Purpose:Health foods have been used by consumers in their daily life. However, there are also products available on the market with poor scientific evidence for their efficacy and safety. From the point of view of food safety for consumers, we have evaluated the efficacy and safety of health food ingredients that are particularly relevant to the health of bones and knee joints.
Methods: Several health food ingredients were evaluated using an osteoporotic animal model. Some ingredients were evaluated in a randomized placebo-controlled trial in healthy postmenopausal Japanese women following approval by the institutional Research Ethics Committee.
Results: For soy isoflavones, it appeared that dose dependence differed in the effects on the reproductive organs from that of bone tissue in osteoporotic mice. Bone effects of isoflavones revealed a dependence on the production of equol, which is a gut bacterial metabolite of daidzein in healthy postmenopausal women. For vitamin K study, a suggested possibility was that vitamin K intake from daily meal was insufficient in healthy postmenopausal Japanese women in terms of preserving bone health; menaquinone-4 supplementation improved bone quality in these women. It was also demonstrated that excess intake of collagen peptide, methylsulfonylmethane, spirulina, and resveratrol should be avoided.
Discussion:Recently, a new food labeling system Foods with Function Claims has been established in Japan. Under these circumstances, research on the efficacy and health effects of health foods is yet considered to be important in terms of regulatory science. These studies would be on the leading edge with respect to consumer food safety.
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