The author had tried to examine, from the functional standpoint of the hypothalamus-pituitary-system, how stands the clinical relationship between that system and sellaprofil in the special case of“Criminal”(516 healthy inmates of ages ranging from 17 to 61 were used as objectives).
The inmates were divided, according to sellaprofil, into 5 (8) groups of the disharmonic variation, defective development, deformity observed over the each region on their body from the anatomic-morphological point of view (so-called hypothalamus-pituitary-syndrome) and various symptoms which include, swelling of lymphatic neck gland, palpitation, thirst-feeling, being easily fatigued, spasmodic diathesis etc. (so-called hyperthyreoidism) and the past anamneses that seem orginate in the hypothalamus-pituitary-system and the psycho-neuropathic disposition etc.
The result the stereoscopic sellacontur are as follow; that is I. oval-shaped 28%, II. round 23%, III. flat-circular 23%, IV. four-cornered 11%and V. so-called abnormal-shaped 14%which include 1. indeterminate 5.4%, 2. triangular 4.3%, 3. saucer 2.1%and 4. bridged sella 1.9%.
It is found that the so-called abnormal-shaped sella seemed to the author more frequent in the case of criminals, comparing with normal people but there are nothing remarkable on the morphological observation of sella turcica with regards to the criminal-quality.
The author has found marked defferences among the groups of sella turcica. So far as the so-called hypothalamuspituitary-syndromes are concerned, crooked nose, narrow and close eye-brows, narrowed middle face, asynmetric face, deep set-eyes, are not only more frequently found in the so-called abnormal-shaped sella comparing with the normal-shaped sella, but such deformities as infantile face, bird-shaped face, hare-lip, ear-verruca, bifurcate uvula etc on their face. In the oral cavity, there are found more irregular rows of tee that the mandibulas than at the upper jaws and the incisor II and the canine have been relatively oblique situated. At the extermity, there are many bending at the little and the index-fingers, and also the peak-finger has more frequency, as far as the finger is concerned, in the case of the so-called abnormal-shaped sella comparing than the normal-shaped sella. It is peculiar that there exist a large number of too small testicles (or atrophy) of the cutaneus-urogenital apparatus, and a few femine pelvis on the physique of men, and then Aschner's reaction to positive, the past anameneses orginated from the hypotahlamus-pituitary-system and such complaint as so-called hyperthyreoidism are recognized very often in the so-called abnormal-shaped sella.
The stasticus teaches us that there ia a significance in the difference of frequency among the various symptoms that appear between the normal and the so-called abnormal-shaped sella, such as asynmetric face, narrowed middle face, turned eye-brows up, deep set-eyes (or gloomy look), crooked nose, projected lower jaw, asynmetric mouth-jaw-ears, bendingfinger, too small testicles (or atrophy), so-called hyperthyreoidism, so-called hypothalamus-pituitary-past-anamneses etc.
The results are of great interest from the standpoint of the function of the sella turcica and the hypothalamus-pituitary-system in view of the fact that more the so-called abnormal-shaped sellas are not only recognized among criminals through stereoscopic sella profils but a large number of the so-called hypothalamus-pituitary-syndromes exist in the so-called abnormal-shaped sella.

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I injected alloxan of 150-200mg per Kilogramm of body weight intravenously into normal rabbits (asingle injection) and as much into the rabbits which had become normal after diabetic course (2nd injection).
Hemogram, Diameter of erythrocytes, Reticulocyte Count, Heintz's Corpuscles Count, blood sugar curve after insulin and glucose injection glycolytic effort of the blood and so on were investigated.
By these investigations, the Relation between Alloxan and human diabetes, mechanism of Alloan anemia, cause of initial hyperglycemia and generative prossess of Hypoglycemia were discussed as follows.
1. Alloxan anemia seems to be secondary Anemia by blood-toxin, because of Pseudoeosinophil leucocytosis, reticulocytosis, and erythrocyte diameters initial reduction and then enlargement of it.
2. Cause of Initial hyperglycemia seems to be due to hypersecretion of Adrenalin, because of pseudoeosinophil leucocytosis and reduction of erythroyte Diameter, but it is concerning with another factor. (Reticulocytosis is not recognised),
3. Mechanism of Hypoglycemia seems to be due to Insulin hypersecretion.
4. Relation between human diabetes.
i. Analogous Points a. Tendency of lymphocytosis Lymphopenia and abnormality of leucocyte count are symptoms of bad Prognosis.
b. Enlargement of erythrocyte diameter and leaning to the right of Price Jones' curve c. Reticulocytosis d. Glycoregulation disturbance.
e. Sensitiveness upon insulin is recongnised. (On 2nd injection, it is not sensitive in most cases)
f. Glycolytic effort of the blood is repressed during hypeglycemia.
ii. Difterent Points a. easily improvimg tendency b. Glycolytic effort of the blood is promoted when normoglycemia.

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1. Alloxan does not inhibit insulin activity.
2. Inactivation of Insulin by the blood of Alloxan rabbits is stronger than that of normal rabbits, and that of the whole blood is always stronger than that of Serum in Alloxan and normal rabbits.
3. Urethan rabbits react sensitively upon insulin, but it can not alway be said that urethan rabbits are more sensitive than normal rabbits upon insulin.
4. Insulinase activity by muscle extracts of Alloxan rabbits is stronger than that of normal rabbits, but that by liver extracts is almost equal in both cases.

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