2-R-5-R'-s-Triazolo[3, 4-b]-1, 3, 4-thiadiazoles (V) were synthesized starting with 2-hydrazino-5-R-1, 3, 4-thiadiazole (III : R=CH
3, C
2H
5, n-C
3H
7, iso-C
4H
9, C
6H
5), reacting them with either ethyl orthoacylate or ethyl acylimidate (R'=H, CH
3, C
2H
5, n-C
3H
7, n-C
4H
9) to form ethyl N'-(5-R-1, 3, 4-thiadiazol-2-yl) hydrazonoacylate (IV), and cyclization with acetic acid. Treatment of (III) by heating with 80% formic acid produced 2-R-s-triazolo[3, 4-b]-1, 3, 4-thiadiazole (V, R'=H).
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