巻号一覧
前身誌
34 巻, 9 号
選択された号の論文の9件中1～9を表示しています
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岡本 耕造1958 年 34 巻 9 号 p. 824-845
発行日: 1958/12/20
公開日: 2012/09/24
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落合 京一郎1958 年 34 巻 9 号 p. 846
発行日: 1958/12/20
公開日: 2012/09/24
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増田 強三1958 年 34 巻 9 号 p. 847-855
発行日: 1958/12/20
公開日: 2012/09/24
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伊藤 清次1958 年 34 巻 9 号 p. 856-873,821
発行日: 1958/12/20
公開日: 2012/09/24
ジャーナル フリーIt is now well konwn that experimental pyridoxine deficiency has inflnences upon various metabolism. My hypothesis is biult around the fact that there may be any central affection in pyridoxine deficinecy which causes extensive changes. Therefore I studied the diencephalon-pituitary system of pyridoxine deficient rats histochemically.
My observation included the eosinophilic and basophilic cell in the anterior pituitary and the neurosecretory substances of the hypothalamus and posterior pituitary concerning the development of pyridoxine deficiency.
Both the eosinophilic and basophilic cell increased in the deficient group compared with the control group in the third week, but decreased slightly in the deficient group in the sixth week and markedly so in the ninth week when the deficiency was completed.
The neurosecretory substances increased also in tne deficient group compared with the control group in the third week, but decreased slightly in the sixth week and markedly so in the ninth week. In addition, regressive changes occurred in the neurosecretory cell of the nucleus supraopticus and the nucleus paraventricularis of the deficient group.
These changes are recovered by the administration of 50γ pyridoxine a day.
Such changes as mentioned above are observed as a result of a short experiment of administering antivitamines such as Desoxypyridoxine, Toxopyrimidin and Isonicotinic acid hydrazide.
In concision, I found hypofunction of diencephalon-pituitary system in the pyridoxine deficient rats. And I presumed that this hypofunction affected on the developement of deficiency.抄録全体を表示PDF形式でダウンロード (3727K) -
倉成 二郎1958 年 34 巻 9 号 p. 874-880,821
発行日: 1958/12/20
公開日: 2012/09/24
ジャーナル フリーIn the first group of experiments the total carbohydrate in liver, glycogen in liver and muscle and sugar in blood were measured following the administration of various amino acids each to starving rats, and the results were compared with those of fasting controls.
In the second group of experiments, the comparisons on liver total carbohydrate and glycogen among the results of following three cases were done ;
(a) the effect of cortisone or ACTH by the feeding of each amino acid to starving rats.
(b) the effect of cortisone or ACTH to starving rats without feeding of amino acids.
(c) starving controls fed amino acids.
The following results have been obtained :
(1) The glyconeogenesis was the most remarkable after dl-Alanine or 1-Aspartic acid administration. dl-Serine and Polytamine (mixed amino acids) caused also a definite deposition of glycogen, however, no evidence of glycogenic effects were found by the feeding of 6 amino acids, as Proline, Methionine, Leucine, Tyrosine, Histidine and Lysine.
(2) No effect were observed by ACTH injection of glyconeogenesis after dl-Alanine; dl-Serine, 1-Methionine, 1-Tyrosine, 1-Histidine and 1-Leucine administration.
(3) Feeding of dl-Alanine, 1-Aspartic acid, dl-Serine or Polytamine caused more remarkable glycogenic effect with cortisone injection than which cortisone alone or amino acids alone were given.抄録全体を表示PDF形式でダウンロード (1051K) -
伊勢谷 和三郎1958 年 34 巻 9 号 p. 881-903,822
発行日: 1958/12/20
公開日: 2012/09/24
ジャーナル フリーThis study was designed to clarify the effect and mode of action of the sex hormone preparation upon the essential hypertension both in clinical and experimental ways.
Generally speaking, in the advanced age with the hypertension was shown the hypercorticoidism, as compared with the normal subject.
Among 27 cases of the essential hypertension, the depot preparation of sex hormone was effective of 7 cases and less effective of 8 cases. The effectivity seems to be higher in the advanced age.
