Folia Endocrinologica Japonica

[title in Japanese]

1962 Volume 38 Issue 5 Pages 425-480
Published: August 20, 1962
Released on J-STAGE: September 24, 2012

DOIhttps://doi.org/10.1507/endocrine1927.38.5_425

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Influence of Various Hormones upon the Carbohydrate Metabolism in Vitro

Ryo ISOYA

1962 Volume 38 Issue 5 Pages 481-510,42
Published: August 20, 1962
Released on J-STAGE: September 24, 2012

DOIhttps://doi.org/10.1507/endocrine1927.38.5_481

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Glucose uptake of fasting-rat diaphragm and glucose output of rat liver slice chosen at random, with various hormones added to the incubation medium of 200 mg/dl glucose phosphate chloride buffer solution, were measured.
Diabetogenic action was demonstrated by a decrease of glucose uptake and an increase of glucose output. On the contrary, an increase of glucose uptake and a decrease of glucose output meant antidiabetogenicity.
The results are summarized as follows :
1) Adrenalin and GH showed a strong diabetogenic action and an and insuline effect both in rat diaphragm and rat liver slice experiments.
2) Diabetogenic action of 1-thyroxine seemed to increase the glucose output more in the liver slice experiment than in the diaphragm experiment.
3) On the other hand, diabetogenic action of hydrocortisone in rat diaphragm experiment was more effective than in liver slice experiment. Thus, glucose uptake of rat diaphragm was inhibited.
4) Influence of DOCA upon the carbohydrate metabolism in vitro suggested that it had a slight diabetogenic direction, because when DOCA was added to incubation medium, glucose uptake was slightly decreased and glucose output was increased.
5) TSH and ACTH showed no effectiveness nor any slight diabetogenicity.
6) In adequate concentration, estradiol and testosterone showed antidiabetogenicity and insulin live activity in vitro.

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The Clinical Studies on the Abnormal Thyroid Stimulator

Akito NOGUCHI, Hideo KURIHARA, Seiya SATO, Tetsuo WATANABE

1962 Volume 38 Issue 5 Pages 511-519,424
Published: August 20, 1962
Released on J-STAGE: September 24, 2012

DOIhttps://doi.org/10.1507/endocrine1927.38.5_511

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Using Noguchi's modification of McKenzie's method for bioassay of thyrotropin, which depends on the release into the circulating blood of radio-iodine from thyroid gland of mice, an attempt was made to measure thyrotropin in human serum. The following results were obtained :
1) The abnormal thyroid stimulator in serum from hyperthyroid patients is distinguished from the standard thyrotropin preparations by its prolonged action in assay. It was sought in the serum of 96 patients with hyperthyroidism and was found in 17 of 25 untreated patients.
2) The level of the abnormal thyroid stimulator showed a falling tendency after teatments by the merkazole (1-methyl-2-mercaptoimidazole), Lugol s solution or thyroidectomy.
3) No specific correlation was found between clinical symptoms and the level of abnormal thyroid stimulator in hyperthyroid patients.
4) The abnormal thyroid stimulator was measured before and 24 hours after the thyroidectomy but no significant change was observed.
5) There was no significant difference in the level of the abnormal thyroid stimulator between arterial and venous blood of the thyroid.
6) The abnormal thyroid stimulator was found in only one of six hyperthyroid patients with diabetes mellitus.
7) The level of the abnormal thyroid stimulator showed fairly good correlation with the epithelial proliferation of the thyroidal follicle in the specimen presented at the time of thyroidectomy.

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[title in Japanese]

1962 Volume 38 Issue 5 Pages 520-521
Published: August 20, 1962
Released on J-STAGE: September 24, 2012

DOIhttps://doi.org/10.1507/endocrine1927.38.5_520

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