Although normal-appearing skin among the lesion of Bowen's disease has been thought to represent partial spontaneous regression of the tumor, only a few reports describe the spontaneous regression of Bowen's disease. Herein we report a case of 68-year-old female with a 40×35 mm erythematous patch on her left upper arm. The patient noticed the patch 3 years before seeking treatment. She was initially treated with topical corticosteroids because two biopsies performed in different dermatology clinic did not reveal any malignancy. When we performed a third biopsy, the diagnosis of Bowen's disease was finally established. Histopathological examination of the resected specimen disclosed that foci of atypical keratinocytes were scattered among almost normal-appearing epidermis with a dermal inflammatory infiltrate and fibrosis, which was thought to represent partial spontaneous regression. The characteristic finding was the presence of scattered epidermal nests of sebocytes in the regression areas. Additional biopsies should be considered when a single biopsy failed to demonstrate atypical keratinocytes in a lesion suspected of Bowen's disease. Further cases are needed to evaluate the relation between spontaneous regression and development of intraepidermal nests of sebocytes.
We report the case of a two year-old female infant who had had a slightly depressed lesion on the right lower abdomen which had an irregularly mixed pallor and dark red-colored erythema without local heat from birth. This lesion had remained unchanged for one year and eleven months since birth. Because it had remained unchanged in size and because the vascular endothelial cells were GLUT1 negative in immunohistochemical staining, we diagnosed her lesion as partially involuting congenital hemangioma (PICH) with lipoatrophy. The differential diagnosis was angioblastoma of Nakagawa (tufted angioma). Careful observation and GLUT1 stating in the immonohistochemical studies are important in diagnosing hemangioma in newborns and infants.