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Volume 9, Issue 9
Displaying 1-14 of 14 articles from this issue
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Tadashi Fujita, Akira Ayada, Yoshitaka Mushika1961Volume 9Issue 9 Pages 661-665
Published: September 25, 1961
Released on J-STAGE: March 31, 2008
JOURNAL FREE ACCESSIt became questionable that Dechamps, et al.8) obtained carnitine-carnitate (IV) in their hands as the hydrolysis product of carnitine-nitrile chloride (II), since in our hands the latter, when heated with conc. hydrochloric acid at 130°, yielded mainly apocarnitine hydrochloride (V) containing a certain amount of carnitine hydrochloride (III). By carrying out the hydrolysis of (II) at boiling water-bath temperature the formation of (V) was practically suppressed to give (III) in a satisfactory yield, the formation of (IV) was altogether not observed.View full abstractDownload PDF (577K) -
Yukiho Kubota1961Volume 9Issue 9 Pages 666-675
Published: September 25, 1961
Released on J-STAGE: March 31, 2008
JOURNAL FREE ACCESSA method was described whereby the ether-and water-soluble DNP-amino acids are separated by one-and two-dimensional paper chromatography. The method was applied, as examples, to the N-terminal group analysis of bovine plasma albumin and qualitative amino acid analysis of parotin.View full abstractDownload PDF (1075K) -
Morizo Ishidate, Yoshio Sakurai, Masahiro Torigoe1961Volume 9Issue 9 Pages 676-679
Published: September 25, 1961
Released on J-STAGE: March 31, 2008
JOURNAL FREE ACCESSSeveral derivatives of N-(2-substituted ethoxy)-2, 2'-dichlorodiethylamine were prepared and tested for their latent antitumor activity against Yoshida sarcoma. Mode of activation of these compounds was also discussed.View full abstractDownload PDF (574K) -
Morizo Ishidate, Yoshio Sakurai, Kenichi Sawatari1961Volume 9Issue 9 Pages 679-684
Published: September 25, 1961
Released on J-STAGE: March 31, 2008
JOURNAL FREE ACCESSDerivatives of nitrogen mustard having metal chelate-forming activity and their copper chelates were prepared and their chemical properties and their chemical properties and their antitumor effect on Yoshida sarcoma were discussed.View full abstractDownload PDF (685K) -
Kanzo Sasaki1961Volume 9Issue 9 Pages 684-692
Published: September 25, 1961
Released on J-STAGE: March 31, 2008
JOURNAL FREE ACCESSKitigenin has its four hydroxyl groups all on ring A. One of them is a tertiary, C5-hydroxyl group, since it resists oxidation and acetylation. Subsequently, kitigenin was converted to 4-hydroxy-25D-spirost-4-en-3-one and 25D-spirostan-3β, 4ξ, 5ξ-triol, synthesized from diosgenone. Therefore, it was determined that the three hydroxyl groups are located at C3, C4, and C5 and that the configuration of the C3-hydroxyl group is β and the C4- and C5-hydroxyl groups are in cis relation.View full abstractDownload PDF (993K) -
Kanzo Sasaki1961Volume 9Issue 9 Pages 693-703
Published: September 25, 1961
Released on J-STAGE: March 31, 2008
JOURNAL FREE ACCESSIt has been already established that the three hydroxyl groups in kitigenin, a tetrahydroxy sapogenin, are located at C3, C4 and C5, and that the C3-hydroxyl group is β and the C4- and C5-hydroxyl groups are in cis relation. It is now, clarified that the one remaining hydroxyl group is situated at C1, from the result of the conversion of kitigenin to 25D, 5α-spirostan-1-one synthesized independently from tigogenone. And also, from the results of the C3, C4-acetonide formation and C1, C5-sulfite formation, it was clarified that the four hydroxyl groups are all β. Consequently, it was determined that kitigenin is 25D, 5β-spirostane-1β, 3β, 4β, 5-tetrol.View full abstractDownload PDF (1128K) -
Takeo Naito, Miyoshi Hirata, Tomoyoshi Kawakami, Mitsuji Sano1961Volume 9Issue 9 Pages 703-708
Published: September 25, 1961
Released on J-STAGE: March 31, 2008
JOURNAL FREE ACCESSAs a new method for synthesis of pyrimidine nucleoside, synthesis of glycosylthymine from glycosylurea was carried out. As a model experiment, pyrimidine cyclization was examined with N-methylurea and N-methylthiourea with methyl 2-methyl-3-methoxyacrylate, 2-methyl-3-methoxyacryloyl chloride, and ethyl β-formylpropionate. Starting from 1-D-glucosylurea and 1-D-arabinosylurea, protecting the hydroxyls in the sugar portion by acetylation, condensation with 2-methyl-3-methoxyacryloyl chloride afforded the intermediates, (XI) and (XV), and their cyclization successfully produced 1-β-D-glucopyranosylthymine and 1-D-arabinosylthymine.View full abstractDownload PDF (742K) -
