To evaluate the possible difference in efficacy between brand name and generic formulations of 10% urea moisturizers, we examined their effects on dried skin models in fifteen healthy subjects. Each urea cream, either brand name and generic, was applied twice daily for 10 days, and the water content of the stratum corneum was compared. Among the results, one of the generic creams showed a significant increase in water content compared to other moisturizers. In general, if generic substitutions are used for brand name formulations, physicians must be aware that there might be a significant reduction in therapeutic effectiveness. However, one of the generic urea moisturizers had a higher moisturizing capacity than the brand name.
View full abstract