Journal of Animal Clinical Medicine
Online ISSN : 1881-1574
Print ISSN : 1344-6991
ISSN-L : 1344-6991
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Original Article
  • Yuya KIMURA, Keisuke ENOMOTO, Satoshi KAMESHIMA, Naoyuki ITOH
    2021 Volume 30 Issue 3 Pages 66-71
    Published: September 25, 2021
    Released on J-STAGE: September 25, 2022

    Clostridioides difficile is a common cause of antimicrobial-associated diarrhea in humans. Although C. difficile has been detected in the intestinal tract of dogs, the changes associated with antimicrobials and acid suppressants are not well-understood. In this study, clindamycin with and without omeprazole, or maltitol placebo were orally administered to 9 dogs for 7 days. When their feces were analyzed by immunochromatographic assay, all the 6 dogs treated with clindamycin tested positive for C. difficile antigen on Day 8, then 5 of the 6 tested negative after the treatment period (Day 16), while all the dogs tested negative for toxin A/B throughout the study period. Quantitative PCR of extracted fecal DNA revealed an increase in C. difficile in the treated groups, peaking on Day 8 or 12. These results indicated that the administration of clindamycin with and without omeprazole caused overgrowth of C. difficile in the intestinal tract, even if it was asymptomatic. Furthermore, C. difficile in the placebo group gradually increased later than in the treatment groups, suspecting horizontal transmission within the institution. This suggests the similar effects of clindamycin on canine and human intestinal flora, and also the necessity of hygienic considerations in veterinary practice.KEY WORDS : clindamycin, Clostridioides difficile, omeprazole(J Anim Clin Med. 30(3)66-71, 2021)

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