Chemical and Pharmaceutical Bulletin
日本薬学会は,1880年に創立された,我が国では歴史ある学会の一つです.現在,約18000人の会員を擁しており,毎月3誌の学術誌を刊行しております.英文による学術誌の一つとして「Chemical and Pharmaceutical Bulletin」(Chem. Pharm. Bull.)は, 1953年にPharmaceutical Bulletinとして創刊され,その後Chem. Pharm. Bull. と名称を変え,薬学と健康科学に関する化学分野をカバーしています.二つ目として,「Biological and Pharmaceutical Bulletin」(Biol. Pharm. Bull.) があり,これは1978年に創刊されたJournal Pharmacobio-Dynamicsを起源としており,更に1953年に創刊され,2012年に内容を引き継いだJournal of Health Scienceの後継誌として,薬学と健康科学に関する生物学分野を領域としています.英文と和文両方にて構成される学術誌として,「YAKUGAKU ZASSHI」(薬学雑誌)があり,本学術誌は学会創立の翌年(1881年)に創刊され,最も長い歴史を有しています.薬学雑誌では,和文による原著論文・総説等のほか,臨床薬学領域研究については英文による投稿も受け付けています. 日本薬学会におけるこれら学術誌のスコープは,基礎研究から臨床研究に至る幅広い分野に渡りますが,いずれも薬学・健康科学をベースとしています。3誌に投稿された論文の平均審査期間は,現在,投稿された方へ最初の判定を通知するまでに約1か月ですが,更なる時間短縮を目指しています.3誌ともにJ-STAGEにて無料公開しており,研究成果を世に広める一助となることを期待しております.皆様の研究成果をChem. Pharm. Bull.やBiol. Pharm. Bull.,薬学雑誌へ積極的にご投稿下さいますよう,よろしくお願い申し上げます.

細谷 健一

収録数 27,369本
(更新日 2019/05/22)
Online ISSN : 1347-5223
Print ISSN : 0009-2363
ISSN-L : 0009-2363
2017 インパクトファクター
ジャーナル 査読 フリー HTML 早期公開
67 巻 (2019) 5 号 p. 397-403
Nickel-Catalyzed Hydrocyanation of Allenes and Its Application もっと読む

Regioselective cyanation of simple and non-activated carbon–carbon bonds catalyzed by nickel complexes is described. This protocol enables to use of the substituted allenes for regio- and stereocontrolled transformations and their applications for cyclization, 3-component coupling reaction, heterocycle formation as well as natural product synthesis are demonstrated. The author reveals the origin of the above selectivity by axial chirality transfer process using optically active allenes as substrates. Steric bulk of substituents is found to be a key factor for discrimination of allenyl carbon–carbon double bonds in hydrometallation step.

67 巻 (2019) 5 号 p. 439-444
Measurement of Linezolid and Its Metabolites PNU-142300 and PNU-142586 in Human Plasma Using Ultra-Performance Liquid Chromatography Method もっと読む

This paper describes the development and validation of a method for measuring linezolid and its metabolites PNU-142300 and PNU-142586 in human plasma, using ultra-performance liquid chromatography (UPLC) method. This method enables the simultaneous measurement of these three components within 3 min. Further, plasma concentrations of linezolid, PNU-142300 and PNU-142586 in patients treated with linezolid could be measured. The developed method is a useful tool for therapeutic drug monitoring and clinical pharmacokinetic/pharmacodynamic (PK/PD) profiling of linezolid, as well as for dose optimization during treatment.

67 巻 (2019) 5 号 p. 461-466
Study on Control of pH-Modulation Crystallization Utilizing Concept of Dissociation Equilibrium もっと読む

3-Alkenyl cephem compound is a pharmaceutical intermediate. It is typically crystalized by pH adjustment method. However, since the filtration time in the solid-liquid separator is a bottleneck in the production, there is a need to control crystal morphology while changing the pH. This study could be shorten filtration time by pH-modulation operation that repeating the crystallization operation in the vicinity of solubility. The obtained monodisperse particles were like a pseudo-growth body in which a large number of primary particles were aggregated and increased, rather than being a crystallite growth.

67 巻 (2019) 5 号 p. 476-480
The Revised Structure of the Cyclic Octapeptide Surugamide A もっと読む

Surugamide A, a non-ribosomal peptide with cathepsin B inhibitory activity, and its closely related derivatives, surugamides B-E are cyclic octapeptides produced by several Streptomyces species. All these peptides except for surugamide B contain a D-Ile residue that involve Cβ-epimerization step during its biosynthesis. However, the genes responsible for this conversion is absent in the biosynthetic gene cluster of surugamides. To clarify this issue, surugamide A containing D-Ile as well as its epimer having D-allo-Ile were synthesized. HPLC and Marfey’s analyses showed that surugamide A actually possesses D-allo-Ile instead of D-Ile, requiring structural collection of this group of peptides.

月間アクセス数ランキング 2019年04月
  • Chem. Pharm. Bull. Vol. 67 No. 4
    Current Topics: Recent Progress in Biophysical Research of Biological Membrane Systems

  • Chem. Pharm. Bull. Vol. 67 No. 3
    Current Topics: Drug Discovery: Recent Progress and the Future