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Volume 8, Issue 7
Displaying 1-20 of 20 articles from this issue
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Makoto Yokoo1960 Volume 8 Issue 7 Pages 571-574
Published: July 25, 1960
Released on J-STAGE: March 31, 2008
JOURNAL FREE ACCESSUtilizing the reaction of its secondary amino group, proline in proteins was determined in the presence of other amino acids. The material proteins were first hydrolyzed and then allowed to react with nitrous acid to convert the proline therein into N-nitrosoproline, when all the other amino acids were changed into the corresponding hydroxy acids. N-Nitrosoproline was then reduced to N-aminoproline with zinc dust and hydrochloric acid, and finally the N-amino compound was determined by azotometry by oxidation with potassium ferricyanide. Incidentally, the secondary amino group in the ring of tryptophan, histidine, and prolidine, and the guanidine group of arginine do not interfere with the present method.View full abstractDownload PDF (518K) -
Shoji Takemura1960 Volume 8 Issue 7 Pages 574-577
Published: July 25, 1960
Released on J-STAGE: March 31, 2008
JOURNAL FREE ACCESSRacemonic acid, obtained from the hydrolysate of racemomycin-O in company with β-lysine, roseonine, and glucosamine, was studied. First, the corresponding aldehyde, racemonic aldehyde, was isolated from the ether extract and the acid was obtained as an oxidation product of the aldehyde. Structural studies of this acid were carried out and its structure was determined as (V) by degradation and synthesis. On the basis of these results, racemonic aldehyde (VIII) was found to be a new component of this antibiotic.View full abstractDownload PDF (511K) -
Shoji Takemura1960 Volume 8 Issue 7 Pages 578-582
Published: July 25, 1960
Released on J-STAGE: March 31, 2008
JOURNAL FREE ACCESSRacemomycin-O is composed of β-lysine, roseonine, glucosamine, racemonic aldehyde, carbon dioxide, and ammonia. The linkage of these moieties was examined mainly using paper chromatographic techniques. The proposed structure of racemomycin-O is formulated as (IX).View full abstractDownload PDF (543K) -
Shichiro Akiya, Toshiaki Osawa1960 Volume 8 Issue 7 Pages 583-587
Published: July 25, 1960
Released on J-STAGE: March 31, 2008
JOURNAL FREE ACCESSN, N-Phthaloyl-1-bromo-3, 4, 6-tri-O-acetyl-1-deoxy-β-D-glucosamine (III) reported in Part IV1) of this series is the first example of 1, 2-trans-acetobromo-sugar obtained in glucose and glucosamine series. Several replacement reactions at C-1 position of (III) as well as properties of several new N, N-phthaloyl derivatives of D-glucosamine were described in the present paper. From the results of these reactions, it was concluded that the replacement reaction at C-1 position of N, N-phthaloyl derivatives of D-glucosamine gave β-anomers and there was some steric hinderance for the formation of α-anomers.View full abstractDownload PDF (698K) -
Shichiro Akiya, Toshiaki Osawa1960 Volume 8 Issue 7 Pages 588-591
Published: July 25, 1960
Released on J-STAGE: March 31, 2008
JOURNAL FREE ACCESSSeveral replacement reactions at C-1 position at C-1 position of N, N-succinyl derivatives of D-glucosamine are described. From the results of these reactions, it was concluded that the replacement reactions at C-1 of N, N-succinyl derivatives of D-glucosamine gave mainly β-anomers and there is still some steric hinderance for the formation of α-anomers, as in the case of N-phthaloyl derivatives.View full abstractDownload PDF (522K) -
Shichiro Akiya, Toshiaki Osawa1960 Volume 8 Issue 7 Pages 592-597
Published: July 25, 1960
Released on J-STAGE: March 31, 2008
JOURNAL FREE ACCESSComparative studies on the acid hydrolysis and periodate oxidation of methyl N-acyl-β-D-glucosaminides were carried out. Results of these reactions were discussed in relation to the properties of N-acyl groups.View full abstractDownload PDF (673K) -
Toshiaki Osawa1960 Volume 8 Issue 7 Pages 597-610
Published: July 25, 1960
Released on J-STAGE: March 31, 2008
