Shika Hoshasen

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This study investigated immunological changes in Th1/Th2 and Tc1/Tc2 balances due to Nedaplatin-assisted radiation therapy in patients with oral squamous cell carcinoma.
The subjects were 25 patients with oral squamous cell carcinoma (SCC group) and were compared with 24 cancer-free patients (control group) whose ages were almost the same as those in the SCC group. In the SCC group, 20 patients, who were treated with Nedaplatin-assisted radiation therapy, were investigated before and after treatment. The number of lymphocytes, CD4⁺ T cells and CD8⁺ T cells were measured. Furthermore, the percentage of Th1 cells, Th2 cells, Tc1 cells and Tc2 cells were measured by the intracellular cytokine method.
The following results were obtained:
1. In the comparison between control group and SCC group, the number of lymphocytes, CD4⁺ T cells and CD8⁺ T cells, and Th1/Th2 ratio and Tc1/Tc2 ratio did not change significantly. However, the percentage of Th1 cells and Th2 cells increased significantly in the SCC group, although the percentage of Tc1 cells and Tc2 cells did not change significantly.
2. The number of lymphocytes, CD4⁺ T cells and CD8⁺ T cells decreased significantly, and the percentage of Th1 cells, Th2 cells, Tc1 cells and Tc2 cells, and Th1/Th2 ratio and Tc1/Tc2 ratio did not change significantly after Nedaplatin-assisted radiation therapy.
These results indicated that the Nedaplatin-assisted radiation therapy has immunological merit, because it did not influence either the Th1/Th2 balance or the Tc1/Tc2 balance.

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We report a patient with jaw trismus demonstrating Square-Mandible face.
Clinically, the patient had a square face with prominent masseter muscles and mandibular angles. The interincisal opening was 26mm, with limited lateral and anteroposterior mobility.
The clinical diagnosis was restricted mouth opening due to bilateral hyperplasia of the masseter muscle aponeuorses. Masseter muscle myotomy with aponeurectomy was performed bilaterally by an intraoral approach. Mouth opening improved to 40mm after incision of the aponeuroses.
An examination of the patient one year after surgery demonstrated an interincisal opening of 37mm without strain.

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