日本内分泌学会雑誌
Online ISSN : 2186-506X
Print ISSN : 0029-0661
ISSN-L : 0029-0661
40 巻, 4 号
選択された号の論文の6件中1~6を表示しています
  • 門田 一郎, 西村 与一郎, 石上 隆一, 吉田 著
    1964 年 40 巻 4 号 p. 277-280,271
    発行日: 1964/07/20
    公開日: 2012/09/24
    ジャーナル フリー
    In patients with hypertension and other diseases treated with thiazide derivatives for hypotensive and diuretic purposes, we observed decreased glucose tolerances in comparison with those before treatment. When thiazide diuretics were withdrawn, glucose tolerances were found to recover rapidly to normal. Oral tolbutamide test in these cases showed the blood sugar response curves between those in normal persons and in diabetics, suggesting disturbances in carbohydrate metabolism due to insulin deficiency.
  • 植松 稔
    1964 年 40 巻 4 号 p. 281-289,272
    発行日: 1964/07/20
    公開日: 2012/09/24
    ジャーナル フリー
    Some 10 male white rabbits weighing more than 2 kg were monthly studied for a period of 16 months, totaling 176 animal-months. Radioiodine activities were counted externally by holding the animal's neck region over a shielded scintilation detector every 24-hours for five days after the subctaneous injection of 10μc of carrier-free I131.
    Monthly mean values of the rate of I131 24-hour uptake by the thyroid gland were changed in a di-phasic form of seasonal variation, rising in severe weathers, both hot and cold, and falling in intermediate mild seasons. Averages of biologic I131 half-time also varied every month di-phasically throughout a year, being shortened in the winter and even in the summer and, reversely, prolonged in the spring and the fall.
    From the findings above-mentioned, the author infers that the iodine-uptake by the thyroid gland and the release of hormonal iodine from the gland are accelerated both in hot and cold weather and are depressed in mild weather such as spring and fall.
  • 大峯 英昭
    1964 年 40 巻 4 号 p. 290-299,273
    発行日: 1964/07/20
    公開日: 2012/09/24
    ジャーナル フリー
    Catecholamine (adrenalin and noradrenalin) in Urine was estimated in 14 positive reactors to Regitine, 14 false positive reactors and 34 negative reactors by the modified Euler-Floding method of Yoshinaga. In all cases their maximal blood pressure was over 170 mmHg and their minimal pressure was over 90 mmHg. Those who shwoed a decrease of maximal pressure over 35 mmHg as well as of minimal pressure over 25 mmHg by the Regitine administration were regarded as positive reactors, those showing a decrease of maximal pressure over 35 mmHg and of minimal pressure under 25 mmHg were regarded as false positive reactos, and those showing a decrease of maximal pressure under 35 mmHg and of minimal pressure under 25 mmHg were regarded as negative reactors.
    More adrenalin and noradrenalin in urine were found in the positive reactors than in healthy persons and the negative reactors. But there was found no difference in the amounts of both adrenalin and noradrenaline in urine among the false positive reactors, the negative reactors and healthy persons.
    The correlation of both adrenalin and noradrenalin to both maximal and minimal blood pressure was not found in the positive and the false positive reactors, though a correlation of noradrenalin to maximal blood pressure was found in the negative reactors.
    It was concluded that the Regitine test has a close relation to noradrenalin, but not to adrenalin.
    The positive reactors were found in 11.7% of the 298 examined whose maximal blood pressure was over 170 mmHg.
  • 有滝 世界爺, 飯島 元興, 鈴木 義昭
    1964 年 40 巻 4 号 p. 300-312,274
    発行日: 1964/07/20
    公開日: 2012/09/24
    ジャーナル フリー
    Effects of an anabolic steroid, 4 Chlorotestosterone Acetate (4 CLTA), on the metabolism of the rat bone system were studied by a 20-day daily intraperitoneal injection of its even dose of 0.5mg in respective of the body weight of the rats, which were devided into two groups according to their weight ; of about 70g (group A), about 100g (group B) and their untreated controls.
    i) An evident increase in the body weight compared with the control was observed after the 10th day in group A, and the 15th day in group B, and the difference between the average of the test group was estimable with P. value of 5%.
    ii) Tibia of the test group had larger major axis and wet and dry weight and lower water content than the control with an estimable difference with P. value of 5%. But little estimable difference between the two average were observed in the minor axis.
    iii) Protein and lipid contents of femur of the test group were higher than those of the controls. Their sampling could not be obtained because the materials were minced together in each group.
    iv) Rediograph of Tibia was darker in the tested group especially at the epiphysis. v) Both net weight and content (% of the dry weight) of total ashes, and also their Ca, P and Mg were estimated to be larger with P. of 5%; Percent Ca, P and Mg of the total ashes had an estimable difference in the case where only Ca and the remainder were negligible.
    vi) Physico-chemical properties of tibia, the means of appearent specific gravity, bulk specific gravity, Vicker's hardness and modulous of elasticity were higher while porcity and water absorption were lower with P. valtue of 5%.
    vii) Histological findings of epiphyseal cartilage of the test group showed the promoted growth of the bone, showing regularity and conciderable thickness of the rod shaped cells.
    viii) Promoted metabolism of condroitin sulfate A and C was detected histochemically in epiphyseal and articular cartilage of the test group.