JOURNAL FREE ACCESSChlorination reactions of 1, 3, 4, 6-tetra-O-acetyl-N-acyl-β-D-glucosamines at C-1 position were studied and it was found that these reactions suffered remarkable electronic effect of N-acyl groups. The mechanism of these reactions is discussed.View full abstractDownload PDF (1314K) -
Ko Kaneko1960 Volume 8 Issue 7 Pages 611-614
Published: July 25, 1960
Released on J-STAGE: March 31, 2008
JOURNAL FREE ACCESSIt was found that dl-phenylalanine [2-14C] and dl-methionine [methyl- 14C]are respectively incorporated into the α-carbon of the side chain and methyl-carbon of methoxyl group in anethole molecule produced by Foeniculum vulgare MILLER, in vivo.View full abstractDownload PDF (552K) -
Ken'ichi Takeda, Tokuo Kubota, Jun'ichi Kawanami1960 Volume 8 Issue 7 Pages 615-620
Published: July 25, 1960
Released on J-STAGE: March 31, 2008
JOURNAL FREE ACCESSThe reaction between 4-cholesten-3-one (IV) and thiocyanic acid was investigated and it has been confirmed that thiocyanic acid was added to α, β-unsaturated ketone system to yield 5α-isothiocyanatocholestan-3-one. By this addition reaction, a number of isothiocyanato derivatives of steroidal hormones were prepared.View full abstractDownload PDF (688K) -
Ken'ichi Takeda, Taichiro Komeno, Jun'ichi Kawanami1960 Volume 8 Issue 7 Pages 621-625
Published: July 25, 1960
Released on J-STAGE: March 31, 2008
JOURNAL FREE ACCESSTreatment of methyl 3α-acetoxy-11β-thiocyanato-12α-chloro(or-mesyloxy)cholanate with alkali or lithium aluminium hydride afforded 11β, 12β-episulfides, which could not be further reduced to the 11β-thiol by various reagents.View full abstractDownload PDF (663K) -
Kyosuke Tsuda, Toshinobu Asai, Yoshihiro Sato, Tokuji Tanaka, Takemasa ...1960 Volume 8 Issue 7 Pages 626-628
Published: July 25, 1960
Released on J-STAGE: March 31, 2008
JOURNAL FREE ACCESSDas Dihydroxyprogesteron, welches von diesen Autoren durch Einwirkung von Syncephalastrum racemosum auf Progesteron (I) einst gewonnen wurde und damals nach dem Strukturzeichen von 7α, 15β-Dihydroxyprogesteron genannt wurde, ergibt sich diesmal bei der Umsetzung von (I) sowie von 7β-Hydroxyprogesteron (II) mit Diplodia tubericola. Aus diesen Tatsachen sowie aus den Ergebnissen der vorherigen Mitteilungen ist ersichtlich, dass das richtige Strukturzeichen des Dihydroxyprogesterons 7β, 15β-Dihydroxyprogesteron (III) ist.View full abstractDownload PDF (421K) -
Toshiro Murata1960 Volume 8 Issue 7 Pages 629-633
Published: July 25, 1960
Released on J-STAGE: March 31, 2008
JOURNAL FREE ACCESSPaper chromatography was carried out on the urine of rabbits and men receiving 1-ethynylcyclohexyl carbamate. The chromatogram revealed the presence of six spots by the Tollens reagent and three of them were assumed to be the metabolites, degradation products of the carbamate. One of them was identified as the hydroxylated ethynylcyclohexyl carbamate which was also obtained by extraction of the urine of man receiving 1-ethynylcyclohexyl carbamate. Another spot on the chromatogram was assumed to be that of a conjugated form of the metabolite such as the glucuronide which had been reported by McMahon.View full abstractDownload PDF (519K) -
Yoshinobu Nakai, Yoshio Kubo1960 Volume 8 Issue 7 Pages 634-640
Published: July 25, 1960
Released on J-STAGE: March 31, 2008
JOURNAL FREE ACCESSDisintegration of magnesium oxide granules and tablets was studied by thermal analysis. Disintegration was affected by the quantity of binder and disintegrator, and by granule size. The time at which surface area of disintegrated granule reached the maximum was constant, independent of size and quantity of binder and disintegrator. The effect of compressional force on tablet disintegration was examined and the values and deviations of U.S.P. method and the time, t3, at which all tablet dissolves increased exponentially with larger compressional force. In contrast with this, values of t2 increased linearly with larger compressional force and deviation was smaller than that of U.S.P. method and t3. The values of t2 seemed of value in examining disintegration and it was estimated that U.S.P. and t3 represent localized properties of tablet in disintegration. Integral surface area and th e product of maximum surface area and t3 were both independent of compressional force and the former gave smaller deviation than the latter. It could be seen from this result that when values of t3 increased, the maximum surface area decreased conversely.View full abstractDownload PDF (611K) -
