Numerous clinical studies have suggested that the greater risk for oral bone loss in females may be correlated with osteoporosis after menopause. Knowledge of trabecular changes in edentulous bedding bone in animals with loss of ovarian function may be beneficial in the planning and treating of dental implants in postmenopausal women. The purpose of this study was to evaluate trabeculae changes in edentulous bedding bone for dental implantation in ovariectomized rabbits. Twelve adult female Japanese white rabbits were examined. The mandibular incisors were initially extracted to simulate the edentulous bedding bone for dental implants. Six animals were bilaterally ovariectomized and the other 6 were sham-ovariectomized 12 weeks after tooth extraction. The edentulous parts of distal mandibular bodies were processed undecalcified 12 weeks after ovariectomy or sham-ovariectomy and examined by quantitative trabecular bone histomorphometry. In ovariectomized rabbits, there were significant increases in trabecular separation, osteoid volume, osteoid thickness, osteoid width, eroded surface, and mineral appositional rate, and a significant decrease in trabeculae number. The results of sparser trabecular structure, more trabecular osteoid, and increased trabecular bone turnover demonstrate bone loss of mandibular edentulous trabeculae in ovariectomized rabbits and suggest that the same loss may occur in postmenopausal women
Drug-induced gingival overgrowth is one of the side effects associated with several drugs. The definitive modality for treatment of drug-induced gingival overgrowth has been still discussed. Drug-induced gingival overgrowth in 15 patients who had undergone several types of treatment was classified according to gingival type. Based on these results, the treatment of drug-induced gingival overgrowth is discussed. Discontinuation of the drug resulted in disappearance of gingival overgrowth in 3 cases regardless of gingival type. Drug administration was continued in 12 cases. When dark red and soft gingiva (inflammatory type) was observed, the overgrowth gingiva was treated effectively by debridement. Where patients had pink and elastic gingiva (fibrous type) however, debridement produced no improvement in the condition. Patients in whom both inflammatory and fibrous gingiva (combined type) was observed, some improvement as a result of debridement was noted. Patients of either fibrous type or combined type required follow-up periodontal surgery to correct the problem completely. Based on these results, discontinuation of drug administration should be considered. When this is not possible, treatment should be prescribed according to the enlarged gingival type.