A 5-month-old intact male Shiba Inu was presented with a history of neurological symptoms after meals. Based on medical history and clinicopathological findings, it was suspected that the patient had a portosystemic shunt (PSS). Computed tomography (CT) showed that the patient’s abdominal organs were reversed from left to right. The patient had PSS in addition to segmental aplasia of the caudal vena cava (CVC) with azygos continuation. Heterotaxy was diagnosed. Surgical treatment was performed by gradual shunt vessel ligation. The patient progressed well for 19 months after the first surgery, and the clinicopathological findings were normal and were maintained. This is a rare case report of a PSS with heterotaxy and segmental aplasia of CVC with azygos continuation treated surgically in a dog.
A 6-year-old spayed female Toy Poodle was recognized acute pancreatitis and diabetes mellitus with lipid abnormalities. Hypothyroidism was also suspected and later confirmed. Hyperglycemia persisted even after resolving the pancreatitis. Dyslipidemia drugs, in addition to changes in insulin therapy, improved lipid abnormalities but not hyperglycemia. Hyperglycemia improved after thyroid hormone replacement was introduced, suggesting that insulin resistance was due to hypothyroidism. If hyperglycemia is persistent in diabetic dogs, hypothyroidism may be the cause, although there have not been many clinical reports of insulin resistance caused by hypothyroidism.
An 8-year-old female mongrel dog was referred to our hospital for leukocytosis and splenomegaly. A complete blood count (CBC) showed neutrophilic leukocytosis with left shift. Hyperplastic cellularity was present in the bone marrow. There was no increase in blast cells or morphological abnormalities. The possibility of other disorders such as reactive leukocytosis was excluded. X-chromosome inactivation pattern (XCIP) analysis was performed. Clonality was detected in the peripheral blood cells and bone marrow. The dog was diagnosed with chronic myelogenous leukemia (CML). The dog was in good condition without treatment.
A 13-year-old female Pekingese was presented for treating a conjunctival tumor located in the left eye at the 12 o’clock position. The tumor was 4 × 4 × 1 mm in size and had a rough white-colored surface. Other ophthalmic abnormalities were present including corneal pigmentation associated with trichiasis of the left eye, bulbar conjunctival injection with corneal opacity, and bilateral vascularization. The tumor was surgically resected and identified as squamous cell carcinoma in a histopathological analysis. Two new masses were detected in the keratoconjunctival tissue of the left eye on the 14 day after surgical resection. These masses were similar to the primary tumor, and were located at the 4 o’clock and 6 to 8 o’clock positions, respectively, sites distant from the primary tumor. After cytological examination, the new tumors were suspected to be disseminated squamous cell carcinoma from the primary conjunctival tumor. The new tumors responded to the topical administration of 0.04% mitomycin C (MMC) four times per day, and the neoplastic tissue that remained was treated with cryotherapy. At the 2-month follow-up ophthalmic examination, there was no evidence of tumor recurrence, suggesting that remission had been achieved. Overall, our findings suggest that topical 0.04% MMC combined with cryotherapy may be an effective treatment for keratoconjunctival squamous cell carcinoma, particularly if surgical resection is not an option.