 Issue 5 Pages 395-398
Published: May 25, 1960
Released on J-STAGE: March 31, 2008
JOURNAL FREE ACCESSThe fraction G previously isolated from Micrococcus lysodeikticus mainly consists of a muco-complex. This fraction was further purified by both electrodialysis and zone electrophoresis to separate a small amount of impurities and to obtain a single muco-complex, GIIs. The latter gave a single spot which migrated towards the anode in paper electrophoresis. The homogeneity of GIIs was further investigated by Tiselius electrophoresis and ultracentrifugation. Several measurements of physicochemical properties of GIIs, viscosity, molecular weight, osmotic pressure, and electrometric titration, were carried out. From these results, the muco-complex, GIIs, was established to be a mucopolysaccharidelike substance having a molecular weight of nearly 100, 000.View full abstractDownload PDF (548K) -
Shichiro Akiya, Otomatsu Hoshino1960 Volume 8 Issue 5 Pages 399-404
Published: May 25, 1960
Released on J-STAGE: March 31, 2008
JOURNAL FREE ACCESSThe hydrolysate of muco-complex fraction (GII), isolated from Micrococcus lysodeikticus, was submitted to combined paper electrophoresis and paper chromatography, and was found to contain glucose, glucosamine, alanine, glycine, glutamic acid, lysine, and muramic acid. The last one was identified with the authentic specimen of muramic acid. The nature of the primary amino group of its peptide parts was investigated by dinitrophenylation of the muco-complex. Further, several components of the complex were quantitatively analysed.View full abstractDownload PDF (664K) -
Otomatsu Hoshino1960 Volume 8 Issue 5 Pages 405-410
Published: May 25, 1960
Released on J-STAGE: March 31, 2008
JOURNAL FREE ACCESSA muco-complex (fraction GII) obtained from Micrococcus lysodeikticus in a preparative scale was hydrolyzed with lysozyme and the hydrolysate was fractionated into several components. From one of the fractions, a disaccharide consisting of acetylglucosamine and acetylmuramic acid was isolated. Further, a sequence of peptide linkage, -Lys-Ala- (Ala-Gly), in the muco-complex was established.View full abstractDownload PDF (670K) -
Otomatsu Hoshino1960 Volume 8 Issue 5 Pages 411-416
Published: May 25, 1960
Released on J-STAGE: March 31, 2008
JOURNAL FREE ACCESSA purified lysozyme-hydrolysis product of muco-complex obtained from M.lysodeikticus was further investigated by hypoiodite and periodate oxidations as well as by electrometric titration to elucidate the structure of O-(N-acetylmuramic acid)-(1→4)-N-acetylglucosamine. The enzymatic specificity of lysozyme for a proposed structure of the muco-complex was discussed.View full abstractDownload PDF (686K) -
Yoshio Hirose1960 Volume 8 Issue 5 Pages 417-426
Published: May 25, 1960
Released on J-STAGE: March 31, 2008
JOURNAL FREE ACCESSSyntheses of damnacanthal, damnacanthol, norjuzunal and norjuzunol, the coloring matters of Damnacanthus spp. were described. The structures of juzunal and juzunol were synthetically established respectively as 2-formyl-and 2-hydroxymethyl-1-methoxy-3, 5-dihydroxyanthraquinone. These pigments are the first example of 1, 3, 5-trihydroxyanthraquinones occurring in nature.View full abstractDownload PDF (1194K) -
Yoshinobu Sato, Tadahiro Iwashige, Tetsuo Miyadera1960 Volume 8 Issue 5 Pages 427-435
Published: May 25, 1960
Released on J-STAGE: March 31, 2008
