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Volume 41, Issue 7
Displaying 1-9 of 9 articles from this issue
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1965 Volume 41 Issue 7 Pages 803
Published: October 20, 1965
Released on J-STAGE: September 24, 2012
JOURNAL FREE ACCESSDownload PDF (38K) -
Y. OCHI, K. YOKOTA, S. MARUMOTO1965 Volume 41 Issue 7 Pages 804-807
Published: October 20, 1965
Released on J-STAGE: September 24, 2012
JOURNAL FREE ACCESSDownload PDF (449K) -
1965 Volume 41 Issue 7 Pages 819-855
Published: October 20, 1965
Released on J-STAGE: September 24, 2012
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I. Reduction of C-20-KetoneHiroshi OKADA, Shunsaku IWASAKI, Hirohiko TAKE, Kichisaburo MATSUYOSHI ...1965 Volume 41 Issue 7 Pages 856-859,808
Published: October 20, 1965
Released on J-STAGE: September 24, 2012
JOURNAL FREE ACCESSRecently, Westerhof ann Reerink synthetized a potent progestin, 6-dehydro-retro-progesterone, which has the hydrogen atom at C-9 in the β position and the methyl group at C-10 in the a position (Fig. 1). Up to now no investigations on the metabolism of steroid analogues with this configuration (9β, 10α) have been reported. The following experiments describe the in vitro metabolism of 6-dehydro-retroprogesterone in rabbit liver homogenate.View full abstractDownload PDF (665K) -
Ryoichi URA1965 Volume 41 Issue 7 Pages 860-871,810
Published: October 20, 1965
Released on J-STAGE: September 24, 2012
JOURNAL FREE ACCESS131I labeled T3 red blood cell and resin uptake tests were found to be available as one of the important tests for thyroid function.
Some experiments were taken with regards to the mechanism of these tests.
1) The relative value of free T4
The relative value of free T4 in plasma measured by using the method of dialysis showed the highest in hyperthyroid and the lowest in hypothyroid.
The normal one was between the two.
A close relation was found between the value of free T4 and 131I labeled T3 red blood cell or resin uptake.
2) The determination of T4 exogenous binding capacity
The measurement of TBG-T4 exogenous binding capacity as an indication of 131I labeled T3 resin uptake showed the highest, on the contrary, in hypothyroid patients, and the lowest in hyperthyroid.
This fact approved a negative relation between T4 exogenous binding capacity and 131I labeled T3, red blood cell or resin uptake.
3) The measurement of T4 binding affinity
The definition of T4 binding affinity was done mathematically. In measuring T4 binding affinity of TBC by the method of dialysis, the plasma of hypothyroid patients showed the highest value and hyperthyroid the lowest.
There was a medium in the normal plasma. But there was little if any difference. It follows from these results that the level of free T4 in the plasma is regulated by the T4 exogenous binding capacity and binding affinity of TBG, and that free T4 is indirectly detected by 131I labeled T3 red blood cell or resin uptake.View full abstractDownload PDF (1207K) -
Katsumi AOYAMA1965 Volume 41 Issue 7 Pages 872-884,811
Published: October 20, 1965
Released on J-STAGE: September 24, 2012
JOURNAL FREE ACCESSIt is a well-known fact that an incidence of vascular and/or liver disease is considerably high in case of diabetes ; however, the relationship of diabetes to vascular and liver disease is not yet fully understood. The present study was made to investigate the relationship between vascular & liver disease and diabetes, using pancreatectomized dogs fed by high fat diet over a long time.
The results were as follows,
) In case of total pancreatectomy, fasting hyperglycemia continued, and serum lipid levels like cholesterol, lipid-P and N.E.F.A. showed also a rise, and plasma insulin like activity was nearly zero. However, there was no marked difference of the said components between controls and subtotally pancreatectomized dogs.
2) In a short time after pancreatectomy pyridoxin phosphorylation was disturbed, then returned to normal by the administration of insulin. However, that was not recovered even by administration of insulin long after the pancreatectomy.
3) In case of total pancreatectomy, the microscopic findings revealed edema and fibrous thickening of the intima, rupture of the internal elastic lamella, and calcification and hyalinization of the media of the aorta. Two out of fifteen dogs showed stenosis of the vessels in the heart muscle.
4) Electrocardiogram revealed abnormality in 50 per cent of diabetic dogs, which wos mostly noted in ST and T waves.
5) In case of total pancreatectomy, liver function was markedly disturbed, and microscopic findings showed considerable fatty metamorphosis, abnormal arrangement of liver cells, and focal hemorrhage & necrosis.
These results revealed that high fat loading diet under insulin deficiency play a role of incidence and development of vascular and liver disease. These facts seem to infer the importance of studying the relationship of diabetes mellitus to vascular and liver disease.View full abstractDownload PDF (4000K) -
Michiya KISHIMOTO1965 Volume 41 Issue 7 Pages 885-899,812
Published: October 20, 1965
Released on J-STAGE: September 24, 2012
JOURNAL FREE ACCESSIt is well known that infection, injury and operation cause aggravation of diabetes and an increase of insulin requirement in diabetics. However, the reasons for these phenomena have remained uncertain. The present study deals with the metabolic changes of glucose, fructose and insulin in experimental pneumococcus infected rats.
