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Volume 34, Issue 12
Displaying 1-7 of 7 articles from this issue
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Jiro KURANARI1959 Volume 34 Issue 12 Pages 1254-1259,1251
Published: March 20, 1959
Released on J-STAGE: September 24, 2012
JOURNAL FREE ACCESSThe present study was undertaken to compare the glycogenetic action of sulfonylurea, mesoxalate and insulin by rat's liver and muscle (diaphragm) injected these substances daily for seven days, especially the relation between this action and nutritious components, and the following results have been obtained :
(1) Mesoxalate and insulin have shown marked promoting effects on the formation of liver glycogen from carbohydrate source, and insulin caused inhibitory effect on glycogenesis of liver from protein source.
(2) Increased effect on body weight and decreased effect on blood sugar have been observed in sulfonylurea treated rats from fat nutrition.
(3) As far as the glycogenesis from carbohydrate source of rats diaphragm, these three drugs showed almost same significant promoting effects.View full abstractDownload PDF (812K) -
Hutoshi IIDA, Etsushi SANO, Rikio FURIHATA1959 Volume 34 Issue 12 Pages 1260-1270_5
Published: March 20, 1959
Released on J-STAGE: September 24, 2012
JOURNAL FREE ACCESSIn order to clarify the acting mechanism of antithyroid drugs the histological studies on the thyroid and anterior pituitary of rabbits were performed following the administration of methylthiouracil, 1-methyl-2-mercaptoimidazole or inorganic iodine. The following results were obtained.
1. Methylthiouracil may directly suppress the function of the thyroid and secondarily stimulate the release of TSH from the anterior pituitary in vivo. The direct action of methylthiouracil to the anterior pituitary, however, is not completely proven.
2. It may be deduced that 1-methyl-2-mercaptoimidazole suppresses not only the function of the thyroid, but also suppresses the release of TSH from the anterior pituitary.
3. Inorganic iodine may be considered to suppress first the release of TSH from the anterior pituitary and secondarily suppress the function of the thyroid.View full abstractDownload PDF (7189K) -
Mamoru MAKINO1959 Volume 34 Issue 12 Pages 1271-1280,1252
Published: March 20, 1959
Released on J-STAGE: September 24, 2012
JOURNAL FREE ACCESSIn order to solve the mechanism of hypoglycemic actions of mesoxalate and BZ 55, the author comparing the effects of these two drugs on several blood organic substances (glucose, lactic acid and pyruvic acid) or unorganic ones (unorganic phosphorus, K, Na, Ca and Cl) and this effect of insulin in alloxan diabetic rabbits, obtained following conclusion :
(a) As to the changes of blood sugar curves and serum unorgenic phosphorus contents after injection of these drugs or insulin, there are remarkable differences between the effects of insulin and BZ 55 ; on the other hand the effect of mesoxalate is resemble to that of insulin.
(b) The utilizing action of sugar mediate metabolic products is the most remarkable after injection of BZ 55 among these three antidiabetogenics.View full abstractDownload PDF (1003K) -
Nobuyoshi OJI1959 Volume 34 Issue 12 Pages 1281-1287,1252
Published: March 20, 1959
Released on J-STAGE: September 24, 2012
JOURNAL FREE ACCESSIt has been stated that hyperfunction of pituitary-adrenal system often exists in diabetes mellitus. Such hyperfunction of pituitary-adrenal system may be expected to aggravate the metabolic disturbance in diabetes mellitus. Therefore, in the present study, the relation between the urinary excretion of of steroid hormones and types of disease, complications and other metabolic abnormalities were studied, and following results were obtained :
1) Urinary cxcretion of 17-OHCS was found to be increased in aged diabetics in comparison with that in aged non-diabetics. Urinary 17-OHCS was also increased in young diabetics showing increased urinary excretion of ketone bodies.
2) The urinary excretion of 17-OHCS was in generally parellel to the urinary amount of ketone bodies. 17 KS was increased in diabetics with ketosis.
3) There was no correlation between the urinary excretion of steroid hormones and fasting blood sugar level.
4) No correlation was found between the urinary excretion of steroid hormones and the severity or type of complication.
5) The metabolic significance of the increased urinary excretion of 17-OHCS in aged diabetics was discussed.View full abstractDownload PDF (790K) -
Ikuo MURONE1959 Volume 34 Issue 12 Pages 1288-1293,1253
Published: March 20, 1959
Released on J-STAGE: September 24, 2012
JOURNAL FREE ACCESSIn order to clarify the interaction between the thyroid and the adrenal, histological studies were performed on normal and bilaterally adrenalectomized rabbits. For this experiment, 14 adult male rabbits were sacrificed, 3 as control, 11 adrenalectmized. Extirpation of the adrenals was arried out on two times, first on the right and after 7 days on the left.
The results were as follows :
1) In the normal rabbits' thyroid, there were PAS-positive granules in the cells of follicular epithel as well as inside of the follicles.
Such granules in the follicular epithelial cells accumulated near the colloidal sides from the supranucler parts and then it seemed that the PAS positive granules may be secreted into the lumen of the follicles.
2) A few thin ductlike structures were recognized between epithelial cells, with were stained by the PAS method, and passed through epithelial wall from the follicle lumen to the interstitium. But they were seldom found among the rabbits with lived more than ten days after bilateral extirpation of the suprarenal glands.
From this it is surmised that the functional changes of the thyroid glands may influence upon the existence on the ductlike structures.
3) There was a basement membrane-like structure at the base of the follicular cells which was PAS positive. 4) The adrenalectomized rabbits which lived more than ten days after bilateral extirpation showed that all follicles began to be filled with the PAS positive colloid meterials and the height of the epithial cells became lower and those tendencies were maximum in the survials of 25 days.
Judging from these findings, it seems that both production and discharge of the thyroid hormones would be disturbed in the bilaterally adrenectomized rabbits but the latter may be more markedly inhibited.
The main causes of these phenomena may be attributed to the following two factors : the one is the decrease of TSH secretions from the pituitary gland and the other is the decrease of the thyroxine consumption rate at the peripheral tissues.
5) And thus, within the limited extent of this experimental study, it seems likely that there is a synergic relationship between the functions of the thyroid glands and of the suprarenal glands.View full abstractDownload PDF (3188K) -
1959 Volume 34 Issue 12 Pages 1294-1335
Published: March 20, 1959
Released on J-STAGE: September 24, 2012
JOURNAL FREE ACCESSDownload PDF (5991K) -
1959 Volume 34 Issue 12 Pages 1336-1340
Published: March 20, 1959
Released on J-STAGE: September 24, 2012
JOURNAL FREE ACCESSDownload PDF (674K)
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