Objective: Nutritional deficiency has long been an issue among hemodialysis (HD) patients. Low levels of serum selenium in particular, which are frequently observed in HD patients, are a risk factor for cardiovascular complications and infections, and are also associated with a high mortality rate. Here, we assessed the association between selenium intake and serum selenium levels in HD patients.
Method: Ten HD patients (4 men, 6 women) aged 62.7 ± 5.9 years were enrolled for this study. The mean duration of dialysis treatment was 190 ± 157 months. The patients' dietary selenium intake over 4 days, serum biochemistry profile, and physical conditions were assessed.
Results: Mean dietary selenium intake and serum selenium levels were 51.1 ± 14.3 (31.6~70.8) μg/day and 12.7 ± 2.4 (9.0~17.3) μg/d
l, respectively. Serum selenium levels showed a significant positive correlation with serum urea nitrogen levels (
r = 0.770), and protein (
r = 0.697) and selenium (
r = 0.673) intake. On the other hand, selenium intake showed a significant positive correlation with energy (
r = 0.721), protein (
r = 0.733), phosphorous (
r = 0.662), and potassium (
r = 0.669) intake. The correlation between serum selenium levels (μg/d
l, Y) and protein intake per ideal body weight (g/kgIBW/day, X
1), selenium intake (μg/day, X
2), and potassium intake (mg/day, X
3) produced a regression line as follows: Y = 10.633X
1 + 0.142X
2 – 0.004X
3 + 3.509 (
r = 0.962,
p = 0.001).
Conclusion: These results indicate that reducing protein intake may lower selenium intake, leading to reduced levels of serum selenium.
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