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Volume 45, Issue 3
Displaying 1-6 of 6 articles from this issue
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By the Retention Cannula Method for Collecting Lumbo-Adrenal Venous Blood in the DogMinoru OHTA1969 Volume 45 Issue 3 Pages 284-309,275
Published: June 20, 1969
Released on J-STAGE: September 24, 2012
JOURNAL FREE ACCESSHirai reported that adrenal 17-OHCS secretion increased in dogs breathing 10% oxygen for two hours at ground level. But the relation between 17-0HCS secretion rate and the arterial oxygen content were not described.
In this study, the relation between the degree of hypoxemia and adrenal 17-OHCS secretion was studied.
The adrenal 17-0HCS secretion rate showed no significant increase by inhalation of 21% and 14% O2 gases (Control group and group A).
In the B, C and D group, the adrenal 17-OHCS secretion rates increased markedly.
Group C showed the highest response in adrenal 17-0HCS secretion rate. This response was even higher than that shown by group D.
Therefore, the maxiumm adrenocortical 17-0HCS secretion response to low oxygen gas respiration was obtained by the 7% O2 mixture; indicating that the point to this type of stimulus in these dogs existed possibly between 7% and 5% O2 respiration.
The adrenal 17-0HCS secretion showed no significant increase in the dogs which inhaled 10% O2 gas after administration of Dexamethasone (the E group). From this, it may be suggested that adrenocortical 17-0HCS sectreion is activated by hypoxemia, and its activation is mediated via the hypothalamic-hypophyseal system.View full abstractDownload PDF (2724K) -
Its Effects on Carbohydrate Metabolism in Skeletal MuscleK. INOUE, T. ADACHI, R. OIKAWA1969 Volume 45 Issue 3 Pages 310-320,278
Published: June 20, 1969
Released on J-STAGE: September 24, 2012
JOURNAL FREE ACCESSThe relationship between the effects of the catecholamines and the thyroid hormones have been studied for more than 100 years. The mechanism of this interrelationship has been the subject of many investigations, but the results have been divergent and have not led to any generally accepted explanation.
We confirmed in the previous experiment that reserpine and guanethidine treated hyperthyroid patients showed definite clinical improvement, for example, decrease of palpitation and sweating, while no changes in the basal metabolic rate and uptake of radioactive iodine was observed. Furthermore, no potentiation was found in the effects of catecholamines on the phosphorylase activity in the hyperthyroid rat heart. It was therefore considered desirable to study this relationship between the catecholamine and thyroid hormone in two parts : firstly the relationship in the metabolic system, and secondly the relationship in the cardiovascular system.
This investigation was undertaken to determene the effect of adrenaline on the carbohydrate metabolism in the hyperhtyroid rat muscle using a hind quarter preparation technique.View full abstractDownload PDF (1382K) -
Kyugo ONOE, Kumiki KOBASHI, Saturu MATSUMO, Tomoo NII, Takehisa HAMAJO1969 Volume 45 Issue 3 Pages 321-325,280
Published: June 20, 1969
Released on J-STAGE: September 24, 2012
JOURNAL FREE ACCESSThe significance of the hypophysis in the experimental diabetic state of animals was established by the classical papers of Houssay and Young in the 1930's and 1940's.
Pfeifer and associates have reported that hypophysectomy on dogs resulted in a reduction of serum ILA. (epididymal fat pad) and of blood sugar. In this paper we attempt to ascertain that a reduction of serum insulin by radioimmunoassay will occur after hypophysectomy on rats.View full abstractDownload PDF (612K) -
Susumu ADACHI1969 Volume 45 Issue 3 Pages 326-334,282
Published: June 20, 1969
Released on J-STAGE: September 24, 2012
JOURNAL FREE ACCESSDifferences in the metabolism between epididymal white fat and interscapular brown fat in guinea pigs were investigated in order to determine the effect of prednisolone on the release of free fatty acids (FFA) and the lipogenesis.
1) The release of FFA from adipose tissue in vitro into the incubation medium was increased 3 hrs, after the injection of 5 mg of prednisolone both in brown fat and in white fat.
2) The addition of prednisolone into the incubation medium at the concentration of 0.8 μg/ml caused an increase in the release of FFA from interscapular brown fat, but not from epididymal white fat.
3) The addition of blood serum obtained from a guinea pig which had received an injection of prednisolone did increase the release of FFA in vitro from epididymal white fat obtained from the same animal, but did not increase the release of FFA from interscapular brown fat.
4) The release of FFA from interscapular brown fat in vitro was depressed in the animal which received an injection of 5 mg of prednisolone per day for two weeks.
5) The long term administration of prednisolone resulted in an increase in the incorporation of glucose-U-14C into the nonfatty acid portion of triglyceride in interscapular brown fat.
The fatty acid composition of this tissue showed an increase of palmitic acid and a decrease of linoleic acid after prednisolone treatment.
6) Results obtained in the present investigation show that the decrease in the release of FFA and the increase in lipogenesis in interscapular brown fat make favorable conditions for accumulation of fat in this tissue in giunea pigs treated with a long term administration of prednisolone.View full abstractDownload PDF (972K) -
On the Secretory Activity of the Chief CellSyozo TANAKA1969 Volume 45 Issue 3 Pages 335-338_4,283
Published: June 20, 1969
Released on J-STAGE: September 24, 2012
JOURNAL FREE ACCESSAn electron microscopic observation was made on the normal and EDTA treated parathyroid glands of the rabbit. The parathyroid glands from normal and EDTA treated rabbits were cut into small blocks and fixed for 2 hours in 1 per cent OsO4 in pH 7.4 s-col-lidine buffer at low temperature about 0-4°C, then stained with uranyl acetate for 1 hour. The blocks were dehydrated in a graded series of ethanol and embedded in epoxy resin. Sections cut on a Porter-Blum MT-1 ultramicrotome using glass knives were stained with Lead citrate and examined through an HU-7A or HU-11A electron microscope. The results obtained are summarized as follows :
1) Secretory granules of the parathyroid gland are round, membrane-bound granules 200 to 400 mp in diameter and contain numerous electron-dense, minute particles.
2) A small process containing the material of slightly greater density than the surrounding cytoplasm is seen at a part of the rough-surfaced endoplasmic reticulum facing the Golgi apparatus. The secretory material within the rough-surfaced endoplasmic reticulum seems to be transported to the Golgi apparatus by this process.
3) In the region of the Golgi apparatus there are many membrane-limited vesicles which contain the slightly electron-dense material.
In approaching the plasma membrane, they enlarge and increase the internal density, and become secretory granules.
4) Most of the secretory granules are seen near the plasma membrane. Occasionally, fusion of the limiting membrane of the granule with the plasma membrane has been observed.
5) When the secretory granule is extruded, the limiting membrane of the granule fuses with the plasma membrane and, through the fused plasma and limiting membrane the granule may be extruded. The limiting membrane never vanishes before it fuses with the plasma membrane. On viewing many sections there is some suggestion of a possibility of the eruptocrine mechanism of secretion.
6) At the chief cell coming in no contact with the pericapillary space, secretory substance is thought to be extruded into the intercellular space, through which it is transported to the pericapillary space.View full abstractDownload PDF (6995K) -
1969 Volume 45 Issue 3 Pages 339-367
Published: June 20, 1969
Released on J-STAGE: September 24, 2012
JOURNAL FREE ACCESSDownload PDF (4370K)
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