Shika Hoshasen
Online ISSN : 2185-6311
Print ISSN : 0389-9705
ISSN-L : 0389-9705
Volume 9
Displaying 1-4 of 4 articles from this issue
  • A STUDY OF EFFECTS BY X-RAY IRRADIATION ON FETAL ERYTHROPOIESIS
    Norio TAKEDA, Naonori TAMAKI, Ryuiti YOSINAGA, Yosisige FUJIKI
    1968 Volume 9 Pages 1-7
    Published: 1968
    Released on J-STAGE: October 21, 2010
    JOURNAL FREE ACCESS
    The fetal erythropoiesis of mouse and the effects of x-ray irradiation on fetal erythropoiesis were investigated by tritiated thymidine autoradiography.
    1) On the 11th day of gestation, labeling index of erythroblasts in the peripheral blood, consist of mainly pronormoblasts, was about 50 %. On the 12th day of gestation, most of the pronormoblasts were differenciated to the normoblast and labeling index reduced only 0.7%. On the 13th day of gestation, unlabeled uncleated erythrocytes and also denucleation began to appear in the peripheral blood.
    2) The liver on the 12th day of gestation developed well as the hematopoietic organ.Many newly formed pronormoblasts and normoblasts were seen in the hepatic parenchyma.
    3) The labeling indices of erythroblasts in the peripheral blood after x-ray irradiation with 200 R on the 11th day of gestation, were not different from the control at various stages of the fetal growth.
    4) Labeled cells of the fetal blood were decreased slightly after x-ray irradiation on the 11th day of gestation. But on the 12th day of gestation, labeled cells were increased rapidly in the peripheral blood following 100 R or 200 R x-ray irradiation. This increase was confirmed histologically due to the emission of pronormoblasts and normoblasts out of the liv
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  • Hajime FUCHIHATA, Yoshimasa TOKUNAGA, Tsutomu FUJII, Yoshishige FUJIKI ...
    1968 Volume 9 Pages 8-17
    Published: 1968
    Released on J-STAGE: October 21, 2010
    JOURNAL FREE ACCESS
    A hundred patients with malignant tumors of head and neck regions treated by irradiation at the Department of Radiology, Osaka University Medical School, from January 1965 to December 1966, were reviewed and discussed on radiation stomatitis.
    A criteria of stage-classification for radiation stomatitis according to objective and subjective symptoms adding to pathological findings was proposed by the authors.
    The course of stomatitic changes was divided into five stages. the latent stage, the initial stage, the middle stage, the maximal stage, and the reparative stage. And according to the intensity of lesion, the middle stage was subdiv lied into two grades: the early middle stage and late middle stage.
    The initial stage is indicated by thirstiness due to the disturbance of salivary secretion, disgeusia, hyperemia, and marked edema. The middle stage is indicated by dysgeusia or hypogeusia, causlgia, and spontaneous and stinging pain subjectively, and objectively thin pseudomembrane, and small erosion and ulcer; the early middle stage is indicated by a solitary pseudomembrane, erosion and ulcer, and in the late middle stage, those are widespread pan-orally. The maximal stage is indicated by ageusia, severe pain, wide and thick pseudo-membrane, hemorrhagic ulcer and necrosis.
    Acording to this criteria, those cases were analysed, and radiation stomatitis associated with radiation therapy was studied with reg ard to the site of lesion, the irradiation method, and the dose-time relationship.
    Ninety-nine of 100 cases revealed the early middle stage of radiation stomatitis with an administered dose of 1500-2500 R/5-22 days. And 57 of 99 cases of the early middle stage advanced to the late middle stage in 2400-5800 R/16-45 days level. the maximal stage of radiation stomatitis was found in 13 of 100 cases.
    The repair of stomatitic changes used to occur for 1 or 2 weeks after irradiation discontinued. In cases the muosal reaction was below the early middle stage, it finishes a primary healing for 2 or 3 weeks. It, however, asks for 1 or 3 months to repair the disturbance of salivary secretion and dysgeusia. On the other hand, in cases the mucosal reaction was above the late middle stage, it is scarecely found the repairing signs of irradiated salivary glands clinically and histologically (experimental study) after a year or more the radiation therapy discontinued.
    A relationship between the advance of radiation stomatitis and the irradiated site was as follows in cases irradiated upper half of oral cavity such as carcinomas of maxillary antrum or hard palate, mucosal reaction appeared later, allowing larger administered dose, than in cases irradiated lower half of oral cavity chiefly, such as carcinomas of lower jaw, tongue and floor of the mouth, or than in cases of tonsil and pharynx tumors irradiated nasopharynx chiefly.
    And it was found that in cases irradiated with large field, mucosal reaction appeared more early and severely than in cases with small field.
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  • Masatugu SHIMIZU, Ken-ichi MICHI, Saburo SEKIYAMA, Akira KOTANI, Tadas ...
    1968 Volume 9 Pages 18-25
    Published: 1968
    Released on J-STAGE: October 21, 2010
    JOURNAL FREE ACCESS
    A 30 years old female refered us because of ulcer and pain of the tongue on 15th, July in 1961. The lesion was localized at the right borber of the tongue and diagnosed as squamouse cell carcinoma by biopsy. The tumour was relatively small in size and treated by the implantation of radon seeds of 14 m Ci with estimated dose 8, 000 R. The reccurences were observed repeatedly after this treatment. And these were treated by radiation therapy (90-Sr and superficial irradiation by x-rays). The total dose delivered was about 40, 000 R during 13 months of over all time.
    But the succesful treatment results were not obtained.
    Finally, the tumour is operated by hemi-glossectomy. Histological findings show that the operation was complete.
    Presently, after 6 years from operation, she keeps normal conditions.
    From the end result of this case, the radiation therapy was of the limited value except the radon seed implantation applied at the first chance. This case show the importance of the combination of surgery and radiation therapy and the difficulity of choice of the adequate period when the second method is applied.
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  • 1968 Volume 9 Pages 26-46
    Published: 1968
    Released on J-STAGE: October 21, 2010
    JOURNAL FREE ACCESS
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