We have previously set about nutritional studies on smoking, and have handled some foundational experiments related to these works.
Lately we proved that serum cholesterol contents was increased constantly by chronic poisoning by nicotine. And so we proceeded to investigate the influence to serum cholesterol contents adding Wakame-flour to a diet. At this time, we thought that iodine and sitosterol known as the effective components of Wakame might lead the similar result, and then prepared the following five experimental groups-1. Contrast, 2. Nicotine (means adding nicotine to a diet), 3. Nicotine and Iodine, 4. Nicotine and Wakame-flour, 5. Nicotine and Sitosterol-in each group we kept five female rats.
After sixteen weeks, we decapitated them and depleted of blood, and analyzed total and ester cholesterol in serum by the method of Zlatkis-Zak. The result were as follows.
1. Total cholesterol was increased about 20 per cent compared with the contrast by feeding nicotine.
2. When we fed adding Wakame-flour, total cholesterol was slightly increased about 7 per cent.
3. To add iodine did not show the same effect, while to add sitosterol displayed restraining effect as well as adding Wakame-flour.
Besides, when we tried to add ether extract of Wakame-flour we observed restraining effect as adding Wakame-flour.
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