The relationship between epilepsy and psychoses has long been debated, and descriptions regarding symptoms of interictal psychoses in patients with epilepsy date back to even the Babylonian era. However, scant attention has been paid to this issue lately. Adequate recognition of psychoses in epilepsy is essential for physicians caring for the affected patients, because the impact on their quality of life is too devastating to be overlooked. Investigations of the associations between epilepsy and psychoses were initially conducted by French and German neuropsychiatrists in the 19th century, while much of the literature came from England in the second half of the last century. It is widely recognized that the epoch-making reports by Slater, Beard and Glithero in 1963 raised important clinical questions regarding so-called "schizophrenia-like" psychoses of epilepsy. Although some of those questions have been answered, many remain controversial. In this review, current knowledge regarding schizophrenia-like psychoses of epilepsy is examined in light of the questions posed by Slater and colleagues.
Oseltamivir phosphate has been reported to change spike discharges on electroencephalograms (EEGs) of epilepsy-prone El mice. The present study shows that two anti-epileptic drugs (sodium valproate and diazepam) counteract such alterations. Our observations suggest that short-term supplemental administration of sodium valproate or diazepam may be considered as an option when patients with epileptic tendencies but are not on a regular course of anti-epileptic drugs are taking oseltamivir phosphate.