巻号一覧
64 巻 (2024)
- 2 号 p. 35-
- 1 号 p. 1-
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解説
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大庭 伸介, 池田 悠希2025 年 64 巻 2 号 p. 35-39
発行日: 2025年
公開日: 2025/04/17
ジャーナル フリーMammalian skeleton is formed through two distinct modes of ossification （intramembranous ossification and endochondral ossification） from three distinct origins （neural crest, paraxial mesoderm, and lateral plate mesoderm）. Cell type-distinct transcription factors are supposed to construct gene regulatory networks （GRNs）, which underlie the process of skeletal development. Although Sox9, Runx2, and Sp7 have been shown as master transcription factors for skeletal development, their genome-scale actions remain to be elucidated. Here we review our recent studies, which are designed to understand skeletal GRNs by taking advantage of next-generation sequencer （NGS）-based studies and human pluripotent stem cell-based modeling of skeletal development.抄録全体を表示PDF形式でダウンロード (482K)
臨床
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和田 大岳, 音成 実佳, 中島 啓, 有泉 高晴, 松元 秀樹, 佐藤 仁美, 渡邊 章, 松坂 賢一, 後藤 多津子2025 年 64 巻 2 号 p. 40-45
発行日: 2025年
公開日: 2025/04/17
ジャーナル フリーOsteoid osteoma is a benign osseous neoplasm. On radiography, it presents as multiple spotted or scattered calcified masses surrounded by a radiolucent rim. Differential diagnoses include fibro-osseous lesions and osteogenic tumors. Histopathologically, it is composed of immature trabeculae and osteoids as well as osteoblasts in the intertrabecular bone. It typically occurs in the femur and tibia; however, cases in jawbones are rare. Herein, we present a case of osteoid osteoma that occurred at the predilection site of torus mandibularis, focusing on the imaging findings and diagnosis.
A 30-year-old woman presented with pain and swelling on the lingual side of her second premolar in the left mandible. Intraoral findings revealed a hard, bone-like swelling from the canine to the second premolar, with slight redness and contact pain in the mucosa.
Panoramic radiography revealed an oval radiopaque lesion with a radiolucent border superimposed on the alveolar margins of the mandibular left lateral incisor to the first premolar. CT revealed an inhomogeneous high-density mass with a low-density rim at the left torus mandibularis, suggesting a tumorous lesion.
The lesion was resected. Histopathology confirmed osteoid osteoma. Several months later, the patient reported pain at the resection site, and CT revealed coarse bone margins. A second resection was performed, and histopathology showed recurrence. No further recurrence was noted after the second surgery.
Osteoid osteoma should be considered as a differential diagnosis when a painful lesion smaller than 2cm presents in the mandible, particularly if imaging shows a radiopaque mass with a radiolucent rim, despite its rare occurrence in the jawbone.抄録全体を表示PDF形式でダウンロード (1327K) -
久米 咲子, 栗林 亜実, 中村 伸, 大山 潤, 前原 健寿, 菅原 貴志, 三浦 雅彦2025 年 64 巻 2 号 p. 46-50
発行日: 2025年
公開日: 2025/04/17
ジャーナル フリーEpidermoid cysts are benign lesions of epithelial origin that account for 1％ of all intracranial masses. Epidermoid cysts are frequently found in the cerebellopontine angle and tend to progress slowly. However, they can cause symptoms such as trigeminal neuralgia due to their involvement with the cranial nerves and surrounding organs. Herein, we report a case of an epidermoid cyst that was first detected with trigeminal neuralgia-like symptoms.
A man in his 50s was referred to our dental clinic with a complaint of left facial pain lasting several seconds that occurred while shaving or washing his face. Left trigeminal neuralgia was suspected, and magnetic resonance imaging （MRI） was performed. Although no clear lesions were noted on T1-FLAIR and T2-weighted imaging, T2-SPACE revealed the presence of a heterogeneous signal intensity area in the cerebrospinal fluid. A mass lesion was suspected, and the patient was referred to our neurosurgery department. Diffusion-weighted imaging showed a high-signal area extending from the bridge to the anterior surface of the midbrain, leading to a diagnosis of a epidermoid cyst. The lesion completely encircled the left trigeminal nerve and was in contact with multiple cranial nerves. The patient underwent craniofacial mass excision. He experienced left mixed hearing loss and nystagmus complications; however, both subsequently resolved. The patient remains under observation, but trigeminal neuralgia has not recurred.
Approximately 80％ of trigeminal neuralgia patients initially seek care from a dentist; therefore, dentists should include intracranial lesion as a differential diagnosis and conduct MRI to investigate the cause.抄録全体を表示PDF形式でダウンロード (575K)
テクニカルリポート
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前田 直樹, 吉田 みどり, 誉田 栄一, 吉原 穂積, 水頭 英樹, 鳥井 浩平, 阪間 稔, 細木 秀彦2025 年 64 巻 2 号 p. 51-56
発行日: 2025年
公開日: 2025/04/17
ジャーナル フリーObjectives: We aimed to develop a method to accurately evaluate the image distortion caused by the rotating system of cone beam computed tomography （CBCT） for dental use and to assess its accuracy.
Materials and Methods: A 100μm diameter tungsten wire was suspended along a plumb line using a hanging weight inside an acrylic cylindrical container. Images of the wire were acquired using a dedicated dental CBCT machine. Reconstructed images perpendicular to the rotation axis （Z-axis） were obtained with a slice thickness of 80μm and a slice interval of 80μm. The images were converted to 16-bit TIFF files, and an average pixel value image was created from seven scans. Image distortion was evaluated through image subtraction using ImageJ 1.54d.
Results and Discussion: In the enlarged average pixel value image, the tungsten wire appeared rectangular rather than circular in shape. Subtraction of individual images from the average pixel value image revealed no noticeable differences. However, examining subtraction images at different vertical positions of the tungsten wire indicated that the image deviated by approximately 400μm between positions 4 cm above and below the center. This deviation is likely due to eccentricity in the rotation axis, suggesting that the CBCT machine has an accuracy error of several pixels.抄録全体を表示PDF形式でダウンロード (955K)
写真供覧
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嶋田 雄介, 小嶋 郁穂, 飯久保 正弘2025 年 64 巻 2 号 p. 57-59
発行日: 2025年
公開日: 2025/04/17
ジャーナル フリーPDF形式でダウンロード (461K)
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