A 59-year-old male with brown macules on his trunk and extremities for 9 years was diagnosed with mycosis fungoides (MF) on the basis of skin manifestation and pathological findings. Topical application of corticosteroid and narrow-band UVB irradiation was administered. Two years later, a lesion arose and enlarged rapidly on left temporal skin, progressing to tumor stage. Ordinary treatments including interferon, chemotherapy, and/or radiotherapy could not be administered because of financial problems of the patient. A single-fraction palliative radiotherapy of 8 Gy electron beam was irradiated on the tumor at an outpatient clinic. The tumor vanished after two weeks, and fully epithelized after six weeks. Single fraction radiotherapy can be a useful method to control the tumor of MF when the patient can't undergo ordinary treatments. This is the first case of single-fraction palliative radiotherapy for an MF tumor in Japan.
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