The tourism industry is a labor-intensive industry with multiple levels of employment, a wide range of areas, and a broad market, which has a great driving effect on employment in the entire society. Since the beginning of 2020, the COVID-19 epidemic has begun to spread all over the world. So far, the medical and health fields have not yet been able to adopt effective methods to completely control the epidemic. Many industries have encountered almost “shutdown” control or impact. As an important carrier of cultural exchanges, social communication, and trade circulation, the operation of the tourism industry is based on the movement of people, and it is particularly affected by the rapid development and continuous spread of the global epidemic. This article first conducts a more detailed analysis of the basic situation of tourism cooperation in Northeast Asia since the outbreak of the epidemic and a series of issues that have emerged, and then explores a preliminary analysis of how countries and regions can deepen cooperation and promote development in the tourism industry in the era of symbiosis of the epidemic.