In order to clarify the relation between smoking, obesity and dietary habits and thiobarbituric acid reactive substances (TBARS), we carried out a cross-sectional study in 1991 in a rural town of Akabane in Japan. The subjects were 372 males and 459 females aged 35-65 years who participated in a health screening. The response rate was 63.3%. We evaluated the complete data obtained from 297 males and 379 females. The results were as follows:
1) Serum TBARS showed substantially logarithmic-normal distribution. The arithmetic mean of TBARS was higher in men than in women in two age groups (35-45, 50-65), and was higher in the latter than in the former.
2) Body mass index (BMI) was related to serum TBARS both in men and women, and habitual smoking increased serum TBARS in men aged 35-45 years.
3) Dietary habits were evaluated as the intake frequencies of foodstuffs such as meat, fish, beans, vegetables, eggs and milk in a typical week in the past year. There was observed a relation between fish intake and serum TBARS in the age group of 35-45, and a less frequent intake of vegetables was related to high serum TBARS in women. In the multiple linear regression analysis, the standardized regression coefficients for fish and vegetable intakes in women aged 35-45 years were 0.19 and -0.10 respectively. These findings show the importance of intake of various kinds of food.
4) Of the blood chemical parameters, triglyceride showed the strongest association with TBARS, and serum total cholesterol, uric acid and leukocyte count were also positively related with TBARS.
5) The study revealed that dietary habits, smoking, obesity and some blood chemical findings were related with serum TBARS. Further prospective studies are necessary to clarify the relationship between serum TBARS and the occurrence of cardiovascular diseases.
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