The present study was carried out to examine the effect of iron deficiency on the fetal growth. Female rats of the Sprague-Dawley strain, weighing about 240g were mated. The animals were given three kinds of diet with different iron levels (control; 4.10mg%, low iron group; 1.83mg%, iron deficiency group; 0.38mg%) during pregnancy. The blood levels of hemoglobin (Hb), hematocrit (Ht) and red blood cells (RBC) were observed. The iron content in the maternal tissues was analysed after the experiment. The litter size, body weight and iron contents in the liver and carcass of fetus were also observed.
The following results were obtained.
1) Hb, Ht and RBC values in the iron deficient group on day 21 of pregnancy were apparently lower than those in the control and the low iron groups.
2) Iron contents in the maternal liver, spleen and muscle of the deficient group were observed to decrease on day 21 of pregnancy when compared with those of other groups. Iron contents in the uterus, placenta and amniotic fluid of the three groups were almost the same.
3) The litter size and mean fetal weight and the placenta weight in all the groups were almost the same. Iron contents in the fetal liver and carcass of the deficient group were slightly lower than those of the control group.
4) Although the iron intake of the dams was restricted during pregnancy, the fetal weight gain was normal. It appears that the maternal tissue iron was preferentially utilized for the fetal growth.
View full abstract