Chemical and Pharmaceutical Bulletin
日本薬学会は,1880年に創立された,我が国では歴史ある学会の一つです.現在,約18000人の会員を擁しており,毎月3誌の学術誌を刊行しております.英文による学術誌の一つとして「Chemical and Pharmaceutical Bulletin」(Chem. Pharm. Bull.)は, 1953年にPharmaceutical Bulletinとして創刊され,その後Chem. Pharm. Bull. と名称を変え,薬学と健康科学に関する化学分野をカバーしています.二つ目として,「Biological and Pharmaceutical Bulletin」(Biol. Pharm. Bull.) があり,これは1978年に創刊されたJournal Pharmacobio-Dynamicsを起源としており,更に1953年に創刊され,2012年に内容を引き継いだJournal of Health Scienceの後継誌として,薬学と健康科学に関する生物学分野を領域としています.英文と和文両方にて構成される学術誌として,「YAKUGAKU ZASSHI」(薬学雑誌)があり,本学術誌は学会創立の翌年(1881年)に創刊され,最も長い歴史を有しています.薬学雑誌では,和文による原著論文・総説等のほか,臨床薬学領域研究については英文による投稿も受け付けています. 日本薬学会におけるこれら学術誌のスコープは,基礎研究から臨床研究に至る幅広い分野に渡りますが,いずれも薬学・健康科学をベースとしています。3誌に投稿された論文の平均審査期間は,現在,投稿された方へ最初の判定を通知するまでに約1か月ですが,更なる時間短縮を目指しています.3誌ともにJ-STAGEにて無料公開しており,研究成果を世に広める一助となることを期待しております.皆様の研究成果をChem. Pharm. Bull.やBiol. Pharm. Bull.,薬学雑誌へ積極的にご投稿下さいますよう,よろしくお願い申し上げます.

大槻 純男

収録数 27,709本
(更新日 2021/01/16)
Online ISSN : 1347-5223
Print ISSN : 0009-2363
ISSN-L : 0009-2363
2019 Journal Impact Factor (JIF)
ジャーナル 査読 フリー HTML 早期公開
Scopus Pubmed
69 巻 (2021) 1 号 p. 48-51
Four New Pregnane-10,2-carbolactones from an Epipolasis sp. Marine Sponge もっと読む

The extract of an Epipolasis sp. marine sponge collected in the Republic of Palau provided four new pregnane 10,2 carbolactone derivatives. The structures of these rare pregnane analogues were fully elucidated through HRMS measurements and detailed analysis of their one- and two-dimensional NMR spectroscopic data. Pregnane steroids possessing a 10,2-carbolactone ring have only been reported previously from Hawaiian collections of Myrmekioderma and Petrosia (Stongylophora) sponges, so the current results suggest this class of steroid is more widely distributed in the marine environment than previously recognized.

69 巻 (2021) 1 号 p. 72-80
Phase Separation in Lipid Lamellae Result from Ceramide Conformations and Lateral Packing Structure もっと読む

The packing structure of intercellular lipids in the stratum corneum plays a critical role in the skin’s barrier function. The mechanism of packing structure disruption is not fully understood. The authors constructed models for collapsed skin intercellular lipids composed of short-chain free fatty acids and α-hydroxy ceramide. To investigate the packing structure’s characteristics, they changed the lipid composition and used temperature-scanning, simultaneous small-angle and wide-angle X-ray diffraction to determine resulting structural changes. The results suggest a change in ceramide conformation into a V-shape structure. The authors discussed the relationship between the V-shape structure formation and a reduction in the skin’s barrier function.

69 巻 (2021) 1 号 p. 92-98
Characteristics of Raw and Acid-Activated Bentonite and Its Application for Improving Electrical Conductivity of Tap Water もっと読む

Authors evaluate the characteristics of acid-activated bentonite by focusing on its capability of improving the quality of tap water used during wire electrical discharge machining. This study shows that the acid activation of bentonite using sulfuric acid, nitric acid, and phosphoric acid solutions increases the specific surface area and pore volume. Additionally, authors revealed that the relationship between the concentrations of the removed ions and electrical conductivity were negatively correlated (correlation coefficient: -0.950). Thus, the acid-activated bentonite is useful in controlling the reduction in the electrical conductivity of tap water.

69 巻 (2021) 1 号 p. 118-123
Absolute Purity Determination of a Hygroscopic Substance, Indocyanine Green, Using Quantitative NMR (qNMR) もっと読む

Quantitative NMR (qNMR) has emerged as a new absolute quantitation method for small molecules. Authors examined the absolute purity determination of a hygroscopic substance indocyanine green (ICG) using qNMR. The three different humidity conditions yielded comparable purity means of 86.12 ± 2.70%, 84.19 ± 0.47%, and 82.26 ± 0.19% under non-controlled humidity, controlled humidity using a saturated NaBr solution, and using a constant temperature and humidity box, respectively. As the results using the constant temperature and humidity box showed the lowest variability, it is recommended to use it if the reference standard of ICG with its purity value is needed for Japanese Pharmacopoeia assays.

69 巻 (2021) 1 号 p. 124-140
β-Selective Glycosylation Using Axial-Rich and 2-O-Rhamnosylated Glucosyl Donors Controlled by the Protecting Pattern of the Second Sugar もっと読む

Stereoselectivity in chemical glycosylation frequently varies in reaction substrates. This paper describes the influence of the protecting groups on rhamnose connected to the 2-O position of a glucosyl donor with axial-rich conformation on stereoselectivity in its glycosylation with cholestanol. The authors revealed that two bulky silyl groups existing at the 3-O and 4-O positions of rhamnose synergistically enhanced β-selectivity. In contrast, the silyl group introduced to the 2-O position decreased the selectivity. These results suggest that appropriately designing a protecting-group pattern for another sugar far from the reaction center of a glycosyl donor can control the stereoselectivity of glycosylation.

月間アクセス数ランキング 2020年12月
  • Chem. Pharm. Bull. Vol. 69 No. 1
    Current Topics: Pharmaceutical Research for Quality Evaluation and Characterization of Foods and Natural Products
  • Chem. Pharm. Bull. Vol. 68 No. 12
    Current Topics: New Era of Polyphenol Research