In the first experiment, Wister rats weighing 120-150 gm. were made granuloma pouch on their back, and pneumococcus (type II) was administered in the pouch. The rats were sacrificed 24 hours after injection, and hemidiaphragm was prepared and incubated with labbeled glucose or fructose. Glucose or fructose uptake, incorporation of glucose or fructose into carbon dioxide or incorporation of glucose or fructose into glycogen were measured. The uptake and the incorporation into carbon dioxide or glycogen from labelled glucose or fructose were decreased in pneumococcus infected group.
In the second experiment, rat serum was incubated with I-131 insulin. Then the protein fractions were separated electrophoretically using cellulose acetate membrane, and radioactivity of each protein fractions was counted. The radioactivity of I-131 insulin was found in the albumin, α1 and α2 globulin fractions in the rat serum. This I-131 insulin bound serum was reincubated with normal rat hemidiaphragm, and this was also separated electrophoretically and counted. Glucose uptake of the hemidiaphragm was measured simultaneously. The radioactivity before and after incubation with normal rat hemidiaphragm was compared.
In infected rat serum, the separation of I-131 insulin from albumin fraction after incubation with hemidiaphragm was markedly less than that of normal rat serum and glucose uptake was decreased. There was a close relation with the separation of I-131 insulin from albumin fraction and glucose uptake. The author found the same phenomenon in the sera of patients who have infections.
These results indicate that the difficulty of the peripheral utilization of protein bound insulin may be one reason for aggravation of diabetes in infection.View full abstractDownload PDF (1790K) -
Toshiya KAWASHIMA1965 Volume 41 Issue 7 Pages 900-911,813
Published: October 20, 1965
Released on J-STAGE: September 24, 2012
JOURNAL FREE ACCESSPigeon crop-sac test had been employed as the only practical way for the determination of Prolaction (PL) since Riddle et al. (1932). Strictly speaking, this reaction was not specific, because a similar macroscopically positive finding was caused by PL (pituitary) and PL-like substances, extracted from blood and urine. But microscopically, a diffuse fat deposition in the pigeon crop-sac tissue (“diffuse cytoplasmic sudanophily” by FUJII) was detected by only pituitary PL.
To be described in the present paper is a Gas-chromatographic estimation of total and individual higher fatty acids in the pigeon crop-sac tissue injected with materials. Methods : The materials were injected intradermally four successive days just over the right crop-sac of young pigeons, and saline was injected over the left-side as the control.
On the fifth day autopsy was carried out.
After the macroscopic detection, crop-sac tissue was stretched over a cork-board, divided 2 cm. in diameter with cork-borer, and wet weight was recorded. Following fat extraction, saponification and BF3 methylation, fatty-acids were analysed on gas-chromatography.
Weights of fatty-acids were calculated on the chromatographic chart comparing to previously added margaric acid as an internal standard.
Results :
1) Total neutral fat in unit wet weight of pigeon crop-sac increased linearly to the logarism of Prolaction doses and gave the experimental equation as :
=1.56 log × +13.7 (mg/g)
x : doses of bovine Prolaction (i.u.).
y : (total fat in right crop-sac. mg/g) - (total fat in left crop-sac mg/g).
2) Among the higher fatty-acids fractions, oleic acid and linolic acid were markedly increased by the injection of bovine Prolaction, and O-S or L-S ratio ranged 1.4 to 2.0.
Oleic acid in right crop-sac Stearic acid in right crop-sac ÷ Oleic acid in left crop-sac Stealic acid in left crop-sac O-S ratio.
Linolic acid in right crop-sac Stearic acid in right crop-sac ÷ Linolic acid in left crop-sac Stearic acid in left crop-sac L-S ratio.
3) Those responses were characteristic of pituitary Prolaction, but not of PL-like substances or placental and pituitary gonadotropinesView full abstractDownload PDF (1932K) -
H. YOSHIDA, I. FUKUI, Y. TAKESHITA, T. YAMAZAKI, H. YOSHIOKA, N. HIROT ...1965 Volume 41 Issue 7 Pages 912-915,814
Published: October 20, 1965
Released on J-STAGE: September 24, 2012
JOURNAL FREE ACCESSOne hundred sixty-five thyroid patients, consisting of 51 euthyroid, 56 simple goiter, 48 hyperthyroid, and 10 hypothyroid patients in our thyroid clinic, were tested for the uptake of I131-triiodothyronine (I131T3) by the red blood cells and compared with other thyroid function tests (PBI, BMR, I131 Uptake of thyroid, Conversion rate and total Cholesterol.).
The uptake of the red cells in various thyroid diseases was as follows : Range (in %) and Mean ± SD
Euthyroid 9.0 -22.0 15.0 ± 3.0
Simple goiter 8.6 -40.5 19.6
11.6
Hyperthyroid 9.3-56.0 27.8 ± 11.6
Hypothyroid 7.7-17.5 12.8±3.8
The uptake of red cells significantly differed in hyperthyroid from euthyroid and simple goiter, especially from hypothyroid group (p = 0.05).
Also, our results show that this test coincides with other thyroid function tests.View full abstractDownload PDF (459K)
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