The Japanese Journal of Dermatology
Online ISSN : 1346-8146
Print ISSN : 0021-499X
ISSN-L : 0021-499X
Volume 124 , Issue 3
Showing 1-8 articles out of 8 articles from the selected issue
Committee Report
Seminar for Medical Education
Original Articles
  • Eriko Takayama, Kaori Nakata, Koji Chiyomaru, Akihisa Yamamoto, Kimiko ...
    2014 Volume 124 Issue 3 Pages 331-337
    Published: March 20, 2014
    Released: March 28, 2014
    A 76-year-old woman with a perianal erythema was found to have extramammary Paget's disease by histopathologic examination. The Paget's cells were immunohistochemically positive for CK20 and villin, but negative for CK7 and GCDFP15. These results strongly suggested that her lesion was secondary from ano-rectal adenocarcinoma. We decided to perform a laparoscopic abdomino-perineal resection in spite of the negative results of pre-operative proctoscopy and lower gastro interstitial endoscopy. Histologically, Paget's cells were seen in the epithelium throughout the perianal skin to the dentate line. In addition, there were some discrete foci of glandular structures composed of signet ring-like atypical cells in the submucosa of the dentate line. She was finally diagnosed with occult anal canal carcinoma secondary to perianal Paget's disease.
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Letter to the Editor