The two parameters, K and λ
1 or which were obtained by the two-compartment model analysis of bone scintigraphy show the values specific to individual bone disease in maxillofacial region. We assumed the K to be the saturated accumlation of the tracer in bone blood pools in region of interest (ROT) and the λ
1 to be the transition speed of the radioisotope from bone blood pools to the bone. The formar and the latter reflect the amount of blood flow and bone metabolism, respectively. These two parameters are thought out by mathematical analysis theoretically. Therefore we produced experimental bone disease models and revealed the meaning of the two parameters. The following results were obtained.
1) Femoral arteries and veins in rabbits were ligated by suture to induce tibial bone blood flow. The K was compared with the bone blood flow obtained by clearance of hydrogen gas generated by electrolysis.
(1) The computer-generated curve obtained by the two-compartment model analysis approximately accorded with the time-activity curve by dynamic bone scintigraphy. This rusult suggests the correctness of this two-compartment model analysis.
(2) Both the K ratio (K/K': K' as contralateral accumulation) and the bone blood flow ratio (blood flow at ROT/blood flow at contralateral side) showed significant decrease after the ligation.
(3) The K ratio was correlated with the bone blood flow ratio at less than 1% level (correlation coefficient: 0.75). Therefore, we think the K is a parameter representing bone blood flow as we assumed. 2) Tibial bone in rabbits was inoculated with 4-nitroquinoline-n-oxide to induce tibial bone metabolism. The λ
1 and the bone mineral density (BMD) by quantitative computerized tomography were determined 1, 2, 3 and 4weeks after inoculation, and the λ
1 was compared with BMD.
(1) Both the BMD and the amount of radioisotope transported from bone blood pool to bone from one after inoculation to 4weeks (∫
4week1week λ
1·Kdt) increased as the week proceeds.
(2) The ∫
4week1week λ
1·Kdt was correlated with BMD which increased during the same period of time at less than 0.1 % level (correlation coefficient: 0.91). The λ
1 which was assumed to be the transition speed of radioisotope from bone blood pool to bone was found to be an index for an increase in BMD.
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