From 2005 November through 2010 July, ten cases of feline mediastinal lymphoma which had been treated according to the University of Wisconsin-Madison chemotherapy protocol for dogs (UW 25) were surveyed retrospectively regarding complete remission rate, survival time, and adverse effects of this compound chemotherapy. The average complete remission rate was 90%. Six cats survived for less than one year, one of which is still alive. Another cat survived for over one year, and is still alive. Yet another cat survived for over two years, and is still alive. The remaining two survived for over three years, and one of them is still alive. In general, side effects were slight, and were cured with symptomatic treatment. This multi-agent protocol, UW 25, proved to be much better than conventional COP protocol in respect of survival time, showing that long-term survival could be achieved with its use.
This study is the first to investigate the intestinal parasites in kittens kept in pet shops in Japan. A total of 186 fecal samples were collected from kittens (less than three months old) of four pet shops in the Tohoku/Kanto Districts. Giardia spp. were examined with an ELISA kit, and the other intestinal parasites were determined microscopically using a formalin-ethyl acetate sedimentation technique. Overall prevalence was 19.4% (36/186) in all kittens, and only two species, protozoa Giardia spp. (9.7%: 18/186) and Isospora spp. (11.3%: 21/186) were detected. The total prevalence and the prevalence of Isospora in each shop were significantly different from each other. The results of this study suggest that there are serious problems in kittens raised in pet shops, namely, insanitary environment, and underestimation of the amount of intestinal protozoan parasites.
The efficacy of Plasmacluster Ion® (PCI) on bacteria and viruses has been proved, but its inhibitory effects on airborne bacteria and ammonia in the air are unknown. In this study, the effectiveness of PCI was tested using an experimental box, or a model of dogs' daily living space. Experimentally, a box equipped with a PCI generator was filled with gaseous ammonia, and 45 minutes after the device was started (7,000 or 25,000 ions/cm3), the concentration of ammonia was significantly reduced (p<0.05 and p<0.01, respectively). Further, in a model room where two caged dogs could eat and drink, two PCI generators were setup. Two weeks after the generators were turned on, the concentration of ammonia in the room had decreased by more than 50%, and continued to decrease day by day. In addition, the number of colonies of airborne bacteria was suppressed during the deodorization, but rebounded when the generators were turned off. From these results, it appears that PCI is useful for keeping an animal husbandry environment sanitary.
Objective : Since the sensitivity to prostacyclin differs widely depending on the animal species, it is essential to investigate the dose setting from the safety point of view before using beraprost (BPS) in diseased cats. Design : One week multiple administration toxicity study of BPS (10, 30, 70, 100 μg/kg, twice a day) compared with vehicle as control. Procedure : BPS group (n=6) at 10, 30, 70 and 100 μg/kg and vehicle group (n=5) were administered to healthy cats twice a day for 7 days. Both in BPS and vehicle groups, cessation period of the drug was provided 2 weeks between each doses of BPS. In addition hemodynamic parameters were also noted at 0.5 hour before initial administration on the first day and at 1 hour after final administration on the 7th day of each dose of BPS and vehicle. Results : Though BPS from 30 μg/kg upward transiently and dose-dependently increased the heart rate but had no influence on the blood pressure. Compared with the vehicle group, serum creatinine slightly but significantly decreased at 70 and 100 μg/kg and this decrease was also significant against the pre-administration value at the same dose. The influence of BPS on the blood parameters was nil or negligible, if any. Diarrhea were sporadically noted at 70 μg/kg, and mild and transient vomiting and sedation occurred at 100 μg/kg. However, each symptom soonerly disappeared without treatment. Conclusion : The pharmacological action and types of adverse effects of BPS in the cats were almost similar to those observed in other animals and the repeated oral administration of BPS can be safely conducted in cats at least up to 30 μg/kg twice a day.
A 12-year-old, female Shih Tzu was brought in because of a left forelimb swelling. X-rays and fine needle aspirates showed a mass in the distal antebrachium, and the lesion was tentatively diagnosed as a parosteal osteosarcoma. Ten days later, the left forelimb was amputated. Histopathologically, the disease was confirmed as parosteal osteosarcoma. In thoracic X-ray examinations, two definite pulmonary metastases were found on the 557th day after amputation, in spite of occasional chemotherapy with carboplatin. Because the tumors in the lung gradually grew larger, and coughing became severer, the cranial lobe of the left lung was removed on the 725th day after amuputation, and the postoperative course was good. However, on the 73rd day after the pulmonary metastasectomy, a number of small nodes were seen everywhere throughout the whole lung, indicating recurrence. Even so, the dog's quality of life was satisfactory, being almost free of coughing for six months after resection of the lung lobe. Finally the coughing worsened, and the dog died on the 230th day after metastasectomy, that is, 955 days after amputation.