The Japanese Journal of Dermatology
Online ISSN : 1346-8146
Print ISSN : 0021-499X
ISSN-L : 0021-499X
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Volume 132, Issue 8
Displaying 1-12 of 12 articles from this issue
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Original Articles
  • Ten Psoriatic Patients with Development of COVID-19 Infection During Biologics Treatments
    Miya Ono, Yoshinori Umezawa, Masahiro Fukuda, Mami Momose, Akihiko Asa ...
    2022 Volume 132 Issue 8 Pages 1843-1848
    Published: July 20, 2022
    Released on J-STAGE: July 20, 2022
    DOIhttps://doi.org/10.14924/dermatol.132.1843
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    The coronavirus disease 2019 (COVID-19) pandemic has increased anxiety in patients regarding psoriasis treatment with biologics. However, the relationship between biological treatment and the severity of the symptoms of COVID-19 is still unclear.

    We investigated the relationship between the severity of the symptoms of COVID-19 and the patients' characteristics by retrospectively analyzing data from ten psoriasis patients who developed COVID-19 during treatment with biologics in our department from April 2020 to July 2021.

    None developed severe symptoms; six and four patients developed moderate and mild symptoms, respectively. Among risk factors, smoking was associated with increased severity of COVID-19 symptoms.

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  • An Analysis of Cytokine Profiles in Serum and Saliva of Palmoplantar Pustulosis Patients with Periodontitis
    Osamu Murai, Toshimi Chiba, Takashi Yaegashi
    2022 Volume 132 Issue 8 Pages 1849-1861
    Published: July 20, 2022
    Released on J-STAGE: July 20, 2022
    DOIhttps://doi.org/10.14924/dermatol.132.1849
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    The chronic inflammation of periodontitis has been reported as a risk factor for palmoplantar pustulosis (PPP). Therefore, we investigated cytokine levels in the serum and saliva of PPP patients. We also evaluated the correlation between eruption severity of PPP, clinical status of periodontal disease, and cytokine levels in the serum and saliva. A total of 10 PPP patients, 4 periodontitis patients without systemic disease, and 23 healthy subjects (controls) were enrolled. Bleeding on probing (BOP) and periodontal inflamed surface area (PISA), which is the inflamed area of the periodontal pocket, were also examined. The palmoplantar pustulosis area and severity index (PPPASI) were recorded as grades of eruption in PPP. Notably, the serum TNF-α and IL-17 in PPP patients were significantly increased compared to controls. Although serum TNF-α and IL-17 were somewhat elevated in periodontitis patients without systemic disease compared with controls, the difference was not significant. BOP and PISA in PPP patients with periodontitis showed significant positive correlation with PPPASI, serum IL-6 and IL-17. This investigation also found a marked increases in serum levels of the inflammatory cytokines, TNF-α and IL-17. In PPP patients with periodontitis, periodontal inflammation and serum IL-6 and IL-17 may be correlated with the developments of eruption in PPP.

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  • Skin Cancer Trends among Residents of the National Leprosy Sanatorium in Japan
    Mayumi Baba
    2022 Volume 132 Issue 8 Pages 1863-1868
    Published: July 20, 2022
    Released on J-STAGE: July 20, 2022
    DOIhttps://doi.org/10.14924/dermatol.132.1863
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    This paper is a reorganization of the National Leprosy Sanatorium Study "Frequency of Skin Cancer Occurrence in the National Leprosy Sanatorium Residents".

    The average age of residents of the National Leprosy Sanatorium in Japan is 87 years. As the population ages, we have examined the breakdown and trends of skin cancer and the frequency of scar cancers.

    In the last 10 years, 156 cases (Basal Cell Carcinoma: 25 cases, Bowen's disease: 17 cases, Actinic Keratosis: 84 cases, Squamous Cell Carcinoma: 28 cases, Malignant Melanoma: 2 cases) occurred at the 12 facilities that reported responses. There were many actinic keratosis in the head and face, and all squamous cell carcinoma that developed on the soles were scar cancers.

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Case Reports
  • A Case of CD56 and CD123 Negative Blastic Plasmacytoid Dendritic Cell Neoplasm Diagnosed by Immunostaining of Skin
    Yuya Nakanishi, Yoshimi Andou, Hiroshi Sakai, Tamotsu Yamagami
    2022 Volume 132 Issue 8 Pages 1869-1874
    Published: July 20, 2022
    Released on J-STAGE: July 20, 2022
    DOIhttps://doi.org/10.14924/dermatol.132.1869
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    The patient was an 85-year-old man who visited our department with a protruding lesion that, had appeared on his head one month earlier. Biopsy of the lesion revealed a nodular neoplastic lesion growing in the dermis. The tumor cells had oval vacuolar nuclei and large central nucleoli. They were positive for CD4, BDCA-2 (CD303), and TCL1 but negative for CD56, CD11c, MPO, CD79a, CD3, and CD123. Consequently, the condition was diagnosed as blastic plasmacytoid dendritic cell neoplasm (BPDCN). The clinical presentation, morphology of tumor cells, immunohistochemical staining images, and the positive results of FISH (fluorescence in situ hybridization) for 8q24 rearrangement suggest that this case has the characteristics of an immunoblastoid BPDCN associated with MYC expression.

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