We report a survey study based on the information in published in original or review article on treatment of patients with Rhododenol (RD) -induced leukoderma in order to evaluate effective treatment methods from a medical point of view and to inform the patients widely. Ultraviolet radiation therapy and vitamin D3 oral administration therapy were reported as effective treatments. As lifestyle guidance, self-tanning agents seemed to be useful for improving the quality of life of patients. Regarding the mechanism of onset of RD leukoderma, we gathered and described the latest information, including cytotoxicity and involvement of the immune system.
The occurrence of venous thromboembolism (VTE) in patients presenting with dermatological conditions is not completely understood. We analyzed 3,988 hospitalized patients at our university hospital over the past 11 years to investigate the presence of VTE in patients presenting with dermatological conditions. Among the patients studied, 56 underwent contrast computed tomography for suspected VTE, and the occurrence of a thrombus was confirmed in 19 of them. VTE was also detected incidentally in 6 patients. An analysis performed on the basis of disease showed the highest incidence of VTE occurred in patients with malignant tumors, and the highest rate of VTE in patients with bullous disease showed. Based on this study, we propose preventive measures against VTE in patients undergoing dermatological surgery.
Bowenoid papulosis (BP) is characterized by brown to black papules frequently occurring on the external genitalia. BP usually has a benign prognosis, but rarely progresses to Bowen's disease and squamous cell carcinoma. Therefore, it is necessary to distinguish it from other benign lesions, especially seborrheic keratosis (SK) and pigmented condyloma acuminatum (CA). However, it is difficult to diagnose BP only by clinical manifestations. We investigated BP suspected nine cases by histopathological findings and the typing of human papilloma virus using PCR. Five of them were diagnosed as BP, two as pigmented CA, and two as SK. Then, we immunostained each case for p16INK4a (p16) and examined the expression of p16 pattern in BP and in other benign tumors. Immunostaining for p16 seems to be very useful in diagnosing BP.