JOURNAL FREE ACCESSNew type 2, 3-disubstituted pyridine lactones were prepared from 2-methylnicotinic acid. The lactones, 2-hydroxymethylnicotinic acid lactone and 2-hydroxymethylpyridine-3-acetic acid lactone, were reacted with various amines to form the corresponding lactams, and the lactams were reduced with lithium aluminium hydride, yielding pyrrolopyridine and 1, 7-naphthyridine derivatives which possessed a fair degree of hypotensive action.View full abstractDownload PDF (968K) -
Tyunosin Ukita, Masachika Irie1960 Volume 8 Issue 5 Pages 436-440
Published: May 25, 1960
Released on J-STAGE: March 31, 2008
JOURNAL FREE ACCESSFor the purpose of isolation and quantitative estimation of the hydrolysis products of FAD, ion exchange column chromatography was used. The hydrolysates were fractionated stepwise from Dowex-1 (Cl-) with two systems of combined solvents : (1) Water, 0.002N hydrochloric acid, and 0.01N hydrochloric acid+0.04N ammonium chloride, and (2) 0.1N ammonium chloride and 0.1N ammonium chloride+0.01N hydrochloric acid. The former solvent system could effectively separate FR, AMP, FMP with FAD, and cyFMP, and the latter AMP, FMP with cyFMP, and FAD. The combined use of these two solvent systems was shown to effect clear-cut separation of the flavin nucleotides and adenine nucleotide contained in the hydrolysate of FAD.View full abstractDownload PDF (577K) -
Nobuo Itoh1960 Volume 8 Issue 5 Pages 441-444
Published: May 25, 1960
Released on J-STAGE: March 31, 2008
JOURNAL FREE ACCESSSynthesis of 1-acetonyl-6, 7-dimethoxy-3, 4-dihydroisoquinoline (IV) was described. On treatment with boiling phosphoryl chloride this underwent a smooth prototropic change to form isoxazole derivative (II) in almost theoretical yield, which had been described previously. Some chemical evidence in support of the structure of (II) was also provided.View full abstractDownload PDF (587K) -
Morizo Ishidate, Yoshio Sakurai, Hiroshi Imamura, Ayako Moriwaki1960 Volume 8 Issue 5 Pages 444-448
Published: May 25, 1960
Released on J-STAGE: March 31, 2008
JOURNAL FREE ACCESSMore than 200 derivatives of 2-chloroethylamine were tested as to their anti-tumor effect on the in vitro-cultured Yoshida sarcoma cells. The results were discussed, especially in connection with conditions of activation of N-methyl-bis(2-chloroethyl)amine N-oxide by the tumor cells.View full abstractDownload PDF (566K) -
Hiroshi Imamura1960 Volume 8 Issue 5 Pages 449-454
Published: May 25, 1960
Released on J-STAGE: March 31, 2008
JOURNAL FREE ACCESSReductive activation of the N-oxide derivatives of 2-chloroethylamine by living cells was discussed in detail and it was found that this experimental method was useful for finding a suitable means of masking of anti-tumor agents with latent activity.View full abstractDownload PDF (575K) -
Tohru Ueda1960 Volume 8 Issue 5 Pages 455-458
Published: May 25, 1960
Released on J-STAGE: March 31, 2008
JOURNAL FREE ACCESSThe syntheses of 5-substituted uridines and their 5'-phosphates were described. 5-Bromo-2', 3'-isopropylideneuridine was phosphorylated with phosphoryl chloride and from the mixture of 5-Bromo-UMP, -UDP, and -UTP obtained, 5-Bromo-UMP was isolated by ion exchange chromatography. Phosphorylation of 5-bromo-2', 3'-isopropylideneuridine with polyphosphoric acid afforded 5-Bromo-UMP in a good yield. 5-Hydroxyuridine and its 5'-phosphate were synthesized by the addition of bromine to uridine or UMP and successive treatment with pyridine. 5-Morpholinouridine and its isopropylidene derivative were obtained from corresponding 5-bromo derivatives and morpholine, and 5-Morpholino-UMP was obtained by phosphorylation of 5-morpholino-2', 3'-isopropylideneuridine with polyphos phoric acid.View full abstractDownload PDF (553K) -