Takeo Naito, Mitsuji Sano1961Volume 9Issue 9 Pages 709-714
Published: September 25, 1961
Released on J-STAGE: March 31, 2008
JOURNAL FREE ACCESSSynthesis of glycosyl-2-thiothymine from glycosylthiourea was carried out. Acetylation of 1-β-D-glucopyranosylthiourea with acetic anhydride, glacial acetic acid, and perchloric acid was found to give 1-(tetra-O-acetyl-β-D-glucosyl) thiourea and it was condensed with 2-methyl-3-methoxyacryloyl chloride. Cyclization of its product afforded 1-β-D-glucopyranosyl-2-thiothymine. In a similar manner, thiourea, prepared from tri-O-benzoyl-D-ribofuranosyl chloride through isothiocyanate, afforded 1-β-D-ribofuranosyl-2-thiothymine by the same method. The structure of all the compounds synthesized was established.View full abstractDownload PDF (751K) -
Toshio Miyazaki1961Volume 9Issue 9 Pages 715-718
Published: September 25, 1961
Released on J-STAGE: March 31, 2008
JOURNAL FREE ACCESSCapsular polysaccharide of Cryptococcus neoformans CRD-1 was isolated by Einbinder's method and purified by zone electrophoresis with starch gel and borate buffer (pH 10.0) or acetate buffer (pH 5.0). This material (potassium salt) showed physical constants of [α]15D +15.5° (c=0.775) and [η]=20 (c=g./100 cc.), and was positive to Molisch, Bial, and naphthoresorcinol reactions, but negative to iodine, biuret and Ninhydrin reactions. On infrared spectrum, its potassium salt showed the presence of carboxylate ion.View full abstractDownload PDF (590K) -
Yoshikata Kuwayama1961Volume 9Issue 9 Pages 719-721
Published: September 25, 1961
Released on J-STAGE: March 31, 2008
JOURNAL FREE ACCESSDihydrodictamnine was prepared in a fairly good yield by the catalytic reduction of 2-(α-methoxy-ο-nitrobenzylidene)-γ-butyrolactone in the presence of an equivalent amount of hydrochloric acid.View full abstractDownload PDF (459K) -
Kikuo Igarashi1961Volume 9Issue 9 Pages 722-729
Published: September 25, 1961
Released on J-STAGE: March 31, 2008
JOURNAL FREE ACCESSThe structure of meteogenin, isolated from the rhizome of Metanarthecium luteoviride MAXIM., was shown to be 1-methyl-19-nor-25D-spirosta-1, 3, 5 (10)-trien-11α-ol (IIa). The relationship between luvigenin (I) and meteogenin (IIa) was established, and at the same time it was proved that the direction of the dienol-benzene rearrangement varied according to the presence of the double bond at C6 or of the C11-ketone.View full abstractDownload PDF (935K) -
Kikuo Igarashi1961Volume 9Issue 9 Pages 729-735
Published: September 25, 1961
Released on J-STAGE: March 31, 2008
JOURNAL FREE ACCESSWhen meteogenone (II) was refluxed in diluted alkaline solution, two kinds of ketols, (IV) and (V), in place of C9-epimeteogenone were obtained in a good yield. The newly introduced hydroxyl groups were synthetically confirmed to be located at C9 and the comformations of those groups were also established from the infrared and ultraviolet spectraas well as from the rotation values.View full abstractDownload PDF (811K) -
Kyosuke Tsuda, Toshinobu Asai, Yoshihiro Sato, Tokuji Tanaka, Hiroko H ...1961Volume 9Issue 9 Pages 735-739
Published: September 25, 1961
Released on J-STAGE: March 31, 2008
JOURNAL FREE ACCESSBei der Inkubation von Progesteron mit Helminthosporium sativum lieβen sich zwei Monohydroxy-und drei Dihydroxy-progesterone gewinnen. Drei davon erwiesen sich als identisch mit den bekannten Verbindungen, namlich 15α-und 15β-Hydroxyprogesteron, und 7β, 15β-Dihydroxyprogesteron. Fur die ubrigen Hydroxylierungsprodukte wurde nach dem chemischen Verhalten die Struktur von 7α, 15β-Dihydroxy-bzw. von 14α, 15β-Dihydroxyprogesteron erteilt.View full abstractDownload PDF (682K) -
Hiroko Hasegawa, Yoshihiro Sato, Tokuji Tanaka, Kyosuke Tsuda1961Volume 9Issue 9 Pages 740-744
Published: September 25, 1961
Released on J-STAGE: March 31, 2008
JOURNAL FREE ACCESSEs wird das chemische Verhalten des 15β- bzw. des 15α-Hydroxyprogesterons gegen p-Toluolsulfonsaure, p-Toluolsulfochlorid und Phosphoroxychlorid beschrieben. Dabei wird gezeigt, daβ sich das 15β-bzw. 15α-Hydroxyl wie die axiale bzw. aquatoriale Hydroxyl-Gruppe in der Cyclohexanreihe verhalt.View full abstractDownload PDF (604K)
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