Epidemiological survey of junior high school and high school students in Kurume city was conducted to determine the frequency of tinea pedis in Japanese teenager. The results of the survey showed that the frequency rate of all students (total: 1,068, male: 993, female: 75) was 1.97% (male: 2.10%, female: 0%). Most of cases were interdigital type. All isolates identified by morphological characteristics were Trichophyton mentagrophytes. Sequence analysis of fungal DNA revealed all isolates were Trichophyton mentagrophytes var. interdigitale/Arthroderma vanbreuseghemii. The frequency rate of students in a dormitory was higher than that of day students. Although our study showed that the frequency rate of tinea pedis in Japanese teenager was relatively low, it is considered that tinea pedis should be treated aggressively to prevent transmissions in school life.
We report the case of a 60-year-old woman with a solitary nodule on the right cheek. Histopathologically, the lesion showed a well-circumscribed nodule in the dermis that was composed mainly of two cell types, type I and type II cells. The former were small lymphocyte-like cells with dark nuclei, and the latter were larger cells with pale vesicular nuclei and abundant eosinophilic cytoplasm. The type I cells were grouped concentrically around type II cells and formed pseudorosettes. Immunohistochemically, the type II cells and most of the type I cells were S100 protein positive, but only the type II cells were CD57 positive. Immunohistochemical studies for S100 protein and CD57 revealed that the type II cells contained copious cytoplasm endowed with a network of slender dendritic cell extensions. Based on these histopathological and immunohistochemical findings, we diagnosed our case as dendritic cell neurofibroma with pseudorosettes (DCNWPR). DCNWPR is a rare peripheral nerve sheath tumor with highly characteristic histological features; to our knowledge, this is the first case report in Japan.
We experienced four patients with cetuximab-induced anaphylactic shock. The diagnosis of infusion reaction was primary given for them. Three of them had beef-specific IgE in their sera, and one of these three also had a history of flounder roe allergy, but none of them had a history of beef allergy. Anti-IgE antibodies against cetuximab and galactose-α-1,3-galactose (α-gal) were detected in the sera of all the patients by IgE-western blotting and CAP-FEIA. These data suggest that the causative allergen of the cetuximab-induced anaphylactic shock was α-gal. We previously reported that clinicians should be aware of the possibility of cetuximab-induced allergy in the patients with red meat and/or flounder roe allergy because of their cross reactivity. The cases presented here confirm our above mentioned reports. Prior testing for anti-IgE antibodies against red meat, cetuximab, and α-gal could possibly prevent cetuximab-induced allergic reactions.