It seems that the sex hormone preparation administered may reduce the hypercorticoidism in hypertensive patients through the inhibition of ACTH production from the pituitary and the activation of gonads.
The administration of Androgen Depot (100mg) depressed the blood pressure of a normal rabbit.
The sex hormone itself seems to act as a hypotensive agent.
In the thirty-five rabbits with DCA-salt hypertension Androgen-Depot (50mg) was all effective in reducing the hypertension. In those with the renal hypertension, after Goldblatt the sex hormone preparation ' was not effective except one. In those with the experimental hypertension the sex hormone was likely to act as an inhibitory agent against the adrenal cortex.
For the mentioned above it is concluded that the sex hormone preparation may be effective to the hypertension of essential type, of the advanced age or obese subjects, in climacteric stage, and due to endocrine disorders, whereas ineffective in those who are hypertensive due to renal or cardiac damage.抄録全体を表示PDF形式でダウンロード (4098K) -
森脇 健1958 年 34 巻 9 号 p. 904-909,822
発行日: 1958/12/20
公開日: 2012/09/24
ジャーナル フリーAs I previously reported, urinary content of ketone bodies reflects the condition of diabetes mellitus fairly precisely. Ketone Wiles consist of acetoacetic acid, β-hydroxybutyric acid and acetone. In diabetic ketosis, it was found that the percentage of these components was different from that in normal adults. In order to ellucidate the metabolic change in diabetes mellitus more precisely, β-hydroxybutyric dehydrogenase activity was measured in heart muscle, liver and kidney of the alloxan diabetic animals and following results were obtained.
I. In alloxan diabetic animals, tissue β-hydroxybutyric dehydrogenase activity was found to be decreased compared with normal animals. This decrease was marked especially in liver.
2. After treatment using insulin and mesoxalate this activity was normalized,. while PEDG was ineffective.
3. Pantothenic acid and nicotinamide treatment caused slight increase in the activity of this enzyme.
4. Sulfonylurea treatment caused decrease in β-hydroxybutyric dehydrogenase activity.抄録全体を表示PDF形式でダウンロード (794K) -
小林 修1958 年 34 巻 9 号 p. 910-922,823
発行日: 1958/12/20
公開日: 2012/09/24
ジャーナル フリーOn determining the androgenic activity of androgens with the uptake of P32 by the accessory sex glands of the castrated male rats, the following results were obtained.
1) The uptake of P32 by the accessory sex glands in the normal male rats, reaches the peak within 3 hours after P32 injection. After 6 hours the activity becomes lower and stable.
2) The uptake of P32 by the accessory sex glands of the castrated male rats decreased slightly on the 3rd day after castration, and after that no striking change was noticed. The weight loss following castration did not run parallel to the decrease of P32 uptake.
3) The peak of the P32 uptake. by the accesory sex glands after androgen administration preceded to the weight increase in the castrated male rats, and the peak of P32 uptake revealed on the 48th hour after the injection of androgens. The P32 uptake rate was noticed more sensitive in the seminal vesicles than in the prostate glands.
4) The administration of estrogen or gestagen had no effect upon the P32 uptake by male accessory sex glands.
5) Androgen depots showed the characteristic long acting forms in the P32 uptake ; and even 3 weeks after testosterone heptanoate or testosterone cyclopentylepropionate administrations showed no remarkable decreases of P32 uptake.
Testosterone adipinate reached the peak of P32 uptake later than other depot preparations and activity of the former was sluggish.
6) By the weight determination method of seminal vesicles, the biological activity of 10μg dose of testosterone propionate could not be well determined, but the P32 uptake method could determine its 10μg dose by single injection or 9μg dose by 3μg injection daily for 3 days.
7) The possibility of determining the anabolic activity of sex steroids with the P32 uptake by M. levator ani was confirmed.抄録全体を表示PDF形式でダウンロード (1623K) -
1958 年 34 巻 9 号 p. 923-930
発行日: 1958/12/20
公開日: 2012/09/24
ジャーナル フリーPDF形式でダウンロード (1112K)
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