Yoshinobu Nakai1960 Volume 8 Issue 7 Pages 641-646
Published: July 25, 1960
Released on J-STAGE: March 31, 2008
JOURNAL FREE ACCESSTheoretical considerations were made and fundamental experiments were carried out for thermal analysis by heat of solution. Acetylsalicylic acid -0.5M sodium citrate solution system was used and it was determined that thermal analysis was possible within a limit concentration of 0.6g./100cc. The particle-size distribution of acetylsalicylic acid powder was measured thermally and compared with microscopic method. Linear relationship was observed between particle diameter by microscopic method and solution time by thermal analysis. Disintegration processes of marketed tablets was elucidated by thermal analysis of heat of solution, same as the heat of reaction.View full abstractDownload PDF (513K) -
Tatsuo Ohta, Toshio Miyazaki, Susumu Mihashi1960 Volume 8 Issue 7 Pages 647-648
Published: July 25, 1960
Released on J-STAGE: March 31, 2008
JOURNAL FREE ACCESSTrifolin, C21H20O111 1/2H2O, the kaempferol 3-galactoside, m.p.236°(decomp.), was isolated from the air-dried, half-opened, white flowers of peach tree, Prunus Persica BATSCH, in 0.037% yield.View full abstractDownload PDF (368K) -
Eisaku Hayashi, Hiroshi Yamanaka, Chihoko Iijima, Shizuo Matsushita1960 Volume 8 Issue 7 Pages 649-652
Published: July 25, 1960
Released on J-STAGE: March 31, 2008
JOURNAL FREE ACCESSCatalytic reduction of 4, 4'-azopyridine 1, 1'-dioxide (I) in methanol with Raney nickel catalyst at atmospheric temperature and pressure results in formation of 4, 4'-hydrazopyridine (IV) via 4, 4'-azopyridine (V). The same reduction with palladium-carbon as a catalyst affords 4, 4'-hydrazopyridine 1, 1'-dioxide (VI) and the reduction stops at this stage. This shows that the reduction of N-oxide group precedes that of azo to hydrazo group when using Raney nickel as a catalyst, but reduction of the azo to hydrazo group alone takes place when palladium-carbon is used as a catalyst. In the case of 4, 4'-azoxypyridine 1, 1'-dioxide (II), the use of Raney nickel as a catalyst effects reduction of (II) to (IV) through (I) and (V), while the use of palladium-carbon produces (VI) through (I). In this case, reduction of azoxy to azo group is the first step and the rest is the same as in the case of (I). In the case of 2-styrylpyridine 1-oxide (III), reduction of N-oxide group precedes that of the double bond and 2-phenethylpyridine (VII) is formed via 2-styrylpyridine (VIII). When palladium-carbon is used as the catalyst, reduction of the double bond is said to precede that of N-oxide group and (VII) is formed via 2-phenethylpyridine 1-oxide (IX). This is in contrast to the use of Raney nickel as a catalyst.View full abstractDownload PDF (531K) -
Yoshio Ban, Osamu Yonemitsu1960 Volume 8 Issue 7 Pages 653-655
Published: July 25, 1960
Released on J-STAGE: March 31, 2008
JOURNAL FREE ACCESSThe enamine, 9, 10-dimethoxy-3, 4, 6, 7-tetrahydro-2H-benzo[a]quinolizine, which was isolated by basifying the aqueous solution of the corresponding immonium chloride, was proved to be reconverted into the immonium cation when dissolved in 85% ethanol to a concentration of ca. 10-4M. The equilibrium between the two is discussed based on its ultraviolet absorption spectra at various pH values.View full abstractDownload PDF (416K) -
Yoshio Sakurai, Keiichi Ito1960 Volume 8 Issue 7 Pages 655-656
Published: July 25, 1960
Released on J-STAGE: March 31, 2008
JOURNAL FREE ACCESSDownload PDF (334K) -
Daisuke Satoh, Hiroshi Ishii, Yohko Oyama1960 Volume 8 Issue 7 Pages 657-658
Published: July 25, 1960
Released on J-STAGE: March 31, 2008
JOURNAL FREE ACCESSDownload PDF (343K) -
Tetsuji Kametani, Yukio Nomura1960 Volume 8 Issue 7 Pages 658-660
Published: July 25, 1960
Released on J-STAGE: March 31, 2008
JOURNAL FREE ACCESSDownload PDF (338K)
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