Tohru Ueda1960 Volume 8 Issue 5 Pages 459-463
Published: May 25, 1960
Released on J-STAGE: March 31, 2008
JOURNAL FREE ACCESSβ-D-Glucose 1-phosphoramidate was synthesized by the reaction of silver benzyl phosphoramidate and acetobromoglucose, and successive hydrogenation and deacetylation. The structure of (VII) was confirmed by acid hydrolysis and optical rotation. The amidate had no ability to form pyrophosphate by phosphorolysis with another phosphate, as the other phosphoramidates do, but afforded the β-D-glucose 1, 2-cyclic phosphate, due to the specific configuration which was favorable to intramolecular cyclization. Some discussion was made about this cyclization.View full abstractDownload PDF (578K) -
Tohru Ueda1960 Volume 8 Issue 5 Pages 464-468
Published: May 25, 1960
Released on J-STAGE: March 31, 2008
JOURNAL FREE ACCESSSyntheses of UDP-β-glucose and 5-Bromo-UDPG was attempted to investigate the stereospecificity of coenzyme UDPG. UMP-amidate and monobrucinium β-D-glucose 1-phosphate were reacted in pyridine, and UDP-β-glucose was obtained as its lithium salt by the aid of ion exchange chromatography. The structure of (VII) thus obtained was ascertained by acid hydrolysis. 5-Bromo-UMP was converted to the phosphoramidate and reacted with α-D-glucose 1-phosphate. 5-Bromo-UDPG was detected on paper chromatogram and ion exchange chromatogram, but the yield was low and 5-Bromo-UMP and another by-product were detected.View full abstractDownload PDF (590K) -
Ken'ichi Takeda, Taichiro Komeno1960 Volume 8 Issue 5 Pages 468-474
Published: May 25, 1960
Released on J-STAGE: March 31, 2008
JOURNAL FREE ACCESSWhen steroidal 11α, 12α-, 11β, 12β-, and 9β, 11β-epoxides were each treated with thiocyanic acid, the corresponding thiocyanatohydrins were obtained. The thiocyanato and hydroxyl groups of these ring-fission products were assumed to be trans and diaxial to each other by Barton's generalization, and from infrared and ultraviolet data. This was also confirmed by chemical methods.View full abstractDownload PDF (810K) -
Hirotaka Otomasu, Kei Yoshida1960 Volume 8 Issue 5 Pages 475-478
Published: May 25, 1960
Released on J-STAGE: March 31, 2008
JOURNAL FREE ACCESS2-Hydroxyquinoxaline was nitrated with potassium nitrate in conc. sulfuric acid and formed 2-hydroxy-6-nitroquinoxaline, m.p. 306°, in 77% yield. This was treated with dimethyl sulfate and 1-methyl-2-oxo-6-nitro-1, 2-dihydroquinoxaline, m.p. 213°, was obtained, which was also prepared by the condensation of 1-methylamino-2-amino-4-nitrobenzene with butyl glyoxylate.View full abstractDownload PDF (503K) -
Suminori Umio, Kazuma Nishitsuji1960 Volume 8 Issue 5 Pages 479-482
Published: May 25, 1960
Released on J-STAGE: March 31, 2008
JOURNAL FREE ACCESSIn the synthesis of 17β-hydroxyandrostan-3-one from 3β-acetoxy-5-androsten-17-one, carbonyl group at 17-position is reduced to 17β-hydroxyl almost quantitatively by means of sodium borohydride without accompanying saponification of 3-ester. By catalytic hydrogenation over Raney nickel under high pressure and heating, double bond at 5-6 position of the steroidal B-ring is saturated and the trans-form is produced. In this case, aromatic ring at 17-ester is first reduced, followed by the double bond at 5-position. 3-Hydroxyl is oxidized to 3-keto group in a good yield on heating with activated alumina and cyclohexanone in nonpolar solvent. Finally, 17-ester is saponified quantitatively to 17β-hydroxyandrostan-3-one.View full abstractDownload PDF (533K)
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