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Volume 36 (1978)
- Issue 6 Pages 245-
- Issue 5 Pages 203-
- Issue 4 Pages 159-
- Issue 3 Pages 107-
- Issue 2 Pages 55-
- Issue 1 Pages 1-
Volume 36, Issue 4
Displaying 1-6 of 6 articles from this issue
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Hitomi Tohjo, Motoyoshi Miyazaki1978 Volume 36 Issue 4 Pages 159-164
Published: May 25, 1978
Released on J-STAGE: October 29, 2010
JOURNAL FREE ACCESSThis paper was planned to study the antioxidative action of vitamin E in the tissues of rats fed on diets with different protein lvels. The animals were fed basal diets with or without supplementation of vitamin E (d, l-α-tocopherol) for 4 weeks. The peroxidation of several tissues was examined by the thiobarbituric acid (TBA) assay.
Results obtained were as follows.
The values of TBA in the liver, kidneys and muscle were significantly higher in the vitamin E deficient groups than in the vitamin E supplemented groups.
Statistical difference of TBA values in the liver between vitamin E supplemented groups and vitamin E dificient groups was relatively higher than those in the kidneys and muscle. When the dietaryprotein level was graded at 1.0, 1.5, 2.0 and 3.0% nitrogen levels, TBA values in the liver showed no difference among the four protein groups.
Some differences in the liver fatty acid pattern were observed between the vitamin E supplemented groups and the vitamin E deficient groups, i.e., the proportion of palmitic acid of the supplemented groups was significantly lower than that of the deficient groups. But, the proportion of oleic acid of the supplemented groups was significantly higher than that of the vitamin E deficient groups.
Cholesterol in plasma and liver, and the total liver lipids were not significantly different among the vitamin E supplemented groups. It was suggested that vitamin E prevented lipid peroxidation in vivo.View full abstractDownload PDF (6330K) -
Distribution and Oxidation of 14C-Phenylalanine in Rats Fed the Excess Phenylalanine DietYoshiki Kobatake1978 Volume 36 Issue 4 Pages 165-174
Published: May 25, 1978
Released on J-STAGE: October 29, 2010
JOURNAL FREE ACCESSThis experiment was designed to study the distribution and metabolism of phenylalanine (Phe) pool in rats fed the diet contained an excess of Phe by using radioactive tracers such as L-Phe-U-14C and L-tyrosine (Tyr)-U-14C
1) When the excess Phe diet caused a rise in Phe-pool in rats, Phe-14C was rapidly oxidized to 14CO2 in the expired air, and L-Phe-14C incorporation into the organ tissue protein was lowered. In addition, 14C-radio-activities in urine increased in the groups ingested excess Phe.
2) In rats fed excess Tyr-diet, the expired 14CO2 from L-Tyr-U-14C also increased. Thus, it is suggested that Tyr metabolism was accelerated when Tyr pool was maintained a high level by the excess Phe-pool.
3) When Phe pool was adjusted to the same level as that of control group even after rats were received the excess Phe or Tyr in diets for 3 weeks, the injected L-Phe-14C was significantly oxidized to 14CO2 in the expired air, these effects were marked in rats fed the excess Tyr in diet. It may be concluded that enzymes in Tyr metabolic pathway were easily adapted to remove excess Tyr pool.
4) When chlorophenylalanine was administered to experimental rats received excess Phe and control rats, the rates of oxidation in both groups were as half as those of groups of non-chlorophenylalanine for five hours after administration.
5) 14C-radio-activity in urine of rats injected DL-Phe-2-14C was higher than that of rats injected L-Phe-U-14C.View full abstractDownload PDF (11230K) -
Yusuke Kanke, Kazuharu Suzuki, Shiro Goto1978 Volume 36 Issue 4 Pages 175-179
Published: May 25, 1978
Released on J-STAGE: October 29, 2010
JOURNAL FREE ACCESSAnemic male and female rats were prepared by feeding iron deficient diet for 2 months. There was no significant difference in body weights between anemic and normal animals. Total hexosamine level in aortic tissues of anemic male rats decreased, whereas that of anemic female animals increased. It is suggested that glycoprotein and hyaluronic acid might be responsible for a significant change in total hexosamine contents of male and female rats.View full abstractDownload PDF (5266K) -
Kuniko Karasawa, Shizuko Muto1978 Volume 36 Issue 4 Pages 181-186
Published: May 25, 1978
Released on J-STAGE: October 29, 2010
JOURNAL FREE ACCESSTaste preference and aversion for sourness in rats was studied by the Two-bottle choice method, using citric acid solutions at 1.0, 2.0, 5.0, 15.0, 25.0 or 50.0mM concentrations and deionized water. The amount of the acid solution consumed was the greatest at the 1mM level. The choice rate being about 20% of total liquid intake, decreased as the concentration rose, suggesting aversion for relatively strong sour taste. When the 0.29M sucrose solution was used as the medium for the acid solution preparation, consumption of the sucrose-acid solution at 1.0, 2.0 and 5.0mM acid levels was 1.8 to 2.9 times as much as the presumed physiological liquid needs and the choice rate was in the vicinity of 100%. Both the intake and choice rates were comparable to those in the plain sugar solution. With elevating acid concentration both the amount and choice rate of the sucrose-acid solution consumed declined, but even at the highest acid level the choice rate was about 40% of the total liquid intake. When sodium chloride was used in place of sucrose at the concentration of 0.15M for preparation of the test solution, the consumption rate and the choice rate of the salt-acid solution were lower than those rates observed in the sugar-acid solution but higher than the plain acid solution.View full abstractDownload PDF (6605K) -
Effect of Dietary Minerals on Hepatic Lipid Accumulation in Fasted-Refed RatsEtsuko Tsuji1978 Volume 36 Issue 4 Pages 187-194
Published: May 25, 1978
Released on J-STAGE: October 29, 2010
JOURNAL FREE ACCESSThe mechanism responsible for the elevation of hepatic lipids is unknown. This paper was designed to study the effects of dietary minerals mixed in a sucrose base as the source of carbohydrate on lipid contents. Total lipids and cholesterol were used as measures to estimate the accumulation of hepatic lipids in fasted rats that were refed later.
The results obtained were as follows:
1) Total lipids and cholesterol contents of the liver were significantly depressed in rats refed a mineral free diet after they were fasted for 48 hours. However, serum cholesterol was elevated under these conditions.
2) Supplementation of KH2PO4 to the mineral free diet caused a remarkable rise in liver lipids and cholesterol. The concentration of liver lipid showed little or no lipotropic effects when rats were fed on diets supplemented with mineral sources such as NaCl, CaCO3 and MgSO4.
3) Lipotropic effect of rats receiving diets containing KH2PO4 and other minerals was not greater than that of rats fed on only KH2PO4.
4) Total liver lipid and cholesterol concentrations increased only by the compounds that contained potassium, when various compounds such as KH2PO4, K2HPO4, K-acetate, K-oxalate, K-citrate, NaH2PO4, Na2HPO4, CaHPO4 and MgHPO4 containing potassium or phosphate were added to the mineral free diet. The results indicate that potassium might induce the accumulation of hepatic lipids.View full abstractDownload PDF (9706K) -
Nobuo Matsuno, Michio Yamaguchi, Miya Nomura1978 Volume 36 Issue 4 Pages 195-200
Published: May 25, 1978
Released on J-STAGE: October 29, 2010
JOURNAL FREE ACCESS
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