  • 山田 弘三, 小出 忠孝, 青山 克己, 久野 勉
    1964 年 40 巻 4 号 p. 313-317,275
    発行日: 1964/07/20
    公開日: 2012/09/24
    ジャーナル フリー
    Plasma Insulin-like activity (ILA) after the oral administration of 50 gr glucose was investigated in normal and diabetic subjects. Diabetics were classified into four groups ; untreated obese maturity-onset type, well controlled obese maturity-onset type, poorly controlled juvenile lean type and well controlled juvenile type. The most typical subjects in each group were selected for this study. Blood sugar and ILA were measured at 0, 60,120 and 180 minutes following glucose administration. ILA was assayed by the in vivo method that extracts insulin fraction with acid ethanol from peripheral venous blood and uses hypophysectomized-adrenalectomized-rats.
    The results are as follows :
    In normal subjects, ILA after glucose administration increased markedly with the rise of blood sugar and reached the peak after 60 minutes. Then ILA decreased with the fall of blood sugar and returned to the fasting level or even below it within 180 minutes. In untreated obese maturity-onset diabetics, whose glucose tolerance is severely disturbed, fasting ILA was as high as in normal subjects in spite of the presence of hyperglycemia. And after glucose administration their ILA increased, although it was lower than that in normal subjects. This increased level was sustained for 180 minutes and scarcely decreased in contrast to that in normal subjects whose increased ILA returned to the basal level after 180 minutes. In poorly controlled juvenile lean diabetics, who were treated with insulin and oral hypoglycemic agents the glucose tolerance was still severely disturbed, and showed very low ILA. And this ILA, after glucose administration, scarcely increased or not at all, despite higher elevation of blood sugar. In either maturity-onset or juvenile diabetics, who were controlled well by orall hypoglycemic agents, ILA after glucose administration increased significantly after 60 minutes, and decreased at fasting levels within 180 minutes. Their response was essentially similar to that of normal subjects.
    From the above results it may be concluded that untreated obese maturity-onset-diabetics can secrete insulin but cannot utilize it well ; poorly controlled-juvenile lean diabetics have absolute deficiency of insulin due to depleted insulin reserve ; and well controlled diabetics, whether at maturity onset or juvenile, recover the ability to secrete and utilize insulin well.
  • 特に実験的上皮小体機能異常時における胆汁Ca無機P.クエン酸, 並びに肝核酸の消長について
    吉成 俊太郎
    1964 年 40 巻 4 号 p. 318-338,276
    発行日: 1964/07/20
    公開日: 2012/09/24
    ジャーナル フリー
    The contents of calcium, inorganic phosphorus, citric acid in the serum and the bile were determined, and the changes of calcium and phosphorus in the bile were studied by isotopic technique in the biliary fistulated dogs with parathyroidal disturbance. And to observe the influence of parathyroidal function on the liver, the contents of nucleic acid were determined in the Wistar-strain rats affected with parathyroidal disorder.
    The condition of hyper or hypofunction of the parathyroid gland was affected by the administration of parathyroid hormone and by surgical extirpation of parathyroid gland and by a low Ca and high phosphorus diet during 6 months.
    Whenever there was hyperfunction of the parathyroid gland, hypercalcinemia, hypophosphatemia and hypercitremia were observed. Where as hypocalcinemia, hyperphosphatemia and hypocitremia were observed when the parathyroid gland was in a hypofunction state as compared with control.
    On the other hand, the excretion of the bile Ca, citrate was increased and 45Ca-excretion of the bile at the trace experiment was found to be 7 times increased as compared with control under the hypofunction condition.
    It is reasonable to conclude that the increase of the citrate contents in the blood is caused by nephrectomy, but a remarkable increase of the citrate in the bile was found by the administration of parathyroid hormone after nephrectomy.
    The excretion of calcium and citrate in the bile was found to be increased, especially 45Ca-excretion which was one-half more than the control.
    The contents of nucleic acid in the livers and kidney's of the Wister-strain rats with parathyroidal function disorders were determined to assume the influence of parathyroidal function upon the liver.
    No significant difference was observed in the hepatic DNA contents between the normal rats and the hyperparathyroidal rats whose condition was induced by the administration of parathyroid hormone or by the nephrectomy.
    It is considered that the difference of the influence on liver is caused by the methods which induce the disorder of parathyroidal function.
    From the above-mentioned results, the author supposed that the biochemical change of calcium, inorganic phosphorus and citric acid and nucleic acid metabolism in the serum and bile indicated the strong influence of the parathyroid gland on the liver and kidney, and thus, proposed that there is an intimate correlation between the liver and parathyroid gland.
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